메뉴 건너뛰기




Volumn 2, Issue 12, 2011, Pages 1633-1653

Opportunities and challenges for oral delivery of hydrophobic versus hydrophilic peptide and protein-like drugs using lipid-based technologies

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; CYCLOSPORIN A; FORTAVASE; INSULIN; LEUPRORELIN; MURAMYL DIPEPTIDE DERIVATIVE; N ACETYLGLUCOSAMINYL N ACETYLMURAMYL; NONIONIC SURFACTANT; SALCATONIN; SAQUINAVIR; SOLID LIPID NANOPARTICLE; UNCLASSIFIED DRUG;

EID: 81255198647     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.11.128     Document Type: Review
Times cited : (30)

References (130)
  • 1
    • 0037393955 scopus 로고    scopus 로고
    • Challenges for the oral delivery of macromolecules
    • Goldberg M, Gomez-Orellana I. Challenges for the oral delivery of macromolecules. Nat. Rev. Drug Discov. 2(4), 289-295 (2003). (Pubitemid 37361687)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.4 , pp. 289-295
    • Goldberg, M.1    Gomez-Orellana, I.2
  • 3
    • 0027396128 scopus 로고
    • Pharmacokinetics of 1-deamino-8-D-arginine vasopressin after various routes of administration in healthy volunteers
    • Fjellestad-Paulsen A, Hoglund P, Lundin S, Paulsen O. Pharmacokinetics of 1-deamino-8-D-arginine vasopressin after various routes of administration in healthy volunteers. Clin. Endocrinol. 38(2), 177-182 (1993). (Pubitemid 23042726)
    • (1993) Clinical Endocrinology , vol.38 , Issue.2 , pp. 177-182
    • Fjellestad-Paulsen, A.1    Hoglund, P.2    Lundin, S.3    Paulsen, O.4
  • 5
    • 33847394968 scopus 로고    scopus 로고
    • Lipids and lipid-based formulations: Optimizing the oral delivery of lipophilic drugs
    • DOI 10.1038/nrd2197, PII NRD2197
    • Porter CJH, Trevaskis NL, Charman WN. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat. Rev. Drug Discov. 6(3), 231-248 (2007). (Pubitemid 46344627)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.3 , pp. 231-248
    • Porter, C.J.H.1    Trevaskis, N.L.2    Charman, W.N.3
  • 6
    • 39149126301 scopus 로고    scopus 로고
    • Biopharmaceutical challenges associated with drugs with low aqueous solubility -The potential impact of lipid-based formulations
    • O'Driscoll CM, Griffin BT. Biopharmaceutical challenges associated with drugs with low aqueous solubility -the potential impact of lipid-based formulations. Adv. Drug Deliv. Rev. 60(6), 617-624 (2008).
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , Issue.6 , pp. 617-624
    • O'driscoll, C.M.1    Griffin, B.T.2
  • 7
    • 0023790699 scopus 로고
    • Systemic delivery of therapeutic peptides and proteins
    • Banga AK, Chien YW. Systemic delivery of therapeutic peptides and proteins. Int. J. Pharm. 48(1-3), 15-50 (1988).
    • (1988) Int. J. Pharm. , vol.48 , Issue.1-3 , pp. 15-50
    • Banga, A.K.1    Chien, Y.W.2
  • 8
    • 3042761213 scopus 로고    scopus 로고
    • Structure-immunogenicity relationships of therapeutic proteins
    • DOI 10.1023/B:PHAM.0000029275.41323.a6
    • Hermeling S, Crommelin DJA, Schellekens H, Jiskoot W. Structure-immunogenicity relationships of therapeutic proteins. Pharm. Res. 21(6), 897-903 (2004). (Pubitemid 38870136)
    • (2004) Pharmaceutical Research , vol.21 , Issue.6 , pp. 897-903
    • Hermeling, S.1    Crommelin, D.J.A.2    Schellekens, H.3    Jiskoot, W.4
  • 9
    • 0029074505 scopus 로고
    • Using microemulsion formulations for oral-drug delivery of therapeutic peptides
    • Sarciaux JM, Acar L, Sado PA. Using microemulsion formulations for oral-drug delivery of therapeutic peptides. Int. J. Pharm. 120(2), 127-136 (1995).
    • (1995) Int. J. Pharm. , vol.120 , Issue.2 , pp. 127-136
    • Sarciaux, J.M.1    Acar, L.2    Sado, P.A.3
  • 10
    • 0029730138 scopus 로고    scopus 로고
    • Oral protein drug delivery
    • Wang W. Oral protein drug delivery. J. Drug Target. 4(4), 195-232 (1996). (Pubitemid 26421822)
    • (1996) Journal of Drug Targeting , vol.4 , Issue.4 , pp. 195-232
    • Wang, W.1
  • 12
    • 0025882648 scopus 로고
    • Microemulsions for improved peptide absorption from the gastrointestinal tract
    • Ritschel WA. Microemulsions for improved peptide absorption from the gastrointestinal tract. Methods Find. Exp. Clin. Pharmacol. 13(3), 205-220 (1991).
    • (1991) Methods Find. Exp. Clin. Pharmacol. , vol.13 , Issue.3 , pp. 205-220
    • Ritschel, W.A.1
  • 13
    • 0023735020 scopus 로고
    • Enzymatic barriers to peptide and protein absorption
    • Lee VH. Enzymatic barriers to peptide and protein absorption. Crit. Rev. Ther. Drug Carrier Syst. 5(2), 69-97 (1988).
    • (1988) Crit. Rev. Ther. Drug Carrier Syst. , vol.5 , Issue.2 , pp. 69-97
    • Lee, V.H.1
  • 15
    • 33646492929 scopus 로고    scopus 로고
    • Tight junction modulation and its relationship to drug delivery
    • Salama NN, Eddington ND, Fasano A. Tight junction modulation and its relationship to drug delivery. Adv. Drug Deliv. Rev. 58(1), 15-28 (2006).
    • (2006) Adv. Drug Deliv. Rev. , vol.58 , Issue.1 , pp. 15-28
    • Salama, N.N.1    Eddington, N.D.2    Fasano, A.3
  • 16
    • 0027972645 scopus 로고
    • Biochemical and morpho-cytochemical evidence for the intestinal absorption of insulin in control and diabetic rats. Comparison between the effectiveness of duodenal and colon mucosa
    • Bendayan M, Ziv E, Gingras D, Ben-Sasson R, Bar-On H, Kidron M. Biochemical and morpho-cytochemical evidence for the intestinal absorption of insulin in control and diabetic rats. Comparison between the effectiveness of duodenal and colon mucosa. Diabetologia 37(2), 119-126 (1994). (Pubitemid 24042878)
    • (1994) Diabetologia , vol.37 , Issue.2 , pp. 119-126
    • Bendayan, M.1    Ziv, E.2    Gingras, D.3    Ben-Sasson, R.4    Bar-On, H.5    Kidron, M.6
  • 17
    • 0027509507 scopus 로고
    • Enteral absorption of octreotide: Absorption enhancement by polyoxyethylene-24-cholesterol ether
    • Drewe J, Fricker G, Vonderscher J, Beglinger C. Enteral absorption of octreotide: absorption enhancement by polyoxyethylene-24-cholesterol ether. Br. J. Pharmacol. 108(2), 298-303 (1993). (Pubitemid 23032529)
    • (1993) British Journal of Pharmacology , vol.108 , Issue.2 , pp. 298-303
    • Drewe, J.1    Fricker, G.2    Vonderscher, J.3    Beglinger, C.4
  • 18
    • 0030903756 scopus 로고    scopus 로고
    • Effect of size and charge on the, passive diffusion of peptides across caco-2 cell monolayers via the paracellular pathway
    • DOI 10.1023/A:1012040425146
    • Pauletti GM, Okumu FW, Borchardt RT. Effect of size and charge on the passive diffusion of peptides across Caco-2 cell monolayers via the paracellular pathway. Pharm. Res. 14(2), 164-168 (1997). (Pubitemid 27146358)
    • (1997) Pharmaceutical Research , vol.14 , Issue.2 , pp. 164-168
    • Pauletti, G.M.1    Okumu, F.W.2    Borchardt, R.T.3
  • 19
    • 0026513211 scopus 로고
    • The influence of peptide structure on transport across Caco-2 cells. II. Peptide bond modification which results in improved permeability
    • Conradi RA, Hilgers AR, Ho NF, Burton PS. The influence of peptide structure on transport across Caco-2 cells. II. Peptide bond modification which results in improved permeability. Pharm. Res. 9(3), 435-439 (1992).
    • (1992) Pharm. Res. , vol.9 , Issue.3 , pp. 435-439
    • Conradi, R.A.1    Hilgers, A.R.2    Ho, N.F.3    Burton, P.S.4
  • 20
    • 0026758261 scopus 로고
    • Structural specificity of mucosal-cell transport and metabolism of peptide drugs: Implication for oral peptide drug delivery
    • Bai JP, Amidon GL. Structural specificity of mucosal-cell transport and metabolism of peptide drugs: implication for oral peptide drug delivery. Pharm. Res. 9(8), 969-978 (1992).
    • (1992) Pharm. Res. , vol.9 , Issue.8 , pp. 969-978
    • Bai, J.P.1    Amidon, G.L.2
  • 21
    • 0342437513 scopus 로고    scopus 로고
    • Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies
    • DOI 10.1016/S0169-409X(97)00045-8, PII S0169409X97000458
    • GM Paulettia, S Gangwara, TJ Siahaana, J Aubéd, RT Borchardt. Improvement of oral peptide bioavailability: peptidomimetics and prodrug strategies. Adv. Drug Deliv. Rev. 27(2-3), 235-256 (1997). (Pubitemid 27417875)
    • (1997) Advanced Drug Delivery Reviews , vol.27 , Issue.2-3 , pp. 235-256
    • Pauletti, G.M.1    Gangwar, S.2    Siahaan, T.J.3    Aube, J.4    Borchardt, R.T.5
  • 22
    • 0033843181 scopus 로고    scopus 로고
    • Oral absorption of peptides through the cobalamin (vitamin B12) pathway in the rat intestine
    • DOI 10.1023/A:1007556108673
    • Alsenz J, Russell-Jones GJ, Westwood S, Levet-Trafit B, De Smidt PC. Oral absorption of peptides through the cobalamin (vitamin B12) pathway in the rat intestine. Pharm. Res. 17(7), 825-832 (2000). (Pubitemid 30666963)
    • (2000) Pharmaceutical Research , vol.17 , Issue.7 , pp. 825-832
    • Alsenz, J.1    Russell-Jones, G.J.2    Westwood, S.3    Levet-Trafit, B.4    De Smidt, P.C.5
  • 23
    • 38949124027 scopus 로고    scopus 로고
    • Currently marketed oral lipid based dosage forms:drug products and excipeints
    • Hauss DJ (Ed.). Informa Healthcare, London, UK
    • Strickley RG. Currently marketed oral lipid based dosage forms:drug products and excipeints. In: Oral Lipid Based Formulations. Hauss DJ (Ed.). Informa Healthcare, London, UK, 1-32 (2007).
    • (2007) Oral Lipid Based Formulations , pp. 1-32
    • Strickley, R.G.1
  • 24
    • 39149098424 scopus 로고    scopus 로고
    • Lipid-based systems for the enhanced delivery of poorly water soluble drugs
    • Porter CJH, Wasan KM, Constantinides P. Lipid-based systems for the enhanced delivery of poorly water soluble drugs. Adv. Drug Deliv. Rev. 60(6), 615-616 (2008).
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , Issue.6 , pp. 615-616
    • Porter, C.J.H.1    Wasan, K.M.2    Constantinides, P.3
  • 26
    • 0007044753 scopus 로고
    • Molecular diffusion in microemulsions
    • Friberg SE, Bothorel P (Eds). CRC Press, FL, USA
    • Lindman B, Stibbs P. Molecular diffusion in microemulsions. In; Microemulsions: Structure and Dynamics. Friberg SE, Bothorel P (Eds). CRC Press, FL, USA, 119-152 (1987).
    • (1987) Microemulsions: Structure and Dynamics , pp. 119-152
    • Lindman, B.1    Stibbs, P.2
  • 27
    • 0034614208 scopus 로고    scopus 로고
    • Microemulsion-based media as novel drug delivery systems
    • Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv. Drug Deliv. Rev. 45(1), 89-121 (2000).
    • (2000) Adv. Drug Deliv. Rev. , vol.45 , Issue.1 , pp. 89-121
    • Lawrence, M.J.1    Rees, G.D.2
  • 28
    • 0028194817 scopus 로고
    • Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs
    • DOI 10.1016/0378-5173(94)90271-2
    • Shah NH, Carvajal MT, Patel CI, Infeld MH, Malick AW. Self emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. Int. J. Pharm. 106(1), 15-23 (1994). (Pubitemid 24110060)
    • (1994) International Journal of Pharmaceutics , vol.106 , Issue.1 , pp. 15-23
    • Shah, N.H.1    Carvajal, M.T.2    Patel, C.I.3    Infeld, M.H.4    Malick, A.W.5
  • 29
    • 0035984949 scopus 로고    scopus 로고
    • Lipid based formulations for intestinal lymphatic delivery
    • O'Driscoll CM. Lipid based formulations for intestinal lymphatic delivery. Eur. J. Pharm. Sci. 15(5), 405-415 (2002).
    • (2002) Eur. J. Pharm. Sci. , vol.15 , Issue.5 , pp. 405-415
    • O'driscoll, C.M.1
  • 30
    • 0034601204 scopus 로고    scopus 로고
    • Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs
    • DOI 10.1016/S0939-6411(00)00089-8, PII S0939641100000898
    • Gershanik T, Benita S. Self dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur. J. Pharm. Biopharm. 50(1), 179-188 (2000). (Pubitemid 30326696)
    • (2000) European Journal of Pharmaceutics and Biopharmaceutics , vol.50 , Issue.1 , pp. 179-188
    • Gershanik, T.1    Benita, S.2
  • 31
    • 0026571249 scopus 로고
    • Intestinal permeability enhancement for proteins, peptides and other polar drugs: Mechanisms and potential toxicity
    • Swenson ES, Curtalo WJ. Intestinal permeability enhancement for proteins, peptides and other polar drugs: mechanisms and potential toxicity. Adv. Drug Deliv. Rev. 8, 39-92 (1992).
    • (1992) Adv. Drug Deliv. Rev. , vol.8 , pp. 39-92
    • Swenson, E.S.1    Curtalo, W.J.2
  • 32
    • 0029562489 scopus 로고
    • Lipid microemulsions for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects
    • DOI 10.1023/A:1016268311867
    • Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption -physical and biopharmaceutical aspects. Pharm. Res. 12(11), 1561-1572 (1995). (Pubitemid 26005509)
    • (1995) Pharmaceutical Research , vol.12 , Issue.11 , pp. 1561-1572
    • Constantinides, P.P.1
  • 33
    • 71949106600 scopus 로고    scopus 로고
    • The drug transporter-metabolism alliance: Uncovering and defining the interplay
    • Benet LZ. The drug transporter-metabolism alliance: uncovering and defining the interplay. Mol. Pharm. 6(6), 1631-1643 (2009).
    • (2009) Mol. Pharm. , vol.6 , Issue.6 , pp. 1631-1643
    • Benet, L.Z.1
  • 34
    • 33751014029 scopus 로고    scopus 로고
    • Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system
    • DOI 10.1016/j.ejps.2006.04.016, PII S0928098706001151
    • Pouton CW. Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. Eur. J. Pharm. Sci. 29(3-4), 278-287 (2006). (Pubitemid 44740131)
    • (2006) European Journal of Pharmaceutical Sciences , vol.29 , Issue.3-4 SPEC. ISS. , pp. 278-287
    • Pouton, C.W.1
  • 35
    • 0028081549 scopus 로고
    • Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions incorporating medium-chain glycerides
    • DOI 10.1023/A:1018927402875
    • Constantinides PP, Scalart JP, Lancaster C et al. Formulation and intestinal-absorption enhancement evaluation of water-in-oil microemulsions incorporating medium-chain glycerides. Pharm. Res. 11(10), 1385-1390 (1994). (Pubitemid 24339642)
    • (1994) Pharmaceutical Research , vol.11 , Issue.10 , pp. 1385-1390
    • Constantinides, P.P.1    Scalart, J.-P.2    Lancaster, C.3    Marcello, J.4    Marks, G.5    Ellens, H.6    Smith, P.L.7
  • 36
    • 0030028851 scopus 로고    scopus 로고
    • Water-in-oil microemulsions containing medium-chain fatty acids/salts: Formulation and intestinal absorption enhancement evaluation
    • DOI 10.1023/A:1016030812272
    • Constantinides PP, Welzel G, Ellens H et al. Water-in-oil microemulsions containing medium-chain fatty acids salts: formulation and intestinal absorption enhancement evaluation. Pharm. Res. 13(2), 210-215 (1996). (Pubitemid 26072140)
    • (1996) Pharmaceutical Research , vol.13 , Issue.2 , pp. 210-215
    • Constantinides, P.P.1    Welzel, G.2    Ellens, H.3    Smith, P.L.4    Sturgis, S.5    Yiv, S.H.6    Owen, A.B.7
  • 37
    • 0029009439 scopus 로고
    • Enhanced intestinal-absorption of an RGD peptide from water-in-oil microemulsions of different composition and particle-size
    • Constantinides PP, Lancaster CM, Marcello J et al. Enhanced intestinal-absorption of an RGD peptide from water-in-oil microemulsions of different composition and particle-size. J. Control. Release 34(2), 109-116 (1995).
    • (1995) J. Control. Release , vol.34 , Issue.2 , pp. 109-116
    • Constantinides, P.P.1    Lancaster, C.M.2    Marcello, J.3
  • 38
    • 0034630042 scopus 로고    scopus 로고
    • Factors limiting the oral bioavailability of N-acetylglucosaminyl-N- acetylmuramyl dipeptide (GMDP) and enhancement of absorption in rats by delivery in a water-in-oil microemulsion
    • DOI 10.1016/S0378-5173(00)00349-5, PII S0378517300003495
    • Lyons KC, Charman WN, Miller R, Porter CJ. Factors limiting the oral bioavailability of N-acetylglucosaminyl-N-acetylmuramyl dipeptide (GMDP) and enhancement of absorption in rats by delivery in a water-in-oil microemulsion. Int. J. Pharm. 199(1), 17-28 (2000). (Pubitemid 30224501)
    • (2000) International Journal of Pharmaceutics , vol.199 , Issue.1 , pp. 17-28
    • Lyons, K.C.1    Charman, W.N.2    Miller, R.3    Porter, C.J.H.4
  • 39
    • 34248648186 scopus 로고    scopus 로고
    • Factors affecting protein release behavior from surfactant-protein complexes under physiological conditions
    • DOI 10.1016/j.ijpharm.2007.01.041, PII S0378517307000993
    • Yoshiura H, Hashida M, Kamiya N, Goto M. Factors affecting protein release behavior from surfactant-protein complexes under physiological conditions. Int. J. Pharm. 338(1-2), 174-179 (2007). (Pubitemid 46777235)
    • (2007) International Journal of Pharmaceutics , vol.338 , Issue.1-2 , pp. 174-179
    • Yoshiura, H.1    Hashida, M.2    Kamiya, N.3    Goto, M.4
  • 40
    • 0036159895 scopus 로고    scopus 로고
    • Evaluation of the in-vitro digestion profiles of long and medium chain glycerides and the phase behaviour of their lipolytic products
    • DOI 10.1211/0022357021771896
    • Sek L, Porter CJH, Kaukonen AM, Charman WN. Evaluation of the in vitro digestion profiles of long and medium chain glycerides and the phase behaviour of their lipolytic products. J. Pharm. Pharmacol. 54(1), 29-41 (2002). (Pubitemid 34116220)
    • (2002) Journal of Pharmacy and Pharmacology , vol.54 , Issue.1 , pp. 29-41
    • Sek, L.1    Porter, C.J.H.2    Kaukonen, A.M.3    Charman, W.N.4
  • 41
    • 57149136074 scopus 로고    scopus 로고
    • Lipid-based formulations for danazol containing a digestible surfactant, Labrafil M2125CS: In vivo bioavailability and dynamic in vitro lipolysis
    • Mullertz A, Larsen A, Holm R, Pedersen ML. Lipid-based formulations for danazol containing a digestible surfactant, Labrafil M2125CS: in vivo bioavailability and dynamic in vitro lipolysis. Pharm. Res. 25(12), 2769-2777 (2008).
    • (2008) Pharm. Res. , vol.25 , Issue.12 , pp. 2769-2777
    • Mullertz, A.1    Larsen, A.2    Holm, R.3    Pedersen, M.L.4
  • 42
    • 0037452443 scopus 로고    scopus 로고
    • Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion
    • DOI 10.1016/S0378-5173(02)00674-9
    • Toorisaka E, Ono H, Arimori K, Kamiya N, Goto M. Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion. Int. J. Pharm. 252(1-2), 271-274 (2003). (Pubitemid 36126637)
    • (2003) International Journal of Pharmaceutics , vol.252 , Issue.1-2 , pp. 271-274
    • Toorisaka, E.1    Ono, H.2    Arimori, K.3    Kamiya, N.4    Goto, M.5
  • 43
    • 24344446947 scopus 로고    scopus 로고
    • An enteric-coated dry emulsion formulation for oral insulin delivery
    • DOI 10.1016/j.jconrel.2005.05.022, PII S016836590500249X
    • Toorisaka E, Hashida M, Kamiya N, Ono H, Kokazu Y, Goto M. An enteric-coated dry emulsion formulation for oral insulin delivery. J. Control. Release 107(1), 91-96 (2005). (Pubitemid 41253705)
    • (2005) Journal of Controlled Release , vol.107 , Issue.1 , pp. 91-96
    • Toorisaka, E.1    Hashida, M.2    Kamiya, N.3    Ono, H.4    Kokazu, Y.5    Goto, M.6
  • 44
    • 0030949023 scopus 로고    scopus 로고
    • Cytotoxicity of solid lipid nanoparticles as a function of the lipid matrix and the surfactant
    • DOI 10.1023/A:1012043315093
    • Muller RH, Ruhl D, Runge S, Schulze-Forster K, Mehnert W. Cytotoxicity of solid lipid nanoparticles as a function of the lipid matrix and the surfactant. Pharm. Res. 14(4), 458-462 (1997). (Pubitemid 27205004)
    • (1997) Pharmaceutical Research , vol.14 , Issue.4 , pp. 458-462
    • Muller, R.H.1    Ruhl, D.2    Runge, S.3    Schulze-Forster, K.4    Mehnert, W.5
  • 45
    • 34547899919 scopus 로고    scopus 로고
    • Solid lipid nanoparticles as a drug delivery system for peptides and proteins
    • DOI 10.1016/j.addr.2007.04.007, PII S0169409X07000439, Lipid Nanoparticles: Recent Advances
    • Almeida AJ, Souto E. Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Adv. Drug Deliv. Rev. 59(6), 478-490 (2007). (Pubitemid 47260710)
    • (2007) Advanced Drug Delivery Reviews , vol.59 , Issue.6 , pp. 478-490
    • Almeida, A.J.1    Souto, E.2
  • 46
    • 24444443072 scopus 로고
    • Incorporation in lipospheres of [d-Trp-6]Lhrh
    • Morel S, Gasco MR, Cavalli R. Incorporation in lipospheres of [d-Trp-6]Lhrh. Int. J. Pharm. 105(2), R1-R3 (1994).
    • (1994) Int. J. Pharm. , vol.105 , Issue.2
    • Morel, S.1    Gasco, M.R.2    Cavalli, R.3
  • 47
    • 0037173520 scopus 로고    scopus 로고
    • Incorporation of cyclosporin A in solid lipid nanoparticles (SLN)
    • DOI 10.1016/S0378-5173(02)00268-5, PII S0378517302002685
    • Ugazio E, Cavalli R, Gasco MR. Incorporation of cyclosporin A in solid lipid nanoparticles (SLN). Int. J. Pharm. 241(2), 341-344 (2002). (Pubitemid 34718035)
    • (2002) International Journal of Pharmaceutics , vol.241 , Issue.2 , pp. 341-344
    • Ugazio, E.1    Cavalli, R.2    Gasco, M.R.3
  • 48
    • 75149175575 scopus 로고    scopus 로고
    • Colloidal nanocarriers: A review on formulation technology, types and applications toward targeted drug delivery
    • Mishra B, Patel BB, Tiwari S. Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery. Nanomedicine 6(1), 9-24 (2010).
    • (2010) Nanomedicine , vol.6 , Issue.1 , pp. 9-24
    • Mishra, B.1    Patel, B.B.2    Tiwari, S.3
  • 50
    • 18044366409 scopus 로고    scopus 로고
    • A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly(ethylene glycol) as carriers for oral calcitonin delivery
    • DOI 10.1016/j.ejps.2005.02.008
    • Garcia-Fuentes M, Prego C, Torres D, Alonso MJ. A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly(ethylene glycol) as carriers for oral calcitonin delivery. Eur. J. Pharm. Sci. 25(1), 133-143 (2005). (Pubitemid 40602203)
    • (2005) European Journal of Pharmaceutical Sciences , vol.25 , Issue.1 , pp. 133-143
    • Garcia-Fuentes, M.1    Prego, C.2    Torres, D.3    Alonso, M.J.4
  • 51
    • 33750501785 scopus 로고    scopus 로고
    • Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin
    • DOI 10.1016/j.ijpharm.2006.07.026, PII S0378517306006016
    • Zhang N, Ping QN, Huang GH, Xu WF, Cheng YN, Han XZ. Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin. Int. J. Pharm. 327(1-2), 153-159 (2006). (Pubitemid 44667334)
    • (2006) International Journal of Pharmaceutics , vol.327 , Issue.1-2 , pp. 153-159
    • Zhang, N.1    Ping, Q.2    Huang, G.3    Xu, W.4    Cheng, Y.5    Han, X.6
  • 52
    • 0028948839 scopus 로고
    • A theoretical basis for a biopharmaceutic drug classification: The correlation in vitro drug product dissolution and in vivo bioavailability
    • Amidon GL, Lennernäs H, Shah VP, Crison JR. A theoretical basis for a biopharmaceutic drug classification: the correlation in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 12(3), 413-420 (1995).
    • (1995) Pharm. Res. , vol.12 , Issue.3 , pp. 413-420
    • Amidon, G.L.1    Lennernäs, H.2    Shah, V.P.3    Crison, J.R.4
  • 54
    • 0035095380 scopus 로고    scopus 로고
    • Wetting behavior of bile salt-lipid dispersions and dissolution media patterned after intestinal fluids
    • Luner PE, Vander Kamp D. Wetting behavior of bile salt-lipid dispersions and dissolution media patterned after intestinal fluids. J. Pharm. Sci. 90(3), 348-359 (2001).
    • (2001) J. Pharm. Sci. , vol.90 , Issue.3 , pp. 348-359
    • Luner, P.E.1    Vander Kamp, D.2
  • 55
    • 0037371606 scopus 로고    scopus 로고
    • Separation and characterization of the colloidal phases produced on digestion of common formulation lipids and assessment of their impact on the apparent solubility of selected poorly water-soluble drugs
    • DOI 10.1002/jps.10329
    • Kossena GA, Boyd BJ, Porter CJ, Charman WN. Separation and characterization of the colloidal phases produced on digestion of common formulation lipids and assessment of their impact on the apparent solubility of selected poorly water-soluble drugs. J. Pharm. Sci. 92(3), 634-648 (2003). (Pubitemid 36258978)
    • (2003) Journal of Pharmaceutical Sciences , vol.92 , Issue.3 , pp. 634-648
    • Kossena, G.A.1    Boyd, B.J.2    Porter, C.J.H.3    Charman, W.N.4
  • 56
    • 0342617694 scopus 로고    scopus 로고
    • Lipid-based vehicles for the oral delivery of poorly water soluble drugs: The potential of oily formulations for drug delivery to the gastro-intestinal tract
    • Humberstone AJ, Charman WN. Lipid-based vehicles for the oral delivery of poorly water soluble drugs: the potential of oily formulations for drug delivery to the gastro-intestinal tract. Adv. Drug Deliv. Rev. 25(1), 103-128 (1997).
    • (1997) Adv. Drug Deliv. Rev. , vol.25 , Issue.1 , pp. 103-128
    • Humberstone, A.J.1    Charman, W.N.2
  • 57
    • 0034633851 scopus 로고    scopus 로고
    • A comparison of the permeation enhancement potential of simple bile salt and mixed bile salt :fatty acid micellar systems using the Caco-2 cell culture model
    • Meaney CM, O'Driscoll CM. A comparison of the permeation enhancement potential of simple bile salt and mixed bile salt :fatty acid micellar systems using the Caco-2 cell culture model. Int. J. Pharm. 207(1-2), 21-30 (2000).
    • (2000) Int. J. Pharm. , vol.207 , Issue.1-2 , pp. 21-30
    • Meaney, C.M.1    O'driscoll, C.M.2
  • 58
    • 0033805858 scopus 로고    scopus 로고
    • Lipid formulations for oral administration of drugs: Non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems
    • Pouton CW. Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems. Eur. J. Pharm. Sci. 11(Suppl. 2), S93-S98 (2000).
    • (2000) Eur. J. Pharm. Sci. , vol.11 , Issue.SUPPL. 2
    • Pouton, C.W.1
  • 59
    • 12344312013 scopus 로고    scopus 로고
    • Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model
    • DOI 10.1211/0022357055434
    • Lane ME, O'Driscoll C M, Corrigan OI. Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model. J. Pharm. Pharmacol. 57(2), 169-175 (2005). (Pubitemid 40129083)
    • (2005) Journal of Pharmacy and Pharmacology , vol.57 , Issue.2 , pp. 169-175
    • Lane, M.E.1    O'Driscoll, C.M.2    Corrigan, O.I.3
  • 60
    • 41849105252 scopus 로고    scopus 로고
    • Lipid-based colloidal carriers for peptide and protein delivery -Liposomes versus lipid nanoparticles
    • Martins S, Sarmento B, Ferreira DC, Souto EB. Lipid-based colloidal carriers for peptide and protein delivery -liposomes versus lipid nanoparticles. Int. J. Nanomedicine 2(4), 595-607 (2007).
    • (2007) Int. J. Nanomedicine , vol.2 , Issue.4 , pp. 595-607
    • Martins, S.1    Sarmento, B.2    Ferreira, D.C.3    Souto, E.B.4
  • 61
    • 0027174290 scopus 로고
    • Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route
    • DOI 10.1023/A:1018909210879
    • Anderberg EK, Lindmark T, Artursson P. Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route. Pharm. Res. 10(6), 857-864 (1993). (Pubitemid 23167568)
    • (1993) Pharmaceutical Research , vol.10 , Issue.6 , pp. 857-864
    • Anderberg, E.K.1    Lindmark, T.2    Artursson, P.3
  • 62
    • 0033816196 scopus 로고    scopus 로고
    • Intestinal permeation enhancers
    • Aungst BJ. Intestinal permeation enhancers. J. Pharm. Sci. 89(4), 429-442 (2000).
    • (2000) J. Pharm. Sci. , vol.89 , Issue.4 , pp. 429-442
    • Aungst, B.J.1
  • 63
    • 28244457371 scopus 로고    scopus 로고
    • Delivery of parathyroid hormone for the treatment of osteoporosis
    • DOI 10.1517/17425247.2.6.993
    • Morley P. Delivery of parathyroid hormone for the treatment of osteoporosis. Expert Opin. Drug Deliv. 2(6), 993-1002 (2005). (Pubitemid 41701199)
    • (2005) Expert Opinion on Drug Delivery , vol.2 , Issue.6 , pp. 993-1002
    • Morley, P.1
  • 64
    • 0028033391 scopus 로고
    • Intestinal permeability enhancement: Efficacy, acute local toxicity, and reversibility
    • DOI 10.1023/A:1018984731584
    • Swenson ES, Milsen WB, Curtalo WJ. Intestinal permeability enhancement: efficacy, acute local toxicity, and reversibility. Pharm. Res. 11(8), 1132-1142 (1994). (Pubitemid 24259853)
    • (1994) Pharmaceutical Research , vol.11 , Issue.8 , pp. 1132-1142
    • Swenson, E.S.1    Milisen, W.B.2    Curatolo, W.3
  • 65
    • 0027173738 scopus 로고
    • Epithelial transport of drugs in cell culture. VIII: Effects of sodium dodecyl sulfate on cell membrane and tight junction permeability in human intestinal epithelial (Caco-2) cells
    • DOI 10.1002/jps.2600820412
    • Anderberg EK, Artursson P. Epithelial transport of drugs in cell culture. VIII: Effects of sodium dodecyl sulfate on cell membrane and tight junction permeability in human intestinal epithelial (Caco-2) cells. J. Pharm. Sci. 82(4), 392-398 (1993). (Pubitemid 23150434)
    • (1993) Journal of Pharmaceutical Sciences , vol.82 , Issue.4 , pp. 392-398
    • Anderberg, E.K.1    Artursson, P.2
  • 68
    • 71549130146 scopus 로고    scopus 로고
    • Safety and efficacy of sodium caprate in promoting oral drug absorption: From in vitro to the clinic
    • Maher S, Leonard TW, Jacobsen J, Brayden DJ. Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic. Adv. Drug Deliv. Rev. 61(15), 1427-1449 (2009).
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , Issue.15 , pp. 1427-1449
    • Maher, S.1    Leonard, T.W.2    Jacobsen, J.3    Brayden, D.J.4
  • 69
    • 33748641168 scopus 로고    scopus 로고
    • Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET™
    • DOI 10.1517/17425247.3.5.685
    • Leonard TW, Lynch J, Mckenna MJ, Brayden DJ. Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET. Expert Opin. Drug Deliv. 3(5), 685-692 (2006). (Pubitemid 44383494)
    • (2006) Expert Opinion on Drug Delivery , vol.3 , Issue.5 , pp. 685-692
    • Leonard, T.W.1    Lynch, J.2    McKenna, M.J.3    Brayden, D.J.4
  • 72
    • 16844382684 scopus 로고    scopus 로고
    • Oral delivery of insulin with the eligen® technology: Mechanistic studies
    • DOI 10.2174/1567201053586001
    • Malkov D, Angelo R, Wang HZ, Flanders E, Tang H, Gomez-Orellana I. Oral delivery of insulin with the eligen technology: mechanistic studies. Curr. Drug Deliv. 2(2), 191-197 (2005). (Pubitemid 40488628)
    • (2005) Current Drug Delivery , vol.2 , Issue.2 , pp. 191-197
    • Malkov, D.1    Angelo, R.2    Wang, H.-Z.3    Flanders, E.4    Tang, H.5    Gomez-Orellana, I.6
  • 75
    • 79951615188 scopus 로고    scopus 로고
    • Lessons learned from the development of oral calcitonin: The first tablet formulation of a protein in phase III clinical trials
    • Karsdal MA, Henriksen K, Bay-Jensen AC et al. Lessons learned from the development of oral calcitonin: the first tablet formulation of a protein in phase III clinical trials. J. Clin. Pharmacol. 51(4), 460-471 (2011).
    • (2011) J. Clin. Pharmacol. , vol.51 , Issue.4 , pp. 460-471
    • Karsdal, M.A.1    Henriksen, K.2    Bay-Jensen, A.C.3
  • 76
    • 0029028792 scopus 로고
    • Overlapping substrate specificities and tissue distribution of cytochrome-P450 3a and p-glycoprotein -Implications for drug-delivery and activity in cancer-chemotherapy
    • Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome-P450 3a and p-glycoprotein -implications for drug-delivery and activity in cancer-chemotherapy. Mol. Carcinog. 13(3), 129-134 (1995).
    • (1995) Mol. Carcinog. , vol.13 , Issue.3 , pp. 129-134
    • Wacher, V.J.1    Wu, C.Y.2    Benet, L.Z.3
  • 78
    • 2442719906 scopus 로고    scopus 로고
    • Unmasking the dynamic interplay between efflux transporters and metabolic enzymes
    • DOI 10.1016/j.ijpharm.2002.12.002, PII S0378517304001255
    • Benet LZ, Cummins CL, Wu CY. Unmasking the dynamic interplay between efflux transporters and metabolic enzymes. Int. J. Pharm. 277(1-2), 3-9 (2004). (Pubitemid 38670415)
    • (2004) International Journal of Pharmaceutics , vol.277 , Issue.1-2 , pp. 3-9
    • Benet, L.Z.1    Cummins, C.L.2    Wu, C.Y.3
  • 81
    • 2442671307 scopus 로고    scopus 로고
    • Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo
    • DOI 10.1016/j.ijpharm.2004.03.001, PII S037851730400170X
    • Cornaire G, Woodley J, Hermann P, Cloarec A, Arellano C, Houin G. Impact of excipients on the absorption of P glycoprotein substrates in vitro and in vivo. Int. J. Pharm. 278(1), 119-131 (2004). (Pubitemid 38670443)
    • (2004) International Journal of Pharmaceutics , vol.278 , Issue.1 , pp. 119-131
    • Cornaire, G.1    Woodley, J.2    Hermann, P.3    Cloarec, A.4    Arellano, C.5    Houin, G.6
  • 82
    • 0029875543 scopus 로고    scopus 로고
    • The use of surfactants to enhance the permeability of peptides through caco-2 cells by inhibition of an apically polarized efflux system
    • DOI 10.1023/A:1016033702220
    • Nerurkar MM, Burton PS, Borchardt RT. The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system. Pharm. Res. 13(4), 528-534 (1996). (Pubitemid 26119054)
    • (1996) Pharmaceutical Research , vol.13 , Issue.4 , pp. 528-534
    • Nerurkar, M.M.1    Burton, P.S.2    Borchardt, R.T.3
  • 83
    • 0032714228 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein by D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)
    • DOI 10.1023/A:1015000503629
    • Dintaman JM, Silverman JA. Inhibition of P-glycoprotein by D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS). Pharm. Res. 16(10), 1550-1556 (1999). (Pubitemid 29510551)
    • (1999) Pharmaceutical Research , vol.16 , Issue.10 , pp. 1550-1556
    • Dintaman, J.M.1    Silverman, J.A.2
  • 84
  • 86
    • 0036741452 scopus 로고    scopus 로고
    • Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers
    • Rege BD, Kao JP, Polli JE. Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers. Eur. J. Pharm. Sci. 16(4-5), 237-246 (2002).
    • (2002) Eur. J. Pharm. Sci. , vol.16 , Issue.4-5 , pp. 237-246
    • Rege, B.D.1    Kao, J.P.2    Polli, J.E.3
  • 88
    • 2442671307 scopus 로고    scopus 로고
    • Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo
    • DOI 10.1016/j.ijpharm.2004.03.001, PII S037851730400170X
    • Cornaire G, Woodley J, Hermann P, Cloarec A, Arellano C, Houin G. Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo. Int. J. Pharm. 278(1), 119-131 (2004). (Pubitemid 38670443)
    • (2004) International Journal of Pharmaceutics , vol.278 , Issue.1 , pp. 119-131
    • Cornaire, G.1    Woodley, J.2    Hermann, P.3    Cloarec, A.4    Arellano, C.5    Houin, G.6
  • 89
    • 21544438456 scopus 로고    scopus 로고
    • A bitter melon extract inhibits the P-glycoprotein activity in intestinal Caco-2 cells: Monoglyceride as an active compound
    • Konishi T, Satsu H, Hatsugai Y et al. A bitter melon extract inhibits the P-glycoprotein activity in intestinal Caco-2 cells: monoglyceride as an active compound. Biofactors 22(1-4), 71-74 (2004).
    • (2004) Biofactors , vol.22 , Issue.1-4 , pp. 71-74
    • Konishi, T.1    Satsu, H.2    Hatsugai, Y.3
  • 90
    • 0033963413 scopus 로고    scopus 로고
    • Effects of sodium deoxycholate and sodium caprate on the transport of epirubicin in human intestinal epithelial Caco-2 cell layers and everted gut sacs of rats
    • Lo YL, Huang JD. Effects of sodium deoxycholate and sodium caprate on the transport of epirubicin in human intestinal epithelial Caco-2 cell layers and everted gut sacs of rats. Biochem. Pharmacol. 59(6), 665-672 (2000).
    • (2000) Biochem. Pharmacol. , vol.59 , Issue.6 , pp. 665-672
    • Lo, Y.L.1    Huang, J.D.2
  • 92
    • 17644380257 scopus 로고    scopus 로고
    • Predicting drug disposition via application of BCS: Transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system
    • DOI 10.1007/s11095-004-9004-4
    • Wu CY, Benet LZ. Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm. Res. 22(1), 11-23 (2005). (Pubitemid 40558141)
    • (2005) Pharmaceutical Research , vol.22 , Issue.1 , pp. 11-23
    • Wu, C.-Y.1    Benet, L.Z.2
  • 93
    • 39149115065 scopus 로고    scopus 로고
    • Predicting drug disposition, absorption/elimination/ transporter interplay and the role of food on drug absorption
    • Custodio JM, Wu C-Y, Benet LZ. Predicting drug disposition, absorption/elimination/ transporter interplay and the role of food on drug absorption. Adv. Drug Deliv. Rev. 60(6), 717-733 (2008).
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , Issue.6 , pp. 717-733
    • Custodio, J.M.1    Wu, C.-Y.2    Benet, L.Z.3
  • 94
    • 0035984949 scopus 로고    scopus 로고
    • Lipid-based formulations for intestinal lymphatic delivery
    • O'Driscoll CM. Lipid-based formulations for intestinal lymphatic delivery. Eur. J. Pharm. Sci. 15(5), 405-415 (2002).
    • (2002) Eur. J. Pharm. Sci. , vol.15 , Issue.5 , pp. 405-415
    • O'driscoll, C.M.1
  • 95
    • 0002277225 scopus 로고
    • Anatomy and physiology of the lymphatics
    • Charman WN, Stella VJ (Eds). CRC Press, FL, USA
    • O'Driscoll CM. Anatomy and physiology of the lymphatics. In: Lymphatic Transport of Drugs. Charman WN, Stella VJ (Eds). CRC Press, FL, USA, 1-35 (1992).
    • (1992) Lymphatic Transport of Drugs , pp. 1-35
    • O'driscoll, C.M.1
  • 97
    • 0037224816 scopus 로고    scopus 로고
    • Intestinal lymphatic targeting of drugs
    • O'Driscoll C. intestinal lymphatic targeting of drugs. STP Pharm. Sci. 13(1), 17-25 (2003).
    • (2003) STP Pharm. Sci. , vol.13 , Issue.1 , pp. 17-25
    • O'driscoll, C.1
  • 98
    • 0022254252 scopus 로고
    • Promotion of the selective lymphatic delivery of cyclosporin A by lipid-surfactant mixed micelles
    • Takada K, Shibata N, Yoshimura H et al. Promotion of the selective lymphatic delivery of cyclosporin A by lipid-surfactant mixed micelles. J. Pharmacobiodyn. 8(4), 320-323 (1985). (Pubitemid 15055791)
    • (1985) Journal of Pharmacobio-Dynamics , vol.8 , Issue.4 , pp. 320-323
    • Takada, K.1    Shibata, N.2    Yoshimura, H.3
  • 99
    • 33745656817 scopus 로고    scopus 로고
    • A comparison of intestinal lymphatic transport and systemic bioavailability of saquinavir from three lipid-based formulations in the anaesthetised rat model
    • DOI 10.1211/jpp.58.7.0006
    • Griffin BT, O'Driscoll CM. A comparison of intestinal lymphatic transport and systemic bioavailability of saquinavir from three lipid-based formulations in the anaesthetised rat model. J. Pharm. Pharmacol. 58(7), 917-925 (2006). (Pubitemid 43967108)
    • (2006) Journal of Pharmacy and Pharmacology , vol.58 , Issue.7 , pp. 917-925
    • Griffin, B.T.1    O'Driscoll, C.M.2
  • 100
    • 0031058158 scopus 로고    scopus 로고
    • Potential for lymphatic targeting of peptides
    • DOI 10.1016/S0168-3659(96)01588-X, PII S016836599601588X
    • Muranishi S, Fujita T, Murakami M, Yamamoto A. Potential for lymphatic targeting of peptides. J. Control. Release 46(1-2), 157-164 (1997). (Pubitemid 27110895)
    • (1997) Journal of Controlled Release , vol.46 , Issue.1-2 , pp. 157-164
    • Muranishi, S.1    Fujita, T.2    Murakami, M.3    Yamamoto, A.4
  • 101
    • 0025069886 scopus 로고
    • Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the Peyer's patches
    • Eldridge JH, Hammond CJ, Meulbroek JA, Staas JK, Gilley RM, Tice TR. Controlled vaccine release in the gut associated lymphoid tissues. 1. Orally adminstered biodegradable microspheres target the peyers patches. J. Control. Release 11(1-3), 205-214 (1990). (Pubitemid 20070098)
    • (1990) Journal of Controlled Release , vol.11 , Issue.1-3 , pp. 205-214
    • Eldridge, J.H.1    Hammond, C.J.2    Meulbroek, J.A.3    Staas, J.K.4    Gilley, R.M.5    Tice, T.R.6
  • 102
    • 0025153296 scopus 로고
    • Absorption of peptides and proteins from the respiratory tract and the potential for development of locally administered vaccine
    • O' Hagan DT, Illum L. Absorption of peptides and proteins from the respiratory tract and the potential for development of locally administered vaccine. Crit. Rev. Ther. Drug Carrier Syst. 7(1), 35-97 (1990). (Pubitemid 20355577)
    • (1990) Critical Reviews in Therapeutic Drug Carrier Systems , vol.7 , Issue.1 , pp. 35-97
    • O'Hagan, D.T.1    Illum, L.2
  • 103
    • 0024565173 scopus 로고
    • Enhanced intestinal absorption of cyclosporin in rats through the reduction of emulsion droplet size
    • DOI 10.1023/A:1015843517762
    • Tarr BD, Yalkowsky SH. Enhanced intestinal absorption of cyclosporin in rats through the reduction of emulsion droplet size. Pharm. Res. 6(1), 40-43 (1989). (Pubitemid 19060820)
    • (1989) Pharmaceutical Research , vol.6 , Issue.1 , pp. 40-43
    • Tarr, B.D.1    Yalkowsky, S.H.2
  • 104
    • 0032498581 scopus 로고    scopus 로고
    • Physicochemical characterization and evaluation of a microemulsion system for oral delivery of cyclosporin A
    • Gao ZG, Choi HG, Shin HJ et al. Physicochemical characterization and evaluation of a microemulsion system for oral delivery of cyclosporin A. Int. J. Pharm. 161(1), 75-86 (1998).
    • (1998) Int. J. Pharm. , vol.161 , Issue.1 , pp. 75-86
    • Gao, Z.G.1    Choi, H.G.2    Shin, H.J.3
  • 105
    • 0028079609 scopus 로고
    • Influence of a fat-rich meal on the pharmacokinetics of a new oral formulation of cyclosporine in a crossover comparison with the market formulation
    • DOI 10.1023/A:1018922517162
    • Mueller EA, Kovarik JM, Van Bree JB, Grevel J, Lucker PW, Kutz K. Influence of a fat-rich meal on the pharmacokinetics of a new oral formulation of cyclosporine in a crossover comparison with the market formulation. Pharm. Res. 11(1), 151-155 (1994). (Pubitemid 24040779)
    • (1994) Pharmaceutical Research , vol.11 , Issue.1 , pp. 151-155
    • Mueller, E.A.1    Kovarik, J.M.2    Van Bree, J.B.3    Grevel, J.4    Lucker, P.W.5    Kutz, K.6
  • 106
    • 0342940805 scopus 로고    scopus 로고
    • Human immunodeficiency virus protease inhibitors From drug design to clinical studies
    • DOI 10.1016/S0169-409X(97)00044-6, PII S0169409X97000446
    • Lin JH. Human immunodeficiency virus protease inhibitors. From drug design to clinical studies. Adv. Drug Deliv. Rev. 27(2-3), 215-233 (1997). (Pubitemid 27417874)
    • (1997) Advanced Drug Delivery Reviews , vol.27 , Issue.2-3 , pp. 215-233
    • Lin, J.H.1
  • 107
    • 0021837759 scopus 로고
    • Effect of new chymotrypsin inhibitor (FK-448) on intestinal absorption of insulin
    • Shinomiya M, Shirai K, Saito Y, Yoshida S, Matsuoka N. Effect of new chymotrypsin inhibitor (FK-448) on intestinal absorption of insulin. Lancet 1(8437), 1092-1093 (1985). (Pubitemid 15075521)
    • (1985) Lancet , vol.1 , Issue.8437 , pp. 1092-1093
    • Shinomiya, M.1    Shirai, K.2    Saito, Y.3
  • 108
    • 36248965689 scopus 로고    scopus 로고
    • Current challenges in non-invasive insulin delivery systems: A comparative review
    • DOI 10.1016/j.addr.2007.08.019, PII S0169409X07001913
    • Khafagy El S, Morishita M, Onuki Y, Takayama K. Current challenges in non-invasive insulin delivery systems: a comparative review. Adv. Drug Deliv. Rev. 59(15), 1521-1546 (2007). (Pubitemid 350122777)
    • (2007) Advanced Drug Delivery Reviews , vol.59 , Issue.15 , pp. 1521-1546
    • Khafagy, E.-S.1    Morishita, M.2    Onuki, Y.3    Takayama, K.4
  • 109
    • 33748752402 scopus 로고    scopus 로고
    • Is the oral route possible for peptide and protein drug delivery?
    • DOI 10.1016/j.drudis.2006.08.005, PII S1359644606003084
    • Morishita M, Peppas NA. Is the oral route possible for peptide and protein drug delivery? Drug Discov. Today 11(19-20), 905-910 (2006). (Pubitemid 44403178)
    • (2006) Drug Discovery Today , vol.11 , Issue.19-20 , pp. 905-910
    • Morishita, M.1    Peppas, N.A.2
  • 111
    • 0036379293 scopus 로고    scopus 로고
    • Oral insulin product hexyl-insulin monoconjugate 2 (HIM2) in Type 1 diabetes mellitus: The glucose stabilization effects of HIM2
    • Clement S, Still JG, Kosutic G, Mcallister RG. Oral insulin product hexyl-insulin monoconjugate 2 (HIM2) in Type 1 diabetes mellitus: the glucose stabilization effects of HIM2. Diabetes Technol. Ther. 4(4), 459-466 (2002).
    • (2002) Diabetes Technol. Ther. , vol.4 , Issue.4 , pp. 459-466
    • Clement, S.1    Still, J.G.2    Kosutic, G.3    McAllister, R.G.4
  • 112
    • 77957285711 scopus 로고    scopus 로고
    • Microemulsions for oral delivery of insulin: Design, development and evaluation in streptozotocin induced diabetic rats
    • Sharma G, Wilson K, Van Der Walle CF, Sattar N, Petrie JR, Ravi Kumar MN. Microemulsions for oral delivery of insulin: design, development and evaluation in streptozotocin induced diabetic rats. Eur. J. Pharm. Biopharm. 76(2), 159-169 (2010).
    • (2010) Eur. J. Pharm. Biopharm. , vol.76 , Issue.2 , pp. 159-169
    • Sharma, G.1    Wilson, K.2    Van Der Walle, C.F.3    Sattar, N.4    Petrie, J.R.5    Ravi Kumar, M.N.6
  • 113
    • 50249175117 scopus 로고    scopus 로고
    • Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of protein drugs III. in vivo oral absorption study
    • Shao J, Rao SVR, Yajurvedi K. Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of protein drugs III. In vivo oral absorption study. Int. J. Pharm. 362(1-2), 16-19 (2008).
    • (2008) Int. J. Pharm. , vol.362 , Issue.1-2 , pp. 16-19
    • Shao, J.1    Rao, S.V.R.2    Yajurvedi, K.3
  • 114
    • 50249090401 scopus 로고    scopus 로고
    • Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of protein drugs II. in vitro transport study
    • Shao J, Rao SVR, Agarwal P. Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of protein drugs II. In vitro transport study. Int. J. Pharm. 362(1-2), 10-15 (2008).
    • (2008) Int. J. Pharm. , vol.362 , Issue.1-2 , pp. 10-15
    • Shao, J.1    Rao, S.V.R.2    Agarwal, P.3
  • 115
    • 80051781559 scopus 로고    scopus 로고
    • Improved intestinal delivery of salmon calcitonin by water-in-oil microemulsions
    • Fan Y, Li X, Zhou Y et al. Improved intestinal delivery of salmon calcitonin by water-in-oil microemulsions. Int. J. Pharm. 416(1), 323-330 (2011).
    • (2011) Int. J. Pharm. , vol.416 , Issue.1 , pp. 323-330
    • Fan, Y.1    Li, X.2    Zhou, Y.3
  • 116
    • 29244491192 scopus 로고    scopus 로고
    • Decrease of genital organ weights and plasma testosterone levels in rats following oral administration of leuprolide microemulsion
    • DOI 10.1016/j.ijpharm.2005.10.007, PII S0378517305006654
    • Zheng JY, Fulu MY. Decrease of genital organ weights and plasma testosterone levels in rats following oral administration of leuprolide microemulsion. Int. J. Pharm. 307(2), 209-215 (2006). (Pubitemid 41820416)
    • (2006) International Journal of Pharmaceutics , vol.307 , Issue.2 , pp. 209-215
    • Zheng, J.Y.1    Fulu, M.-Y.2
  • 117
    • 0037020528 scopus 로고    scopus 로고
    • Effects of epidermal growth factor microemulsion formulation on the healing of stress-induced gastric ulcers in rats
    • DOI 10.1016/S0168-3659(02)00198-0, PII S0168365902001980
    • Celebi N, Turkyilmaz A, Gonul B, Ozogul C. Effects of epidermal growth factor microemulsion formulation on the healing of stress-induced gastric ulcers in rats. J. Control. Release 83(2), 197-210 (2002). (Pubitemid 35279465)
    • (2002) Journal of Controlled Release , vol.83 , Issue.2 , pp. 197-210
    • Celebi, N.1    Turkyilmaz, A.2    Gonul, B.3    Ozogul, C.4
  • 118
  • 119
    • 0036222307 scopus 로고    scopus 로고
    • In-vitro release and oral bioactivity of insulin in diabetic rats using nanocapsules dispersed in biocompatible microemulsion
    • DOI 10.1211/0022357021778736
    • Watnasirichaikul S, Rades T, Tucker IG, Davies NM. In vitro release and oral bioactivity of insulin in diabetic rats using nanocapsules dispersed in biocompatible microemulsion. J. Pharm. Pharmacol. 54(4), 473-480 (2002). (Pubitemid 34308489)
    • (2002) Journal of Pharmacy and Pharmacology , vol.54 , Issue.4 , pp. 473-480
    • Watnasirichaikul, S.1    Rades, T.2    Tucker, I.G.3    Davies, N.M.4
  • 120
    • 0023358438 scopus 로고
    • Studies on the promoting effect of lipid-surfactant mixed micelles (MM) on intestinal absorption of colloidal particles. Dependence on particle size and administration site
    • Fukui H, Murakami M, Yoshikawa H, Takada K, Muranishi S. Studies on the promoting effect of lipid-surfactant mixed micelles (MM) on intestinal absorption of colloidal particles. Dependence on particle size and administration site. J. Pharmacobiodyn. 10(6), 236-242 (1987)
    • (1987) J. Pharmacobiodyn. , vol.10 , Issue.6 , pp. 236-242
    • Fukui, H.1    Murakami, M.2    Yoshikawa, H.3    Takada, K.4    Muranishi, S.5
  • 121
    • 60749095944 scopus 로고    scopus 로고
    • Oral insulin delivery using nanoparticles based on microemulsions with different structure-types: Optimisation and in vivo evaluation
    • Graf A, Rades T, Hook SM. Oral insulin delivery using nanoparticles based on microemulsions with different structure-types: optimisation and in vivo evaluation. Eur. J. Pharm. Sci. 37(1), 53-61 (2009).
    • (2009) Eur. J. Pharm. Sci. , vol.37 , Issue.1 , pp. 53-61
    • Graf, A.1    Rades, T.2    Hook, S.M.3
  • 122
    • 70349303363 scopus 로고    scopus 로고
    • Formulation and characterization of an oily-based system for oral delivery of insulin
    • Elsayed A, Remawi MA, Qinna N, Farouk A, Badwan A. Formulation and characterization of an oily-based system for oral delivery of insulin. Eur. J. Pharm. Biopharm. 73(2), 269-279 (2009).
    • (2009) Eur. J. Pharm. Biopharm. , vol.73 , Issue.2 , pp. 269-279
    • Elsayed, A.1    Remawi, M.A.2    Qinna, N.3    Farouk, A.4    Badwan, A.5
  • 123
    • 0036598634 scopus 로고    scopus 로고
    • Bioequivalence and the immunogenicity of biopharmaceuticals
    • Schellekens H. Bioequivalence and the immunogenicity of biopharmaceuticals. Nat. Rev. Drug Discov. 1(6), 457-462 (2002). (Pubitemid 37361488)
    • (2002) Nature Reviews Drug Discovery , vol.1 , Issue.6 , pp. 457-462
    • Schellekens, H.1
  • 125
    • 20444505044 scopus 로고    scopus 로고
    • A lecithin-based microemulsion of rh-insulin with aprotinin for oral administration: Investigation of hypoglycemic effects in non-diabetic and STZ-induced diabetic rats
    • DOI 10.1016/j.ijpharm.2005.04.016, PII S0378517305002693
    • Cilek A, Celebi N, Tirnaksiz F, Tay A. A lecithin-based microemulsion of rh-insulin with aprotinin for oral administration: investigation of hypoglycemic effects in non-diabetic and STZ-induced diabetic rats. Int. J. Pharm. 298(1), 176-185 (2005). (Pubitemid 40828338)
    • (2005) International Journal of Pharmaceutics , vol.298 , Issue.1 , pp. 176-185
    • Cilek, A.1    Celebi, N.2    Tirnaksiz, F.3    Tay, A.4
  • 126
    • 0031799394 scopus 로고    scopus 로고
    • The effect of a drug-delivery system consisting of soybean phosphatidyl choline and medium-chain monoacylglycerol on the intestinal permeability of hexarelin in the rat
    • Fagerholm U, Sjostrom B, Sroka-Markovic J, Wijk A, Svensson M, Lennernas H. The effect of a drug-delivery system consisting of soybean phosphatidyl choline and medium-chain monoacylglycerol on the intestinal permeability of hexarelin in the rat. The J. Pharm. Pharmacol. 50(5), 467-473 (1998). (Pubitemid 28241132)
    • (1998) Journal of Pharmacy and Pharmacology , vol.50 , Issue.5 , pp. 467-473
    • Fagerholm, U.1    Sjostrom, B.2    Sroka-Markovic, J.3    Wijk, A.4    Svensson, M.5    Lennernas, H.6
  • 128
    • 0026587985 scopus 로고
    • Absorption of human calcitonin across the rat colon in vivo
    • Hastewell J, Lynch S, Williamson I, Fox R, Mackay M. Absorption of human calcitonin across the rat colon in vivo. Clin. Sci. 82(5), 589-594 (1992).
    • (1992) Clin. Sci. , vol.82 , Issue.5 , pp. 589-594
    • Hastewell, J.1    Lynch, S.2    Williamson, I.3    Fox, R.4    MacKay, M.5
  • 130
    • 47849089487 scopus 로고    scopus 로고
    • Design and in vivo evaluation of solid-in-oil suspension for oral delivery of human growth hormone
    • Yoshiura H, Tahara Y, Hashida M et al. Design and in vivo evaluation of solid-in-oil suspension for oral delivery of human growth hormone. Biochem. Eng. J. 41(2), 106-110 (2008).
    • (2008) Biochem. Eng. J. , vol.41 , Issue.2 , pp. 106-110
    • Yoshiura, H.1    Tahara, Y.2    Hashida, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.