메뉴 건너뛰기




Volumn 19, Issue 8, 2014, Pages 1097-1108

Mucus models to evaluate nanomedicines for diffusion

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN; CHITOSAN; CLARITHROMYCIN; ENOXAPARIN; IBUPROFEN; MACROGOL; MUCIN; PACLITAXEL; POLOXAMER; DRUG; NANOPARTICLE;

EID: 84906309496     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2014.01.011     Document Type: Review
Times cited : (76)

References (106)
  • 1
    • 78650196945 scopus 로고    scopus 로고
    • Nanomedicine
    • B.Y. Kim et al. Nanomedicine N. Engl. J. Med. 363 2010 2434 2443
    • (2010) N. Engl. J. Med. , vol.363 , pp. 2434-2443
    • Kim, B.Y.1
  • 2
    • 84859510563 scopus 로고    scopus 로고
    • The journey of a drug-carrier in the body: An anatomo-physiological perspective
    • N. Bertrand, and J.C. Leroux The journey of a drug-carrier in the body: an anatomo-physiological perspective J. Control. Release 161 2012 152 163
    • (2012) J. Control. Release , vol.161 , pp. 152-163
    • Bertrand, N.1    Leroux, J.C.2
  • 3
    • 0035844741 scopus 로고    scopus 로고
    • Drug transfer through mucus
    • K. Khanvilkar et al. Drug transfer through mucus Adv. Drug Deliv. Rev. 48 2001 173 193
    • (2001) Adv. Drug Deliv. Rev. , vol.48 , pp. 173-193
    • Khanvilkar, K.1
  • 4
    • 79957582850 scopus 로고    scopus 로고
    • Common gene therapy viral vectors do not efficiently penetrate sputum from cystic fibrosis patients
    • K. Hida et al. Common gene therapy viral vectors do not efficiently penetrate sputum from cystic fibrosis patients PLoS ONE 6 2011 e19919
    • (2011) PLoS ONE , vol.6 , pp. 19919
    • Hida, K.1
  • 5
    • 0030981578 scopus 로고    scopus 로고
    • Diffusion of drugs in native and purified gastrointestinal mucus
    • A.W. Larhed et al. Diffusion of drugs in native and purified gastrointestinal mucus J. Pharm. Sci. 86 1997 660 665
    • (1997) J. Pharm. Sci. , vol.86 , pp. 660-665
    • Larhed, A.W.1
  • 6
    • 0029593339 scopus 로고
    • The limiting role of mucus in drug absorption: Drug permeation through mucus solution
    • P.G. Bhat et al. The limiting role of mucus in drug absorption: drug permeation through mucus solution Int. J. Pharm. 126 1995 179 187
    • (1995) Int. J. Pharm. , vol.126 , pp. 179-187
    • Bhat, P.G.1
  • 7
    • 0031104076 scopus 로고    scopus 로고
    • Effect of size, surface charge, and hydrophobicity on the translocation of polystyrene microspheres through gastrointestinal mucin
    • D.A. Norris, and P.J. Sinko Effect of size, surface charge, and hydrophobicity on the translocation of polystyrene microspheres through gastrointestinal mucin J. Appl. Polym. Sci. 63 1997 1481 1492
    • (1997) J. Appl. Polym. Sci. , vol.63 , pp. 1481-1492
    • Norris, D.A.1    Sinko, P.J.2
  • 8
    • 78649835810 scopus 로고    scopus 로고
    • Barrier properties of gastrointestinal mucus to nanoparticle transport
    • J.S. Crater, and R.L. Carrier Barrier properties of gastrointestinal mucus to nanoparticle transport Macromol. Biosci. 10 2010 1473 1483
    • (2010) Macromol. Biosci. , vol.10 , pp. 1473-1483
    • Crater, J.S.1    Carrier, R.L.2
  • 9
    • 78649945616 scopus 로고    scopus 로고
    • Disruption of the mucus barrier by topically applied exogenous particles
    • S.L. McGill, and H.D. Smyth Disruption of the mucus barrier by topically applied exogenous particles Mol. Pharm. 7 2010 2280 2288
    • (2010) Mol. Pharm. , vol.7 , pp. 2280-2288
    • McGill, S.L.1    Smyth, H.D.2
  • 10
    • 73949114804 scopus 로고    scopus 로고
    • PGSE-NMR and SANS studies of the interaction of model polymer therapeutics with mucin
    • P.C. Griffiths et al. PGSE-NMR and SANS studies of the interaction of model polymer therapeutics with mucin Biomacromolecules 11 2010 120 125
    • (2010) Biomacromolecules , vol.11 , pp. 120-125
    • Griffiths, P.C.1
  • 11
    • 0031810654 scopus 로고    scopus 로고
    • Factors affecting solubility and penetration of clarithromycin through gastric mucus
    • P. Grubel, and D.R. Cave Factors affecting solubility and penetration of clarithromycin through gastric mucus Aliment. Pharmacol. Ther. 12 1998 569 576
    • (1998) Aliment. Pharmacol. Ther. , vol.12 , pp. 569-576
    • Grubel, P.1    Cave, D.R.2
  • 12
    • 2942735394 scopus 로고    scopus 로고
    • Transport of polymeric nanoparticle gene carriers in gastric mucus
    • M. Dawson et al. Transport of polymeric nanoparticle gene carriers in gastric mucus Biotechnol. Prog. 20 2004 851 857
    • (2004) Biotechnol. Prog. , vol.20 , pp. 851-857
    • Dawson, M.1
  • 13
    • 0013562371 scopus 로고    scopus 로고
    • The influence of intestinal mucus components on the diffusion of drugs
    • A.W. Larhed et al. The influence of intestinal mucus components on the diffusion of drugs Pharm. Res. 15 1998 66 71
    • (1998) Pharm. Res. , vol.15 , pp. 66-71
    • Larhed, A.W.1
  • 14
    • 84862599039 scopus 로고    scopus 로고
    • Novel mucus-penetrating liposomes as a potential oral drug delivery system: Preparation, in vitro characterization, and enhanced cellular uptake
    • X. Li et al. Novel mucus-penetrating liposomes as a potential oral drug delivery system: preparation, in vitro characterization, and enhanced cellular uptake Int. J. Nanomedicine 6 2011 3151 3162
    • (2011) Int. J. Nanomedicine , vol.6 , pp. 3151-3162
    • Li, X.1
  • 15
    • 12344314225 scopus 로고    scopus 로고
    • The influence of excipients on the diffusion of ibuprofen and paracetamol in gastric mucus
    • L.R. Shaw et al. The influence of excipients on the diffusion of ibuprofen and paracetamol in gastric mucus Int. J. Pharm. 290 2005 145 154
    • (2005) Int. J. Pharm. , vol.290 , pp. 145-154
    • Shaw, L.R.1
  • 16
    • 0029979921 scopus 로고    scopus 로고
    • Drug diffusion through cystic fibrotic mucus: Steady-state permeation, rheologic properties, and glycoprotein morphology
    • P.G. Bhat et al. Drug diffusion through cystic fibrotic mucus: steady-state permeation, rheologic properties, and glycoprotein morphology J. Pharm. Sci. 85 1996 624 630
    • (1996) J. Pharm. Sci. , vol.85 , pp. 624-630
    • Bhat, P.G.1
  • 17
    • 84868599371 scopus 로고    scopus 로고
    • Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus
    • J. Kirch et al. Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus Proc. Natl. Acad. Sci. U. S. A. 109 2012 18355 18360
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 18355-18360
    • Kirch, J.1
  • 18
    • 76249115874 scopus 로고    scopus 로고
    • Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses
    • S.K. Lai et al. Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses Proc. Natl. Acad. Sci. U. S. A. 107 2010 598 603
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 598-603
    • Lai, S.K.1
  • 19
    • 33846841057 scopus 로고    scopus 로고
    • Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus
    • S.K. Lai et al. Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus Proc. Natl. Acad. Sci. U. S. A. 104 2007 1482 1487
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 1482-1487
    • Lai, S.K.1
  • 20
    • 57049085726 scopus 로고    scopus 로고
    • Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier
    • Y.Y. Wang et al. Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier Angew. Chem. Int. Ed. 47 2008 9726 9729
    • (2008) Angew. Chem. Int. Ed. , vol.47 , pp. 9726-9729
    • Wang, Y.Y.1
  • 21
    • 0027957542 scopus 로고
    • Antibody diffusion in human cervical mucus
    • W.M. Saltzman et al. Antibody diffusion in human cervical mucus Biophys. J. 66 Pt 1 1994 508 515
    • (1994) Biophys. J. , vol.66 , Issue.PART 1 , pp. 508-515
    • Saltzman, W.M.1
  • 22
    • 59549095796 scopus 로고    scopus 로고
    • Altering mucus rheology to "solidify" human mucus at the nanoscale
    • S.K. Lai et al. Altering mucus rheology to "solidify" human mucus at the nanoscale PLoS ONE 4 2009
    • (2009) PLoS ONE , vol.4
    • Lai, S.K.1
  • 23
    • 73349140554 scopus 로고    scopus 로고
    • Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier
    • B.C. Tang et al. Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier Proc. Natl. Acad. Sci. U. S. A. 106 2009 19268 19273
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 19268-19273
    • Tang, B.C.1
  • 24
    • 81255158505 scopus 로고    scopus 로고
    • Biodegradable nanoparticles meet the bronchial airway barrier: How surface properties affect their interaction with mucus and epithelial cells
    • S. Mura et al. Biodegradable nanoparticles meet the bronchial airway barrier: how surface properties affect their interaction with mucus and epithelial cells Biomacromolecules 12 2011 4136 4143
    • (2011) Biomacromolecules , vol.12 , pp. 4136-4143
    • Mura, S.1
  • 25
    • 84857363579 scopus 로고    scopus 로고
    • A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles
    • O. Mert et al. A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles J. Control. Release 157 2012 455 460
    • (2012) J. Control. Release , vol.157 , pp. 455-460
    • Mert, O.1
  • 26
    • 0034816264 scopus 로고    scopus 로고
    • Diffusion of macromolecules and virus-like particles in human cervical mucus
    • S.S. Olmsted et al. Diffusion of macromolecules and virus-like particles in human cervical mucus Biophys. J. 81 2001 1930 1937
    • (2001) Biophys. J. , vol.81 , pp. 1930-1937
    • Olmsted, S.S.1
  • 27
    • 84874239794 scopus 로고    scopus 로고
    • Nanoparticle diffusion in respiratory mucus from humans without lung disease
    • B.S. Schuster et al. Nanoparticle diffusion in respiratory mucus from humans without lung disease Biomaterials 34 2013 3439 3446
    • (2013) Biomaterials , vol.34 , pp. 3439-3446
    • Schuster, B.S.1
  • 28
    • 60149110687 scopus 로고    scopus 로고
    • The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles
    • J.S. Suk et al. The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles Biomaterials 30 2009 2591 2597
    • (2009) Biomaterials , vol.30 , pp. 2591-2597
    • Suk, J.S.1
  • 29
    • 0033711408 scopus 로고    scopus 로고
    • Cystic fibrosis sputum: A barrier to the transport of nanospheres
    • N.N. Sanders et al. Cystic fibrosis sputum: a barrier to the transport of nanospheres Am. J. Respir. Crit. Care Med. 162 2000 1905 1911
    • (2000) Am. J. Respir. Crit. Care Med. , vol.162 , pp. 1905-1911
    • Sanders, N.N.1
  • 30
    • 79959868168 scopus 로고    scopus 로고
    • Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus
    • S.K. Lai et al. Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus Biomaterials 32 2011 6285 6290
    • (2011) Biomaterials , vol.32 , pp. 6285-6290
    • Lai, S.K.1
  • 31
    • 0025748718 scopus 로고
    • Dihydrofolate reductase gene amplification-associated shift of differentiation in methotrexate-adapted HT-29 cells
    • T. Lesuffleur et al. Dihydrofolate reductase gene amplification- associated shift of differentiation in methotrexate-adapted HT-29 cells J. Cell Biol. 115 1991 1409 1418
    • (1991) J. Cell Biol. , vol.115 , pp. 1409-1418
    • Lesuffleur, T.1
  • 32
    • 0036692366 scopus 로고    scopus 로고
    • Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: The effect of mucus on particle adsorption and transport
    • I. Behrens et al. Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: the effect of mucus on particle adsorption and transport Pharm. Res. 19 2002 1185 1193
    • (2002) Pharm. Res. , vol.19 , pp. 1185-1193
    • Behrens, I.1
  • 33
    • 0034763048 scopus 로고    scopus 로고
    • HT29-MTX and Caco-2/TC7 monolayers as predictive models for human intestinal absorption: Role of the mucus layer
    • C. Pontier et al. HT29-MTX and Caco-2/TC7 monolayers as predictive models for human intestinal absorption: role of the mucus layer J. Pharm. Sci. 90 2001 1608 1619
    • (2001) J. Pharm. Sci. , vol.90 , pp. 1608-1619
    • Pontier, C.1
  • 34
    • 0027437938 scopus 로고
    • Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations
    • T. Lesuffleur et al. Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations J. Cell Sci. 106 1993 771 783
    • (1993) J. Cell Sci. , vol.106 , pp. 771-783
    • Lesuffleur, T.1
  • 35
    • 37549062630 scopus 로고    scopus 로고
    • Transport and metabolism of ferulic acid through the colonic epithelium
    • L. Poquet et al. Transport and metabolism of ferulic acid through the colonic epithelium Drug Metab. Dispos. 36 2008 190 197
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 190-197
    • Poquet, L.1
  • 36
    • 0034807847 scopus 로고    scopus 로고
    • Transport of lipophilic drug molecules in a new mucus-secreting cell culture model based on HT29-MTX cells
    • I. Behrens et al. Transport of lipophilic drug molecules in a new mucus-secreting cell culture model based on HT29-MTX cells Pharm. Res. 18 2001 1138 1145
    • (2001) Pharm. Res. , vol.18 , pp. 1138-1145
    • Behrens, I.1
  • 37
    • 67651015406 scopus 로고    scopus 로고
    • Characterization of Caco-2 and HT29-MTX cocultures in an in vitro digestion/cell culture model used to predict iron bioavailability
    • G.J. Mahler et al. Characterization of Caco-2 and HT29-MTX cocultures in an in vitro digestion/cell culture model used to predict iron bioavailability J. Nutr. Biochem. 20 2009 494 502
    • (2009) J. Nutr. Biochem. , vol.20 , pp. 494-502
    • Mahler, G.J.1
  • 38
    • 0033165880 scopus 로고    scopus 로고
    • Mucus as a barrier to the permeability of hydrophilic and lipophilic compounds in the absence and presence of sodium taurocholate micellar systems using cell culture models
    • C. Meaney, and C. O'Driscoll Mucus as a barrier to the permeability of hydrophilic and lipophilic compounds in the absence and presence of sodium taurocholate micellar systems using cell culture models Eur. J. Pharm. Sci. 8 1999 167 175
    • (1999) Eur. J. Pharm. Sci. , vol.8 , pp. 167-175
    • Meaney, C.1    O'Driscoll, C.2
  • 39
    • 0345643513 scopus 로고    scopus 로고
    • Chitosans as absorption enhancers of poorly absorbable drugs. 3. Influence of mucus on absorption enhancement
    • N.G.M. Schipper et al. Chitosans as absorption enhancers of poorly absorbable drugs. 3. Influence of mucus on absorption enhancement Eur. J. Pharm. Sci. 8 1999 335 343
    • (1999) Eur. J. Pharm. Sci. , vol.8 , pp. 335-343
    • Schipper, N.G.M.1
  • 40
    • 0027441125 scopus 로고
    • The mucus layer as a barrier to drug absorption in monolayers of human intestinal epithelial HT29-H goblet cells
    • J. Karlsson et al. The mucus layer as a barrier to drug absorption in monolayers of human intestinal epithelial HT29-H goblet cells Int. J. Pharm. 99 1993 209 218
    • (1993) Int. J. Pharm. , vol.99 , pp. 209-218
    • Karlsson, J.1
  • 41
    • 84855870732 scopus 로고    scopus 로고
    • Barrier characteristics of epithelial cultures modelling the airway and intestinal mucosa: A comparison
    • D. Vllasaliu et al. Barrier characteristics of epithelial cultures modelling the airway and intestinal mucosa: a comparison Biochem. Biophys. Res. Commun. 415 2011 579 585
    • (2011) Biochem. Biophys. Res. Commun. , vol.415 , pp. 579-585
    • Vllasaliu, D.1
  • 42
    • 77952292395 scopus 로고    scopus 로고
    • Defining conditions for the co-culture of Caco-2 and HT29-MTX cells using Taguchi design
    • X.M. Chen et al. Defining conditions for the co-culture of Caco-2 and HT29-MTX cells using Taguchi design J. Pharmacol. Toxicol. Methods 61 2010 334 342
    • (2010) J. Pharmacol. Toxicol. Methods , vol.61 , pp. 334-342
    • Chen, X.M.1
  • 43
    • 0029836840 scopus 로고    scopus 로고
    • HT29-MTX/Caco-2 cocultures as an in vitro model for the intestinal epithelium: In vitro-in vivo correlation with permeability data from rats and humans
    • E. Walter et al. HT29-MTX/Caco-2 cocultures as an in vitro model for the intestinal epithelium: in vitro-in vivo correlation with permeability data from rats and humans J. Pharm. Sci. 85 1996 1070 1076
    • (1996) J. Pharm. Sci. , vol.85 , pp. 1070-1076
    • Walter, E.1
  • 44
    • 0029090391 scopus 로고
    • Co-cultures of human intestinal goblet (HT29-H) and absorptive (Caco-2) cells for studies of drug and peptide absorption
    • A. Wikman-Larhed, and P. Artursson Co-cultures of human intestinal goblet (HT29-H) and absorptive (Caco-2) cells for studies of drug and peptide absorption Eur. J. Pharm. Sci. 3 1995 171 183
    • (1995) Eur. J. Pharm. Sci. , vol.3 , pp. 171-183
    • Wikman-Larhed, A.1    Artursson, P.2
  • 45
    • 0344141322 scopus 로고    scopus 로고
    • Nasal drug delivery - Evaluation of an in vitro model using porcine nasal mucosa
    • C. Wadell et al. Nasal drug delivery - evaluation of an in vitro model using porcine nasal mucosa Eur. J. Pharm. Sci. 7 1999 197 206
    • (1999) Eur. J. Pharm. Sci. , vol.7 , pp. 197-206
    • Wadell, C.1
  • 46
    • 28444456377 scopus 로고    scopus 로고
    • Enhancement of intestinal absorption of poorly absorbed hydrophilic compounds by simultaneous use of mucolytic agent and non-ionic surfactant
    • S. Takatsuka et al. Enhancement of intestinal absorption of poorly absorbed hydrophilic compounds by simultaneous use of mucolytic agent and non-ionic surfactant Eur. J. Pharm. Biopharm. 62 2006 52 58
    • (2006) Eur. J. Pharm. Biopharm. , vol.62 , pp. 52-58
    • Takatsuka, S.1
  • 47
    • 84863783683 scopus 로고    scopus 로고
    • Oral administration of paclitaxel with pegylated poly(anhydride) nanoparticles: Permeability and pharmacokinetic study
    • V. Zabaleta et al. Oral administration of paclitaxel with pegylated poly(anhydride) nanoparticles: permeability and pharmacokinetic study Eur. J. Pharm. Biopharm. 81 2012 514 523
    • (2012) Eur. J. Pharm. Biopharm. , vol.81 , pp. 514-523
    • Zabaleta, V.1
  • 48
    • 84862682798 scopus 로고    scopus 로고
    • The counterbalanced effect of size and surface properties of chitosan-coated poly(isobutylcyanoacrylate) nanoparticles on mucoadhesion due to pluronic F68 addition
    • B. Petit et al. The counterbalanced effect of size and surface properties of chitosan-coated poly(isobutylcyanoacrylate) nanoparticles on mucoadhesion due to pluronic F68 addition Pharm. Res. 29 2012 943 952
    • (2012) Pharm. Res. , vol.29 , pp. 943-952
    • Petit, B.1
  • 49
    • 70349840419 scopus 로고    scopus 로고
    • Combined hydroxypropyl-β-cyclodextrin and poly(anhydride) nanoparticles improve the oral permeability of paclitaxel
    • M. Agüeros et al. Combined hydroxypropyl-β-cyclodextrin and poly(anhydride) nanoparticles improve the oral permeability of paclitaxel Eur. J. Pharm. Sci. 38 2009 405 413
    • (2009) Eur. J. Pharm. Sci. , vol.38 , pp. 405-413
    • Agüeros, M.1
  • 50
    • 83355173904 scopus 로고    scopus 로고
    • Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport
    • Y. Jin et al. Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport Biomaterials 33 2011 1573 1582
    • (2011) Biomaterials , vol.33 , pp. 1573-1582
    • Jin, Y.1
  • 51
    • 84866161947 scopus 로고    scopus 로고
    • Size-dependent absorption mechanism of polymeric nanoparticles for oral delivery of protein drugs
    • C. He et al. Size-dependent absorption mechanism of polymeric nanoparticles for oral delivery of protein drugs Biomaterials 33 2012 8569 8578
    • (2012) Biomaterials , vol.33 , pp. 8569-8578
    • He, C.1
  • 52
    • 0030948511 scopus 로고    scopus 로고
    • Light microscopical observations on luminally administered dyes, dextrans, nanospheres and microspheres in the pre-epithelial mucus gel layer of the rat distal colon
    • L. Szentkuti Light microscopical observations on luminally administered dyes, dextrans, nanospheres and microspheres in the pre-epithelial mucus gel layer of the rat distal colon J. Control. Release 46 1997 233 242
    • (1997) J. Control. Release , vol.46 , pp. 233-242
    • Szentkuti, L.1
  • 53
    • 0030818767 scopus 로고    scopus 로고
    • Enhancing effects of monohexanoin and two other medium-chain glyceride vehicles on intestinal absorption of desmopressin (dDAVP)
    • P.D.P. Lundin et al. Enhancing effects of monohexanoin and two other medium-chain glyceride vehicles on intestinal absorption of desmopressin (dDAVP) J. Pharmacol. Exp. Ther. 282 1997 585 590
    • (1997) J. Pharmacol. Exp. Ther. , vol.282 , pp. 585-590
    • Lundin, P.D.P.1
  • 54
    • 84870309616 scopus 로고    scopus 로고
    • Biodistribution and pharmacokinetics of a telodendrimer micellar paclitaxel nanoformulation in a mouse xenograft model of ovarian cancer
    • W. Xiao et al. Biodistribution and pharmacokinetics of a telodendrimer micellar paclitaxel nanoformulation in a mouse xenograft model of ovarian cancer Int. J. Nanomedicine 7 2012 1587 1597
    • (2012) Int. J. Nanomedicine , vol.7 , pp. 1587-1597
    • Xiao, W.1
  • 55
    • 70349787587 scopus 로고    scopus 로고
    • Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium
    • A. Mistry et al. Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium J. Drug Target. 17 2009 543 552
    • (2009) J. Drug Target. , vol.17 , pp. 543-552
    • Mistry, A.1
  • 56
    • 84879464127 scopus 로고    scopus 로고
    • Enhanced vaginal drug delivery through the use of hypotonic formulations that induce fluid uptake
    • L.M. Ensign et al. Enhanced vaginal drug delivery through the use of hypotonic formulations that induce fluid uptake Biomaterials 34 2013 6922 6929
    • (2013) Biomaterials , vol.34 , pp. 6922-6929
    • Ensign, L.M.1
  • 57
    • 84862519335 scopus 로고    scopus 로고
    • Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus
    • L.M. Ensign et al. Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus Sci. Transl. Med. 4 2012 138 179
    • (2012) Sci. Transl. Med. , vol.4 , pp. 138-179
    • Ensign, L.M.1
  • 58
    • 0030043137 scopus 로고    scopus 로고
    • Drug binding to gastric mucus glycoproteins
    • P.G. Bhat et al. Drug binding to gastric mucus glycoproteins Int. J. Pharm. 134 1996 15 25
    • (1996) Int. J. Pharm. , vol.134 , pp. 15-25
    • Bhat, P.G.1
  • 59
    • 0037314682 scopus 로고    scopus 로고
    • A self-sampling method to obtain large volumes of undiluted cervicovaginal secretions
    • E.R. Boskey et al. A self-sampling method to obtain large volumes of undiluted cervicovaginal secretions Sex. Transm. Dis. 30 2003 107 109
    • (2003) Sex. Transm. Dis. , vol.30 , pp. 107-109
    • Boskey, E.R.1
  • 60
    • 0029055473 scopus 로고
    • Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
    • T.T. Kararli Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals Biopharm. Drug Dispos. 16 1995 351 380
    • (1995) Biopharm. Drug Dispos. , vol.16 , pp. 351-380
    • Kararli, T.T.1
  • 61
    • 84887371418 scopus 로고    scopus 로고
    • Fate of paclitaxel lipid nanocapsules in intestinal mucus in view of their oral delivery
    • A-C. Groo et al. Fate of paclitaxel lipid nanocapsules in intestinal mucus in view of their oral delivery Int. J. Nanomedicine 8 2013 4291 4302
    • (2013) Int. J. Nanomedicine , vol.8 , pp. 4291-4302
    • Groo, A.-C.1
  • 62
    • 0029779942 scopus 로고    scopus 로고
    • Characterization of pig colonic mucins
    • F.J. Fogg et al. Characterization of pig colonic mucins Biochem. J. 316 1996 937 942
    • (1996) Biochem. J. , vol.316 , pp. 937-942
    • Fogg, F.J.1
  • 65
    • 0024797084 scopus 로고
    • Donnan mechanism of mucin release and conditioning in goblet cells: The role of polyions
    • M.L. Aitken, and P. Verdugo Donnan mechanism of mucin release and conditioning in goblet cells: the role of polyions Symp. Soc. Exp. Biol. 43 1989 73 80
    • (1989) Symp. Soc. Exp. Biol. , vol.43 , pp. 73-80
    • Aitken, M.L.1    Verdugo, P.2
  • 66
    • 77952261296 scopus 로고    scopus 로고
    • Characterization of particle translocation through mucin hydrogels
    • O. Lieleg et al. Characterization of particle translocation through mucin hydrogels Biophys. J. 98 2010 1782 1789
    • (2010) Biophys. J. , vol.98 , pp. 1782-1789
    • Lieleg, O.1
  • 67
    • 33845309114 scopus 로고    scopus 로고
    • A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms
    • H. Matsui et al. A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms Proc. Natl. Acad. Sci. U. S. A. 103 2006 18131 18136
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 18131-18136
    • Matsui, H.1
  • 68
    • 84878663137 scopus 로고    scopus 로고
    • Ex vivo characterization of particle transport in mucus secretions coating freshly excised mucosal tissues
    • L.M. Ensign et al. Ex vivo characterization of particle transport in mucus secretions coating freshly excised mucosal tissues Mol. Pharm. 10 2013 2176 2182
    • (2013) Mol. Pharm. , vol.10 , pp. 2176-2182
    • Ensign, L.M.1
  • 69
    • 84859719708 scopus 로고    scopus 로고
    • Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers
    • L.M. Ensign et al. Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers Adv. Drug Deliv. Rev. 64 2012 557 570
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 557-570
    • Ensign, L.M.1
  • 70
    • 84870360366 scopus 로고    scopus 로고
    • Chitosan-Pluronic nanoparticles as oral delivery of anticancer gemcitabine: Preparation and in vitro study
    • H. Hosseinzadeh et al. Chitosan-Pluronic nanoparticles as oral delivery of anticancer gemcitabine: preparation and in vitro study Int. J. Nanomedicine 7 2012 1851 1863
    • (2012) Int. J. Nanomedicine , vol.7 , pp. 1851-1863
    • Hosseinzadeh, H.1
  • 71
    • 84879883429 scopus 로고    scopus 로고
    • Thiopyrazole preactivated chitosan: Combining mucoadhesion and drug delivery
    • C. Mûller et al. Thiopyrazole preactivated chitosan: combining mucoadhesion and drug delivery Acta Biomater. 9 2013 6585 6593
    • (2013) Acta Biomater. , vol.9 , pp. 6585-6593
    • Mûller, C.1
  • 72
    • 84864013044 scopus 로고    scopus 로고
    • Polyelectrolyte stabilized multilayered liposomes for oral delivery of paclitaxel
    • S. Jain et al. Polyelectrolyte stabilized multilayered liposomes for oral delivery of paclitaxel Biomaterials 33 2012 6758 6768
    • (2012) Biomaterials , vol.33 , pp. 6758-6768
    • Jain, S.1
  • 73
    • 0032751949 scopus 로고    scopus 로고
    • Preparation of Ulex europaeus lectin-gliadin nanoparticle conjugates and their interaction with gastrointestinal mucus
    • I. Ezpeleta et al. Preparation of Ulex europaeus lectin-gliadin nanoparticle conjugates and their interaction with gastrointestinal mucus Int. J. Pharm. 191 1999 25 32
    • (1999) Int. J. Pharm. , vol.191 , pp. 25-32
    • Ezpeleta, I.1
  • 74
    • 0033891387 scopus 로고    scopus 로고
    • Multiple-particle tracking measurements of heterogeneities in solutions of actin filaments and actin bundles
    • J. Apgar et al. Multiple-particle tracking measurements of heterogeneities in solutions of actin filaments and actin bundles Biophys. J. 79 2000 1095 1106
    • (2000) Biophys. J. , vol.79 , pp. 1095-1106
    • Apgar, J.1
  • 75
    • 7044269314 scopus 로고    scopus 로고
    • Real-time multiple-particle tracking: Applications to drug and gene delivery
    • J. Suh et al. Real-time multiple-particle tracking: applications to drug and gene delivery Adv. Drug Deliv. Rev. 57 2005 63 78
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , pp. 63-78
    • Suh, J.1
  • 76
    • 79959641957 scopus 로고    scopus 로고
    • Mucoadhesive nanoparticles may disrupt the protective human mucus barrier by altering its microstructure
    • Y.Y. Wang et al. Mucoadhesive nanoparticles may disrupt the protective human mucus barrier by altering its microstructure PLoS ONE 6 2011 e21547
    • (2011) PLoS ONE , vol.6 , pp. 21547
    • Wang, Y.Y.1
  • 77
    • 43249118137 scopus 로고    scopus 로고
    • Specific permeability modulation of intestinal paracellular pathway by chitosan-poly(isobutylcyanoacrylate) core-shell nanoparticles
    • I. Bravo-Osuna et al. Specific permeability modulation of intestinal paracellular pathway by chitosan-poly(isobutylcyanoacrylate) core-shell nanoparticles Eur. J. Pharm. Biopharm. 69 2008 436 444
    • (2008) Eur. J. Pharm. Biopharm. , vol.69 , pp. 436-444
    • Bravo-Osuna, I.1
  • 78
    • 84864401367 scopus 로고    scopus 로고
    • Methylated N-(4-N,N-dimethylaminobenzyl) chitosan coated liposomes for oral protein drug delivery
    • J. Kowapradit et al. Methylated N-(4-N,N-dimethylaminobenzyl) chitosan coated liposomes for oral protein drug delivery Eur. J. Pharm. Sci. 47 2012 359 366
    • (2012) Eur. J. Pharm. Sci. , vol.47 , pp. 359-366
    • Kowapradit, J.1
  • 79
    • 79955032379 scopus 로고    scopus 로고
    • Enhanced cellular association of paclitaxel delivered in chitosan-PLGA particles
    • S.S. Chakravarthi, and D.H. Robinson Enhanced cellular association of paclitaxel delivered in chitosan-PLGA particles Int. J. Pharm. 409 2011 111 120
    • (2011) Int. J. Pharm. , vol.409 , pp. 111-120
    • Chakravarthi, S.S.1    Robinson, D.H.2
  • 80
    • 55749092436 scopus 로고    scopus 로고
    • Quantifying diffusion in mucosal systems by pulsed-gradient spin-echo NMR
    • P. Occhipinti, and P.C. Griffiths Quantifying diffusion in mucosal systems by pulsed-gradient spin-echo NMR Adv. Drug Deliv. Rev. 60 2008 1570 1582
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 1570-1582
    • Occhipinti, P.1    Griffiths, P.C.2
  • 81
    • 84904267805 scopus 로고    scopus 로고
    • Development of 2D and 3D mucus models and their interactions with mucus penetrating paclitaxel loaded lipid nanocapsules
    • 10.1007/s11095-013-1280-4 (in press)
    • A.-C. Groo et al. Development of 2D and 3D mucus models and their interactions with mucus penetrating paclitaxel loaded lipid nanocapsules Pharm. Res. 2014 10.1007/s11095-013-1280-4 (in press)
    • (2014) Pharm. Res.
    • Groo, A.-C.1
  • 82
    • 33644922361 scopus 로고    scopus 로고
    • Efficacy and mechanism of action of chitosan nanocapsules for oral peptide delivery
    • C. Prego et al. Efficacy and mechanism of action of chitosan nanocapsules for oral peptide delivery Pharm. Res. 23 2006 549 556
    • (2006) Pharm. Res. , vol.23 , pp. 549-556
    • Prego, C.1
  • 83
    • 84883582500 scopus 로고    scopus 로고
    • Enhanced oral delivery of paclitaxel using acetylcysteine functionalized chitosan-vitamin e succinate nanomicelles based on a mucus bioadhesion and penetration mechanism
    • H. Lian et al. Enhanced oral delivery of paclitaxel using acetylcysteine functionalized chitosan-vitamin E succinate nanomicelles based on a mucus bioadhesion and penetration mechanism Mol. Pharm. 10 2013 3447 3458
    • (2013) Mol. Pharm. , vol.10 , pp. 3447-3458
    • Lian, H.1
  • 84
    • 84884514812 scopus 로고    scopus 로고
    • Exploration of hydrophobic modification degree of chitosan-based nanocomplexes on the oral delivery of enoxaparin
    • L. Wang et al. Exploration of hydrophobic modification degree of chitosan-based nanocomplexes on the oral delivery of enoxaparin Eur. J. Pharm. Sci. 50 2013 263 271
    • (2013) Eur. J. Pharm. Sci. , vol.50 , pp. 263-271
    • Wang, L.1
  • 85
    • 84855846254 scopus 로고    scopus 로고
    • Highly compacted DNA nanoparticles with low MW PEG coatings: In vitro, ex vivo and in vivo evaluation
    • N.J. Boylan et al. Highly compacted DNA nanoparticles with low MW PEG coatings: in vitro, ex vivo and in vivo evaluation J. Control. Release 157 2012 72 79
    • (2012) J. Control. Release , vol.157 , pp. 72-79
    • Boylan, N.J.1
  • 86
    • 0033823140 scopus 로고    scopus 로고
    • The physical properties of biogels and their permeability for macromolecular drugs and colloidal drug carriers
    • N.N. Sanders et al. The physical properties of biogels and their permeability for macromolecular drugs and colloidal drug carriers J. Pharm. Sci. 89 2000 835 849
    • (2000) J. Pharm. Sci. , vol.89 , pp. 835-849
    • Sanders, N.N.1
  • 87
    • 84950818553 scopus 로고
    • The diaphragm cell method of measuring diffusion
    • A.R. Gordon The diaphragm cell method of measuring diffusion Ann. N. Y. Acad. Sci. 46 1945 285 308
    • (1945) Ann. N. Y. Acad. Sci. , vol.46 , pp. 285-308
    • Gordon, A.R.1
  • 88
    • 0013927720 scopus 로고
    • An examination of the evidence for membrane pores in frog skin
    • J. Dainty, and C.R. House An examination of the evidence for membrane pores in frog skin J. Physiol. 185 1966 172 184
    • (1966) J. Physiol. , vol.185 , pp. 172-184
    • Dainty, J.1    House, C.R.2
  • 89
    • 0013874881 scopus 로고
    • Unstirred layers in frog skin
    • J. Dainty, and C.R. House Unstirred layers in frog skin J. Physiol. 182 1966 66 78
    • (1966) J. Physiol. , vol.182 , pp. 66-78
    • Dainty, J.1    House, C.R.2
  • 90
    • 71649100500 scopus 로고    scopus 로고
    • Analysis of unstirred water layer in in vitro permeability experiments
    • T. Korjamo et al. Analysis of unstirred water layer in in vitro permeability experiments J. Pharm. Sci. 98 2009 4469 4479
    • (2009) J. Pharm. Sci. , vol.98 , pp. 4469-4479
    • Korjamo, T.1
  • 92
    • 0033022229 scopus 로고    scopus 로고
    • PH-dependent conformational change of gastric mucin leads to sol-gel transition
    • X. Cao et al. pH-dependent conformational change of gastric mucin leads to sol-gel transition Biophys. J. 76 1999 1250 1258
    • (1999) Biophys. J. , vol.76 , pp. 1250-1258
    • Cao, X.1
  • 93
    • 0024395077 scopus 로고
    • Human cervical mucus and its interaction with sperm: A fine-structural view
    • A.I. Yudin et al. Human cervical mucus and its interaction with sperm: a fine-structural view Biol. Reprod. 40 1989 661 671
    • (1989) Biol. Reprod. , vol.40 , pp. 661-671
    • Yudin, A.I.1
  • 94
    • 84862493233 scopus 로고    scopus 로고
    • Novel mucoadhesive polymers - A review
    • G. Mythri et al. Novel mucoadhesive polymers - a review JAPS 1 2011 37 42
    • (2011) JAPS , vol.1 , pp. 37-42
    • Mythri, G.1
  • 95
    • 67349238210 scopus 로고    scopus 로고
    • Preparation and in vitro evaluation of mucoadhesion and permeation enhancement of thiolated chitosan-pHEMA core-shell nanoparticles
    • F.A. Moghaddam et al. Preparation and in vitro evaluation of mucoadhesion and permeation enhancement of thiolated chitosan-pHEMA core-shell nanoparticles Nanomedicine 5 2009 208 215
    • (2009) Nanomedicine , vol.5 , pp. 208-215
    • Moghaddam, F.A.1
  • 96
    • 84870330102 scopus 로고    scopus 로고
    • Chemical coupling of thiolated chitosan to preformed liposomes improves mucoadhesive properties
    • K. Gradauer et al. Chemical coupling of thiolated chitosan to preformed liposomes improves mucoadhesive properties Int. J. Nanomedicine 7 2012 2523 2534
    • (2012) Int. J. Nanomedicine , vol.7 , pp. 2523-2534
    • Gradauer, K.1
  • 97
    • 84877018963 scopus 로고    scopus 로고
    • ®) F127-modified liposomes and chitosan-modified liposomes for mucus penetration and oral absorption of cyclosporine A in rats
    • ®) F127-modified liposomes and chitosan-modified liposomes for mucus penetration and oral absorption of cyclosporine A in rats Int. J. Pharm. 449 2013 1 9
    • (2013) Int. J. Pharm. , vol.449 , pp. 1-9
    • Chen, D.1
  • 98
    • 84859770683 scopus 로고    scopus 로고
    • Interaction of chitosan and mucin in a biomembrane model environment
    • C.A. Silva et al. Interaction of chitosan and mucin in a biomembrane model environment J. Colloid Interface Sci. 376 2012 289 295
    • (2012) J. Colloid Interface Sci. , vol.376 , pp. 289-295
    • Silva, C.A.1
  • 99
    • 15244340396 scopus 로고    scopus 로고
    • Pegylated nanoparticles based on poly(methyl vinyl ether-co-maleic anhydride): Preparation and evaluation of their bioadhesive properties
    • K. Yoncheva et al. Pegylated nanoparticles based on poly(methyl vinyl ether-co-maleic anhydride): preparation and evaluation of their bioadhesive properties Eur. J. Pharm. Sci. 24 2005 411 419
    • (2005) Eur. J. Pharm. Sci. , vol.24 , pp. 411-419
    • Yoncheva, K.1
  • 100
    • 33947124235 scopus 로고    scopus 로고
    • Evaluation of bioadhesive potential and intestinal transport of pegylated poly(anhydride) nanoparticles
    • K. Yoncheva et al. Evaluation of bioadhesive potential and intestinal transport of pegylated poly(anhydride) nanoparticles Int. J. Pharm. 334 2007 156 165
    • (2007) Int. J. Pharm. , vol.334 , pp. 156-165
    • Yoncheva, K.1
  • 101
    • 0034000923 scopus 로고    scopus 로고
    • Molecular aspects of muco- and bioadhesion: Tethered structures and site-specific surfaces
    • Y. Huang et al. Molecular aspects of muco- and bioadhesion: tethered structures and site-specific surfaces J. Control. Release 65 2000 63 71
    • (2000) J. Control. Release , vol.65 , pp. 63-71
    • Huang, Y.1
  • 102
    • 84879482486 scopus 로고    scopus 로고
    • Scalable method to produce biodegradable nanoparticles that rapidly penetrate human mucus
    • Q. Xu et al. Scalable method to produce biodegradable nanoparticles that rapidly penetrate human mucus J. Control. Release 170 2013 279 286
    • (2013) J. Control. Release , vol.170 , pp. 279-286
    • Xu, Q.1
  • 103
    • 84877267457 scopus 로고    scopus 로고
    • Improved transport and absorption through gastrointestinal tract by PEGylated solid lipid nanoparticles
    • H. Yuan et al. Improved transport and absorption through gastrointestinal tract by PEGylated solid lipid nanoparticles Mol. Pharm. 10 2013 1865 1873
    • (2013) Mol. Pharm. , vol.10 , pp. 1865-1873
    • Yuan, H.1
  • 104
    • 34548813855 scopus 로고    scopus 로고
    • Actin limits enhancement of nanoparticle diffusion through cystic fibrosis sputum by mucolytics
    • V.J. Broughton-Head et al. Actin limits enhancement of nanoparticle diffusion through cystic fibrosis sputum by mucolytics Pulm. Pharmacol. Ther. 20 2007 708 717
    • (2007) Pulm. Pharmacol. Ther. , vol.20 , pp. 708-717
    • Broughton-Head, V.J.1
  • 105
    • 84870826859 scopus 로고    scopus 로고
    • Preparation and characterization of mucus-penetrating papainpoly(acrylic acid) nanoparticles for oral drug delivery applications
    • C. Müller et al. Preparation and characterization of mucus-penetrating papainpoly(acrylic acid) nanoparticles for oral drug delivery applications J. Nanopart. Res. 15 2013 1 13
    • (2013) J. Nanopart. Res. , vol.15 , pp. 1-13
    • Müller, C.1
  • 106
    • 84864130324 scopus 로고    scopus 로고
    • Mucus penetrating nanoparticles: Biophysical tool and method of drug and gene delivery
    • L.M. Ensign et al. Mucus penetrating nanoparticles: biophysical tool and method of drug and gene delivery Adv. Mater. 24 2012 3887 3894
    • (2012) Adv. Mater. , vol.24 , pp. 3887-3894
    • Ensign, L.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.