In vivo evaluation of an oral self-microemulsifying drug delivery system (SMEDDS) for leuprorelin

International Journal of Pharmaceutics

Volumn 472, Issue 1-2, 2014, Pages 20-26

  Hintzen, Fabian ^a   Perera, Glen ^a   Hauptstein, Sabine ^a   Müller, Christiane ^a   Laffleur, Flavia ^a   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Hydrophobic ion pairing; Leuprorelin; Protection against enzymatic degradation; Self microemulsifying drug delivery system

Indexed keywords

CHYMOTRYPSIN A; CREMOPHOR; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; INTESTINE ENZYME; ION; LEUPRORELIN; OCTANOIN; OLEATE SODIUM; OLEIC ACID; PROPYLENE GLYCOL; TRYPSIN; ACYLGLYCEROL; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; EMULSION; FERTILITY PROMOTING AGENT; GLYCEROL; OCTANOIC ACID DERIVATIVE; OSTEUM; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; ENZYMATIC DEGRADATION; ENZYME METABOLISM; EVALUATION STUDY; HYDROPHOBICITY; IN VIVO STUDY; MALE; MICROEMULSION; NONHUMAN; PRIORITY JOURNAL; RAT; SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM; TIGHT JUNCTION; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMISTRY; EMULSION; ORAL DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; CAPRYLATES; DRUG DELIVERY SYSTEMS; EMULSIONS; FERTILITY AGENTS, FEMALE; GLYCERIDES; GLYCEROL; LEUPROLIDE; MALE; OLEIC ACID; PROPYLENE GLYCOL; RATS, SPRAGUE-DAWLEY; TRIGLYCERIDES; TRYPSIN;

EID: 84902771662     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.05.047     Document Type: Article

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