In vitro and in vivo preclinical evaluation of a minisphere emulsion-based formulation (SmPill®) of salmon calcitonin

European Journal of Pharmaceutical Sciences

Volumn 79, Issue , 2015, Pages 102-111

  Aguirre, Tanira A S ^a,b   Rosa, Mónica ^b   Coulter, Ivan S ^b   Brayden, David J ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b DUBLIN CITY UNIVERSITY   (Ireland)

Author keywords

Intestinal permeation enhancers; Oil in water emulsions; Oral bioavailability; Oral peptide and protein delivery; Salmon calcitonin

Indexed keywords

CALCIUM; CITRIC ACID; COCO GLUCOSIDE; CYCLIC AMP; GLUCOSIDE; PENETRATION ENHANCING AGENT; SALCATONIN; TAURODEOXYCHOLIC ACID; UNCLASSIFIED DRUG; WATER OIL CREAM; CALCITONIN; DECANOIC ACID; DECANOIC ACID DERIVATIVE; EMULSION; MICROSPHERE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BIOLOGICAL ACTIVITY; CALCIUM BLOOD LEVEL; COLON; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG HALF LIFE; DRUG SCREENING; DRUG STABILITY; GOBLET CELL; HISTOLOGY; HYPOCALCEMIA; INTESTINE LOOP; JEJUNUM; LIGHT SCATTERING; MALE; MUCUS SECRETION; NONHUMAN; PH; PHARMACODYNAMICS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SHEAR RATE; TIME TO MAXIMUM PLASMA CONCENTRATION; VISCOSITY; ANIMAL; BIOAVAILABILITY; DRUG INSTILLATION; EMULSION; IN VITRO STUDY; INTESTINE ABSORPTION; ORAL DRUG ADMINISTRATION; PROCEDURES; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CALCITONIN; COLON; DECANOIC ACIDS; DRUG DELIVERY SYSTEMS; EMULSIONS; IN VITRO TECHNIQUES; INSTILLATION, DRUG; INTESTINAL ABSORPTION; JEJUNUM; MALE; MICROSPHERES; RATS; RATS, WISTAR; TAURODEOXYCHOLIC ACID;

EID: 84942258290     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.09.001     Document Type: Article

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