Nanoemulsions coated with alginate/chitosan as oral insulin delivery systems: Preparation, characterization, and hypoglycemic effect in rats

International Journal of Nanomedicine

Volumn 8, Issue , 2012, Pages 23-32

  Li, Xiaoyang ^a   Qi, Jianping ^a   Xie, Yunchang ^a   Zhang, Xi ^a   Hu, Shunwen ^a   Xu, Ying ^a   Lu, Yi ^a   Wu, Wei ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Alginate; Chitosan; Insulin; Nanoemulsion; Oral delivery

Indexed keywords

ALGINIC ACID; CALCIUM CHLORIDE; CHITOSAN; CREMOPHOR; EXCIPIENT; GLUCOSE; LABRAFAC CC; PHOSPHOLIPID; PIG INSULIN; POLYELECTROLYTE; SORBITAN OLEATE; UNCLASSIFIED DRUG; WATER OIL CREAM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; CROSS LINKING; DIABETES MELLITUS; DISPERSION; DRUG BIOAVAILABILITY; DRUG COATING; DRUG CONFORMATION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG DOSE COMPARISON; DRUG STABILITY; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; MALE; NANOEMULSION; NONHUMAN; PARTICLE SIZE; RAT; SIMULATION; STOMACH JUICE; ZETA POTENTIAL;

ALGINATE; CHITOSAN; INSULIN; NANOEMULSION; ORAL DELIVERY;

ADMINISTRATION, ORAL; ALGINATES; ANALYSIS OF VARIANCE; ANIMALS; BLOOD GLUCOSE; CHITOSAN; CIRCULAR DICHROISM; DIABETES MELLITUS, EXPERIMENTAL; DRUG CARRIERS; DRUG STABILITY; EMULSIONS; GASTRIC JUICE; GLUCURONIC ACID; HEXURONIC ACIDS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MODELS, BIOLOGICAL; NANOPARTICLES; PARTICLE SIZE; RATS; RATS, WISTAR;

RATTUS;

EID: 84872308929     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S38507     Document Type: Article

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