Improved intestinal delivery of salmon calcitonin by water-in-oil microemulsions

International Journal of Pharmaceutics

Volumn 416, Issue 1, 2011, Pages 323-330

  Fan, Yating ^a   Li, Xinru ^a   Zhou, Yanxia ^a   Fan, Chao ^a   Wang, Xiaoning ^a   Huang, Yanqing ^a   Liu, Yan ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Dilution; Hypocalcemic efficacy; Oral drug delivery; Peptides; Salmon calcitonin; Water in oil microemulsion

Indexed keywords

CARBOMER; HYDROXYPROPYLMETHYLCELLULOSE; MEDIUM CHAIN TRIACYLGLYCEROL; PHOSPHATE SALINE; POLYSORBATE 80; PROPYLENE GLYCOL; SALCATONIN; SORBITAN OLEATE; SOYBEAN PHOSPHATIDYLCHOLINE; UNCLASSIFIED DRUG; WATER OIL CREAM;

ANIMAL EXPERIMENT; ARTICLE; DILUTION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG FORMULATION; DRUG SYNTHESIS; ENCAPSULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOCALCEMIA; IN VITRO STUDY; IONIC STRENGTH; MICROEMULSION; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; RAT; VISCOSITY;

ANIMALS; CALCITONIN; CALCIUM; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; EMULSIONS; INTESTINAL ABSORPTION; MALE; OILS; PARTICLE SIZE; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SURFACE-ACTIVE AGENTS; WATER;

EID: 80051781559     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.06.029     Document Type: Article

References (42)

1. D. Attwood, and A.T. Florence H. Schott, Surfactant Systems: Their Chemistry, Pharmacy and Biology 1983 Chapman & Hall London 519 524
2. M. Baluom, D.I. Friedman, and A. Rubinstein Absorption enhancement of calcitonin in the rat intestine by carbopol-containing submicron emulsions Int. J. Pharm. 154 1997 235 243 (Pubitemid 27351328)
3. M. Chen, X.R. Li, Y.X. Zhou, K.W. Yang, X.W. Chen, Q. Deng, Y. Liu, and L.J. Ren Improved absorption of salmon calcitonin by ultraflexible liposomes through intranasal delivery Peptides 30 2009 1288 1295
4. M.B. Cheng, J.C. Wang, Y.H. Li, X.Y. Liu, X. Zhang, D.W. Chen, S.F. Zhou, and Q. Zhang Characterization of water-in-oil microemulsion for oral delivery of earthworm fibrinolytic enzyme J. Control. Release 129 2008 41 48
5. A. Cilek, N. Celebi, F. Tirnaksiz, and A. Tay A lecithin-based microemulsion of rh-insulin with aprotinin for oral administration: investigation of hypoglycemic effects in non-diabetic and STZ-induced diabetic rats Int. J. Pharm. 298 2005 176 185 (Pubitemid 40828338)
6. S. Clement, P. Dandona, J.G. Still, and G. Kosutic Oral modified insulin (HIM2) in patients with type 1 diabetes mellitus: results from a phase I/II clinical trial Metabolism-Clin. Exp. 53 2004 54 58 (Pubitemid 38071936)
7. P.P. Constantinides, J.P. Scalart, C. Lancaster, J. Marcello, G. Marks, H. Ellens, and P.L. Smith Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions incorporating medium-chain glycerides Pharm. Res. 11 1994 1385 1390 (Pubitemid 24339642)
8. P.P. Constantinides, G. Welzel, H. Ellens, P.L. Smith, S. Sturgis, S.H. Yiv, and A.B. Owen Water-in-oil microemulsions containing medium-chain fatty acids salts: formulation and intestinal absorption enhancement evaluation Pharm. Res. 13 1996 210 215 (Pubitemid 26072140)
9. P.P. Constantinides, and S.H. Yiv Particle-size determination of phase-inverted water-in-oil microemulsions under different dilution and storage-conditions Int. J. Pharm. 115 1995 225 234
10. A.S. Cunha, J.L. Grossiord, F. Puisieux, and M. Seiller Insulin in w/o/w multiple emulsions: preparation, characterization and determination of stability towards proteases in vitro J. Microencapsul. 14 1997 311 319 (Pubitemid 27190279)
11. S. Frokjaer, and D.E. Otzen Protein drug stability: a formulation challenge Nat. Rev. Drug Discov. 4 2005 298 306 (Pubitemid 41130943)
12. Z.G. Gao, H.G. Choi, H.J. Shin, K.M. Park, S.J. Lim, K.J. Hwang, and C.K. Kim Physicochemical characterization and evaluation of a microemulsion system for oral delivery of cyclosporin A Int. J. Pharm. 161 1998 75 86
13. M. Grit, and J.A. Crommelin Chemical-stability of liposomes - implications for their physical stability Chem. Phys. Lipids 64 1993 3 18 (Pubitemid 23290861)
14. M. Grit, W.J.M. Underberg, and D.J.A. Crommelin Hydrolysis of saturated soybean phosphatidylcholine in aqueous liposome dispersions J. Pharm. Sci. 82 1993 362 366 (Pubitemid 23150427)
15. J.H. Hamman, G.M. Enslin, and A.F. Kotze Oral delivery of peptide drugs - barriers and developments BioDrugs 19 2005 165 177 (Pubitemid 40994232)
16. Y. Hee Lee, G.D. Leesman, V. Makhey, H. Yu, P. Hu, B. Perry, J.P. Sutyak, E.J. Wagner, L.M. Falzone, W. Stern, and P.J. Sinko Regional oral absorption, hepatic first-pass effect, and non-linear disposition of salmon calcitonin in beagle dogs Eur. J. Pharm. Biopharm. 50 2000 205 211
17. S. Hirai, T. Yashiki, and H. Mima Effect of surfactants on the nasal absorption of insulin in rats Int. J. Pharm. 9 1981 165 172 (Pubitemid 11021847)
18. E. Ilan, S. Amselem, M. Weisspapir, J. Schwarz, A. Yogev, E. Zawoznik, and D. Friedman Improved oral delivery of desmopressin via a novel vehicle: mucoadhesive submicron emulsion Pharm. Res. 13 1996 1083 1087 (Pubitemid 26259012)
19. K.R. Jadhav, I.M. Shaikh, K.W. Ambade, and V.J. Kadam Applications of microemulsion based drug delivery system Curr. Drug Deliv. 3 2006 267 273 (Pubitemid 44031625)
20. M.A. Kisel, L.N. Kulik, I.S. Tsybovsky, A.P. Vlasov, M.S. Vorob'yov, E.A. Kholodova, and Z.V. Zabarovskaya Liposomes with phosphatidylethanol as a carrier for oral delivery of insulin: studies in the rat Int. J. Pharm. 216 2001 105 114 (Pubitemid 32232100)
21. Y.H. Lee, B.A. Perry, J.P. Sutyak, W. Stern, and P.J. Sinko Regional differences in intestinal spreading and pH recovery and the impact on salmon calcitonin absorption in dogs Pharm. Res. 17 2000 284 290 (Pubitemid 30225131)
22. Y.H. Lee, and P.J. Sinko Oral delivery of salmon calcitonin Adv. Drug Deliv. Rev. 42 2000 225 238 (Pubitemid 30645779)
23. P. Li, A. Ghosh, R.F. Wagner, S. Krill, Y.M. Joshi, and A.T.M. Serajuddin Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions Int. J. Pharm. 288 2005 27 34 (Pubitemid 39656452)
24. W. Liu, M.L. Hu, W.S. Liu, C.B. Xue, H.B. Xu, and X.L. Yang Investigation of the carbopol gel of solid lipid nanoparticles for the transdermal iontophoretic delivery of triamcinolone acetonide acetate Int. J. Pharm. 364 2008 135 141
25. P.D.P. Lundin, M. Bojrup, H. LjusbergWahren, B.R. Westrom, and S. Lundin Enhancing effects of monohexanoin and two other medium-chain glyceride vehicles on intestinal absorption of desmopressin (dDAVP) J. Pharmacol. Exp. Ther. 282 1997 585 590 (Pubitemid 27340155)
26. N.M. Mehta Oral delivery and recombinant production of peptide hormones. Part I. Making oral delivery possible Biopharm. Int. 17 2004 38 43 (Pubitemid 38737849)
27. G.M. Pauletti, S. Gangwar, G.T. Knipp, M.M. Nerurkar, F.W. Okumu, K. Tamura, T.J. Siahaan, and R.T. Borchardt Structural requirements for intestinal absorption of peptide drugs J. Control. Release 41 1996 3 17 (Pubitemid 26246359)
28. A. Petrovic, N. Cvetkovic, S. Ibric, S. Trajkovic, Z. Djuric, D. Popadic, and R. Popovic Application of mixture experimental design in the formulation and optimization of matrix tablets containing carbomer and hydroxypropylmethylcellulose Arch. Pharm. Res. 32 2009 1767 1774
29. Y.V. Prasad, S.P. Puthli, S. Eaimtrakarn, M. Ishida, Y. Yoshikawa, N. Shibata, and K. Takada Enhanced intestinal absorption of vancomycin with Labrasol and D-alpha-tocopheryl PEG 1000 succinate in rats Int. J. Pharm. 250 2003 181 190 (Pubitemid 35447948)
30. C. Prego, M. Fabre, D. Torres, and M.J. Alonso Efficacy and mechanism of action of chitosan nanocapsules for oral peptide delivery Pharm. Res. 23 2006 549 556
31. D.M. Qian, G.Q. Shen, and R.L. Ke Biological assay of calcitonin by blood calcium determination in rats Chin. J. Pharm. Anal. 14 1994 30 34
32. J.M. Sarciaux, L. Acar, and P.A. Sado Using microemulsion formulations for oral-drug delivery of therapeutic peptides Int. J. Pharm. 120 1995 127 136
33. A. Silva-Cunha, M. Cheron, J.L. Grossiord, F. Puisieux, and M. Seiller W/O/W multiple emulsions of insulin containing a protease inhibitor and an absorption enhancer: biological activity after oral administration to normal and diabetic rats Int. J. Pharm. 169 1998 33 44 (Pubitemid 28352596)
34. P.J. Sinko, C.L. Smith, L.T. Mcwhorter, W. Stern, E. Wagner, and J.P. Gilligan Utility of pharmacodynamic measures for assessing the oral bioavailability of peptides. 1. Administration of recombinant salmon-calcitonin in rats J. Pharm. Sci. 84 1995 1374 1378
35. K.H. Song, S.J. Chung, and C.K. Shim Preparation and evaluation of proliposomes containing salmon calcitonin J. Control. Release 84 2002 27 37
36. A. Spernath, and A. Aserin Microemulsions as carriers for drugs and nutraceuticals Adv. Colloid Interface Sci. 128 2006 47 64 (Pubitemid 46215528)
37. L.B. Tanko, Y.Z. Bagger, P. Alexandersen, J.P. Devogelaer, J.Y. Reginster, R. Chick, M. Olson, H. Benmammar, L. Mindeholm, M. Azria, and C. Christiansen Safety and efficacy of a novel salmon calcitonin (sCT) technology-based oral formulation in healthy postmenopausal women: acute and 3-month effects on biomarkers of bone turnover J. Bone Miner. Res. 19 2004 1531 1538 (Pubitemid 41094356)
38. N. Thirawong, J. Thongborisute, H. Takeuchi, and P. Sriamornsak Improved intestinal absorption of calcitonin by mucoadhesive delivery of novel pectin-liposome nanocomplexes J. Control. Release 125 2008 236 245
39. S. Watnasirichaikul, T. Rades, I.G. Tucker, and N.M. Davies In-vitro release and oral bioactivity of insulin in diabetic rats using nanocapsules dispersed in biocompatible microemulsion J. Pharm. Pharmacol. 54 2002 473 480 (Pubitemid 34308489)
40. J. Werling, S. Graham, H. Owen, L. Nair, T. Gonyon, and P.W. Carter Physicochemical stability of phospholipid-dispersed suspensions of crystalline itraconazole Eur. J. Pharm. Biopharm. 69 2008 1104 1113
41. A. Yamamoto, T. Okagawa, A. Kotani, T. Uchiyama, T. Shimura, S. Tabata, S. Kondo, and S. Muranishi Effects of different absorption enhancers on the permeation of ebiratide, an ACTH analogue, across intestinal membranes J. Pharm. Pharmacol. 49 1997 1057 1061 (Pubitemid 27496716)
42. Y.H. Zhang, X.R. Li, Y.X. Zhou, X.N. Wang, Y.T. Fan, Y.Q. Huang, and Y. Liu Preparation and evaluation of poly(ethylene glycol)-poly(lactide) micelles as nanocarriers for oral delivery of cyclosporine A Nanoscale Res. Lett. 5 2010 917 925