Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. the effect of bile salt concentration and drug loading on the performance of type I, II, IIIA, IIIB, and IV formulations during in vitro digestion

Molecular Pharmaceutics

Volumn 9, Issue 11, 2012, Pages 3286-3300

  Williams, Hywel D ^a   Anby, Mette U ^a   Sassene, Philip ^b   Kleberg, Karen ^b   Bakala Ngoma, Jean Claude ^c   Calderone, Marilyn ^d   Jannin, Vincent ^e   Igonin, Annabel ^f   Partheil, Anette ^g   Marchaud, Delphine ^e   Jule, Eduardo ^f   Vertommen, Jan ^f   Maio, Mario ^g   Blundell, Ross ^d   Benameur, Hassan ^f   Carrière, Frédéric ^c   Müllertz, Anette ^b   Pouton, Colin W ^a   Porter, Christopher J H ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c CNRS   (France)

^d SANOFI   (France)

^e GATTEFOSSÉ SAS   (France)

^f CAPSUGEL   (France)

^g MERCK KGAA   (Germany)

Author keywords

bioavailability; drug solubilization; in vitro digestion testing; in vitro models; LFCS Consortium; lipid based drug delivery systems; poorly water soluble drug; precipitation; SEDDS; solubility; supersaturation

Indexed keywords

BILE SALT; DANAZOL; FATTY ACID; LIPID; TAURODEOXYCHOLIC ACID;

ARTICLE; DIGESTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; EMULSION; IN VITRO STUDY; PARTICLE SIZE; PRECIPITATION; PRIORITY JOURNAL; SOLUBILIZATION;

BILE ACIDS AND SALTS; CHEMISTRY, PHARMACEUTICAL; DANAZOL; DIGESTION; KINETICS; LIPIDS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 84868549081     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300331z     Document Type: Article

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