Goblet cell targeting nanoparticle containing drug-loaded micelle cores for oral delivery of insulin

International Journal of Pharmaceutics

Volumn 496, Issue 2, 2015, Pages 993-1005

  Zhang, Peiwen ^a,b   Xu, Yining ^a   Zhu, Xi ^a   Huang, Yuan ^a  

^a SICHUAN UNIVERSITY   (China)

^b People s Hospital of Deyang City   (China)

Author keywords

CSKSSDYQC; Epithelium; Insulin; Nanoparticles; Oral delivery

Indexed keywords

COPOLYMER; DODECYLAMINE; GLUCOSE; INSULIN; NANOCARRIER; POLYELECTROLYTE; POLYGLUTAMIC ACID; PROTEIN ZO1; CHITOSAN; MICELLE; N-TRIMETHYL CHITOSAN CHLORIDE; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CACO 2 CELL LINE; CELL PERMEABILIZATION; CELL VIABILITY; COCULTURE; COLLOID; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; DIABETES MELLITUS; DRUG BIOAVAILABILITY; DRUG COATING; DRUG RELEASE; ENCAPSULATION; ENZYME STABILITY; EPITHELIUM; EX VIVO STUDY; GLUCOSE BLOOD LEVEL; GOBLET CELL; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN DEGRADATION; INSULIN RELEASE; INTERNALIZATION; INTESTINE CELL; IONIC STRENGTH; MALE; MICELLE; NONHUMAN; PARTICLE SIZE; PINOCYTOSIS; PRIORITY JOURNAL; RAT; STATIC ELECTRICITY; STOMACH JUICE; ZETA POTENTIAL; ANIMAL; CACO-2 CELL LINE; CHEMISTRY; DRUG DELIVERY SYSTEM; HUMAN; METABOLISM; ORAL DRUG ADMINISTRATION; PH; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; CACO-2 CELLS; CHITOSAN; DRUG DELIVERY SYSTEMS; GOBLET CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; INSULIN; MALE; MICELLES; NANOPARTICLES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84949555613     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.10.078     Document Type: Article

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