Design and evaluation of solid lipid nanoparticles modified with peptide ligand for oral delivery of protein drugs

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 88, Issue 2, 2014, Pages 518-528

  Fan, Tingting ^a   Chen, Chunhui ^a   Guo, Han ^a   Xu, Juan ^a   Zhang, Jian ^a   Zhu, Xi ^a   Yang, Yang ^a   Zhou, Zhou ^a   Li, Lian ^a   Huang, Yuan ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Absolute bioavailability; Caco 2 HT29 MTX co cultured cells; CSKSSDYQC peptide; IRQRRRR peptide; Relative pharmacodynamic bioavailability; Salmon calcitonin; Solid lipid nanoparticles; Ussing chamber

Indexed keywords

CALCIUM; CLATHRIN; CSKSSDYQC PEPTIDE; IRQRRRR PEPTIDE; LIGAND; MACROGOL STEARATE; PEPTIDE DERIVATIVE; SALCATONIN; SOLID LIPID NANOPARTICLE; UNCLASSIFIED DRUG; DRUG CARRIER; LIPID; NANOPARTICLE; PEPTIDE;

ACTIVE TRANSPORT; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CALCIUM BLOOD LEVEL; CAVEOLA; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DOSAGE FORM COMPARISON; DRUG PENETRATION; DRUG SCREENING; DRUG UPTAKE; ENDOCYTOSIS; GOBLET CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; MUCUS; NONHUMAN; PARTICLE SIZE; TIME TO MAXIMUM PLASMA CONCENTRATION; ZETA POTENTIAL; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; COCULTURE; ORAL DRUG ADMINISTRATION; RAT; TUMOR CELL LINE;

ADMINISTRATION, ORAL; AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TUMOR; COCULTURE TECHNIQUES; DRUG CARRIERS; HUMANS; LIGANDS; LIPIDS; NANOPARTICLES; PEPTIDES; RATS;

EID: 84908370833     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2014.06.011     Document Type: Article

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