Hypoglycemic activity and oral bioavailability of insulin-loaded liposomes containing bile salts in rats: The effect of cholate type, particle size and administered dose

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 81, Issue 2, 2012, Pages 265-272

  Niu, Mengmeng ^a   Lu, Yi ^a   Hovgaard, Lars ^b   Guan, Peipei ^a   Tan, Yanan ^a   Lian, Ruyue ^a   Qi, Jianping ^a   Wu, Wei ^a  

^a FUDAN UNIVERSITY   (China)

^b NOVO NORDISK A S   (Denmark)

Author keywords

Bile salts; Bioavailability; Insulin; Liposomes; Oral; Sodium glycocholate

Indexed keywords

BILE SALT; DEOXYCHOLATE SODIUM; INSULIN; LIPOSOME; TAUROCHOLIC ACID;

ANIMAL EXPERIMENT; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG CONFORMATION; DRUG DELIVERY SYSTEM; DRUG STABILITY; INSULIN BLOOD LEVEL; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PARTICLE SIZE; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; BILE ACIDS AND SALTS; BIOLOGICAL AVAILABILITY; DEOXYCHOLIC ACID; DRUG CARRIERS; GLYCOCHOLIC ACID; HYPOGLYCEMIC AGENTS; INSULIN; LIPOSOMES; MALE; MICE; MICE, INBRED ICR; PARTICLE SIZE; RATS; RATS, WISTAR; TAUROCHOLIC ACID;

EID: 84862824387     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2012.02.009     Document Type: Article

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