Preliminary evaluation of a novel oral delivery system for rhPTH1-34: In vitro and in vivo

International Journal of Pharmaceutics

Volumn 420, Issue 1, 2011, Pages 172-179

  Guo, Liting ^a   Ma, Erli ^a   Zhao, Haiwei ^a   Long, Yingfang ^a   Zheng, Changxue ^a   Duan, Mingxing ^a  

^a TSINGHUA UNIVERSITY   (China)

Author keywords

Microemulsion; Oral delivery system; Osteoporosis; rhPTH1 34

Indexed keywords

ALPHA TOCOPHEROL; LABRASOL; PARATHYROID HORMONE[1-34]; SOLUTOL HS 15;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DENSITY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG STABILITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROEMULSION; NONHUMAN; OSTEOPOROSIS; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN DEGRADATION; RANDOMIZED CONTROLLED TRIAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; CACO-2 CELLS; CHEMISTRY, PHARMACEUTICAL; DISEASE MODELS, ANIMAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; EMULSIONS; FEMALE; HUMANS; ILEUM; INTESTINAL ABSORPTION; MALE; NANOTECHNOLOGY; OSTEOPOROSIS; OVARIECTOMY; PARTICLE SIZE; PEPTIDE HYDROLASES; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SOLUBILITY; STOMACH; TECHNOLOGY, PHARMACEUTICAL; TERIPARATIDE; TIBIA;

EID: 80054696375     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.08.029     Document Type: Article

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