Development of novel lipophilic derivatives of DADLE (Leucine enkephalin analogue): Intestinal permeability characteristics of DADLE derivatives in rats

Pharmaceutical Research

Volumn 17, Issue 12, 2000, Pages 1461-1467

  Uchiyama, Tomomi ^a   Kotani, Atsushi ^a   Tatsumi, Hiroyuki ^a   Kishida, Takeshi ^a   Okamoto, Aya ^a   Okada, Naoki ^a   Murakami, Masahiro ^a   Fujita, Takuya ^a   Fujiwara, Youichi ^a   Kiso, Yoshiaki ^a   Muranishi, Shozo ^a   Yamamoto, Akira ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Absorption enhancement; Chemical modification; Drug absorption; Enkephalin; Peptide delivery; Protease inhibitor

Indexed keywords

ACETYL ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; BUTYRYL ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; CAPROYL ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; CAPRYLYL ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; LEUCINE ENKEPHALIN DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG HALF LIFE; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; INTESTINE ABSORPTION; JEJUNUM; LIPOPHILICITY; MALE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEINASE INHIBITION; RAT; SMALL INTESTINE ABSORPTION;

ANIMALS; CHEMISTRY, PHYSICAL; COLON; ENKEPHALIN, LEUCINE; ENKEPHALIN, LEUCINE-2-ALANINE; HALF-LIFE; INTESTINAL ABSORPTION; INTESTINES; JEJUNUM; LIPIDS; MEMBRANES; RATS;

EID: 0034467999     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007644706286     Document Type: Article

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