Oral insulin delivery using nanoparticles based on microemulsions with different structure-types: Optimisation and in vivo evaluation

European Journal of Pharmaceutical Sciences

Volumn 37, Issue 1, 2009, Pages 53-61

  Graf, Anja ^a   Rades, Thomas ^a   Hook, Sarah M ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Alkylcyanoacrylate; Insulin; Microemulsions; Nanoparticles; Oral delivery

Indexed keywords

ACYLGLYCEROL; CYANOACRYLATE DERIVATIVE; ENBUCRILATE; INSULIN; ISOPHANE INSULIN; LABRASOL; MINITAB; MONOMER; MYRISTIC ACID ISOPROPYL ESTER; NANOPARTICLE; OLEIC ACID; PLUROL OLEIQUE; POLY(ALKYLCYANOACRYLATE); POLY(BUTYLCYANOACRYLATE); POLY(ETHYLCYANOACRYLATE); POLYGLYCERYL OLEATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCOMPATIBILITY; CONCENTRATION (PARAMETERS); DISPERSION; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG FORMULATION; DRUG RELEASE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOGLYCEMIA; IN VIVO STUDY; INSULIN BLOOD LEVEL; MICROEMULSION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPE; STREPTOZOCIN DIABETES;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; BLOOD GLUCOSE; CYANOACRYLATES; DIABETES MELLITUS, EXPERIMENTAL; DRUG CARRIERS; EMULSIONS; ENBUCRILATE; FEMALE; GLYCEROL; INSULIN; MICROSCOPY, ATOMIC FORCE; MYRISTATES; NANOPARTICLES; OLEIC ACIDS; ORGANIC CHEMICALS; PARTICLE SIZE; PHARMACEUTIC AIDS; RATS; RATS, INBRED LEW;

EID: 60749095944     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2008.12.017     Document Type: Article

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