Stabilization of insulin against agitation-induced aggregation by the GMO cubic phase gel

International Journal of Pharmaceutics

Volumn 191, Issue 1, 1999, Pages 51-64

  Sadhale, Yogesh ^a,b   Shah, Jaymin C ^a,c  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b Pentech Pharmaceuticals Inc   (United States)

^c PFIZER INC   (United States)

Author keywords

Aggregation; CD; Cubic phase gel; GMO; Insulin; Proteins

Indexed keywords

GLYCEROL OLEATE; GMORPHIC 80; HUMAN INSULIN; INSULIN; INSULIN ZINC SUSPENSION; UNCLASSIFIED DRUG;

AGITATION; ARTICLE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; DRUG STABILITY; GEL; OPTICAL DENSITY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN SECONDARY STRUCTURE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; EXCIPIENTS; GELS; GLYCERIDES; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; RECOMBINANT PROTEINS; SOLUTIONS;

EID: 0032737961     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00288-4     Document Type: Article

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