Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse

Journal of Controlled Release

Volumn 197, Issue , 2015, Pages 48-57

  Maisel, Katharina ^a,b   Ensign, Laura ^a   Reddy, Mihika ^a,b   Cone, Richard ^a,c   Hanes, Justin ^a,b,d  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b Johns Hopkins University   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Johns Hopkins University   (United States)

Author keywords

Colon; Drug delivery; Inflammatory bowel disease (IBD); Mucus penetrating particles; Nanoparticles; Ulcerative colitis

Indexed keywords

AGGLOMERATION; BODY FLUIDS; DERMATOLOGY; DISEASES; DRUG DELIVERY; DRUG PRODUCTS; MAMMALS; NANOPARTICLES; SURFACE CHEMISTRY; TISSUE;

BARRIER PROPERTIES; COLON; GASTROINTESTINAL TRACT; INFLAMMATORY BOWEL DISEASE; MUCUS-PENETRATING PARTICLES; NANOPARTICLE INTERACTION; PARTICLE DISTRIBUTIONS; ULCERATIVE COLITIS;

WATER ABSORPTION;

MACROGOL; MUCOADHESIVE PARTICLE; MUCUS PENETRATING PARTICLE; NANOPARTICLE; UNCLASSIFIED DRUG; CARBOXYLIC ACID; DEXTRAN SULFATE; MACROGOL DERIVATIVE; POLYSTYRENE DERIVATIVE; TRINITROBENZENESULFONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLON MUCOSA; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; FEEDING; FEMALE; HYDROPHILICITY; ILEUM; INTESTINE LOOP; JEJUNUM; MOUSE; MUCOADHESION; MUCUS SECRETION; NONHUMAN; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; RECTAL DRUG ADMINISTRATION; SMALL INTESTINE; STOMACH MUCUS; SURFACE PROPERTY; ULCERATIVE COLITIS; WATER ABSORPTION; ADHESION; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; GASTROINTESTINAL TRACT; METABOLISM; MUCUS;

ADHESIVENESS; ADMINISTRATION, ORAL; ADMINISTRATION, RECTAL; ANIMALS; CARBOXYLIC ACIDS; COLITIS, ULCERATIVE; DEXTRAN SULFATE; FEMALE; GASTROINTESTINAL TRACT; MICE; MUCUS; NANOPARTICLES; POLYETHYLENE GLYCOLS; POLYSTYRENES; SURFACE PROPERTIES; TRINITROBENZENESULFONIC ACID;

EID: 84910618859     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.10.026     Document Type: Article

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