A lipid-based liquid crystalline matrix that provides sustained release and enhanced oral bioavailability for a model poorly water soluble drug in rats

International Journal of Pharmaceutics

Volumn 340, Issue 1-2, 2007, Pages 52-60

  Boyd, Ben J ^a   Khoo, Shui Mei ^b   Whittaker, Darryl V ^b   Davey, Greg ^b   Porter, Christopher J H ^a  

^a MONASH UNIVERSITY   (Australia)

^b Mayne Pharma   (Australia)

Author keywords

Bioavailability; Cinnarizine; Lipid formulation; Liquid crystal; Poorly water soluble drug

Indexed keywords

CINNARIZINE; GLYCERIC ACID; GLYCEROL OLEATE; LIPID; OLEYL GLYCERATE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULARY; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; LIPOLYSIS; LIQUID CRYSTAL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; SUSPENSION; SUSTAINED DRUG RELEASE;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CINNARIZINE; DELAYED-ACTION PREPARATIONS; DIGESTION; DRUG CARRIERS; DRUG COMPOUNDING; GLYCERIC ACIDS; GLYCERIDES; INTESTINAL ABSORPTION; INTESTINAL SECRETIONS; LIPIDS; LIPOLYSIS; LIQUID CRYSTALS; MALE; OLEIC ACIDS; PANCREATIN; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; WATER;

EID: 34447265979     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.03.020     Document Type: Article

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