Nano-emulsions and micro-emulsions: Clarifications of the critical differences

Pharmaceutical Research

Volumn 28, Issue 5, 2011, Pages 978-985

  Anton, Nicolas ^a   Vandamme, Thierry F ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

emulsion; micro emulsion; nano emulsion; SEDDS; self emulsifying drug delivery system

Indexed keywords

ANTIMALARIAL AGENT; FAT DROPLET; SURFACTANT;

DRUG DELIVERY SYSTEM; DRUG FORMULATION; HYDROPHILICITY; LIGHT SCATTERING; MICELLE; MICROEMULSION; NANOEMULSION; NANOPHARMACEUTICS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW; SOLUBILITY; THERMODYNAMICS;

DRUG DELIVERY SYSTEMS; EMULSIFYING AGENTS; EMULSIONS; NANOSTRUCTURES; PHARMACEUTICAL PREPARATIONS; THERMODYNAMICS;

EID: 79955629340     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0309-1     Document Type: Review

References (23)

1. N Anton T Vandamme 2009 The universality of low-energy nano-emulsification Int J Pharm 377 142 147 19454306 10.1016/j.ijpharm.2009.05. 014 1:CAS:528:DC%2BD1MXotlOls7o%3D
2. N Anton J Benoit P Saulnier 2008 Design and production of nanoparticles formulated from nano-emulsion templates-a review J Control Release 128 185 199 18374443 10.1016/j.jconrel.2008.02.007 1:CAS:528:DC%2BD1cXmvVCrsrY%3D
3. M Antonietti K Landfester 2002 Polyreactions in miniemulsions Prog Polym Sci 27 689 757 10.1016/S0079-6700(01)00051-X 1:CAS:528:DC%2BD38Xjt1Crsr8%3D (Pubitemid 34440818)
4. JM Asua 2002 Miniemulsion polymerization Prog Polym Sci 27 1283 1346 10.1016/S0079-6700(02)00010-2 1:CAS:528:DC%2BD38XksFersLc%3D (Pubitemid 34648981)
5. F Hallouard N Anton P Choquet A Constantinesco T Vandamme 2010 Iodinated blood pool contrast media for preclinical x-ray imaging applications-a review Biomaterials 31 6249 6268 20510444 10.1016/j.biomaterials.2010.04.066 1:CAS:528:DC%2BC3cXnt12rtb4%3D
6. P Izquierdo J Esquena TF Tadros C Dederen MJ Garcia N Azemar, et al. 2002 Formation and stability of nano-emulsions prepared using the phase inversion temperature method Langmuir 18 26 30 10.1021/la010808c 1:CAS:528: DC%2BD3MXovF2qtr0%3D (Pubitemid 35382274)
7. M Kahlweit R Strey 1988 Phase behavior of quinary mixtures of the type water-oil-nonionic amphiphile-ionic amphiphile-salt J Phys Chem 92 1557 1563 10.1021/j100317a037 1:CAS:528:DyaL1cXhtlyhs70%3D
8. M Kahlweit R Strey P Firman D Haase J Jen R Schomaecker 1988 General patterns of the phase behavior of mixtures of water, nonpolar solvents, amphiphiles, and electrolytes. 1 Langmuir 4 499 511 10.1021/la00081a002 1:CAS:528:DyaL1cXitFSltrw%3D
9. M Kahlweit R Strey R Schomaecker D Haase 1989 General patterns of the phase behavior of mixtures of water, nonpolar solvents, amphiphiles, and electrolytes. 2 Langmuir 5 305 315 10.1021/la00086a002 1:CAS:528: DyaL1MXht1Wqs7s%3D
10. M Kahlweit R Strey G Busse 1990 Microemulsions: a quantitative thermodynamic approach J Phys Chem 94 3881 3894 10.1021/j100373a006 1:CAS:528:DyaK3cXit1ersL0%3D
11. M Kahlweit R Strey G Busse 1993 Weakly to strongly structured mixtures Phys Rev E 47 4197 4209 10.1103/PhysRevE.47.4197 1:CAS:528:DyaK3sXkvVWjtrs%3D
12. M Kahlweit G Busse B Faulhaber 1994 Weakly to strongly structured mixtures. 2. Ionic amphiphiles Langmuir 10 1134 1139 10.1021/la00016a027 1:CAS:528:DyaK2cXit1Oqsr0%3D
13. M Kahlweit G Busse B Faulhaber J Jen 1996 Shape changes of globules in nonionic microemulsions J Phys Chem 100 14,991 14,994 10.1021/jp961260z 1:CAS:528:DyaK28XkvFCntbo%3D
14. Klibanov A. Long circulating liposomes old drugs new therapeutics. Berlin: Springer; 1998.
15. A Klibanov K Maruyama V Torchilin L Huang 1990 Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes FEBS Lett 268 235 237 2384160 10.1016/0014-5793(90)81016-H 1:CAS:528: DyaK3cXmtFOqtbc%3D (Pubitemid 20233874)
16. C Pouton 1997 Formulation of self-emulsifying drug delivery systems Adv Drug Deliv Rev 25 47 58 10.1016/S0169-409X(96)00490-5 1:CAS:528: DyaK2sXhtlOqsrc%3D (Pubitemid 27107790)
17. S Ramana Rao P Agarwal J Shao 2008 Self-nanoemulsifying drug delivery systems (snedds) for oral delivery of protein drugs: 2. in vitro transport study Int J Pharm 362 10 15 10.1016/j.ijpharm.2008.05.016
18. JL Salager A Forgiarini L Marquez A Pena M Pizzino P Rodriguez, et al. 2004 Using emulsion inversion in industrial processes Adv Colloid Interface Sci 108-109 259 272 15072945 10.1016/j.cis.2003.10.008
19. C Solans P Izquierdo J Nolla N Azemar MJ Garcia-Celma 2005 Nano-emulsions Curr Opin Colloid Interface Sci 10 102 110 10.1016/j.cocis.2005.06.004 1:CAS:528:DC%2BD2MXhtFyisr3I (Pubitemid 41565542)
20. TF Tadros P Izquierdo J Esquena C Solans 2004 Formation and stability of nanoemulsions Adv Colloid Interface Sci 108-109 303 318 15072948 10.1016/j.cis.2003.10.023
21. T Thi M Van Speybroeck V Barillaro J Martens P Annaert P Augustijns, et al. 2009 Formulate-ability of ten compounds with different physicochemical profiles in smedds Eur J Pharm Sci 38 479 488 19782131 10.1016/j.ejps.2009.09. 012 1:CAS:528:DC%2BD1MXhsVKgsL%2FF
22. V Torchilin V Trubetskoy 1995 Which polymers can make nanoparticulates drug carriers long circulating? Adv Drug Deliv Rev 16 141 155 10.1016/0169-409X(95)00022-Y 1:CAS:528:DyaK2MXpt1amtro%3D
23. T Yi J Wan H Xu X Yang 2008 Controlled poorly soluble drug release from solid self-microemulsifying formulations with high viscosity hydroxypropylmethylcellulose Eur J Pharm Sci 34 274 280 18541418 10.1016/j.ejps.2008.04.010 1:CAS:528:DC%2BD1cXoslOgtrk%3D