Solid lipid nanoparticles modified with stearic acid-octaarginine for oral administration of insulin

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 3333-3339

  Zhang, Zhen Hai ^a,b   Zhang, Yin Long ^b   Zhou, Jian Ping ^b   Lv, Hui Xia ^b  

^a Jiangsu Province Academy of Traditional Chinese Medicine   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Cell penetration peptides; Insulin; Oral administration; Solid lipid nanoparticles; Stearic acid octaarginine

Indexed keywords

ARGININE; INSULIN; OCTAARGININE; SOLID LIPID NANOPARTICLE; STEARIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG STABILITY; DRUG UPTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LIGHT SCATTERING; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; RAT; STRUCTURE ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; DIABETES MELLITUS, EXPERIMENTAL; DRUG CARRIERS; HUMANS; HYPOGLYCEMIA; INSULIN; NANOPARTICLES; OLIGOPEPTIDES; RATS; STEARIC ACIDS;

RATTUS;

EID: 84870361288     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S31711     Document Type: Article

References (22)

1. Bernkop-Schnurch A, Kast CE, Guggi D. Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systems. J Control Release. 2003;93(2):95-103.
2. Joshi SR, Parikh RM, Das AK. Insulin-history, biochemistry, physiology and pharmacology. J Assoc Physicians India. 2007;55 Suppl:19-25.
3. Xiong XY, Li YP, Li ZL, etal. Vesicles from Pluronic/poly(lactic acid) block copolymers as new carriers for oral insulin delivery. J Control Release. 2007;120(1-2):11-17.
4. Müller RH, Keck CM. Challenges and solutions for the delivery of biotech drugs-a review of drug nanocrystal technology and lipid nanoparticles. J Biotechnol. 2004;113(1-3):151-170.
5. Elsayed A, Remawi MA, Qinna N, Farouk A, Badwan A. Formulation and characterization of an oily-based system for oral delivery of insulin. Eur J Pharm Biopharm. 2009;73(2):269-279.
6. Morishita M, Peppas NA. Is the oral route possible for peptide and protein drug delivery? Drug Discov Today. 2006;11(19-20):905-910.
7. Garcia-Fuentes M, Torres D, Alonso MJ. Design of lipid nanoparticles for the oral delivery of hydrophilic macromolecules. Colloids Surf B Biointerfaces. 2002;27:159-168.
8. Lee JY, Bae KH, Kim JS, Nam YS, Park TJ. Intracellular delivery of paclitaxel using oil-free, shell cross-linked HSA-multi-armed PEG nanocapsules. Biomaterials. 2011;32(33):8635-8644.
9. Barnes MP, Shen WC. Disulfide and thioether linked cytochrome c-oligoarginine conjugates in HeLa cells. Int J Pharm. 2009;369(1-2): 79-84.
10. Walrant A, Correia I, Jiao CY, etal. Different membrane behaviour and cellular uptake of three basic arginine-rich peptides. Biochim Biophys Acta. 2011;1808(1):382-393.
11. Takayama K, Tadokoro A, Pujals S, Nakase I, Giralt E, Futaki S. Novel system to achieve one-pot modification of cargo molecules with oligoarginine vectors for intracellular delivery. Bioconjug Chem. 2009;20(2):249-257.
12. Wender PA, Mitchell DJ, Pattabiraman K, Pelkey ET, Steinman L, Rothbard JB. The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters. Proc Natl Acad Sci U S A. 2000;97(24):13003-13008.
13. Kamei N, Morishita M, Eda Y, Ida N, Nishio R, Takayama K. Usefulness of cell-penetrating peptides to improve intestinal insulin absorption. J Control Release. 2008;132(1):21-25.
14. Futaki S, Ohashi W, Suzuki T, etal. Stearylated arginine-rich peptides: a new class of transfection systems. Bioconjug Chem. 2001;12(6): 1005-1011.
15. Katayama S, Hirose H, Takayama K, Nakase I, Futaki S. Acylation of octaarginine: implication to the use of intracellular delivery vectors. J Control Release. 2011;149(1):29-35.
16. Mae M, El Andaloussi S, Lundin P, etal. A stearylated CPP for delivery of splice correcting oligonucleotides using a non-covalent co-incubation strategy. J Control Release. 2009;134(3):221-227.
17. Mao S, Germershaus O, Fischer D, Linn T, Schnepf R, Kissel T. Uptake and transport of PEG-graft-trimethyl-chitosan copolymer-insulin nanocomplexes by epithelial cells. Pharm Res. 2005;22(12): 2058-2068.
18. Nakamura K, Murray RJ, Joseph JI, Peppas NA, Morishita M, Lowman AM. Oral insulin delivery using P(MAA-g-EG) hydrogels: effects of network morphology on insulin delivery characteristics. J Control Release. 2004;95(3):589-599.
19. Zhang L, Song L, Zhang C, Ren Y. Improving intestinal insulin absorption efficiency through coadministration of cell-penetrating peptide and hydroxypropyl-β-cyclodextrin. Carbohyd Polym. 2012; 87(2):1822-1827.
20. Schilling RJ, Mitra AK. Degradation of insulin by trypsin and alpha-chymotrypsin. Pharm Res. 1991;8(6):721-727.
21. Riemen MW, Pon LA, Carpenter FH. Preparation of semisynthetic insulin analogues from bis(tert-butyloxycarbonyl)-desoctapeptide-insulin phenylhydrazide: importance of the aromatic region B24-B26. Biochemistry. 1983;22(6):1507-1515.
22. Fasano A, Uzzau S. Modulation of intestinal tight junctions by zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model. J Clin Invest. 1997;99(6): 1158-1164.