Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion

International Journal of Pharmaceutics

Volumn 252, Issue 1-2, 2003, Pages 271-274

  Toorisaka, Eiichi ^a   Ono, Hiroshige ^b   Arimori, Kazuhiko ^b   Kamiya, Noriho ^a   Goto, Masahiro ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF MIYAZAKI HOSPITAL   (Japan)

Author keywords

Drug delivery; Insulin; Oral administration; S O W emulsion; Surfactant

Indexed keywords

ER 290; GLASS; INSULIN; REBAMIPIDE; SURFACTANT; WATER OIL CREAM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL MEMBRANE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG COATING; DRUG EFFECT; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; EMULSION; MALE; NONHUMAN; OBSERVATION; PRIORITY JOURNAL; RAT; SOLID; STREPTOZOCIN DIABETES;

EID: 0037452443     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00674-9     Document Type: Article

References (10)

1. Hinds K.D., Kim S.W. Effect of PEG conjugation on insulin properties. Adv. Drug. Deliv. Rev. 54:2002;505-530.
2. Kamiya N., Inoue M., Goto M., Naruta Y. Catalytic and structural properties of surfactant-horseradish peroxidase complex in organic media. Biotechnol. Prog. 16:2000;52-58.
3. Mine Y., Shimizu M., Nakashima T. Preparation and stabilization of simple and multiple emulsions using a microporous glass membrane. Colloids Surfaces B. 6:1996;261-268.
4. Morishita M., Matsuzawa A., Takayama K., Isowa K., Nagai T. Improving insulin enteral adsorption using water-in-oil-in-water emulsion. Int. J. Pharm. 172:1998;189-198.
5. Morita T., Sakamura Y., Horikiri Y., Suzuki T., Yoshino H. Protein encapsulation into biodegradable microspheres by a novel S/O/W emulsion method using poly(ethylene glycol) as a protein micronization adjuvant. J. Control. Rel. 69:2000;435-444.
6. Nakashima T., Shimizu M., Kukizaki M. Particle control of emulsion by membrane emulsification and its applications. Adv. Drug. Deliv. Rev. 45:2000;47-56.
7. Okazaki S., Goto M., Furusaki S. Surfactant-protease complex as a novel biocatalyst for peptide synthesis in hydrophilic organic solvents. Enzyme Microb. Technol. 26:2000;159-164.
8. Putney S.D., Burke P.A. Improving protein therapeutics with sustained-release formulations. Nat. Biotechnol. 16:1998;153-157.
9. Sah H. Protein behavior at the water/methylene chloride interface. J. Pharm. Sci. 88:1999;1320-1325.
10. Yamamoto A., Muranishi S. Rectal drug delivery systems. Improvement of rectal peptide adsorption by adsorption enhancers, protease inhibitors and chemical modification. Adv. Drug. Deliv. Rev. 28:1997;275-299.