Solid lipid particles for oral delivery of peptide and protein drugs i - Elucidating the release mechanism of lysozyme during lipolysis

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 85, Issue 3 PART A, 2013, Pages 473-480

  Christophersen, P C ^a   Zhang, L ^a   Yang, M ^a   Nielsen, H Mørck ^a   Mullertz A ^a   Mu, H ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Lipase; Lipid hydrolysis; Lipid based drug delivery system; Oral drug delivery; Protein loaded microparticle; Solid lipid particle

Indexed keywords

BILE SALT; DIACYLGLYCEROL; FATTY ACID; LIPID; LYSOZYME; MONOACYLGLYCEROL; PEPTIDES AND PROTEINS; PHOSPHOLIPID; SOLID LIPID NANOPARTICLE; TRIACYLGLYCEROL; TRIMYRISTIN; TRISTEARIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; ENZYME DEGRADATION; LIPID HYDROLYSIS; LIPOLYSIS; LIPOPROTEIN SECRETION; PROTEIN DEGRADATION; SURFACE PROPERTY;

DL; DRUG LOADING; EE; ENTRAPMENT EFFICIENCY; FA; FATTY ACID; FDA; FFA; FOOD AND DRUG ADMINISTRATION; FREE FATTY ACID; GASTROINTESTINAL TRACT; GDS; GIT; GLYCEROL DISTEARATE TYPE 1; GLYCEROL MONOSTEARATE 40-55 TYPE 1; GMS; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY; HPLC; HPTLC; LIPASE; LIPID HYDROLYSIS; LIPID-BASED DRUG DELIVERY SYSTEM; ORAL DRUG DELIVERY; POLYVINYL ALCOHOL; PROTEIN-LOADED MICROPARTICLE; PVA; ROOM TEMPERATURE; RT; SCANNING ELECTRON MICROSCOPY; SEM; SLM; SOLID LIPID MICROPARTICLES; SOLID LIPID PARTICLE; TFA; TG; TG14; TG16; TG18; TRIFLUOROACETIC ACID; TRIGLYCERIDE; TRIMYRISTIN; TRIPALMITIN; TRISTEARIN;

ADMINISTRATION, ORAL; BILE ACIDS AND SALTS; DRUG DELIVERY SYSTEMS; EXCIPIENTS; FATTY ACIDS, NONESTERIFIED; LIPASE; LIPIDS; LIPOLYSIS; MICROSCOPY, ELECTRON, SCANNING; MODELS, BIOLOGICAL; MURAMIDASE; PEPTIDES; PHOSPHOLIPIDS; PROTEINS;

EID: 84888315416     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.07.017     Document Type: Article

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