Improvement of intestinal absorption of human calcitonin by chemical modification with fatty acids: Synergistic effects of acylation and absorption enhancers

International Journal of Pharmaceutics

Volumn 134, Issue 1-2, 1996, Pages 47-57

  Fujita, Takuya ^a   Fujita, Tadashi ^a   Morikawa, Keiko ^a   Tanaka, Hiroko ^a   Iemura, Osamu ^a   Yamamoto, Akira ^a   Muranishi, Shozo ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Acetylated human calcitonin; Acylation; Caproylated human calcitonin; Chemical modification; Intestinal absorption; Peptide delivery

Indexed keywords

ACETYLATED CALCITONIN; CALCITONIN; CALCITONIN DERIVATIVE; CAPROYLATED CALCITONIN; DEOXYCHOLATE SODIUM; GLYCOCHOLATE SODIUM; N LAURYL BETA DEXTRO MALTOSIDE; SALICYLATE SODIUM; UNCLASSIFIED DRUG;

ACYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DEGRADATION; DRUG ABSORPTION; DRUG STABILITY; DRUG SYNTHESIS; HYPOCALCEMIA; INTESTINE ABSORPTION; LIPOPHILICITY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

EID: 0030039663     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(95)04395-0     Document Type: Article

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