Efficacious intestinal permeation enhancement induced by the sodium salt of 10-undecylenic acid, a medium chain fatty acid derivative

AAPS Journal

Volumn 16, Issue 5, 2014, Pages 1064-1076

  Brayden, David J ^a   Walsh, Edwin ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

10 undecylenic acid; Caco 2 cells; intestinal permeation enhancement; medium chain fatty acids; oral peptides

Indexed keywords

10 UNDECENOIC ACID; DECANOATE SODIUM; DECENOIC ACID; DEXTRAN 40; MEDIUM CHAIN FATTY ACID; SODIUM; UNCLASSIFIED DRUG; DECANOIC ACID; DECANOIC ACID DERIVATIVE; DEXTRAN; FLUORESCEIN ISOTHIOCYANATE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; MANNITOL; TABLET;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CACO 2 CELL LINE; CELL MEMBRANE PERMEABILITY; COLON; CONCENTRATION (PARAMETERS); CONTENT ANALYSIS; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; HISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; INTESTINAL PERMEATION ENHANCEMENT; INTESTINE MUCOSA; JEJUNUM; LIPOPHILICITY; MALE; MAXIMUM PLASMA CONCENTRATION; MEMBRANE TRANSPORT; MONOLAYER CULTURE; MTT ASSAY; NONHUMAN; RAT; TABLET FORMULATION; TIME TO MAXIMUM PLASMA CONCENTRATION; ANALOGS AND DERIVATIVES; ANIMAL; CELL SURVIVAL; CHEMISTRY; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECTS; ELECTRIC CONDUCTIVITY; HUMAN; INTESTINE ABSORPTION; KINETICS; MEDICINAL CHEMISTRY; METABOLISM; PATHOLOGY; PERMEABILITY; TABLET;

ANIMALS; CACO-2 CELLS; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; DECANOIC ACIDS; DEXTRANS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC CONDUCTIVITY; FLUORESCEIN-5-ISOTHIOCYANATE; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; KINETICS; MANNITOL; PERMEABILITY; RATS; TABLETS; UNDECYLENIC ACIDS;

EID: 84908357169     PISSN: None     EISSN: 15507416     Source Type: Journal    
DOI: 10.1208/s12248-014-9634-3     Document Type: Article

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