Glucose-Reducing Effect of the ORMD-0801 Oral Insulin Preparation in Patients with Uncontrolled Type 1 Diabetes: A Pilot Study

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Eldor, Roy ^a   Arbit, Ehud ^b   Corcos, Asher ^c   Kidron, Miriam ^b  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b Oramed Pharmaceuticals   (Israel)

^c HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; INSULIN; ORAL ANTIDIABETIC AGENT; ORMD 0801; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD GLUCOSE MONITORING; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; DIABETES CONTROL; DISEASE ASSOCIATION; DISEASE DURATION; DRUG CAPSULE; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; MALE; PILOT STUDY; TREATMENT DURATION;

ADMINISTRATION, ORAL; ADULT; BLOOD GLUCOSE; CAPSULES; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; INSULIN; MALE; MIDDLE AGED; PILOT PROJECTS; TREATMENT OUTCOME;

EID: 84876059641     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059524     Document Type: Article

References (11)

1. Schade DS, Burge MR, (1995) Brittle diabetes: etiology and treatment. Adv Endocrinol Metab 6: 289-319.
2. DeFronzo RA, Simonson D, Ferrannini E, (1982) Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus. Diabetologia 23: 313-319.
3. Meyer C, Dostou JM, Welle SL, Gerich JE, (2002) Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis. Am J Physiol Endocrinol Metab 282: E419-427.
4. Singhal P, Caumo A, Carey PE, Cobelli C, Taylor R, (2002) Regulation of endogenous glucose production after a mixed meal in type 2 diabetes. Am J Physiol Endocrinol Metab 283: E275-283.
5. Taylor R, Magnusson I, Rothman DL, Cline GW, Caumo A, et al. (1996) Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects. J Clin Invest 97: 126-132.
6. Sindelar DK, Balcom JH, Chu CA, Neal DW, Cherrington AD, (1996) A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes 45: 1594-1604.
7. Felig P, Wahren J, (1971) Influence of endogenous insulin secretion on splanchnic glucose and amino acid metabolism in man. J Clin Invest 50: 1702-1711.
8. Maheux P, Chen YD, Polonsky KS, Reaven GM, (1997) Evidence that insulin can directly inhibit hepatic glucose production. Diabetologia 40: 1300-1306.
9. Bischof MG, Krssak M, Krebs M, Bernroider E, Stingl H, et al. (2001) Effects of short-term improvement of insulin treatment and glycemia on hepatic glycogen metabolism in type 1 diabetes. Diabetes 50: 392-398.
10. DeVries JH, Eskes SA, Snoek FJ, Pouwer F, Van Ballegooie E, et al. (2002) Continuous intraperitoneal insulin infusion in patients with 'brittle' diabetes: favourable effects on glycaemic control and hospital stay. Diabet Med 19: 496-501.
11. Arbit E, Kidron M, (2009) Oral insulin: the rationale for this approach and current developments. J Diabetes Sci Technol 3: 562-567.