Transmembrane mutations in toll-like receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation

Immunity

Volumn 35, Issue 5, 2011, Pages 721-732

  Mouchess, Maria L ^a   Arpaia, Nicholas ^a   Souza, Gianne ^a   Barbalat, Roman ^a   Ewald, Sarah E ^a   Lau, Laura ^a   Barton, Gregory M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; TOLL LIKE RECEPTOR 9;

ANEMIA; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEATH; DENDRITIC CELL; HUMAN; HUMAN CELL; INFLAMMATION; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; AUTOIMMUNITY; B-LYMPHOCYTES; CELL MEMBRANE; DENDRITIC CELLS; GENE EXPRESSION; GENES, LETHAL; HEK293 CELLS; HUMANS; INFLAMMATION; LIGANDS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PROTEOLYSIS; RECEPTOR, INTERFERON ALPHA-BETA; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TOLL-LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR-ALPHA;

EID: 81955161805     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2011.10.009     Document Type: Article

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