Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis

Gastroenterology

Volumn 122, Issue 5, 2002, Pages 1428-1441

  Rachmilewitz, Daniel ^a   Karmeli, Fanny ^a   Takabayashi, Kenji ^b   Hayashi, Tomoko ^b   Leider Trejo, Leonor ^c   Lee, Jongdae ^b   Leoni, Lorenzo M ^b   Raz, Eyal ^b  

^a SHAARE ZEDEK MEDICAL CENTER   (Israel)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c Tel Aviv Sourasky Medical Centerr ^*  (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; CASPASE 3; CASPASE 9; CHEMOKINE; CYCLOOXYGENASE 2; CYTOKINE; DEXTRAN SULFATE; GAMMA INTERFERON; GELATINASE B; HAPTEN; IMMUNOSTIMULATING AGENT; IMMUNOSTIMULATORY DNA; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERSTITIAL COLLAGENASE; MACROPHAGE INFLAMMATORY PROTEIN 2; MATRIX METALLOPROTEINASE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 3; OLIGODEOXYNUCLEOTIDE; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; STROMELYSIN; STROMELYSIN 2; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL SURVIVAL; COLITIS; COLON MUCOSA; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; ENTERITIS; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; KNOCKOUT MOUSE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0036241068     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2002.32994     Document Type: Article

References (45)

1. Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases
2. Current concepts of inflammatory bowel disease; etiology and pathogenesis
3. Role of cytokines in the pathogenesis of inflammatory bowel disease
4. Chronic colitis in IL-10-/- mice: Insufficient counter regulation of a Th1 response
5. Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with anti-bodies to interleukin 4
6. Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses
7. Animal models of mucosal inflammation and their relation to human inflammatory bowel disease
8. Mucosal immunity and inflammation. V. Innate mechanisms of mucosal defense and repair: The best offense is a good defense
9. Immunostimulatory DNA and applications to allergic disease
10. Toll meets bacterial CpG-DNA
11. Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences
12. Immunostimulatory-sequence DNA is an effective mucosal adjuvant
13. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
14. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
15. Bacterial CpG DNA activates immune cells to signal infectious danger
16. Rescue of B cells from apoptosis by immune stimulatory CpG DNA
17. Unmethylated CpG-containing oligodeoxynucleotides inhibit apoptosis in WEHI 231 B lymphocytes induced by several agents: Evidence for blockade of apoptosis at a distal signalling step
18. Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker
19. Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats
20. Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria
21. Low endogenous prostaglandin E2 predisposes to relapsing inflammation in experimental rat enterocolitis
22. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
23. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity
24. CpG motifs in bacterial DNA trigger direct B-cell activation
25. Functions for DNA methylation in vertebrates
26. Innate immunity: The virtues of a nonclonal system of recognition
27. A Toll-like receptor recognizes bacterial DNA
28. DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA
29. DNA activates human immune cells through a CpG sequence-dependent manner
30. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
31. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice
32. Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis
33. DNA-based immunotherapeutics for the treatment of allergic disease
34. Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism
35. Macrophage activation by immunostimulatory DNA
36. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in crohn disease and experimental colitis in vivo
37. Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2
38. Spontaneous chronic colitis in TCR alpha-mutant mice; an experimental model of human ulcerative colitis
39. IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice
40. The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimental colitis
41. The key role of macrophages in the immunopathogenesis of inflammatory bowel disease
42. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
43. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
44. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations
45. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease