Bifurcation of toll-like receptor 9 signaling by adaptor protein 3

Science

Volumn 329, Issue 5998, 2010, Pages 1530-1534

  Sasai, Miwa ^a   Linehan, Melissa M ^a   Iwasaki, Akiko ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ADAPTOR PROTEIN 3; CYTOKINE; INTERFERON; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; AP3B1 PROTEIN, MOUSE; BETA ADAPTIN; CARRIER PROTEIN; CELLUBREVIN; HYBRID PROTEIN; INTERFERON REGULATORY FACTOR 7; IRF7 PROTEIN, MOUSE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MYD88 PROTEIN, MOUSE; MYELOID DIFFERENTIATION FACTOR 88; OLIGODEOXYRIBONUCLEOTIDE; TLR9 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; UNC93B1 PROTEIN, MOUSE; VESICLE-ASSOCIATED MEMBRANE PROTEIN 3, MOUSE;

BIOCHEMISTRY; GENE EXPRESSION; NUCLEIC ACID; PATHOGEN; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL COMPARTMENTALIZATION; CELL ORGANELLE; CELLULAR DISTRIBUTION; CYTOKINE PRODUCTION; ENDOSOME; HUMAN; HUMAN CELL; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOPLASM VESICLE; DENDRITIC CELL; GENETICS; IMMUNOLOGY; MACROPHAGE; METABOLISM;

ADAPTOR PROTEIN COMPLEX 3; ANIMALS; CELLS, CULTURED; CYTOKINES; CYTOPLASMIC VESICLES; DENDRITIC CELLS; ENDOSOMES; INTERFERON REGULATORY FACTOR-7; INTERFERON TYPE I; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; MACROPHAGES; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED C57BL; MYELOID DIFFERENTIATION FACTOR 88; OLIGODEOXYRIBONUCLEOTIDES; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 3; TOLL-LIKE RECEPTOR 9; TRANSCRIPTIONAL ACTIVATION; VESICLE-ASSOCIATED MEMBRANE PROTEIN 3; ADAPTOR PROTEIN COMPLEX BETA SUBUNITS;

EID: 77956689533     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1187029     Document Type: Article

References (32)

1. Y. J. Liu, Annu. Rev. Immunol. 23, 275 (2005).
2. M. M. Brinkmann et al., J. Cell Biol. 177, 265 (2007).
3. K. Tabeta et al., Nat. Immunol. 7, 156 (2006).
4. S. E. Ewald et al., Nature 456, 658 (2008).
5. B. Park et al., Nat. Immunol. 9, 1407 (2008).
6. A. Takaoka et al., Nature 434, 243 (2005).
7. K. Honda et al., Nature 434, 772 (2005).
8. R. Medzhitov et al., Mol. Cell 2, 253 (1998).
9. S. Uematsu et al., J. Exp. Med. 201, 915 (2005).
10. H. Häcker et al., Nature 439, 204 (2006).
11. G. Oganesyan et al., Nature 439, 208 (2006).
12. K. Hoshino et al., Nature 440, 949 (2006).
13. M. L. Shinohara et al., Nat. Immunol. 7, 498 (2006).
14. H. Watarai et al., Proc. Natl. Acad. Sci. U.S.A. 105, 2993 (2008).
15. K. Gotoh et al., J. Exp. Med. 207, 721 (2010).
16. C. Guiducci et al., J. Exp. Med. 203, 1999 (2006).
17. K. Honda et al., Nature 434, 1035 (2005).
18. Materials and methods are available as supporting material on Science Online.
19. J. S. Bonifacino, L. M. Traub, Annu. Rev. Biochem. 72, 395 (2003).
20. M. Matsumoto et al., J. Immunol. 171, 3154 (2003).
21. J. C. Kagan et al., Nat. Immunol. 9, 361 (2008).
22. C. Asselin-Paturel et al., Nat. Immunol. 2, 1144 (2001).
23. E. Latz et al., Nat. Immunol. 5, 190 (2004).
24. C. A. Leifer et al., J. Immunol. 173, 1179 (2004).
25. Y. M. Kim, M. M. Brinkmann, M. E. Paquet, H. L. Ploegh, Nature 452, 234 (2008).
26. E. S. Trombetta, I. Mellman, Annu. Rev. Immunol. 23, 975 (2005).
27. E. C. Dell'Angelica, V. Shotelersuk, R. C. Aguilar, W. A. Gahl, J. S. Bonifacino, Mol. Cell 3, 11 (1999).
28. A. A. Peden et al., J. Cell Biol. 164, 1065 (2004).
29. O. C. Ikonomov, D. Sbrissa, A. Shisheva, Am. J. Physiol. Cell Physiol. 291, C393 (2006).
30. M. A. De Matteis, A. Godi, Nat. Cell Biol. 6, 487 (2004).
31. S. Dowler et al., Biochem. J. 351, 19 (2000).
32. We thank R. Medzhitov for critical reading of the manuscript and W. Mothes for helpful discussion. This work is supported by NIH grants to A.I. (AI054359, AI081884, and AI064705). M.S. is a Japan Society for the Promotion of Science fellow and a recipient of Uehara Memorial Foundation fellowship. A.I. acknowledges support by Gilead Sciences. A.I. is a recipient of the Burroughs Wellcome Investigators in Pathogenesis of Infectious Disease.