The Human Antimicrobial Peptide LL-37 Transfers Extracellular DNA Plasmid to the Nuclear Compartment of Mammalian Cells via Lipid Rafts and Proteoglycan-dependent Endocytosis

Journal of Biological Chemistry

Volumn 279, Issue 17, 2004, Pages 17951-17956

  Sandgren, Staffan ^a   Wittrup, Anders ^a   Cheng, Fang ^a   Jönsson, Mats ^a   Eklund, Erik ^a   Busch, Susann ^a   Belting, Mattias ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; DNA; FLUORESCENCE; GENES; LIPIDS; MICROSCOPIC EXAMINATION; PATHOLOGY;

CONFOCAL FLUORESCENCE MICROSCOPY; PATHOBIOLOGICAL ACTIVITY; PEPTIDE-MEDIATED LYSIS;

PROTEINS;

CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CAVEOLIN; CHOLERA TOXIN B SUBUNIT; NUCLEASE; PEPTIDE; PROTEOGLYCAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; CAVEOLA; CELL NUCLEUS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; DNA DEGRADATION; DNA PROTEIN COMPLEX; DNA TRANSFER; ENDOCYTOSIS; FLOW CYTOMETRY; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNITY; MAMMAL CELL; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; REPORTER GENE;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL DIVISION; CELL LINE; CELL MEMBRANE; CELL NUCLEUS; CHO CELLS; COS CELLS; CRICETINAE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCYTOSIS; FLOW CYTOMETRY; GENE TRANSFER TECHNIQUES; HUMANS; LUCIFERASES; MEMBRANE MICRODOMAINS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; PEPTIDES; PLASMIDS; PROTEOGLYCANS; TIME FACTORS;

ANIMALIA; BACTERIA (MICROORGANISMS); MAMMALIA; VERTEBRATA;

EID: 2342520028     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M311440200     Document Type: Article

References (46)

1. Boman, H. G. (1998) Scand. J. Immunol. 48, 15-25
2. Bals, R., Weiner, D. J., Mosciono, A. D., Meegalla, R. L., and Wilson, J. M. (1999) Infect. Immun. 67, 6084-6089
3. Lehrer, R. I., and Ganz, T. (1999) Curr. Opin. Immunol. 11, 23-27
4. Hancock, R. E., and Scott, M. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 8856-8861
5. Zasloff, M. (2002) Nature 415, 389-395
6. Boman, H. G. (1995) Annu. Rev. Immunol. 13, 61-92
7. Gudmundsson, G. H., and Agerberth, B. (1999) J. Immunol. Methods 232, 45-54
8. Ganz, T. (2002) J. Clin. Investig. 109, 693-697
9. Zanetti, M., Del Sal, G., Storici, P., Schneider, C., and Romeo, D. (1993) J. Biol. Chem 268, 522-526
10. Zanetti, M., Gennaro, R., and Romeo, D. (1995) FEBS Lett. 374, 1-5
11. Agerberth, B., Gunne, H., Odeberg, J., Kogner, P., Boman, H. G., and Gudmundsson, G. H. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 195-199
12. Larrick, J., Hirata, M., Balint, R., Lee, J., Zhong, J., and Wright, S. (1995) Infect. Immun. 63, 1291-1297
13. Cowland, J. B., Johnsen, A. H., and Borregaard, N. (1995) FEBS Lett. 368, 173-176
14. Gallo, R. L., Kim, K. J., Bernfield, M., Kozak, C. A., Zanetti, M., Merluzzi, L., and Gennaro, R. (1997) J. Biol. Chem. 272, 13088-13093
15. Bals, R., Wang, X., Zasloff, M., and Wilson, J. M. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 9541-9546
16. Davidson, D. J., Currie, A. J., Reid, G. S., Bowdish, D. M., MacDonald, K. L., Ma, R. C., Hancock, R. E., and Speert, D. P. (2004) J. Immunol. 172, 1146-1156
17. Frohm, M., Agerberth, B., Ahangari, G., Ståhle-Bäckdahl, M., Lidén, S., Wigzell, H., and Gudmundsson, G. H. (1997) J. Biol. Chem. 272, 15258-15263
18. Dorschner, R. A., Pestonjamasp, V., Tamakuwala, S., Ohtake, T., Rudisill, J., Nizet, V., Agerberth, B., Gudmundsson, G. H., and Gallo, R. L. (2001) J. Investig. Dermatol. 117, 91-97
19. Lehrer, R. I., and Ganz, T. (2002) Curr. Opin. Hematol. 9, 18-22
20. Johansson, J., Gudmundsson, G. H., Rottenberg, M. E., Berndt, K. D., and Agerberth, B. (1998) J. Biol. Chem. 273, 3718-3724
21. Bals, R., Weiner, D. J., Meegalla, R. L., and Wilson, J. M. (1999) J. Clin. Investig. 103, 1113-1117
22. Ponting, C. P. (2001) Trends Genet. 17, 235-237
23. De Yang, B., Chen, Q., Schmidt, A. P., Anderson, M., Wang, J. M., Wooters, J., Oppenheim, J. J., and Chertov, O. (2000) J. Exp. Med. 192, 1069-1074
24. Agerberth, B., Charo, J., Werr, J., Olsson, B., Idali F., Lindbom, L., Kiessling, R., Jörnvall, H., Wigzell, H., and Gudmundsson, G. H. (2000) Blood 96, 3086-3093
25. Islam, D., Bandholtz, B., Nilsson, J., Wigzell, H., Christensson, B., Agerberth, B., and Gudmundsson, H. G. (2001) Nat. Med. 7, 180-185
26. Nichols, B. J., and Lippincott-Schwartz, J. (2001) Trends Cell Biol. 11, 406-412
27. Belting, M., and Petersson, P. (1999) J. Biol. Chem. 274, 19375-19382
28. Cheng, F., Petersson, P., Arroyo-Yanguas, Y., and Westergren-Thorsson, G. (2001) J. Cell. Biochem. 83, 597-606
29. Belting, M., Havsmark, B., Jönsson, M., Persson, S., and Fransson, L.-Å. (1996) Glycobiology 6, 121-129
30. Mislick, K. A., and Baldeschwieler, J. D. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 12349-12354
31. Sandgren, S., and Belting, M. (2002) J. Biol. Chem. 277, 38877-38883
32. Kilsdonk, E. P., Yancey, P., Stoudt, G. W., Bangerter, F. W., Johnson, W. J., Phillips, M. C., and Rothblat, G. H. (1995) J. Biol. Chem. 270, 17250-17256
33. Ono, A., and Freed, E. O. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 13925-139230
34. Pelkmans, L., Kartenbeck, J., and Helenius, A. (2001) Nat. Cell Biol. 3, 473-483
35. Roepstorff, K., Thomsen, P., Sandvig, K., and van Deurs, B. (2002) J. Biol. Chem. 277, 18954-18260
36. Nichols, B. (2003) J. Cell Sci. 116, 4707-4714
37. Nichols, B. J. (2003) Curr. Biol. 13, 686-690
38. Belting, M. (2003) Trends Biochem. Sci. 28, 145-151
39. Esko, J. D., Stewart T. E., and Taylor W. H. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 3197-3201
40. Gallo, R. L., Ono, M., Povsic, T., Page, C., Eriksson, E., Klagsbrun, M., and Bernfield, M. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 11035-11039
41. Kichler, A., Leborgne, C., März, J., Danos, O., and Bechinger, B. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 1564-1568
42. Malm, J., Sørensen, O., Persson, T., Frohm-Nilsson, M., Johansson, B., Bjartell, A., Lilja, H., Ståhle-Bäkdahl, M., Borregaard, N., and Egesten, A. (2000) Infect. Immun. 68, 4297-4302
43. Frohm-Nilsson, M., Sandstedt, B., Sørensen, O., Weber, G., Borregaard, N., and Ståhle-Bäckdahl, M. (1999) Infect. Immun. 67, 2561-2566
44. International Human Genome Sequencing Consortium (2001) Nature 409, 860-921
45. Stanhope, M. J., Lupas, A., Itlaia, M. J., Koretke, K. K., Volker, C., and Brown, J. R. (2001) Nature 411, 940-944
46. Salzberg, S. L., White, O., Peterson, J., and Eisen, J. A. (2001) Science 292, 1903-1906