Essential role for Toll-like receptor 7 (TLR7)-unique cysteines in an intramolecular disulfide bond, proteolytic cleavage and RNA sensing

International Immunology

Volumn 25, Issue 7, 2013, Pages 413-422

  Kanno, Atsuo ^a   Yamamoto, Chikako ^a   Onji, Masahiro ^a   Fukui, Ryutaro ^a   Saitoh, Shin ichiroh ^a   Motoi, Yuji ^a   Shibata, Takuma ^a   Matsumoto, Fumi ^a   Muta, Tatsushi ^b   Miyake, Kensuke ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Innate immunity; Monoclonal antibody; TLR7

Indexed keywords

CYSTEINE; MUTANT PROTEIN; TOLL LIKE RECEPTOR 7;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; DENDRITIC CELL; DISULFIDE BOND; ENDOPLASMIC RETICULUM; ENDOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT;

INNATE IMMUNITY; MONOCLONAL ANTIBODY; TLR7;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; CELLS, CULTURED; CYSTEINE; DENDRITIC CELLS; DISULFIDES; HEK293 CELLS; HUMANS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PROTEOLYSIS; RNA; TOLL-LIKE RECEPTOR 7;

EID: 84880260267     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxt007     Document Type: Article

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