Structural biology: Crystal structure of human toll-like receptor 3 (TLR3) ectodomain

Science

Volumn 309, Issue 5734, 2005, Pages 581-585

  Choe, Jungwoo ^a   Kelker, Matthew S ^a   Wilson, Ian A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; HYDROGEN BONDS; OLIGOMERS; RNA; SOLENOIDS;

ECTODOMAIN STRUCTURE; IMMUNE RESPONSES; LEUCINE-RICH REPEATS (LRR); TOLL-LIKE RECEPTORS (TLR);

HUMAN ENGINEERING;

DOUBLE STRANDED RNA; LEUCINE; LIGAND; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; CELL SURFACE RECEPTOR; MEMBRANE PROTEIN; TLR3 PROTEIN, HUMAN;

BIOLOGY;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DIMERIZATION; GLYCOSYLATION; HUMAN; IMMUNE SYSTEM; INNATE IMMUNITY; LIGAND BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGOMERIZATION; PRIORITY JOURNAL; SENSOR; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; ELECTRICITY; HYDROGEN BOND; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE; SURFACE PROPERTY; X RAY CRYSTALLOGRAPHY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ELECTROSTATICS; GLYCOSYLATION; HUMANS; HYDROGEN BONDING; LEUCINE; LIGANDS; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; REPETITIVE SEQUENCES, AMINO ACID; RNA, DOUBLE-STRANDED; SIGNAL TRANSDUCTION; SURFACE PROPERTIES; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTORS;

EID: 23044445303     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1115253     Document Type: Article

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51. We thank R. Ulevitch for kindly providing template TLR3 DNA; X. Dai and R. Stanfield for help with data collection; staff members at the Stanford Synchrotron Radiation Laboratory beamline 11-1 and Advanced Light Source 8.2.1; and B. Beutler and R. Ulevitch for helpful comments and suggestions. Supported by NIH grant nos. AI-42266 and CA-58896 (I.A.W.); a Skaggs Institute post-doctoral fellowship (J.C.); and NIH postdoctoral training grant no. T32 AI077606, a TSRI Skaggs predoctoral fellowship, and a TSRI Jairo H. Arévelo fellowship (M.S.K.). This is manuscript number 17439-MB from the Scripps Research Institute. Structure factors and the coordinates are deposited in the Protein Data Bank under accession code 1ZIW.