Meta-analysis demonstrates association between TLR polymorphisms and rheumatoid arthritis

Genetics and Molecular Research

Volumn 12, Issue 1, 2013, Pages 328-334

  Lee, Y H ^a   Bae, S C ^b   Song, G G ^a  

^a Korea University College of Medicine   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Polymorphism; Rheumatoid arthritis; Toll like receptor

Indexed keywords

TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9;

ARTICLE; DATA ANALYSIS; DISEASE ACTIVITY; GENE; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; META ANALYSIS; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; RHEUMATOID ARTHRITIS; SYSTEMATIC REVIEW; TLR GENE; TLR2 GENE; TLR4 GENE; TLR8 GENE; TLR9 GENE; CASE CONTROL STUDY; ETHNIC GROUP; FEMALE; GENETIC PREDISPOSITION; GENETICS; INTRON; MALE;

ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; ETHNIC GROUPS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTRONS; MALE; POLYMORPHISM, GENETIC; TOLL-LIKE RECEPTORS;

EID: 84886752677     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/2013.February.7.2     Document Type: Article

References (24)

1. Adam R, Sturrock RD and Gracie JA (2006). TLR4 mutations (Asp299Gly and Thr399Ile) are not associated with ankylosing spondylitis. Ann. Rheum. Dis. 65: 1099-1101.
2. Choi SJ, Rho YH, Ji JD, Song GG, et al. (2006). Genome scan meta-analysis of rheumatoid arthritis. Rheumatology 45: 166-170.
3. Cromartie WJ, Craddock JG, Schwab JH, Anderle SK, et al. (1977). Arthritis in rats after systemic injection of streptococcal cells or cell walls. J. Exp. Med. 146: 1585-1602.
4. Deighton CM, Walker DJ, Griffiths ID and Roberts DF (1989). The contribution of HLA to rheumatoid arthritis. Clin. Genet. 36: 178-182.
5. Drexler SK and Foxwell BM (2010). The role of toll-like receptors in chronic inflammation. Int. J. Biochem. Cell Biol. 42: 506-518.
6. Enevold C, Radstake TR, Coenen MJ, Fransen J, et al. (2010). Multiplex screening of 22 single-nucleotide polymorphisms in 7 Toll-like receptors: an association study in rheumatoid arthritis. J. Rheumatol. 37: 905-910.
7. Etem EO, Elyas H, Ozgocmen S, Yildirim A, et al. (2011). The investigation of toll-like receptor 3, 9 and 10 gene polymorphisms in Turkish rheumatoid arthritis patients. Rheumatol. Int. 31: 1369-1374.
8. Hurst J and von Landenberg P (2008). Toll-like receptors and autoimmunity. Autoimmun. Rev. 7: 204-208.
9. Jaen O, Petit-Teixeira E, Kirsten H, Ahnert P, et al. (2009). No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis. Arthritis Res. Ther. 11: R5.
10. Kang ES and Lee J (2007). Genotypic analysis of Asp299Gly and Thr399Ile polymorphism of Toll-like receptor 4 in systemic autoimmune diseases of Korean population. Rheumatol. Int. 27: 887-889.
11. Kilding R, Akil M, Till S, Amos R, et al. (2003). A biologically important single nucleotide polymorphism within the toll-like receptor-4 gene is not associated with rheumatoid arthritis. Clin. Exp. Rheumatol. 21: 340-342.
12. Kuuliala K, Orpana A, Leirisalo-Repo M, Kautiainen H, et al. (2006). Polymorphism at position +896 of the toll-like receptor 4 gene interferes with rapid response to treatment in rheumatoid arthritis. Ann. Rheum. Dis. 65: 1241-1243.
13. Lee EY, Yim JJ, Lee HS, Lee YJ, et al. (2006). Dinucleotide repeat polymorphism in intron II of human Toll-like receptor 2 gene and susceptibility to rheumatoid arthritis. Int. J. Immunogenet. 33: 211-215.
14. Mockenhaupt FP, Cramer JP, Hamann L, Stegemann MS, et al. (2006). Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria. Proc. Natl. Acad. Sci. U. S. A. 103: 177-182.
15. Moon SJ, Park MK, Oh HJ, Lee SY, et al. (2010). Engagement of toll-like receptor 3 induces vascular endothelial growth factor and interleukin-8 in human rheumatoid synovial fibroblasts. Korean J. Intern. Med. 25: 429-435.
16. Radstake TR, Franke B, Hanssen S, Netea MG, et al. (2004). The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome. Arthritis Rheum. 50: 999-1001.
17. Roelofs MF, Abdollahi-Roodsaz S, Joosten LA, van den Berg WB, et al. (2008). The orchestra of Toll-like receptors and their potential role in frequently occurring rheumatic conditions. Arthritis Rheum. 58: 338-348.
18. Sanchez E, Orozco G, Lopez-Nevot MA, Jimenez-Alonso J, et al. (2004). Polymorphisms of toll-like receptor 2 and 4 genes in rheumatoid arthritis and systemic lupus erythematosus. Tissue Antigens 63: 54-57.
19. Sheedy FJ, Marinou I, O'Neill LA and Wilson AG (2008). The Mal/TIRAP S180L and TLR4 G299D polymorphisms are not associated with susceptibility to, or severity of, rheumatoid arthritis. Ann. Rheum. Dis. 67: 1328-1331.
20. Sung IH, Kim TH, Bang SY, Kim TJ, et al. (2009). IL-23R polymorphisms in patients with ankylosing spondylitis in Korea. J. Rheumatol. 36: 1003-1005.
21. Takeda K, Kaisho T and Akira S (2003). Toll-like receptors. Annu. Rev. Immunol. 21: 335-376.
22. Wang X, Huang J, Lin Z, Liao Z, et al. (2010). Single-nucleotide polymorphisms and expression of IL23R in Chinese ankylosing spondylitis patients. Rheumatol. Int. 30: 955-959.
23. Wordsworth P and Bell J (1991). Polygenic susceptibility in rheumatoid arthritis. Ann. Rheum. Dis. 50: 343-346.
24. Zheng B, Li Q, Wei C, Qin J, et al. (2010). Lack of association of TLR4 gene Asp299Gly and Thr399Ile polymorphisms with rheumatoid arthritis in Chinese Han population of Yunnan Province. Rheumatol. Int. 30: 1249-1252.