메뉴 건너뛰기




Volumn 12, Issue 4, 2012, Pages 510-518

New developments in Toll-like receptor targeted therapeutics

Author keywords

[No Author keywords available]

Indexed keywords

852A; ANA 773; AVE 0675; AZD 1419; AZD 8848; BEVACIZUMAB; CBLB 502; CETUXIMAB; CHEMICAL COMPOUND; CPG 52364; DIMS 1050; DV 1179; ERITORAN; ERLOTINIB; FLUOROURACIL; FOLINIC ACID; GLUCOCORTICOID; HEPATITIS B VACCINE; IBUDILAST; IMIQUIMOD; IMO 2055; IMO 2125; IMO 3100; IMO 8400; IRINOTECAN; KAPPAPROCT; NI 0101; OPN 305; PLANT EXTRACT; POLLINEX QUATTRO; QAX 935; RAGWEED POLLEN EXTRACT; RESIQUIMOD; RINTATOLIMOD; SAR 21609; SD 101; SMP 105; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; UNINDEXED DRUG; VAX 102; VAX 125; VTX 1463;

EID: 84865032889     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2012.06.002     Document Type: Review
Times cited : (122)

References (68)
  • 2
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
    • T. Kawai, and S. Akira The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors Nat Immunol 11 2010 373 384
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 3
    • 4644335083 scopus 로고    scopus 로고
    • The long acidic tail of high mobility group box 1 (HMGB1) protein forms an extended and flexible structure that interacts with specific residues within and between the HMG boxes
    • S. Knapp, S. Muller, G. Digilio, T. Bonaldi, M.E. Bianchi, and G. Musco The long acidic tail of high mobility group box 1 (HMGB1) protein forms an extended and flexible structure that interacts with specific residues within and between the HMG boxes Biochemistry 43 2004 11992 11997
    • (2004) Biochemistry , vol.43 , pp. 11992-11997
    • Knapp, S.1    Muller, S.2    Digilio, G.3    Bonaldi, T.4    Bianchi, M.E.5    Musco, G.6
  • 5
    • 34247566510 scopus 로고    scopus 로고
    • The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
    • L.A. O'Neill, and A.G. Bowie The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling Nat Rev Immunol 7 2007 353 364
    • (2007) Nat Rev Immunol , vol.7 , pp. 353-364
    • O'Neill, L.A.1    Bowie, A.G.2
  • 6
    • 5444254408 scopus 로고    scopus 로고
    • Toll-like receptors in the pathogenesis of human disease
    • D.N. Cook, D.S. Pisetsky, and D.A. Schwartz Toll-like receptors in the pathogenesis of human disease Nat Immunol 5 2004 975 979
    • (2004) Nat Immunol , vol.5 , pp. 975-979
    • Cook, D.N.1    Pisetsky, D.S.2    Schwartz, D.A.3
  • 8
    • 39549123040 scopus 로고    scopus 로고
    • Toll-like receptor polymorphisms and susceptibility to human disease
    • E.A. Misch, and T.R. Hawn Toll-like receptor polymorphisms and susceptibility to human disease Clin Sci (Lond) 114 2008 347 360
    • (2008) Clin Sci (Lond) , vol.114 , pp. 347-360
    • Misch, E.A.1    Hawn, T.R.2
  • 9
    • 78449263222 scopus 로고    scopus 로고
    • Anti-interleukin-6 therapy in rheumatoid arthritis
    • R. Woodrick, and E.M. Ruderman Anti-interleukin-6 therapy in rheumatoid arthritis Bull NYU Hosp Jt Dis 68 2010 211 217
    • (2010) Bull NYU Hosp Jt Dis , vol.68 , pp. 211-217
    • Woodrick, R.1    Ruderman, E.M.2
  • 12
    • 74649084593 scopus 로고    scopus 로고
    • The ABC of clinical and experimental adjuvants - A brief overview
    • R. Brunner, E. Jensen-Jarolim, and I. Pali-Scholl The ABC of clinical and experimental adjuvants - a brief overview Immunol Lett 128 2010 29 35
    • (2010) Immunol Lett , vol.128 , pp. 29-35
    • Brunner, R.1    Jensen-Jarolim, E.2    Pali-Scholl, I.3
  • 13
    • 31344461659 scopus 로고    scopus 로고
    • Innate immune recognition of viral infection
    • T. Kawai, and S. Akira Innate immune recognition of viral infection Nat Immunol 7 2006 131 137
    • (2006) Nat Immunol , vol.7 , pp. 131-137
    • Kawai, T.1    Akira, S.2
  • 14
    • 67649884707 scopus 로고    scopus 로고
    • Beyond a decade of 5% imiquimod topical therapy
    • A. AG, S.K. Tyring, and T. Rosen Beyond a decade of 5% imiquimod topical therapy J Drugs Dermatol 8 2009 467 474
    • (2009) J Drugs Dermatol , vol.8 , pp. 467-474
    • Ag, A.1    Tyring, S.K.2    Rosen, T.3
  • 15
    • 23044496046 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of actinic keratoses
    • N. Somani, and J.K. Rivers Imiquimod 5% cream for the treatment of actinic keratoses Skin Therapy Lett 10 2005 1 6
    • (2005) Skin Therapy Lett , vol.10 , pp. 1-6
    • Somani, N.1    Rivers, J.K.2
  • 16
    • 0036737628 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: A double-blind, randomized, vehicle-controlled study
    • J.K. Geisse, P. Rich, A. Pandya, K. Gross, K. Andres, A. Ginkel, and M. Owens Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: a double-blind, randomized, vehicle-controlled study J Am Acad Dermatol 47 2002 390 398
    • (2002) J Am Acad Dermatol , vol.47 , pp. 390-398
    • Geisse, J.K.1    Rich, P.2    Pandya, A.3    Gross, K.4    Andres, K.5    Ginkel, A.6    Owens, M.7
  • 17
    • 34548787163 scopus 로고    scopus 로고
    • Treatment of all basal cell carcinoma variants including large and high-risk lesions with 5% imiquimod cream: Histological and clinical changes, outcome, and follow-up
    • C. Schiessl, C. Wolber, M. Tauber, F. Offner, and R. Strohal Treatment of all basal cell carcinoma variants including large and high-risk lesions with 5% imiquimod cream: histological and clinical changes, outcome, and follow-up J Drugs Dermatol 6 2007 507 513
    • (2007) J Drugs Dermatol , vol.6 , pp. 507-513
    • Schiessl, C.1    Wolber, C.2    Tauber, M.3    Offner, F.4    Strohal, R.5
  • 19
    • 37249041922 scopus 로고    scopus 로고
    • First in human phase i trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer
    • A.Z. Dudek, C. Yunis, L.I. Harrison, S. Kumar, R. Hawkinson, S. Cooley, J.P. Vasilakos, K.S. Gorski, and J.S. Miller First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer Clin Cancer Res 13 2007 7119 7125
    • (2007) Clin Cancer Res , vol.13 , pp. 7119-7125
    • Dudek, A.Z.1    Yunis, C.2    Harrison, L.I.3    Kumar, S.4    Hawkinson, R.5    Cooley, S.6    Vasilakos, J.P.7    Gorski, K.S.8    Miller, J.S.9
  • 20
    • 34447632621 scopus 로고    scopus 로고
    • Pharmacokinetics of 852A, an imidazoquinoline Toll-like receptor 7-specific agonist, following intravenous, subcutaneous, and oral administrations in humans
    • L.I. Harrison, C. Astry, S. Kumar, and C. Yunis Pharmacokinetics of 852A, an imidazoquinoline Toll-like receptor 7-specific agonist, following intravenous, subcutaneous, and oral administrations in humans J Clin Pharmacol 47 2007 962 969
    • (2007) J Clin Pharmacol , vol.47 , pp. 962-969
    • Harrison, L.I.1    Astry, C.2    Kumar, S.3    Yunis, C.4
  • 25
    • 79958832035 scopus 로고    scopus 로고
    • VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis
    • F. Horak VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis Expert Opin Investig Drugs 20 2011 981 986
    • (2011) Expert Opin Investig Drugs , vol.20 , pp. 981-986
    • Horak, F.1
  • 26
    • 34249677845 scopus 로고    scopus 로고
    • Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
    • H. Kanzler, F.J. Barrat, E.M. Hessel, and R.L. Coffman Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists Nat Med 13 2007 552 559
    • (2007) Nat Med , vol.13 , pp. 552-559
    • Kanzler, H.1    Barrat, F.J.2    Hessel, E.M.3    Coffman, R.L.4
  • 27
    • 37749044421 scopus 로고    scopus 로고
    • Synthetic agonists of Toll-like receptors 7, 8 and 9
    • S. Agrawal, and E.R. Kandimalla Synthetic agonists of Toll-like receptors 7, 8 and 9 Biochem Soc Trans 35 2007 1461 1467
    • (2007) Biochem Soc Trans , vol.35 , pp. 1461-1467
    • Agrawal, S.1    Kandimalla, E.R.2
  • 28
    • 84862785552 scopus 로고    scopus 로고
    • Demonstration of safety and enhanced seroprotection against hepatitis B with investigational HBsAg-1018 ISS vaccine compared to a licensed hepatitis B vaccine
    • B.P. Sablan, D.J. Kim, N.G. Barzaga, W.C. Chow, M. Cho, S.H. Ahn, S.G. Hwang, J.H. Lee, H. Namini, and W.L. Heyward Demonstration of safety and enhanced seroprotection against hepatitis B with investigational HBsAg-1018 ISS vaccine compared to a licensed hepatitis B vaccine Vaccine 30 2012 2689 2696
    • (2012) Vaccine , vol.30 , pp. 2689-2696
    • Sablan, B.P.1    Kim, D.J.2    Barzaga, N.G.3    Chow, W.C.4    Cho, M.5    Ahn, S.H.6    Hwang, S.G.7    Lee, J.H.8    Namini, H.9    Heyward, W.L.10
  • 29
    • 84862812420 scopus 로고    scopus 로고
    • Comparison of safety and immunogenicity of two doses of investigational hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide and three doses of a licensed hepatitis B vaccine in healthy adults 18-55 years of age
    • S.A. Halperin, B. Ward, C. Cooper, G. Predy, F. Diaz-Mitoma, M. Dionne, J. Embree, A. McGeer, P. Zickler, and K.H. Moltz Comparison of safety and immunogenicity of two doses of investigational hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide and three doses of a licensed hepatitis B vaccine in healthy adults 18-55 years of age Vaccine 30 2012 2556 2563
    • (2012) Vaccine , vol.30 , pp. 2556-2563
    • Halperin, S.A.1    Ward, B.2    Cooper, C.3    Predy, G.4    Diaz-Mitoma, F.5    Dionne, M.6    Embree, J.7    McGeer, A.8    Zickler, P.9    Moltz, K.H.10
  • 30
    • 58149466086 scopus 로고    scopus 로고
    • Toll-like receptors in systemic lupus erythematosus; Prospects for therapeutic intervention
    • W.U. Kim, A. Sreih, and R. Bucala Toll-like receptors in systemic lupus erythematosus; prospects for therapeutic intervention Autoimmun Rev 8 2009 204 208
    • (2009) Autoimmun Rev , vol.8 , pp. 204-208
    • Kim, W.U.1    Sreih, A.2    Bucala, R.3
  • 32
    • 37549066665 scopus 로고    scopus 로고
    • Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms
    • F.J. Barrat, T. Meeker, J.H. Chan, C. Guiducci, and R.L. Coffman Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms Eur J Immunol 37 2007 3582 3586
    • (2007) Eur J Immunol , vol.37 , pp. 3582-3586
    • Barrat, F.J.1    Meeker, T.2    Chan, J.H.3    Guiducci, C.4    Coffman, R.L.5
  • 33
    • 34548608447 scopus 로고    scopus 로고
    • Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
    • M.S. Jin, S.E. Kim, J.Y. Heo, M.E. Lee, H.M. Kim, S.G. Paik, H. Lee, and J.O. Lee Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide Cell 130 2007 1071 1082
    • (2007) Cell , vol.130 , pp. 1071-1082
    • Jin, M.S.1    Kim, S.E.2    Heo, J.Y.3    Lee, M.E.4    Kim, H.M.5    Paik, S.G.6    Lee, H.7    Lee, J.O.8
  • 37
    • 74549178528 scopus 로고    scopus 로고
    • Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody
    • F. Arslan, M.B. Smeets, L.A. O'Neill, B. Keogh, P. McGuirk, L. Timmers, C. Tersteeg, I.E. Hoefer, P.A. Doevendans, and G. Pasterkamp Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody Circulation 121 2010 80 90
    • (2010) Circulation , vol.121 , pp. 80-90
    • Arslan, F.1    Smeets, M.B.2    O'Neill, L.A.3    Keogh, B.4    McGuirk, P.5    Timmers, L.6    Tersteeg, C.7    Hoefer, I.E.8    Doevendans, P.A.9    Pasterkamp, G.10
  • 38
    • 84859409484 scopus 로고    scopus 로고
    • Ischaemia-induced up-regulation of Toll-like receptor 2 in circulating monocytes in cardiogenic shock
    • S. Selejan, J. Poss, F. Walter, M. Hohl, R. Kaiser, A. Kazakov, M. Bohm, and A. Link Ischaemia-induced up-regulation of Toll-like receptor 2 in circulating monocytes in cardiogenic shock Eur Heart J 33 2011 1085 1094
    • (2011) Eur Heart J , vol.33 , pp. 1085-1094
    • Selejan, S.1    Poss, J.2    Walter, F.3    Hohl, M.4    Kaiser, R.5    Kazakov, A.6    Bohm, M.7    Link, A.8
  • 40
    • 84856521251 scopus 로고    scopus 로고
    • Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia-reperfusion injury
    • C.A. Farrar, B. Keogh, W. McCormack, A. O'Shaughnessy, A. Parker, M. Reilly, and S.H. Sacks Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia-reperfusion injury FASEB J 26 2012 799 807
    • (2012) FASEB J , vol.26 , pp. 799-807
    • Farrar, C.A.1    Keogh, B.2    McCormack, W.3    O'Shaughnessy, A.4    Parker, A.5    Reilly, M.6    Sacks, S.H.7
  • 42
    • 44449120076 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 2 by a novel preparation of cell wall skeleton from Mycobacterium bovis BCG Tokyo (SMP-105) sufficiently enhances immune responses against tumors
    • M. Murata Activation of Toll-like receptor 2 by a novel preparation of cell wall skeleton from Mycobacterium bovis BCG Tokyo (SMP-105) sufficiently enhances immune responses against tumors Cancer Sci 99 2008 1435 1440
    • (2008) Cancer Sci , vol.99 , pp. 1435-1440
    • Murata, M.1
  • 44
    • 0033532629 scopus 로고    scopus 로고
    • MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    • R. Shimazu, S. Akashi, H. Ogata, Y. Nagai, K. Fukudome, K. Miyake, and M. Kimoto MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4 J Exp Med 189 1999 1777 1782
    • (1999) J Exp Med , vol.189 , pp. 1777-1782
    • Shimazu, R.1    Akashi, S.2    Ogata, H.3    Nagai, Y.4    Fukudome, K.5    Miyake, K.6    Kimoto, M.7
  • 45
    • 0025166114 scopus 로고
    • CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
    • S.D. Wright, R.A. Ramos, P.S. Tobias, R.J. Ulevitch, and J.C. Mathison CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein Science 249 1990 1431 1433
    • (1990) Science , vol.249 , pp. 1431-1433
    • Wright, S.D.1    Ramos, R.A.2    Tobias, P.S.3    Ulevitch, R.J.4    Mathison, J.C.5
  • 46
    • 1242284201 scopus 로고    scopus 로고
    • Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia
    • T. Mizuno, T. Kurotani, Y. Komatsu, J. Kawanokuchi, H. Kato, N. Mitsuma, and A. Suzumura Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia Neuropharmacology 46 2004 404 411
    • (2004) Neuropharmacology , vol.46 , pp. 404-411
    • Mizuno, T.1    Kurotani, T.2    Komatsu, Y.3    Kawanokuchi, J.4    Kato, H.5    Mitsuma, N.6    Suzumura, A.7
  • 49
    • 17644414137 scopus 로고    scopus 로고
    • The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy
    • F.Y. Tanga, N. Nutile-McMenemy, and J.A. DeLeo The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy Proc Natl Acad Sci USA 102 2005 5856 5861
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 5856-5861
    • Tanga, F.Y.1    Nutile-Mcmenemy, N.2    Deleo, J.A.3
  • 52
    • 34249650685 scopus 로고    scopus 로고
    • E5564 (Eritoran) inhibits lipopolysaccharide-induced cytokine production in human blood monocytes
    • E. Czeslick, A. Struppert, A. Simm, and A. Sablotzki E5564 (Eritoran) inhibits lipopolysaccharide-induced cytokine production in human blood monocytes Inflamm Res 55 2006 511 515
    • (2006) Inflamm Res , vol.55 , pp. 511-515
    • Czeslick, E.1    Struppert, A.2    Simm, A.3    Sablotzki, A.4
  • 53
    • 0037635980 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and pharmacodynamics of E5564, a lipid A antagonist, during an ascending single-dose clinical study
    • Y.N. Wong, D. Rossignol, J.R. Rose, R. Kao, A. Carter, and M. Lynn Safety, pharmacokinetics, and pharmacodynamics of E5564, a lipid A antagonist, during an ascending single-dose clinical study J Clin Pharmacol 43 2003 735 742
    • (2003) J Clin Pharmacol , vol.43 , pp. 735-742
    • Wong, Y.N.1    Rossignol, D.2    Rose, J.R.3    Kao, R.4    Carter, A.5    Lynn, M.6
  • 55
    • 33846456617 scopus 로고    scopus 로고
    • A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass
    • E. Bennett-Guerrero, H.P. Grocott, J.H. Levy, K.A. Stierer, C.W. Hogue, A.T. Cheung, M.F. Newman, A.A. Carter, D.P. Rossignol, and C.D. Collard A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass Anesth Analg 104 2007 378 383
    • (2007) Anesth Analg , vol.104 , pp. 378-383
    • Bennett-Guerrero, E.1    Grocott, H.P.2    Levy, J.H.3    Stierer, K.A.4    Hogue, C.W.5    Cheung, A.T.6    Newman, M.F.7    Carter, A.A.8    Rossignol, D.P.9    Collard, C.D.10
  • 58
    • 84255183707 scopus 로고    scopus 로고
    • The search for effective therapy for sepsis: Back to the drawing board?
    • D.C. Angus The search for effective therapy for sepsis: back to the drawing board? JAMA 306 2011 2614 2615
    • (2011) JAMA , vol.306 , pp. 2614-2615
    • Angus, D.C.1
  • 59
    • 0034995781 scopus 로고    scopus 로고
    • A well-tolerated grass pollen-specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseasonal injections
    • K.J. Drachenberg, A.W. Wheeler, P. Stuebner, and F. Horak A well-tolerated grass pollen-specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseasonal injections Allergy 56 2001 498 505
    • (2001) Allergy , vol.56 , pp. 498-505
    • Drachenberg, K.J.1    Wheeler, A.W.2    Stuebner, P.3    Horak, F.4
  • 60
    • 84858187358 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome
    • D.R. Strayer, W.A. Carter, B.C. Stouch, S.R. Stevens, L. Bateman, P.J. Cimoch, C.W. Lapp, D.L. Peterson, and W.M. Mitchell A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome PLoS ONE 7 2012 e31334
    • (2012) PLoS ONE , vol.7 , pp. 31334
    • Strayer, D.R.1    Carter, W.A.2    Stouch, B.C.3    Stevens, S.R.4    Bateman, L.5    Cimoch, P.J.6    Lapp, C.W.7    Peterson, D.L.8    Mitchell, W.M.9
  • 62
    • 77952878989 scopus 로고    scopus 로고
    • Toll-like receptor-3 as a target to enhance bioactivity of cancer immunotherapy
    • e601-608
    • C.F. Nicodemus, L. Wang, J. Lucas, B. Varghese, and J.S. Berek Toll-like receptor-3 as a target to enhance bioactivity of cancer immunotherapy Am J Obstet Gynecol 202 2010 608 e601-608
    • (2010) Am J Obstet Gynecol , vol.202 , pp. 608
    • Nicodemus, C.F.1    Wang, L.2    Lucas, J.3    Varghese, B.4    Berek, J.S.5
  • 65
    • 79959736816 scopus 로고    scopus 로고
    • Induction of a potent immune response in the elderly using the TLR-5 agonist, flagellin, with a recombinant hemagglutinin influenza-flagellin fusion vaccine (VAX125, STF2.HA1 SI)
    • D.N. Taylor, J.J. Treanor, C. Strout, C. Johnson, T. Fitzgerald, U. Kavita, K. Ozer, L. Tussey, and A. Shaw Induction of a potent immune response in the elderly using the TLR-5 agonist, flagellin, with a recombinant hemagglutinin influenza-flagellin fusion vaccine (VAX125, STF2.HA1 SI) Vaccine 29 2011 4897 4902
    • (2011) Vaccine , vol.29 , pp. 4897-4902
    • Taylor, D.N.1    Treanor, J.J.2    Strout, C.3    Johnson, C.4    Fitzgerald, T.5    Kavita, U.6    Ozer, K.7    Tussey, L.8    Shaw, A.9
  • 67
    • 84856988610 scopus 로고    scopus 로고
    • Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific immune responses
    • J. Garaude, A. Kent, N. van Rooijen, and J.M. Blander Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific immune responses Sci Transl Med 4 2012 120ra116
    • (2012) Sci Transl Med , vol.4
    • Garaude, J.1    Kent, A.2    Van Rooijen, N.3    Blander, J.M.4
  • 68
    • 84856558003 scopus 로고    scopus 로고
    • Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-gamma+IL-17+ polyfunctional T cells that mediate rejection of murine tumors
    • N.A. Marshall, K.C. Galvin, A.M. Corcoran, L. Boon, R. Higgs, and K.H. Mills Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-gamma+IL-17+ polyfunctional T cells that mediate rejection of murine tumors Cancer Res 72 2012 581 591
    • (2012) Cancer Res , vol.72 , pp. 581-591
    • Marshall, N.A.1    Galvin, K.C.2    Corcoran, A.M.3    Boon, L.4    Higgs, R.5    Mills, K.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.