Herpes simplex virus encephalitis in human UNC-93B deficiency

Science

Volumn 314, Issue 5797, 2006, Pages 308-312

  Casrouge, Armanda ^a   Zhang, Shen Ying ^a,b   Eidenschenk, Céline ^a   Jouanguy, Emmanuelle ^a,b   Puel, Anne ^a   Yang, Kun ^a,b   Alcais, Alexandre ^a   Picard, Capucine ^a,c   Mahfoufi, Nora ^a   Nicolas, Nathalie ^a   Lorenzo, Lazaro ^a   Plancoulaine, Sabine ^a   Sénéchal, Brigitte ^c   Geissmann, Frédéric ^c   Tabeta, Koichi ^d,i   Hoebe, Kasper ^d   Du, Xin ^d   Miller, Richard L ^e   Héron, Bénédicte ^f   Mignot, Cyril ^f   Billette De Villemeur, Thierry ^f   Lebon, Pierre ^g   Dulac, Olivier ^c   Rozenberg, Flore ^g   Beutler, Bruce ^d   Tardieu, Marc ^h   Abel, Laurent ^a   Casanova, Jean Laurent ^a,b,c   more..

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e 3M COMPANY   (United States)

^f ARMAND TROUSSEAU HOSPITAL   (France)

^g HÔPITAL SAINT VINCENT DE PAUL   (France)

^h BICÊTRE HOSPITAL   (France)

ⁱ NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GENETIC ETIOLOGY; INTRACELLULAR PROTEIN; SINGLE-GENE IMMUNODEFICIENCY; VIRAL ENCEPHALITIS;

DISEASES; GENES; IMMUNOLOGY; PATIENT TREATMENT;

VIRUSES;

ALPHA INTERFERON; BETA INTERFERON; CELL PROTEIN; INTERFERON; LAMBDA INTERFERON; PROTEIN UNC 93B; UNCLASSIFIED DRUG;

GENE EXPRESSION; HEALTH IMPACT; IMMUNITY; INFECTIOUS DISEASE; PATHOGEN; PROTEIN; VIRUS;

ARTICLE; AUTOSOMAL RECESSIVE DISORDER; HERPES SIMPLEX VIRUS 1; HUMAN; IMMUNE DEFICIENCY; IMMUNITY; MONOGENIC DISORDER; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEFICIENCY; VIRUS ENCEPHALITIS;

CHILD, PRESCHOOL; CYTOKINES; ENCEPHALITIS, HERPES SIMPLEX; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HERPESVIRUS 1, HUMAN; HUMANS; INFANT; INTERFERON TYPE II; INTERFERON-ALPHA; INTERFERON-BETA; INTERFERONS; LEUKOCYTES, MONONUCLEAR; MALE; MEMBRANE TRANSPORT PROTEINS; MUTATION; PEDIGREE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTORS;

HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 33750016788     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1128346     Document Type: Article

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32. We thank all members of the laboratory, F. Barrat, E. Vivier, P. Benaroch, S. Amigorena, I. Gresser, S. Virgin, M. E. Conley, and X. Li, for helpful discussions, and the children and their families for agreeing to participate in this study. This study was supported by grants from the Fondation pour la Recherche Médicale, the Schlumberger Foundation, the Banque Nationale de Paris-Paribas Foundation, the Groupement d'Intérêt Scientifique Maladies Rares, the Action Concertée Incitative de Microbiologie, the Agence Nationale pour la Recherche, and the March of Dimes. J.-L.C. is an International Scholar of the Howard Hughes Medical Institute.