Primary blood neutrophils express a functional cell surface Toll-like receptor 9

European Journal of Immunology

Volumn 43, Issue 8, 2013, Pages 2101-2113

  Lindau, Dennis ^a,d   Mussard, Julie ^b   Wagner, Britta J ^a   Ribon, Matthieu ^b   Rönnefarth, Viktoria M ^a,e   Quettier, Maude ^b   Jelcic, Ivan ^a,f   Boissier, Marie Christophe ^b,c   Rammensee, Hans Georg ^a   Decker, Patrice ^a,b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITÉ PARIS 13   (France)

^c AVICENNE HOSPITAL   (France)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^e HAIN LIFESCIENCE GMBH   (Germany)

^f UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Activation; Cell surface expression; Functionality; Neutrophils; TLR9

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; OLIGONUCLEOTIDE; TOLL LIKE RECEPTOR 9;

ACIDIFICATION; ANIMAL CELL; ARTICLE; BLOOD; BONE MARROW CELL; CELL ACTIVATION; CELL SURFACE; CROSS LINKING; ENDOSOME; HUMAN; HUMAN CELL; LYMPHOID CELL; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; UPREGULATION;

ACTIVATION; CELL-SURFACE EXPRESSION; FUNCTIONALITY; NEUTROPHILS; TLR9;

ANIMALS; ANTIGENS, SURFACE; CELLS, CULTURED; CPG ISLANDS; HUMANS; INFLAMMATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHIL ACTIVATION; NEUTROPHILS; OLIGODEOXYRIBONUCLEOTIDES; TOLL-LIKE RECEPTOR 9;

EID: 84881536267     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201142143     Document Type: Article

References (39)

1. Nathan, C., Neutrophils and immunity: challenges and opportunities. Nat. Rev. Immunol. 2006. 6: 173-182.
2. Pelletier, M., Maggi, L., Micheletti, A., Lazzeri, E., Tamassia, N., Costantini, C., Cosmi, L. et al., Evidence for a cross-talk between human neutrophils and Th17 cells. Blood 2010. 115: 335-343.
3. Garcia-Romo, G. S., Caielli, S., Vega, B., Connolly, J., Allantaz, F., Xu, Z., Punaro, M. et al., Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Sci. Transl. Med. 2011. 3: 73ra20.
4. Lande, R., Ganguly, D., Facchinetti, V., Frasca, L., Conrad, C., Gregorio, J., Meller, S. et al., Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Sci. Transl. Med. 2011. 3: 73ra19.
5. Yamashiro, S., Kamohara, H., Wang, J. M., Yang, D., Gong, W. H. and Yoshimura, T., Phenotypic and functional change of cytokine-activated neutrophils: inflammatory neutrophils are heterogeneous and enhance adaptive immune responses. J. Leukoc. Biol. 2001. 69: 698-704.
6. Bennouna, S., Bliss, S. K., Curiel, T. J. and Denkers, E. Y., Cross-talk in the innate immune system: neutrophils instruct recruitment and activation of dendritic cells during microbial infection. J. Immunol. 2003. 171: 6052-6058.
7. van Gisbergen, K. P., Sanchez-Hernandez, M., Geijtenbeek, T. B. and van Kooyk, Y., Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN. J. Exp. Med. 2005. 201: 1281-1292.
8. Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M. et al., A Toll-like receptor recognizes bacterial DNA. Nature 2000. 408: 740-745.
9. Yasuda, K., Yu, P., Kirschning, C. J., Schlatter, B., Schmitz, F., Heit, A., Bauer, S. et al., Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways. J. Immunol. 2005. 174: 6129-6136.
10. Okabe, Y., Kawane, K., Akira, S., Taniguchi, T. and Nagata, S., Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation. J. Exp. Med. 2005. 202: 1333-1339.
11. Yasuda, K., Rutz, M., Schlatter, B., Metzger, J., Luppa, P. B., Schmitz, F., Haas, T. et al., CpG motif-independent activation of TLR9 upon endosomal translocation of "natural" phosphodiester DNA. Eur. J. Immunol. 2006. 36: 431-436.
12. Haas, T., Metzger, J., Schmitz, F., Heit, A., Muller, T., Latz, E. and Wagner, H., The DNA sugar backbone 2′ deoxyribose determines Toll-like receptor 9 activation. Immunity 2008. 28: 315-323.
13. Latz, E., Schoenemeyer, A., Visintin, A., Fitzgerald, K. A., Monks, B. G., Knetter, C. F., Lien, E. et al., TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat. Immunol. 2004. 5: 190-198.
14. Ahmad-Nejad, P., Hacker, H., Rutz, M., Bauer, S., Vabulas, R. M. and Wagner, H., Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol. 2002. 32: 1958-1968.
15. Rutz, M., Metzger, J., Gellert, T., Luppa, P., Lipford, G. B., Wagner, H. and Bauer, S., Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. Eur. J. Immunol. 2004. 34: 2541-2550.
16. Ewald, S. E., Lee, B. L., Lau, L., Wickliffe, K. E., Shi, G. P., Chapman, H. A. and Barton, G. M., The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature 2008. 456: 658-662.
17. Park, B., Brinkmann, M. M., Spooner, E., Lee, C. C., Kim, Y. M. and Ploegh, H. L., Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9. Nat. Immunol. 2008. 9: 1407-1414.
18. Hacker, H., Mischak, H., Miethke, T., Liptay, S., Schmid, R., Sparwasser, T., Heeg, K. et al., CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 1998. 17: 6230-6240.
19. Kim, Y. M., Brinkmann, M. M., Paquet, M. E. and Ploegh, H. L., UNC93B1 delivers nucleotide-sensing Toll-like receptors to endolysosomes. Nature 2008. 452: 234-238.
20. Brinkmann, M. M., Spooner, E., Hoebe, K., Beutler, B., Ploegh, H. L. and Kim, Y. M., The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J. Cell Biol. 2007. 177: 265-275.
21. Barton, G. M., Kagan, J. C. and Medzhitov, R., Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat. Immunol. 2006. 7: 49-56.
22. Park, B., Buti, L., Lee, S., Matsuwaki, T., Spooner, E., Brinkmann, M. M., Nishihara, M. et al., Granulin is a soluble cofactor for Toll-like receptor 9 signaling. Immunity 2011. 34: 505-513.
23. Hayashi, F., Means, T. K. and Luster, A. D., Toll-like receptors stimulate human neutrophil function. Blood 2003. 102: 2660-2669.
24. Dasari, P., Nicholson, I. C., Hodge, G., Dandie, G. W. and Zola, H., Expression of Toll-like receptors on B lymphocytes. Cell Immunol. 2005. 236: 140-145.
25. Baiyee, E. E., Flohe, S., Lendemans, S., Bauer, S., Mueller, N., Kreuzfelder, E. and Grosse-Wilde, H., Expression and function of Toll-like receptor 9 in severely injured patients prone to sepsis. Clin. Exp. Immunol. 2006. 145: 456-462.
26. Cunningham-Rundles, C., Radigan, L., Knight, A. K., Zhang, L., Bauer, L. and Nakazawa, A., TLR9 activation is defective in common variable immune deficiency. J. Immunol. 2006. 176: 1978-1987.
27. Cognasse, F., Hamzeh-Cognasse, H., Lafarge, S., Chavarin, P., Pozzetto, B., Richard, Y. and Garraud, O., Identification of two subpopulations of purified human blood B cells. Immunology 2008. 125: 430-437.
28. Eaton-Bassiri, A., Dillon, S. B., Cunningham, M., Rycyzyn, M. A., Mills, J., Sarisky, R. T. and Mbow, M. L., Toll-like receptor 9 can be expressed at the cell surface of distinct populations of tonsils and human peripheral blood mononuclear cells. Infect. Immun. 2004. 72: 7202-7211.
29. Saikh, K. U., Kissner, T. L., Sultana, A., Ruthel, G. and Ulrich, R. G., Human monocytes infected with Yersinia pestis express cell surface TLR9 and differentiate into dendritic cells. J. Immunol. 2004. 173: 7426-7434.
30. Lee, J., Mo, J. H., Katakura, K., Alkalay, I., Rucker, A. N., Liu, Y. T., Lee, H. K. et al., Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat. Cell Biol. 2006. 8: 1327-1336.
31. Van Strijp, J. A., Van Kessel, K. P., van der Tol, M. E. and Verhoef, J., Complement-mediated phagocytosis of herpes simplex virus by granulocytes. Binding or ingestion. J. Clin. Invest. 1989. 84: 107-112.
32. Lindau, D., Rönnefarth, V., Erbacher, A., Rammensee, H. G. and Decker, P., Nucleosome-induced neutrophil activation occurs independently of TLR9 and endosomal acidification: implications for systemic lupus erythematosus. Eur. J. Immunol. 2011. 41: 669-681.
33. Fuxman Bass, J. I., Gabelloni, M. L., Alvarez, M. E., Vermeulen, M. E., Russo, D. M., Zorreguieta, A., Geffner, J. R. et al., Characterization of bacterial DNA binding to human neutrophil surface. Lab. Invest. 2008. 88: 926-937.
34. Mouchess, M. L., Arpaia, N., Souza, G., Barbalat, R., Ewald, S. E., Lau, L. and Barton, G. M., Transmembrane mutations in Toll-like receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation. Immunity 2011. 35: 721-732.
35. Viglianti, G. A., Lau, C. M., Hanley, T. M., Miko, B. A., Shlomchik, M. J. and Marshak-Rothstein, A., Activation of autoreactive B cells by CpG dsDNA. Immunity 2003. 19: 837-847.
36. Fukui, R., Saitoh, S., Kanno, A., Onji, M., Shibata, T., Ito, A., Onji, M. et al., Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking. Immunity 2011. 35: 69-81.
37. Rönnefarth, V. M., Erbacher, A. I. M., Lamkemeyer, T., Madlung, J., Nordheim, A., Rammensee, H. G. and Decker, P., TLR2/TLR4-independent neutrophil activation and recruitment upon endocytosis of nucleosomes reveals a new pathway of innate immunity in systemic lupus erythematosus. J. Immunol. 2006. 177: 7740-7749.
38. Decker, P., Le Moal, A., Briand, J. P. and Muller, S., Identification of a minimal T cell epitope recognized by antinucleosome Th cells in the C-terminal region of histone H4. J. Immunol. 2000. 165: 654-662.
39. Decker, P., Wolburg, H. and Rammensee, H. G., Nucleosomes induce lymphocyte necrosis. Eur. J. Immunol. 2003. 33: 1978-1987.