Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH

Journal of Biological Chemistry

Volumn 280, Issue 46, 2005, Pages 38133-38145

  De Bouteiller, Odette ^a,b   Merck, Estelle ^a,c   Hasan, Uzma A ^a,d   Hubac, Sylvain ^a   Benguigui, Barbara ^a   Trinchieri, Giorgio ^a,e   Bates, Elizabeth E M ^a   Caux, Christophe ^a,f  

^a MERCK RESEARCH LABORATORIES   (United States)

^b University Lyon i   (France)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Switzerland)

^d INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^f CENTRE LÉON BÉRARD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; CALCIUM; CROSSLINKING; MUTAGENESIS; PH; SIGNALING;

CALCIUM MOBILIZATION; CARBOXYL TERMINAL DOMAINS; CHIMERIC MOLECULE; IMMUNORECEPTOR TYROSINE-BASED MOTIF;

RNA;

BAFILOMYCIN; CD32 ANTIGEN; CHLOROQUINE; CYSTEINE; DOUBLE STRANDED RNA; IMMUNOGLOBULIN ANTIBODY; LEUCINE; POLYADENYLIC POLYURIDYLIC ACID; POLYINOSINIC POLYCYTIDYLIC ACID; TOLL LIKE RECEPTOR 3; TYROSINE; ANTIRHEUMATIC AGENT; BAFILOMYCIN A; CALCIUM; CROSS LINKING REAGENT; CYTOKINE; DNA; ENZYME INHIBITOR; FC GAMMA RECEPTOR IIA; FC RECEPTOR; HYBRID PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUKOCYTE ANTIGEN; LIGAND; LUCIFERASE; MACROLIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; CALCIUM MOBILIZATION; CARBOXY TERMINAL SEQUENCE; CHIMERA; CONTROLLED STUDY; CROSS LINKING; DRUG INHIBITION; GENETIC TRANSFECTION; GLYCOSYLATION; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; INTRACELLULAR SPACE; MEMBRANE POTENTIAL; MUTAGENESIS; PH; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; AMINO ACID SEQUENCE; BINDING SITE; BIOSYNTHESIS; CELL LINE; CELL MEMBRANE; CELL SEPARATION; CELL STRAIN U937; CHEMISTRY; DENDRITIC CELL; DIMERIZATION; DOMINANT GENE; DOSE RESPONSE; ENDOSOME; FLOW CYTOMETRY; LYSOSOME; METABOLISM; MOLECULAR GENETICS; MONONUCLEAR CELL; MUTATION; NUCLEOTIDE SEQUENCE; PHAGOSOME; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; REPORTER GENE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; TIME; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANTIGENS, CD; ANTIRHEUMATIC AGENTS; BASE SEQUENCE; BINDING SITES; BLOTTING, WESTERN; CALCIUM; CELL LINE; CELL MEMBRANE; CELL SEPARATION; CHLOROQUINE; CROSS-LINKING REAGENTS; CYSTEINE; CYTOKINES; DENDRITIC CELLS; DIMERIZATION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOSOMES; ENZYME INHIBITORS; FLOW CYTOMETRY; GENES, DOMINANT; GENES, REPORTER; GLYCOSYLATION; HUMANS; HYDROGEN-ION CONCENTRATION; LEUCINE; LEUKOCYTES, MONONUCLEAR; LIGANDS; LUCIFERASES; LYSOSOMES; MACROLIDES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NF-KAPPA B; PHAGOSOMES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, IGG; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TIME FACTORS; TOLL-LIKE RECEPTOR 3; TRANSFECTION; TYROSINE; U937 CELLS;

EID: 31344476404     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M507163200     Document Type: Article

References (70)

1. Medzhitov, R., and Janeway, C., Jr. (2000) Trends Microbiol. 8, 452-456
2. Akira, S., Takeda, K., and Kaisho, T. (2001) Nat. Immunol. 2, 675-680
3. Takeda, K., Kaisho, T., and Akira, S. (2003) Annu. Rev. Immunol. 21, 335-376
4. Kaisho, T., and Akira, S. (2003) Curr. Mol. Med. 3, 373-385
5. Beutler, B. (2004) Nature 430, 257-263
6. Beg, A. A. (2002) Trends Immunol. 23, 509-512
7. Leadbetter, E. A., Rifkin, I. R., Hohlbaum, A. M., Beaudette, B. C., Shlomchik, M. J., and Marshak-Rothstein, A. (2002) Nature 416, 603-607
8. Alexopoulou, L., Holt, A. C., Medzhitov, R., and Flavell, R. A. (2001) Nature 413, 732-738
9. Wang, T., Town, T., Alexopoulou, L., Anderson, J. F., Fikrig, E., and Flavell, R. A. (2004) Nat. Med. 10, 1366-1373
10. Aksoy, E., Zouain, C. S., Vanhoutte, F., Fontaine, J., Pavelka, N., Thieblemont, N., Willems, F., Ricciardi-Castagnoli, P., Goldman, M., Capron, M., Ryffel, B., and Trottein, F. (2005) J. Biol. Chem. 280, 277-283
11. Kariko, K., Ni, H., Capodici, J., Lamphier, M., and Weissman, D. (2004) J. Biol. Chem. 279, 12542-12550
12. O'Neill, L. A., Fitzgerald, K. A., and Bowie, A. G. (2003) Trends Immunol. 24, 286-290
13. Yamamoto, M., Sato, S., Hemmi, H., Uematsu, S., Hoshino, K., Kaisho, T., Takeuchi, O., Takeda, K., and Akira, S. (2003) Nat. Immunol. 4, 1144-1150
14. Yamamoto, M., Sato, S., Mori, K., Hoshino, K., Takeuchi, O., Takeda, K., and Akira, S. (2002) J. Immunol. 169, 6668-6672
15. Hoebe, K., and Beutler, B. (2004) J. Endotoxin Res. 10, 130-136
16. Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., and Akira, S. (2003) Science 301, 640-643
17. Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S. M., and Maniatis, T. (2003) Nat. Immunol. 4, 491-496
18. Sarkar, S. N., Peters, K. L., Elco, C. P., Sakamoto, S., Pal, S., and Sen, G. C. (2004) Nat. Struct. Mol. Biol. 11, 1060-1067
19. Mukhopadhyay, S., Herre, J., Brown, G. D., and Gordon, S. (2004) Immunology 112, 521-530
20. Ozinsky, A., Underhill, D. M., Fontenot, J. D., Hajjar, A. M., Smith, K. D., Wilson, C. B., Schroeder, L., and Aderem, A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 13766-13771
21. Sandor, F., Latz, F., Re, F., Mandell, L., Repik, G., Golenbock, D. T., Espevik, T., Kurt-Jones, E. A., and Finberg, R. W. (2003) J. Cell Biol. 162, 1099-1110
22. Medzhitov, R., Preston-Hurlburt, P., and Janeway, C. A., Jr. (1997) Nature 388, 394-397
23. Ahmad-Nejad, P., Hacker, H., Rutz, M., Bauer, S., Vabulas, R. M., and Wagner, H. (2002) Eur. J. Immunol. 32, 1958-1968
24. Heil, F., Ahmad-Nejad, P., Hemmi, H., Hochrein, H., Ampenberger, F., Gellert, T., Dietrich, H., Lipford, G., Takeda, K., Akira, S., Wagner, H., and Bauer, S. (2003) Eur. J. Immunol. 33, 2987-2997
25. Lee, J., Chuang, T. H., Redecke, V., She, L., Pitha, P. M., Carson, D. A., Raz, E., and Cottam, H. B. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 6646-6651
26. Latz, E., Schoenemeyer, A., Visintin, A., Fitzgerald, K. A., Monks, B. G., Knetter, C. F., Lien, E., Nilsen, N. J., Espevik, T., and Golenbock, D. T. (2004) Nat. Immunol. 5, 190-198
27. Rutz, M., Metzger, J., Gellert, T., Luppa, P., Lipford, G. B., Wagner, H., and Bauer, S. (2004) Eur. J. Immunol. 34, 2541-2550
28. Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., and Reis e Sousa, C. (2004) Science 303, 1529-1531
29. Matsumoto, M., and Seya, T. (2001) Uirusu 51, 209-214
30. Matsumoto, M., Kikkawa, S., Kohase, M., Miyake, K., and Seya, T. (2002) Biochem. Biophys. Res. Commun. 293, 1364-1369
31. Matsumoto, M., Funami, K., Tanabe, M., Oshiumi, H., Shingai, M., Seto, Y., Yamamoto, A., and Seya, T. (2003) J. Immunol. 171, 3154-3162
32. Hasan, U. A., Dollet, S., and Vlach, J. (2004) Biochem. Biophys. Res. Commun. 321, 124-131
33. Zhang, G., and Ghosh, S. (2002) J. Biol. Chem. 277, 7059-7065
34. Daeron, M. (1997) Annu. Rev. Immunol. 15, 203-234
35. Sallusto, F., and Lanzavecchia, A. (1994) J. Exp. Med. 179, 1109-1118
36. Choe, J., Kelker, M. S., and Wilson, I. A. (2005) Science 309, 581-585
37. Bell, J. K., Botos, I., Hall, P. R., Askins, J., Shiloach, J., Segal, D. M., and Davies, D. R. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 10976-10980
38. Hasan, U. A., Trinchieri, G., and Vlach, J. (2005) J. Biol. Chem. 280, 20620-20627
39. Odin, J. A., Edberg, J. C., Painter, C. J., Kimberly, R. P., and Unkeless, J. C. (1991) Science 254, 1785-1788
40. Shen, L., Chen, Z. W., and Letvin, N. L. (1994) J. Immunol. 153, 5849-5854
41. Van den Herik-Oudijk, I E., Ter Bekke, M. W., Tempelman, M. J., Capel, P. J., and Van de Winkel, J. G. (1995) Blood 86, 3302-3307
42. Weber, S. M., Chen, J. M., and Levitz, S. M. (2002) J. Immunol. 168, 5303-5309
43. Helenius, A., and Aebi, M. (2004) Annu. Rev. Biochem. 73, 1019-1049
44. da Silva Correia, J., and Ulevitch, R. J. (2002) J. Biol. Chem. 277, 1845-1854
45. Shi, X., and Elliott, R. M. (2004) J. Virol. 78, 5414-5422
46. Nishiya, T., and DeFranco, A. L. (2004) J. Biol. Chem 279, 19008-19017
47. Funami, K., Matsumoto, M., Oshiumi, H., Akazawa, T., Yamamoto, A., and Seya, T. (2004) Int. Immunol. 16, 1143-1154
48. Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., and Bauer, S. (2004) Science 303, 1526-1529
49. Weber, A. N., Tauszig-Delamasure, S., Hoffmann, J. A., Lelievre, E., Gascan, H., Ray, K. P., Morse, M. A., Imler, J. L., and Gay, N. J. (2003) Nat. Immunol. 4, 794-800
50. Wu, C. C., Lee, J., Raz, E., Corr, M., and Carson, D. A. (2004) J. Biol. Chem. 279, 33071-33078
51. Lee, H. K., Dunzendorfer, S., and Tobias, P. S. (2004) J. Biol. Chem. 279, 10564-10574
52. Hasan, U., Chaffois, C., Gaillard, C., Saulnier, V., Merck, E., Tancredi, S., Guiet, C., Briere, F., Vlach, J., Lebecque, S., Trinchieri, G., and Bates, E. E. (2005) J. Immunol. 174, 2942-2950
53. Sugimoto, N., Wu, P., Hara, H., and Kawamoto, Y. (2001) Biochemistry 40, 9396-9405
54. Leifer, C. A., Kennedy, M. N., Mazzoni, A., Lee, C., Kruhlak, M. J., and Segal, D. M. (2004) J. Immunol. 173, 1179-1183
55. Kariko, K., Weissman, D., and Welsh, F. A. (2004) J. Cereb. Blood Flow Metab. 24, 1288-1304
56. Kariko, K., Bhuyan, P., Capodici, J., and Weissman, D. (2004) J. Immunol. 172, 6545-6549
57. Albert, M. L. (2004) Nat. Rev. Immunol. 4, 223-231
58. Gallucci, S., Lolkema, M., and Matzinger, P. (1999) Nat. Med. 5, 1249-1255
59. Sauter, B., Albert, M. L., Francisco, L., Larsson, M., Somersan, S., and Bhardwaj, N. (2000) J. Exp. Med. 191, 423-434
60. Basu, S., Binder, R. J., Suto, R., Anderson, K. M., and Srivastava, P. K. (2000) Int. Immunol. 12, 1539-1546
61. Salio, M., Cerundolo, V., and Lanzavecchia, A. (2000) Eur. J. Immunol. 30, 705-708
62. Edelmann, K. H., Richardson-Burns, S., Alexopoulou, L., Tyler, K. L., Flavell, R. A., and Oldstone, M. B. (2004) Virology 322, 231-238
63. Garoff, H., Sjoberg, M., and Cheng, R. H. (2004) Virus Res. 106, 103-116
64. Salonen, A., Vasiljeva, L., Merits, A., Magden, J., Jokitalo, E., and Kaariainen, L. (2003) J. Virol. 77, 1691-1702
65. Sherer, N. M., Lehmann, M. J., Jimenez-Soto, L. F., Ingmundson, A., Horner, S. M., Cicchetti, G., Allen, P. G., Pypaert, M., Cunningham, J. M., and Mothes, W. (2003) Traffic 4, 785-801
66. Pelchen-Matthews, A., Kramer, B., and Marsh, M. (2003) J. Cell Biol. 162, 443-455
67. Akula, S. M., Naranatt, P. P., Walia, N. S., Wang, F. Z., Fegley, B., and Chandran, B. (2003) J. Virol. 77, 7978-7990
68. Guillot, L., Medjane, S., Le-Barillec, K., Balloy, V., Danel, C., Chignard, M., and Si-Tahar, M. (2004) J. Biol. Chem. 279, 2712-2718
69. Tabeta, K., Georgel, P., Janssen, E., Du, X., Hoebe, K., Crozat, K., Mudd, S., Shamel, L., Sovath, S., Goode, J., Alexopoulou, L., Flavell, R. A., and Beutler, B. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 3516-3521
70. Schulz, O., Diebold, S. S., Chen, M., Naslund, T. I., Nolte, M. A., Alexopoulou, L., Azuma, Y. T., Flavell, R. A., Liljestrom, P., and Reis e Sousa, C. (2005) Nature 433, 887-892