Immunology: TLR11 activation of dendritic cells by a protozoan profilin-like protein

Science

Volumn 308, Issue 5728, 2005, Pages 1626-1629

  Yarovinsky, Felix ^a   Zhang, Dekai ^b   Andersen, John F ^a   Bannenberg, Gerard L ^c,d   Serhan, Charles N ^c   Hayden, Matthew S ^b   Hieny, Sara ^a   Sutterwala, Fayyaz S ^b   Flavell, Richard A ^b   Ghosh, Sankar ^b   Sher, Alan ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CELLS; MICROORGANISMS; MOLECULES; PATHOLOGY; PROTEINS; VIRUSES;

DENDRITIC CELLS (DC); EUKARYOTIC MICROORGANISM; PATHOGENS; TOLL-LIKE RECEPTORS (TLR);

IMMUNOLOGY;

INTERLEUKIN 12; MYELOID DIFFERENTIATION FACTOR 88; PROFILIN; PROTOZOAL PROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 11; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; CELL SURFACE RECEPTOR; CONTRACTILE PROTEIN; DIFFERENTIATION ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN RECEPTOR; LIGAND; MEMBRANE PROTEIN; MYD88 PROTEIN, MOUSE; PFN1 PROTEIN, MOUSE; RECOMBINANT PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TLR11 PROTEIN, MOUSE;

IMMUNE RESPONSE;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; BACTERIUM DETECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; EUKARYOTE; INFECTION RESISTANCE; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; TOXOPLASMA GONDII; VIRUS DETECTION; AMINO ACID SEQUENCE; ANIMAL; ANIMAL PARASITOSIS; BIOSYNTHESIS; BLOOD; C57BL MOUSE; CHEMISTRY; GENE; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; MOUSE; PROTEIN MOTIF; SIGNAL TRANSDUCTION; TOXOPLASMA;

ANIMALIA; BACTERIA (MICROORGANISMS); EUKARYOTA; MAMMALIA; MURINAE; PROTOZOA; TOXOPLASMA GONDII;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, DIFFERENTIATION; CONTRACTILE PROTEINS; DENDRITIC CELLS; GENES, PROTOZOAN; IMMUNITY, NATURAL; INTERLEUKIN-12; LIGANDS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICROFILAMENT PROTEINS; MOLECULAR SEQUENCE DATA; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; PROFILINS; PROTOZOAN PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; TOXOPLASMA; TOXOPLASMOSIS, ANIMAL; TRANSFECTION;

EID: 20644433342     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1109893     Document Type: Article

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29. Genomic data were provided by the Institute for Genomic Research (supported by NIH grant AI05093) and the Sanger Center (Wellcome Trust). EST sequences were generated by Washington University (NIH grant 1R01AI045806-01A1). This project was partially supported by NIH grants to S.G. (R01-AI59440) and C.N.S. (R01-GM38765) as well as an Arthritis Foundation fellowship (PO-1DE13499) to G.LB. and by the NIH Intramural AIDS Targeted Antiviral Program (A.S. and F.Y.). We thank C. Reis e Sousa, G. Trinchieri, D. Juckett, J. Aliberti, J. Ribeiro, and R. Medzhitov for their invaluable comments and suggestions during the course of this project.