Ligand-induced conformational changes allosterically activate Toll-like receptor 9

Nature Immunology

Volumn 8, Issue 7, 2007, Pages 772-779

  Latz, Eicke ^a   Verma, Anjali ^a   Visintin, Alberto ^a   Gong, Mei ^a   Sirois, Cherilyn M ^a   Klein, Dionne C G ^b   Monks, Brian G ^a   McKnight, James C ^c   Lamphier, Marc S ^e   Duprex, Paul W ^d   Espevik, Terje ^b   Golenbock, Douglas T ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^e EISAI RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HOMODIMER; TOLL LIKE RECEPTOR 9;

ALLOSTERISM; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CPG ISLAND; CYTOPLASM; DNA BINDING; ENDOSOME; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; STEADY STATE;

EID: 34250698370     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1479     Document Type: Article

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