Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice

Physiological Genomics

Volumn 18, Issue , 2004, Pages 261-272

  Li, Jiang ^a   Stein, Thor D ^a   Johnson, Jeffrey A ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Detoxification; Microarray; Systemic lupus erythematosus

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ANTIOXIDANT; AUTOANTIBODY; COMPLEMENT COMPONENT C3; CYTOKINE; DNA ANTIBODY; DOUBLE STRANDED DNA; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MALONALDEHYDE; NUCLEAR FACTOR; NUCLEAR FACTOR NRF2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

AGED; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; BRAIN; CONTROLLED STUDY; DETOXIFICATION; FEMALE; GENE EXPRESSION; HEART; IMMUNE COMPLEX DEPOSITION; KIDNEY; KNOCKOUT MOUSE; LIPID PEROXIDATION; LIVER; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; SYSTEMIC DISEASE; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

ANIMALS; APOPTOSIS; AUTOANTIBODIES; CROSSES, GENETIC; DEOXYGUANOSINE; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION PROFILING; KIDNEY; LIVER; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; MYOCARDIUM; NF-E2-RELATED FACTOR 2; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; PHENOTYPE; TRANS-ACTIVATORS;

ANIMALIA;

EID: 4844225631     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00209.2003     Document Type: Article

References (50)

1. Ahsan H, Ali A, and Ali R. Oxygen free radicals and systemic autoimmunity. Clin Exp Immunol 131: 398-404, 2003.
2. Bae SC, Kim SJ, and Sung MK. Impaired antioxidant status and decreased dietary intake of antioxidants in patients with systemic lupus erythematosus. Rheumatol Int 22: 238-243, 2002.
3. Bashir S, Harris G, Denman MA, Blake DR, and Winyard PG. Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases. Ann Rheum Dis 52: 659-666, 1993.
4. Bockenstedt LK, Gee RJ, and Mamula MJ. Self-peptides in the initiation of lupus autoimmunity. J Immunol 154: 3516-3524, 1995.
5. Botto M, Dell'Agnola C, Bygrave AE, Thompson EM, Cook HT, Petry F, Loos M, Pandolfi PP, and Walport MJ. Homozygous Clq deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet 19: 56-59, 1998.
6. Casciola-Rosen LA, Anhalt G, and Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 179: 1317-1330, 1994.
7. Chan K, Han XD, and Kan YW. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc Natl Acad Sci USA 98: 4611-4616. 2001.
8. Chan K and Kan YW. Nrf2 is essential for protection against acute pulmonary injury in mice. Proc Natl Acad Sci USA 96: 12731-12736, 1999.
9. Chan K, Lu R, Chang JC, and Kan YW. NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci USA 93: 13943-13948, 1996.
10. Chanas SA, Jiang Q, McMahon M, McWalter GK, McLellan LI, Elcombe CR, Henderson CJ, Wolf CR, Moffat GJ, Itoh K, Yamamoto M, and Hayes JD. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. Biochem J 365: 405-416, 2002.
11. Cornish CJ, Devery JM, Poronnik P, Lackmann M, Cook DI, and Geczy CL. S100 protein CP-10 stimulates myeloid cell chemotaxis without activation. J Cell Physiol 166: 427-437, 1996.
12. Cotran RS, Kumar V, Collins T, and Robbins SL. Robbins Pathologic Basis of Disease. Philadelphia: Saunders, 1999.
13. Courtney PA, Crockard AD, Williamson K, Irvine AE, Kennedy RJ, and Bell AL. Increased apoptotic peripheral blood neutrophils in systemic lupus erythematosus: relations with disease activity, antibodies to double-stranded DNA, and neutropenia. Ann Rheum Dis 58: 309-314, 1999.
14. Davidson A and Diamond B. Autoimmune diseases. N Engl J Med 345: 340-350, 2001.
15. Devery JM, King NJ, and Geczy CL. Acute inflammatory activity of the S100 protein CP-10. Activation of neutrophils in vivo and in vitro. J Immunol 152: 1888-1897, 1994.
16. Emlen W, Niebur J, and Kadera R. Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus. J Immunol 152: 3685-3692, 1994.
17. Enomoto A, Itoh K, Nagayoshi E, Haruta J, Kimura T, O'Connor T, Harada T, and Yamamoto M. High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci 59: 169-177, 2001.
18. Enyedy EJ, Nambiar MP, Liossis SN, Dennis G, Kammer GM, and Tsokos GC. Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus. Arthritis Rheum 44: 1114-1121, 2001.
19. Esterbauer H and Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 186: 407-421, 1990.
20. Fraser PA, Ding WZ, Mohseni M, Treadwell EL, Dooley MA, St Clair EW, Gilkeson GS, and Cooper GS. Glutathione S-transferase M null homozygosity and risk of systemic lupus erythematosus associated with sun exposure: a possible gene-environment interaction for autoimmunity. J Rheumatol 30: 276-282, 2003.
21. Funauchi M, Sugiyama M, SukYoo B, Ikoma S, Ohno M, Kinoshita K, and Kanamaru A. A possible role of apoptosis for regulating autoreactive responses in systemic lupus erythematosus. Lupus 10: 284-288, 2001.
22. Gaffney PM, Kearns GM, Shark KB, Ortmann WA, Selby SA, Malmgren ML, Rohlf KE, Ockenden TC, Messner RP, King RA, Rich SS, and Behrens TW. A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families. Proc Natl Acad Sci USA 95: 14875-14879, 1998.
23. Galloway DC, Blake DG, Shepherd AG, and McLellan LI. Regulation of human gamma-glutamylcysteine synthetase: co-ordinate induction of the catalytic and regulatory subunits in HepG2 cells. Biochem J 328: 99-104, 1997.
24. Hintner H, Romani N, Stanzl U, Grubauer G, Fritsch P, and Lawley TJ. Phagocytosis of keratin filament aggregates following opsonization with IgG-anti-keratin filament autoantibodies. J Invest Dermatol 88: 176-182, 1987.
25. Khan MF, Wu X, and Ansari GA. Anti-malondialdehyde antibodies in MRL+/+ mice treated with trichloroethene and dichloroacetyl chloride: possible role of lipid peroxidation in autoimmunity. Toxicol Appl Pharmacol 170: 88-92, 2001.
26. Khansari N and Fudenberg HH. Phagocytosis of senescent erythrocytes by autologous monocytes: requirement of membrane-specific autologous IgG for immune elimination of aging red blood cells. Cell Immunol 78: 114-121, 1983.
27. Klein JA, Longo-Guess CM, Rossmann MP, Sebum KL, Hurd RE, Frankel WN, Bronson RT, and Ackerman SL. The harlequin mouse mutation downregulates apoptosis-inducing factor. Nature 419: 367-374, 2002.
28. Kotlo KU, Yehiely F, Efimova E, Harasty H, Hesabi B, Shchors K, Einat P, Rozen A, Berent E, and Deiss LP. Nrf2 is an inhibitor of the Fas pathway as identified by Achilles' Heel Method, a new function-based approach to gene identification in human cells. Oncogene 22: 797-806, 2003.
29. Kwak MK, Wakabayashi N, Itoh K, Motohashi H, Yamamoto M, and Kensler TW. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J Biol Chem 278: 8135-8145, 2003.
30. Lackmann M, Rajasekariah P, Iismaa SE, Jones G, Cornish CJ, Hu S, Simpson RJ, Moritz RL, and Geczy CL. Identification of a chemotactic domain of the pro-inflammatory S100 protein CP-10. J Immunol 150: 2981-2991, 1993.
31. Lee JM, Calkins MJ, Chan K, Kan YW, and Johnson JA. Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis. J Biol Chem 278: 12029-12038, 2003.
32. Lehmann PV, Forsthuber T, Miller A, and Sercarz EE. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358: 155-157, 1992.
33. Li J and Johnson JA. Time-dependent changes in ARE-driven gene expression by use of a noise-filtering process for microarray data. Physiol Genomics 9: 137-144, 2002. First published April 9, 2002: 10.1152/ physiolgenomics.00003. 2002.
34. Li J, Lee JM, and Johnson JA. Microarray analysis reveals an antioxidant responsive element-driven gene set involved in conferring protection from an oxidative stress-induced apoptosis in IMR-32 cells. J Biol Chem 277: 388-394, 2002.
35. Michel CJ Jr, McKenna CH, Elveback LR, Kaslow RA, and Kurland LT. Epidemiology of systemic lupus erythematosus and other connective tissue diseases in Rochester, Minnesota, 1950 through 1979. Mayo Clin Proc 60: 105-113, 1985.
36. Moi P, Chan K, Asunis I, Cao A, and Ran YW. Isolation of NF-E2-related factor 2 (NrK), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci USA 91: 9926-9930, 1994.
37. Napirei M, Karsunky H, Zevnik B, Stephan H, Mannherz HG, and Moroy T. Features of systemic lupus erythematosus in Dnase1-deficient mice. Nat Genet 25: 177-181, 2000.
38. Nioi P, McMahon M, Itoh K, Yamamoto M, and Hayes JD. Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence. Biochem J 374: 337-348, 2003.
39. Nishioku T, Hashimoto K, Yamashita K, Liou SY, Kagamiishi Y, Maegawa H, Katsube N, Peters C, von Figura K, Saftig P, Katunuma N, Yamamoto K, and Nakanishi H. Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia. J Biol Chem 277: 4816-4822, 2002.
40. Pollard KM, Pearson DL, Hultman P, Deane TN, Lindh U, and Kono DH. Xenobiotic acceleration of idiopathic systemic autoimmunity in lupus-prone bxsb mice. Environ Health Perspect 109: 27-33, 2001.
41. Stein TD, Fedynyshyn JP, and Kalil RE. Circulating autoantibodies recognize and bind dying neurons following injury to the brain. J Neuropathol Exp Neurol 61: 1100-1108, 2002.
42. Turi S, Nemeth I, Torkos A, Saghy L, Varga I, Matkovics B, and Nagy J. Oxidative stress and antioxidant defense mechanism in glomerular diseases. Free Radic Biol Med 22: 161-168, 1997.
43. Walport MJ, Davies KA, and Botto M. Clq and systemic lupus erythematosus. Immunobiology 199: 265-285, 1998.
44. Wasserman WW and Fahl WE. Functional antioxidant responsive elements. Proc Natl Acad Sci USA 94: 5361-5366, 1997.
45. Weimann BJ and Hermann D. Inhibition of autoimmune deterioration in MRL/lpr mice by vitamin E. Int J Vitam Nutr Res 69: 255-261, 1999.
46. Weimann BJ and Weiser H. Effects of antioxidant vitamins C. E, and beta-carotene on immune functions in MRL/lpr mice and rats. Ann NY Acad Sci 669: 390-392, 1992.
47. Wu X, Jiang N, Deppong C, Singh J, Dolecki G, Mao D, Morel L, and Molina HD. A role for the Cr2 gene in modifying autoantibody production in systemic lupus erythematosus. J Immunol 169: 1587-1592, 2002.
48. Yahya MD, Pinnas JL, Meinke GC, and Lung CC. Antibodies against malondialdehyde (MDA) in MRL/lpr/lpr mice: evidence for an autoimmune mechanism involving lipid peroxidation. J Autoimmun 9: 3-9, 1996.
49. Yasutomo K, Horiuchi T, Kagami S, Tsukamoto H, Hashimura C, Urushihara M, and Kuroda Y. Mutation of DNASE1 in people with systemic lupus erythematosus. Nat Genet 28: 313-314, 2001.
50. Yoh K, Itoh K, Enomoto A, Hirayama A, Yamaguchi N, Kobayashi M, Morito N, Koyama A, Yamamoto M, and Takahashi S. Nrf2-deficient female mice develop lupus-like autoimmune nephritis. Kidney Int 60: 1343-1353, 2001.