Toll-like receptor 9-induced type I IFN protects mice from experimental colitis

Journal of Clinical Investigation

Volumn 115, Issue 3, 2005, Pages 695-702

  Katakura, Kyoko ^a   Lee, Jongdae ^a   Rachmilewitz, Daniel ^b   Li, Gloria ^c   Eckmann, Lars ^a   Raz, Eyal ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SHAARE ZEDEK MEDICAL CENTER   (Israel)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTIBODY; BETA INTERFERON; INTERFERON; TOLL LIKE RECEPTOR 9;

ARTICLE; COLITIS; CYTOKINE PRODUCTION; ENTERITIS; EXPERIMENT; HISTOCHEMISTRY; HOMEOSTASIS; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; SIGNAL TRANSDUCTION; WILD TYPE;

EID: 14644403009     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI22996     Document Type: Article

References (41)

1. Strober, W., Fuss, I.J., and Blumberg, R.S. 2002. The immunology of mucosal models of inflammation. Annu. Rev. Immunol. 20:495-549.
2. Singh, B., et al. 2001. Control of intestinal inflammation by regulatory T cells. Immunol. Rev. 182:190-200.
3. Podolsky, D.K. 2002. Inflammatory bowel disease. N. Engl. J. Med. 347:417-429.
4. Bouma, G., and Strober, W. 2003. The immunological and genetic basis of inflammatory bowel disease. Nat. Rev. Immunol. 3:521-533.
5. Hemmi, H., et al. 2000. A Toll-like receptor recognizes bacterial DNA. Nature. 408:740-745.
6. Krieg, A.M. 2002. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20:709-760.
7. Roman, M., et al. 1997. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat. Med. 3:849-854.
8. Horner, A.A., et al. 1998. Immunostimulatory DNA is a potent mucosal adjuvant. Cell. Immunol. 190:77-82.
9. Klinman, D.M. 2004. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. 4:249-258.
10. Rachmilewitz, D., et al. 2002. Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis. Gastroenterology. 122:1428-1441.
11. Rachmilewitz, D., et al. 2004. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology. 126:520-528.
12. Dieleman, L.A., et al. 1994. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology. 107:1643-1652.
13. Taniguchi, T., Ogasawara, K., Takaoka, A., and Tanaka, N. 2001. IRF family of transcription factors as regulators of host defense. Annu. Rev. Immunol. 19:623-655.
14. Honda, K., et al. 2004. Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc. Natl. Acad. Sci. U. S. A. 101:15416-15421.
15. Kawai, T., et al. 2004. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat. Immunol. 5:1061-1068.
16. Beutler, B. 2004. Innate immunity: an overview. Mol. Immunol. 40:845-859.
17. Takeda, K., Kaisho, T., and Akira, S. 2003. Toll-like receptors. Annu. Rev. Immunol. 21:335-376.
18. Kopp, E., and Medzhitov, R. 2003. Recognition of microbial infection by Toll-like receptors. Curr. Opin. Immunol. 15:396-401.
19. Tsujimura, H., et al. 2004. Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells. J. Immunol. 172:6820-6827.
20. Tsujimura, H., Tamura, T., and Ozato, K. 2003. Cutting edge: IFN consensus sequence binding protein/IFN regulatory factor 8 drives the development of type I IFN-producing plasmacytoid dendritic cells. J. Immunol. 170:1131-1135.
21. Chu, W., et al. 2000. DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell. 103:909-918.
22. Karpova, A.Y., Trost, M., Murray, J.M., Cantley, L.C., and Howley, P.M. 2002. Interferon regulatory factor-3 is an in vivo target of DNA-PK. Proc. Natl. Acad. Sci. U. S. A. 99:2818-2823.
23. Bray, M. 2001. The role of the Type I interferon response in the resistance of mice to filovirus infection. J. Gen. Virol. 82:1365-1373.
24. Verthelyi, D., Ishii, K.J., Gursel, M., Takeshita, F., and Klinman, D.M. 2001. Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs. J. Immunol. 166:2372-2377.
25. Hemmi, H., Kaisho, T., Takeda, K., and Akira, S. 2003. The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J. Immunol. 170:3059-3064.
26. Biron, C.A. 2001. Interferons alpha and beta as immune regulators - a new look. Immunity. 14:661-664.
27. Banchereau, J., Pascual, V., and Palucka, A.K. 2004. Autoimmunity through cytokine-induced dendritic cell activation. Immunity. 20:539-550.
28. Teige, I., et al. 2003. IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis. J. Immunol. 170:4776-4784.
29. Floris, S., et al. 2002. Interferon-beta directly influences monocyte infiltration into the central nervous system. J. Neuroimmunol. 127:69-79.
30. Papadakis, K.A., and Targan, S.R. 2000. Role of cytokines in the pathogenesis of inflammatory bowel disease. Annu. Rev. Med. 51:289-298.
31. Nikolaus, S., et al. 2003. Interferon beta-1a in ulcerative colitis: a placebo controlled, randomised, dose escalating study. Gut. 52:1286-1290.
32. Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., and Medzhitov, R. 2004. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell. 118:229-241.
33. Beamish, H.J., et al. 2000. The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity. Nucleic Acids Res. 28:1506-1513.
34. Kurimasa, A., et al. 1999. Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis. Proc. Natl. Acad. Sci. U. S. A. 96:1403-1408.
35. Martin-Orozco, E., et al. 1999. Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences. Int. Immunol. 11:1111-1118.
36. Datta, S.K., et al. 2003. A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. J. Immunol. 170:4102-4110.
37. Hoebe, K., et al. 2003. Identification of Lps2 as a key transducer of MyD88-independent TIR signaling. Nature. 424:743-748.
38. Lee, J., Mira-Arbibe, L., and Ulevitch, R.J. 2000. TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide. J. Leukoc. Biol. 68:909-915.
39. Au, W.C., and Pitha, P.M. 2001. Recruitment of multiple interferon regulatory factors and histone acetyltransferase to the transcriptionally active interferon a promoters. J. Biol. Chem. 276:41629-41637.
40. Hsu, L.C., et al. 2004. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature. 428:341-345.
41. Woo, R.A., McLure, K.G., Lees-Miller, S.P., Rancourt, D.E., and Lee, P.W. 1998. DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature. 394:700-704.