The processed amino-terminal fragment of human TLR7 acts as a chaperone to direct human TLR7 into endosomes

Journal of Immunology

Volumn 194, Issue 11, 2015, Pages 5417-5425

  Hipp, Madeleine M ^a,c   Shepherd, Dawn ^a   Booth, Sarah ^a   Waithe, Dominic ^a   Reis E Sousa, Caetano ^b   Cerundolo, Vincenzo ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^c CureVac GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; EARLY ENDOSOME ANTIGEN 1; INTERLEUKIN 8; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; CARRIER PROTEIN; IL8 PROTEIN, HUMAN; MYD88 PROTEIN, HUMAN; MYELOID DIFFERENTIATION FACTOR 88; PEPTIDE FRAGMENT; SERINE PROTEINASE; TLR4 PROTEIN, HUMAN; TLR7 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; BIOTINYLATION; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; CELL SURFACE; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISULFIDE BOND; ENDOSOME; FLUORESCENCE ACTIVATED CELL SORTING; HEK293 CELL LINE; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; CELL LINE; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT;

CARRIER PROTEINS; CELL LINE; ENDOSOMES; HEK293 CELLS; HUMANS; INTERLEUKIN-8; MOLECULAR CHAPERONES; MYELOID DIFFERENTIATION FACTOR 88; PEPTIDE FRAGMENTS; PROPROTEIN CONVERTASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; PROTEOLYSIS; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 7;

EID: 84929649112     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1402703     Document Type: Article

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