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Volumn 35, Issue , 2015, Pages S78-S103

Broad targeting of resistance to apoptosis in cancer

(39)  Mohammad, Ramzi M a,b   Muqbil, Irfana a   Lowe, Leroy c   Yedjou, Clement d   Hsu, Hsue Yin e   Lin, Liang Tzung f   Siegelin, Markus David g   Fimognari, Carmela h   Kumar, Nagi B i   Dou, Q Ping a,j   Yang, Huanjie k   Samadi, Abbas K l   Russo, Gian Luigi m   Spagnuolo, Carmela m   Ray, Swapan K n   Chakrabarti, Mrinmay n   Morre, James D o   Coley, Helen M p   Honoki, Kanya q   Fujii, Hiromasa q   more..


Author keywords

Apoptosis; Apoptosis evasion; Autophagy; Necrosis; Nuclear transporters, natural chemopreventive agents

Indexed keywords

ANTINEOPLASTIC AGENT; CURCUMIN; EPIGALLOCATECHIN GALLATE; GOSSYPOL; HEAT SHOCK PROTEIN 90; ISOTHIOCYANIC ACID DERIVATIVE; PLANT MEDICINAL PRODUCT; PROTEASOME; PROTEIN BCL 2; PROTEIN MCL 1; QUERCETIN; RESVERATROL; SELINEXOR; TRIPTOLIDE; UMI 77; UNCLASSIFIED DRUG;

EID: 84928539179     PISSN: 1044579X     EISSN: 10963650     Source Type: Journal    
DOI: 10.1016/j.semcancer.2015.03.001     Document Type: Review
Times cited : (644)

References (497)
  • 2
    • 84891851298 scopus 로고    scopus 로고
    • Quality of life in patients with K-RAS wild-type colorectal cancer: the CO.20 phase 3 randomized trial
    • Ringash J., Au H.J., Siu L.L., Shapiro J.D., Jonker D.J., Zalcberg J.R., et al. Quality of life in patients with K-RAS wild-type colorectal cancer: the CO.20 phase 3 randomized trial. Cancer 2014, 120:181-189.
    • (2014) Cancer , vol.120 , pp. 181-189
    • Ringash, J.1    Au, H.J.2    Siu, L.L.3    Shapiro, J.D.4    Jonker, D.J.5    Zalcberg, J.R.6
  • 3
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 84883143123 scopus 로고    scopus 로고
    • Cell death: balance through a bivalent regulator
    • Du T.A. Cell death: balance through a bivalent regulator. Nat Rev Mol Cell Biol 2013, 14:546.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 546
    • Du, T.A.1
  • 6
    • 0141520276 scopus 로고    scopus 로고
    • Drug resistance and the microenvironment: nature and nurture
    • Morin P.J. Drug resistance and the microenvironment: nature and nurture. Drug Resist Updat 2003, 6:169-172.
    • (2003) Drug Resist Updat , vol.6 , pp. 169-172
    • Morin, P.J.1
  • 7
    • 77958099641 scopus 로고    scopus 로고
    • Multiple drug resistance mechanisms in cancer
    • Baguley B.C. Multiple drug resistance mechanisms in cancer. Mol Biotechnol 2010, 46:308-316.
    • (2010) Mol Biotechnol , vol.46 , pp. 308-316
    • Baguley, B.C.1
  • 8
    • 0027518277 scopus 로고
    • Multidrug resistance and mutagenesis
    • Ferguson L.R., Baguley B.C. Multidrug resistance and mutagenesis. Mutat Res 1993, 285:79-90.
    • (1993) Mutat Res , vol.285 , pp. 79-90
    • Ferguson, L.R.1    Baguley, B.C.2
  • 9
    • 73949102380 scopus 로고    scopus 로고
    • Multidrug resistance in cancer
    • Baguley B.C. Multidrug resistance in cancer. Methods Mol Biol 2010, 596:1-14.
    • (2010) Methods Mol Biol , vol.596 , pp. 1-14
    • Baguley, B.C.1
  • 10
    • 79959745271 scopus 로고    scopus 로고
    • Small molecule inhibitors of bcl-2 family proteins for pancreatic cancer therapy
    • Masood A., Azmi A.S., Mohammad R.M. Small molecule inhibitors of bcl-2 family proteins for pancreatic cancer therapy. Cancers (Basel) 2011, 3:1527-1549.
    • (2011) Cancers (Basel) , vol.3 , pp. 1527-1549
    • Masood, A.1    Azmi, A.S.2    Mohammad, R.M.3
  • 11
    • 84890909335 scopus 로고    scopus 로고
    • Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
    • Czabotar P.E., Lessene G., Strasser A., Adams J.M. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol 2013, 15:49-63.
    • (2013) Nat Rev Mol Cell Biol , vol.15 , pp. 49-63
    • Czabotar, P.E.1    Lessene, G.2    Strasser, A.3    Adams, J.M.4
  • 12
    • 84885922672 scopus 로고    scopus 로고
    • The Bcl-2/Bax and Ras/Raf/MEK/ERK signaling pathways: implications in pediatric leukemia pathogenesis and new prospects for therapeutic approaches
    • Vitagliano O., Addeo R., D'Angelo V., Indolfi C., Indolfi P., Casale F. The Bcl-2/Bax and Ras/Raf/MEK/ERK signaling pathways: implications in pediatric leukemia pathogenesis and new prospects for therapeutic approaches. Expert Rev Hematol 2013, 6:587-597.
    • (2013) Expert Rev Hematol , vol.6 , pp. 587-597
    • Vitagliano, O.1    Addeo, R.2    D'Angelo, V.3    Indolfi, C.4    Indolfi, P.5    Casale, F.6
  • 14
    • 46049103980 scopus 로고    scopus 로고
    • Endothelial cells expressing Bcl-2 promotes tumor metastasis by enhancing tumor angiogenesis, blood vessel leakiness and tumor invasion
    • Kumar P., Ning Y., Polverini P.J. Endothelial cells expressing Bcl-2 promotes tumor metastasis by enhancing tumor angiogenesis, blood vessel leakiness and tumor invasion. Lab Investig: J Techn Methods Pathol 2008, 88:740-749.
    • (2008) Lab Investig: J Techn Methods Pathol , vol.88 , pp. 740-749
    • Kumar, P.1    Ning, Y.2    Polverini, P.J.3
  • 15
    • 42249098698 scopus 로고    scopus 로고
    • Silencing Bcl-2 in models of mantle cell lymphoma is associated with decreases in cyclin D1, nuclear factor-kappaB, p53, bax, and p27 levels
    • Tucker C.A., Kapanen A.I., Chikh G., Hoffman B.G., Kyle A.H., Wilson I.M., et al. Silencing Bcl-2 in models of mantle cell lymphoma is associated with decreases in cyclin D1, nuclear factor-kappaB, p53, bax, and p27 levels. Mol Cancer Ther 2008, 7:749-758.
    • (2008) Mol Cancer Ther , vol.7 , pp. 749-758
    • Tucker, C.A.1    Kapanen, A.I.2    Chikh, G.3    Hoffman, B.G.4    Kyle, A.H.5    Wilson, I.M.6
  • 16
    • 35648977549 scopus 로고    scopus 로고
    • Downregulation of BCL-2 induces downregulation of carbonic anhydrase IX, vascular endothelial growth factor, and pAkt and induces radiation sensitization
    • Anai S., Shiverick K., Medrano T., Nakamura K., Goodison S., Brown B.D., et al. Downregulation of BCL-2 induces downregulation of carbonic anhydrase IX, vascular endothelial growth factor, and pAkt and induces radiation sensitization. Urology 2007, 70:832-837.
    • (2007) Urology , vol.70 , pp. 832-837
    • Anai, S.1    Shiverick, K.2    Medrano, T.3    Nakamura, K.4    Goodison, S.5    Brown, B.D.6
  • 18
    • 19644364034 scopus 로고    scopus 로고
    • Nucleo-cytoplasmic communication in apoptotic response to genotoxic and inflammatory stress
    • Wang J.Y. Nucleo-cytoplasmic communication in apoptotic response to genotoxic and inflammatory stress. Cell Res 2005, 15:43-48.
    • (2005) Cell Res , vol.15 , pp. 43-48
    • Wang, J.Y.1
  • 21
    • 33745501366 scopus 로고    scopus 로고
    • The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death
    • Chowdhury D., Beresford P.J., Zhu P., Zhang D., Sung J.S., Demple B., et al. The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. Mol Cell 2006, 23:133-142.
    • (2006) Mol Cell , vol.23 , pp. 133-142
    • Chowdhury, D.1    Beresford, P.J.2    Zhu, P.3    Zhang, D.4    Sung, J.S.5    Demple, B.6
  • 22
    • 84875876273 scopus 로고    scopus 로고
    • Apoptosome structure, assembly, and procaspase activation
    • Yuan S., Akey C.W. Apoptosome structure, assembly, and procaspase activation. Structure 2013, 21:501-515.
    • (2013) Structure , vol.21 , pp. 501-515
    • Yuan, S.1    Akey, C.W.2
  • 23
    • 58149168589 scopus 로고    scopus 로고
    • Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy
    • Azmi A.S., Mohammad R.M. Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy. J Cell Physiol 2009, 218:13-21.
    • (2009) J Cell Physiol , vol.218 , pp. 13-21
    • Azmi, A.S.1    Mohammad, R.M.2
  • 25
    • 67349136004 scopus 로고    scopus 로고
    • Mcl-1 is a potential therapeutic target in multiple types of cancer
    • Akgul C. Mcl-1 is a potential therapeutic target in multiple types of cancer. Cell Mol Life Sci 2009, 66:1326-1336.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 1326-1336
    • Akgul, C.1
  • 26
    • 42049091619 scopus 로고    scopus 로고
    • Unique biology of Mcl-1: therapeutic opportunities in cancer
    • Warr M.R., Shore G.C. Unique biology of Mcl-1: therapeutic opportunities in cancer. Curr Mol Med 2008, 8:138-147.
    • (2008) Curr Mol Med , vol.8 , pp. 138-147
    • Warr, M.R.1    Shore, G.C.2
  • 28
    • 84894679246 scopus 로고    scopus 로고
    • Down-regulation of Mcl-1 by small interference RNA induces apoptosis and sensitizes HL-60 leukemia cells to etoposide
    • Karami H., Baradaran B., Esfehani A., Sakhinia M., Sakhinia E. Down-regulation of Mcl-1 by small interference RNA induces apoptosis and sensitizes HL-60 leukemia cells to etoposide. Asian Pac J Cancer Prev 2014, 15:629-635.
    • (2014) Asian Pac J Cancer Prev , vol.15 , pp. 629-635
    • Karami, H.1    Baradaran, B.2    Esfehani, A.3    Sakhinia, M.4    Sakhinia, E.5
  • 29
    • 19944432123 scopus 로고    scopus 로고
    • Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
    • Chen L., Willis S.N., Wei A., Smith B.J., Fletcher J.I., Hinds M.G., et al. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 2005, 17:393-403.
    • (2005) Mol Cell , vol.17 , pp. 393-403
    • Chen, L.1    Willis, S.N.2    Wei, A.3    Smith, B.J.4    Fletcher, J.I.5    Hinds, M.G.6
  • 30
    • 77951442337 scopus 로고    scopus 로고
    • Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1
    • Yecies D., Carlson N.E., Deng J., Letai A. Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1. Blood 2010, 115:3304-3313.
    • (2010) Blood , vol.115 , pp. 3304-3313
    • Yecies, D.1    Carlson, N.E.2    Deng, J.3    Letai, A.4
  • 31
    • 85046914188 scopus 로고    scopus 로고
    • Mcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists
    • Lestini B.J., Goldsmith K.C., Fluchel M.N., Liu X., Chen N.L., Goyal B., et al. Mcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists. Cancer Biol Ther 2009, 8:1587-1595.
    • (2009) Cancer Biol Ther , vol.8 , pp. 1587-1595
    • Lestini, B.J.1    Goldsmith, K.C.2    Fluchel, M.N.3    Liu, X.4    Chen, N.L.5    Goyal, B.6
  • 32
    • 84896280569 scopus 로고    scopus 로고
    • A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo
    • Abulwerdi F., Liao C., Liu M., Azmi A.S., Aboukameel A., Mady A.S., et al. A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo. Mol Cancer Ther 2014, 13:565-575.
    • (2014) Mol Cancer Ther , vol.13 , pp. 565-575
    • Abulwerdi, F.1    Liao, C.2    Liu, M.3    Azmi, A.S.4    Aboukameel, A.5    Mady, A.S.6
  • 33
    • 84883319024 scopus 로고    scopus 로고
    • An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules
    • Basu A., Bodycombe N.E., Cheah J.H., Price E.V., Liu K., Schaefer G.I., et al. An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules. Cell 2013, 154:1151-1161.
    • (2013) Cell , vol.154 , pp. 1151-1161
    • Basu, A.1    Bodycombe, N.E.2    Cheah, J.H.3    Price, E.V.4    Liu, K.5    Schaefer, G.I.6
  • 34
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 35
    • 79952291173 scopus 로고    scopus 로고
    • Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors
    • Gandhi L., Camidge D.R., Ribeiro de O.M., Bonomi P., Gandara D., Khaira D., et al. Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors. J Clin Oncol 2011, 29:909-916.
    • (2011) J Clin Oncol , vol.29 , pp. 909-916
    • Gandhi, L.1    Camidge, D.R.2    Ribeiro de, O.M.3    Bonomi, P.4    Gandara, D.5    Khaira, D.6
  • 36
    • 84873540049 scopus 로고    scopus 로고
    • ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
    • Souers A.J., Leverson J.D., Boghaert E.R., Ackler S.L., Catron N.D., Chen J., et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med 2013, 19:202-208.
    • (2013) Nat Med , vol.19 , pp. 202-208
    • Souers, A.J.1    Leverson, J.D.2    Boghaert, E.R.3    Ackler, S.L.4    Catron, N.D.5    Chen, J.6
  • 37
    • 84871576111 scopus 로고    scopus 로고
    • Beta-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis
    • Rosenbluh J., Nijhawan D., Cox A.G., Li X., Neal J.T., Schafer E.J., et al. beta-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell 2012, 151:1457-1473.
    • (2012) Cell , vol.151 , pp. 1457-1473
    • Rosenbluh, J.1    Nijhawan, D.2    Cox, A.G.3    Li, X.4    Neal, J.T.5    Schafer, E.J.6
  • 39
    • 79952244140 scopus 로고    scopus 로고
    • Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells
    • Liu D., Yang Y., Liu Q., Wang J. Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells. Med Oncol 2011, 28:105-111.
    • (2011) Med Oncol , vol.28 , pp. 105-111
    • Liu, D.1    Yang, Y.2    Liu, Q.3    Wang, J.4
  • 40
    • 79957628179 scopus 로고    scopus 로고
    • Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells
    • Xi G., Hu X., Wu B., Jiang H., Young C.Y., Pang Y., et al. Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells. Cancer Lett 2011, 307:141-148.
    • (2011) Cancer Lett , vol.307 , pp. 141-148
    • Xi, G.1    Hu, X.2    Wu, B.3    Jiang, H.4    Young, C.Y.5    Pang, Y.6
  • 41
    • 84866844292 scopus 로고    scopus 로고
    • Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent
    • Sharma N., Thomas S., Golden E.B., Hofman F.M., Chen T.C., Petasis N.A., et al. Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent. Cancer Lett 2012, 326:143-154.
    • (2012) Cancer Lett , vol.326 , pp. 143-154
    • Sharma, N.1    Thomas, S.2    Golden, E.B.3    Hofman, F.M.4    Chen, T.C.5    Petasis, N.A.6
  • 42
    • 77955967679 scopus 로고    scopus 로고
    • Targeting autophagy: a novel anticancer strategy with therapeutic implications for imatinib resistance
    • Carew J.S., Nawrocki S.T., Giles F.J., Cleveland J.L. Targeting autophagy: a novel anticancer strategy with therapeutic implications for imatinib resistance. Biologics 2008, 2:201-204.
    • (2008) Biologics , vol.2 , pp. 201-204
    • Carew, J.S.1    Nawrocki, S.T.2    Giles, F.J.3    Cleveland, J.L.4
  • 43
    • 77958575758 scopus 로고    scopus 로고
    • Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation
    • Carew J.S., Medina E.C., Esquivel J.A., Mahalingam D., Swords R., Kelly K., et al. Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation. J Cell Mol Med 2010, 14:2448-2459.
    • (2010) J Cell Mol Med , vol.14 , pp. 2448-2459
    • Carew, J.S.1    Medina, E.C.2    Esquivel, J.A.3    Mahalingam, D.4    Swords, R.5    Kelly, K.6
  • 44
    • 84867723524 scopus 로고    scopus 로고
    • Autophagy as a target for cancer therapy: new developments
    • Carew J.S., Kelly K.R., Nawrocki S.T. Autophagy as a target for cancer therapy: new developments. Cancer Manag Res 2012, 4:357-365.
    • (2012) Cancer Manag Res , vol.4 , pp. 357-365
    • Carew, J.S.1    Kelly, K.R.2    Nawrocki, S.T.3
  • 45
    • 84876008743 scopus 로고    scopus 로고
    • Vorinostat-induced autophagy switches from a death-promoting to a cytoprotective signal to drive acquired resistance
    • Dupere-Richer D., Kinal M., Menasche V., Nielsen T.H., Del R.S., Pettersson F., et al. Vorinostat-induced autophagy switches from a death-promoting to a cytoprotective signal to drive acquired resistance. Cell Death Dis 2013, 4:e486.
    • (2013) Cell Death Dis , vol.4 , pp. e486
    • Dupere-Richer, D.1    Kinal, M.2    Menasche, V.3    Nielsen, T.H.4    Del, R.S.5    Pettersson, F.6
  • 46
    • 84863834241 scopus 로고    scopus 로고
    • Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell
    • Xu N., Zhang J., Shen C., Luo Y., Xia L., Xue F., et al. Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell. Biochem Biophys Res Commun 2012, 423:826-831.
    • (2012) Biochem Biophys Res Commun , vol.423 , pp. 826-831
    • Xu, N.1    Zhang, J.2    Shen, C.3    Luo, Y.4    Xia, L.5    Xue, F.6
  • 47
    • 79960925702 scopus 로고    scopus 로고
    • Core signaling pathways of survival/death in autophagy-related cancer networks
    • Wang S.Y., Yu Q.J., Zhang R.D., Liu B. Core signaling pathways of survival/death in autophagy-related cancer networks. Int J Biochem Cell Biol 2011, 43:1263-1266.
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 1263-1266
    • Wang, S.Y.1    Yu, Q.J.2    Zhang, R.D.3    Liu, B.4
  • 48
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: crosstalk between autophagy and apoptosis
    • Maiuri M.C., Zalckvar E., Kimchi A., Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007, 8:741-752.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 49
    • 79851515032 scopus 로고    scopus 로고
    • Dihydroptychantol A, a macrocyclic bisbibenzyl derivative, induces autophagy and following apoptosis associated with p53 pathway in human osteosarcoma U2OS cells
    • Li X., Wu W.K., Sun B., Cui M., Liu S., Gao J., et al. Dihydroptychantol A, a macrocyclic bisbibenzyl derivative, induces autophagy and following apoptosis associated with p53 pathway in human osteosarcoma U2OS cells. Toxicol Appl Pharmacol 2011, 251:146-154.
    • (2011) Toxicol Appl Pharmacol , vol.251 , pp. 146-154
    • Li, X.1    Wu, W.K.2    Sun, B.3    Cui, M.4    Liu, S.5    Gao, J.6
  • 50
    • 84875968074 scopus 로고    scopus 로고
    • Knockdown of autophagy-related gene BECLIN1 promotes cell growth and inhibits apoptosis in the A549 human lung cancer cell line
    • Wang W., Fan H., Zhou Y., Duan P., Zhao G., Wu G. Knockdown of autophagy-related gene BECLIN1 promotes cell growth and inhibits apoptosis in the A549 human lung cancer cell line. Mol Med Rep 2013, 7:1501-1505.
    • (2013) Mol Med Rep , vol.7 , pp. 1501-1505
    • Wang, W.1    Fan, H.2    Zhou, Y.3    Duan, P.4    Zhao, G.5    Wu, G.6
  • 51
    • 2642553881 scopus 로고    scopus 로고
    • Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
    • Yu L., Alva A., Su H., Dutt P., Freundt E., Welsh S., et al. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 2004, 304:1500-1502.
    • (2004) Science , vol.304 , pp. 1500-1502
    • Yu, L.1    Alva, A.2    Su, H.3    Dutt, P.4    Freundt, E.5    Welsh, S.6
  • 52
    • 84874138765 scopus 로고    scopus 로고
    • Autophagy inhibition promotes 5-fluorouraci-induced apoptosis by stimulating ROS formation in human non-small cell lung cancer A549 cells
    • Pan X., Zhang X., Sun H., Zhang J., Yan M., Zhang H. Autophagy inhibition promotes 5-fluorouraci-induced apoptosis by stimulating ROS formation in human non-small cell lung cancer A549 cells. PLoS ONE 2013, 8:e56679.
    • (2013) PLoS ONE , vol.8 , pp. e56679
    • Pan, X.1    Zhang, X.2    Sun, H.3    Zhang, J.4    Yan, M.5    Zhang, H.6
  • 53
    • 84873267192 scopus 로고    scopus 로고
    • Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the aging process
    • Salminen A., Kaarniranta K., Kauppinen A. Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the aging process. Ageing Res Rev 2013, 12:520-534.
    • (2013) Ageing Res Rev , vol.12 , pp. 520-534
    • Salminen, A.1    Kaarniranta, K.2    Kauppinen, A.3
  • 54
    • 84883464875 scopus 로고    scopus 로고
    • Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism
    • He C., Wei Y., Sun K., Li B., Dong X., Zou Z., et al. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. Cell 2013, 154:1085-1099.
    • (2013) Cell , vol.154 , pp. 1085-1099
    • He, C.1    Wei, Y.2    Sun, K.3    Li, B.4    Dong, X.5    Zou, Z.6
  • 55
    • 84864667633 scopus 로고    scopus 로고
    • Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch
    • Marquez R.T., Xu L. Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch. Am J Cancer Res 2012, 2:214-221.
    • (2012) Am J Cancer Res , vol.2 , pp. 214-221
    • Marquez, R.T.1    Xu, L.2
  • 56
    • 84983718691 scopus 로고    scopus 로고
    • Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells
    • Tai W.T., Shiau C.W., Chen H.L., Liu C.Y., Lin C.S., Cheng A.L., et al. Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells. Cell Death Dis 2013, 4:e485.
    • (2013) Cell Death Dis , vol.4 , pp. e485
    • Tai, W.T.1    Shiau, C.W.2    Chen, H.L.3    Liu, C.Y.4    Lin, C.S.5    Cheng, A.L.6
  • 57
    • 84875993097 scopus 로고    scopus 로고
    • The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells
    • Cheng P., Ni Z., Dai X., Wang B., Ding W., Rae S.A., et al. The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. Cell Death Dis 2013, 4:e489.
    • (2013) Cell Death Dis , vol.4 , pp. e489
    • Cheng, P.1    Ni, Z.2    Dai, X.3    Wang, B.4    Ding, W.5    Rae, S.A.6
  • 58
    • 0032549704 scopus 로고    scopus 로고
    • The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
    • Pomerantz J., Schreiber-Agus N., Liegeois N.J., Silverman A., Alland L., Chin L., et al. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 1998, 92:713-723.
    • (1998) Cell , vol.92 , pp. 713-723
    • Pomerantz, J.1    Schreiber-Agus, N.2    Liegeois, N.J.3    Silverman, A.4    Alland, L.5    Chin, L.6
  • 60
    • 33646523798 scopus 로고    scopus 로고
    • A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death
    • Reef S., Zalckvar E., Shifman O., Bialik S., Sabanay H., Oren M., et al. A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death. Mol Cell 2006, 22:463-475.
    • (2006) Mol Cell , vol.22 , pp. 463-475
    • Reef, S.1    Zalckvar, E.2    Shifman, O.3    Bialik, S.4    Sabanay, H.5    Oren, M.6
  • 62
    • 0035959742 scopus 로고    scopus 로고
    • Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging
    • Gozuacik D. Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging. Oncogene 2001, 20:6233-6240.
    • (2001) Oncogene , vol.20 , pp. 6233-6240
    • Gozuacik, D.1
  • 63
    • 25444440875 scopus 로고    scopus 로고
    • The role of autophagy in cancer development and response to therapy
    • Kondo Y., Kanzawa T., Sawaya R., Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005, 5:726-734.
    • (2005) Nat Rev Cancer , vol.5 , pp. 726-734
    • Kondo, Y.1    Kanzawa, T.2    Sawaya, R.3    Kondo, S.4
  • 64
    • 80052830566 scopus 로고    scopus 로고
    • Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function
    • Pimkina J., Murphy M.E. Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function. Cancer Biol Ther 2011, 12:503-509.
    • (2011) Cancer Biol Ther , vol.12 , pp. 503-509
    • Pimkina, J.1    Murphy, M.E.2
  • 65
    • 33748670457 scopus 로고    scopus 로고
    • The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
    • Christophorou M.A., Ringshausen I., Finch A.J., Swigart L.B., Evan G.I. The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature 2006, 443:214-217.
    • (2006) Nature , vol.443 , pp. 214-217
    • Christophorou, M.A.1    Ringshausen, I.2    Finch, A.J.3    Swigart, L.B.4    Evan, G.I.5
  • 67
    • 77957681100 scopus 로고    scopus 로고
    • ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy
    • Dewaele M., Maes H., Agostinis P. ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy. Autophagy 2010, 6:838-854.
    • (2010) Autophagy , vol.6 , pp. 838-854
    • Dewaele, M.1    Maes, H.2    Agostinis, P.3
  • 68
    • 82955187599 scopus 로고    scopus 로고
    • Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms
    • Nicolau-Galmes F., Asumendi A., onso-Tejerina E., Perez-Yarza G., Jangi S.M., Gardeazabal J., et al. Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms. Apoptosis 2011, 16:1253-1267.
    • (2011) Apoptosis , vol.16 , pp. 1253-1267
    • Nicolau-Galmes, F.1    Asumendi, A.2    Onso-Tejerina, E.3    Perez-Yarza, G.4    Jangi, S.M.5    Gardeazabal, J.6
  • 69
    • 67549084381 scopus 로고    scopus 로고
    • Superoxide is the major reactive oxygen species regulating autophagy
    • Chen Y., Azad M.B., Gibson S.B. Superoxide is the major reactive oxygen species regulating autophagy. Cell Death Differ 2009, 16:1040-1052.
    • (2009) Cell Death Differ , vol.16 , pp. 1040-1052
    • Chen, Y.1    Azad, M.B.2    Gibson, S.B.3
  • 70
    • 34247186472 scopus 로고    scopus 로고
    • Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
    • Scherz-Shouval R., Shvets E., Fass E., Shorer H., Gil L., Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 2007, 26:1749-1760.
    • (2007) EMBO J , vol.26 , pp. 1749-1760
    • Scherz-Shouval, R.1    Shvets, E.2    Fass, E.3    Shorer, H.4    Gil, L.5    Elazar, Z.6
  • 71
    • 34249863298 scopus 로고    scopus 로고
    • Autophagy suppresses tumor progression by limiting chromosomal instability
    • Mathew R., Kongara S., Beaudoin B., Karp C.M., Bray K., Degenhardt K., et al. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev 2007, 21:1367-1381.
    • (2007) Genes Dev , vol.21 , pp. 1367-1381
    • Mathew, R.1    Kongara, S.2    Beaudoin, B.3    Karp, C.M.4    Bray, K.5    Degenhardt, K.6
  • 72
    • 38949119423 scopus 로고    scopus 로고
    • Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3
    • Azad M.B., Chen Y., Henson E.S., Cizeau J., Millan-Ward E., Israels S.J., et al. Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3. Autophagy 2008, 4:195-204.
    • (2008) Autophagy , vol.4 , pp. 195-204
    • Azad, M.B.1    Chen, Y.2    Henson, E.S.3    Cizeau, J.4    Millan-Ward, E.5    Israels, S.J.6
  • 73
    • 84870591168 scopus 로고    scopus 로고
    • Autophagy protects against oxaliplatin-induced cell death via ER stress and ROS in Caco-2 cells
    • Shi Y., Tang B., Yu P.W., Tang B., Hao Y.X., Lei X., et al. Autophagy protects against oxaliplatin-induced cell death via ER stress and ROS in Caco-2 cells. PLoS ONE 2012, 7:e51076.
    • (2012) PLoS ONE , vol.7 , pp. e51076
    • Shi, Y.1    Tang, B.2    Yu, P.W.3    Tang, B.4    Hao, Y.X.5    Lei, X.6
  • 74
    • 0242299705 scopus 로고    scopus 로고
    • Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress
    • Boldogh I., Roy G., Lee M.S., Bacsi A., Hazra T.K., Bhakat K.K., et al. Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress. Toxicology 2003, 193:137-152.
    • (2003) Toxicology , vol.193 , pp. 137-152
    • Boldogh, I.1    Roy, G.2    Lee, M.S.3    Bacsi, A.4    Hazra, T.K.5    Bhakat, K.K.6
  • 75
    • 58249098507 scopus 로고    scopus 로고
    • A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress
    • Huang Q., Wu Y.T., Tan H.L., Ong C.N., Shen H.M. A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress. Cell Death Differ 2009, 16:264-277.
    • (2009) Cell Death Differ , vol.16 , pp. 264-277
    • Huang, Q.1    Wu, Y.T.2    Tan, H.L.3    Ong, C.N.4    Shen, H.M.5
  • 79
    • 0036373335 scopus 로고    scopus 로고
    • Morphological and biochemical aspects of apoptosis, oncosis and necrosis
    • Van C.S., Van den B.W. Morphological and biochemical aspects of apoptosis, oncosis and necrosis. Anat Histol Embryol 2002, 31:214-223.
    • (2002) Anat Histol Embryol , vol.31 , pp. 214-223
    • Van, C.S.1    Van den, B.W.2
  • 81
    • 0032700751 scopus 로고    scopus 로고
    • Sequence of apoptosis and inflammatory necrosis within the formative ovulatory site of sheep follicles
    • Murdoch W.J., Wilken C., Young D.A. Sequence of apoptosis and inflammatory necrosis within the formative ovulatory site of sheep follicles. J Reprod Fertil 1999, 117:325-329.
    • (1999) J Reprod Fertil , vol.117 , pp. 325-329
    • Murdoch, W.J.1    Wilken, C.2    Young, D.A.3
  • 82
    • 0033250829 scopus 로고    scopus 로고
    • Plasmin-tumour necrosis factor interaction in the ovulatory process
    • Murdoch W.J. Plasmin-tumour necrosis factor interaction in the ovulatory process. J Reprod Fertil Suppl 1999, 54:353-358.
    • (1999) J Reprod Fertil Suppl , vol.54 , pp. 353-358
    • Murdoch, W.J.1
  • 83
    • 0038731167 scopus 로고    scopus 로고
    • Caspase-independent cell death in T lymphocytes
    • Jaattela M., Tschopp J. Caspase-independent cell death in T lymphocytes. Nat Immunol 2003, 4:416-423.
    • (2003) Nat Immunol , vol.4 , pp. 416-423
    • Jaattela, M.1    Tschopp, J.2
  • 84
    • 0034068977 scopus 로고    scopus 로고
    • Physiological cell death of chondrocytes in vivo is not confined to apoptosis. New observations on the mammalian growth plate
    • Roach H.I., Clarke N.M. Physiological cell death of chondrocytes in vivo is not confined to apoptosis. New observations on the mammalian growth plate. J Bone Joint Surg Br 2000, 82:601-613.
    • (2000) J Bone Joint Surg Br , vol.82 , pp. 601-613
    • Roach, H.I.1    Clarke, N.M.2
  • 85
    • 0032820396 scopus 로고    scopus 로고
    • The fate of epithelial cells in the human large intestine
    • Barkla D.H., Gibson P.R. The fate of epithelial cells in the human large intestine. Pathology 1999, 31:230-238.
    • (1999) Pathology , vol.31 , pp. 230-238
    • Barkla, D.H.1    Gibson, P.R.2
  • 86
    • 0033539141 scopus 로고    scopus 로고
    • Interdigital cell death can occur through a necrotic and caspase-independent pathway
    • Chautan M., Chazal G., Cecconi F., Gruss P., Golstein P. Interdigital cell death can occur through a necrotic and caspase-independent pathway. Curr Biol 1999, 9:967-970.
    • (1999) Curr Biol , vol.9 , pp. 967-970
    • Chautan, M.1    Chazal, G.2    Cecconi, F.3    Gruss, P.4    Golstein, P.5
  • 87
    • 0036233343 scopus 로고    scopus 로고
    • Cytopathic killing of peripheral blood CD4(+) T lymphocytes by human immunodeficiency virus type 1 appears necrotic rather than apoptotic and does not require env
    • Lenardo M.J., Angleman S.B., Bounkeua V., Dimas J., Duvall M.G., Graubard M.B., et al. Cytopathic killing of peripheral blood CD4(+) T lymphocytes by human immunodeficiency virus type 1 appears necrotic rather than apoptotic and does not require env. J Virol 2002, 76:5082-5093.
    • (2002) J Virol , vol.76 , pp. 5082-5093
    • Lenardo, M.J.1    Angleman, S.B.2    Bounkeua, V.3    Dimas, J.4    Duvall, M.G.5    Graubard, M.B.6
  • 88
    • 0033815330 scopus 로고    scopus 로고
    • Salmonella induces macrophage death by caspase-1-dependent necrosis
    • Brennan M.A., Cookson B.T. Salmonella induces macrophage death by caspase-1-dependent necrosis. Mol Microbiol 2000, 38:31-40.
    • (2000) Mol Microbiol , vol.38 , pp. 31-40
    • Brennan, M.A.1    Cookson, B.T.2
  • 89
    • 80051481307 scopus 로고    scopus 로고
    • RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation
    • Cho Y., McQuade T., Zhang H., Zhang J., Chan F.K. RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. PLoS ONE 2011, 6:e23209.
    • (2011) PLoS ONE , vol.6 , pp. e23209
    • Cho, Y.1    McQuade, T.2    Zhang, H.3    Zhang, J.4    Chan, F.K.5
  • 90
    • 77957854088 scopus 로고    scopus 로고
    • HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans
    • Marubayashi S., Koppikar P., Taldone T., bdel-Wahab O., West N., Bhagwat N., et al. HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans. J Clin Invest 2010, 120:3578-3593.
    • (2010) J Clin Invest , vol.120 , pp. 3578-3593
    • Marubayashi, S.1    Koppikar, P.2    Taldone, T.3    bdel-Wahab, O.4    West, N.5    Bhagwat, N.6
  • 91
    • 22244485706 scopus 로고    scopus 로고
    • Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins
    • Shimamura T., Lowell A.M., Engelman J.A., Shapiro G.I. Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins. Cancer Res 2005, 65:6401-6408.
    • (2005) Cancer Res , vol.65 , pp. 6401-6408
    • Shimamura, T.1    Lowell, A.M.2    Engelman, J.A.3    Shapiro, G.I.4
  • 92
    • 44649083135 scopus 로고    scopus 로고
    • Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance
    • Shimamura T., Li D., Ji H., Haringsma H.J., Liniker E., Borgman C.L., et al. Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance. Cancer Res 2008, 68:5827-5838.
    • (2008) Cancer Res , vol.68 , pp. 5827-5838
    • Shimamura, T.1    Li, D.2    Ji, H.3    Haringsma, H.J.4    Liniker, E.5    Borgman, C.L.6
  • 93
    • 84866414082 scopus 로고    scopus 로고
    • Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer
    • Shimamura T., Perera S.A., Foley K.P., Sang J., Rodig S.J., Inoue T., et al. Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer. Clin Cancer Res 2012, 18:4973-4985.
    • (2012) Clin Cancer Res , vol.18 , pp. 4973-4985
    • Shimamura, T.1    Perera, S.A.2    Foley, K.P.3    Sang, J.4    Rodig, S.J.5    Inoue, T.6
  • 94
    • 84878971581 scopus 로고    scopus 로고
    • A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer
    • Socinski M.A., Goldman J., El-Hariry I., Koczywas M., Vukovic V., Horn L., et al. A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer. Clin Cancer Res 2013, 19:3068-3077.
    • (2013) Clin Cancer Res , vol.19 , pp. 3068-3077
    • Socinski, M.A.1    Goldman, J.2    El-Hariry, I.3    Koczywas, M.4    Vukovic, V.5    Horn, L.6
  • 95
    • 35348887850 scopus 로고    scopus 로고
    • Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network
    • Kang B.H., Plescia J., Dohi T., Rosa J., Doxsey S.J., Altieri D.C. Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network. Cell 2007, 131:257-270.
    • (2007) Cell , vol.131 , pp. 257-270
    • Kang, B.H.1    Plescia, J.2    Dohi, T.3    Rosa, J.4    Doxsey, S.J.5    Altieri, D.C.6
  • 96
    • 5644259582 scopus 로고    scopus 로고
    • Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin
    • Masuda Y., Shima G., Aiuchi T., Horie M., Hori K., Nakajo S., et al. Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin. J Biol Chem 2004, 279:42503-42515.
    • (2004) J Biol Chem , vol.279 , pp. 42503-42515
    • Masuda, Y.1    Shima, G.2    Aiuchi, T.3    Horie, M.4    Hori, K.5    Nakajo, S.6
  • 99
    • 65649128567 scopus 로고    scopus 로고
    • Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90
    • Kang B.H., Plescia J., Song H.Y., Meli M., Colombo G., Beebe K., et al. Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90. J Clin Invest 2009, 119:454-464.
    • (2009) J Clin Invest , vol.119 , pp. 454-464
    • Kang, B.H.1    Plescia, J.2    Song, H.Y.3    Meli, M.4    Colombo, G.5    Beebe, K.6
  • 100
    • 84876740528 scopus 로고    scopus 로고
    • Inhibition of the mitochondrial Hsp90 chaperone network: a novel, efficient treatment strategy for cancer
    • Siegelin M.D. Inhibition of the mitochondrial Hsp90 chaperone network: a novel, efficient treatment strategy for cancer. Cancer Lett 2013, 333:133-146.
    • (2013) Cancer Lett , vol.333 , pp. 133-146
    • Siegelin, M.D.1
  • 101
    • 11244309014 scopus 로고    scopus 로고
    • Proteolysis: from the lysosome to ubiquitin and the proteasome
    • Ciechanover A. Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat Rev Mol Cell Biol 2005, 6:79-87.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 79-87
    • Ciechanover, A.1
  • 102
    • 0034685889 scopus 로고    scopus 로고
    • Why does threonine, and not serine, function as the active site nucleophile in proteasomes
    • Kisselev A.F., Songyang Z., Goldberg A.L. Why does threonine, and not serine, function as the active site nucleophile in proteasomes. J Biol Chem 2000, 275:14831-14837.
    • (2000) J Biol Chem , vol.275 , pp. 14831-14837
    • Kisselev, A.F.1    Songyang, Z.2    Goldberg, A.L.3
  • 104
    • 33947659939 scopus 로고    scopus 로고
    • 20S proteasome and its inhibitors: crystallographic knowledge for drug development
    • Borissenko L., Groll M. 20S proteasome and its inhibitors: crystallographic knowledge for drug development. Chem Rev 2007, 107:687-717.
    • (2007) Chem Rev , vol.107 , pp. 687-717
    • Borissenko, L.1    Groll, M.2
  • 105
    • 0036483901 scopus 로고    scopus 로고
    • Deadly encounter: ubiquitin meets apoptosis
    • Jesenberger V., Jentsch S. Deadly encounter: ubiquitin meets apoptosis. Nat Rev Mol Cell Biol 2002, 3:112-121.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 112-121
    • Jesenberger, V.1    Jentsch, S.2
  • 106
    • 33144469102 scopus 로고    scopus 로고
    • The proteasome and proteasome inhibitors in cancer therapy
    • Voorhees P.M., Orlowski R.Z. The proteasome and proteasome inhibitors in cancer therapy. Annu Rev Pharmacol Toxicol 2006, 46:189-213.
    • (2006) Annu Rev Pharmacol Toxicol , vol.46 , pp. 189-213
    • Voorhees, P.M.1    Orlowski, R.Z.2
  • 107
    • 0142054051 scopus 로고    scopus 로고
    • Bortezomib (PS-341): a novel, first-in-class proteasome inhibitor for the treatment of multiple myeloma and other cancers
    • Richardson P.G., Hideshima T., Anderson K.C. Bortezomib (PS-341): a novel, first-in-class proteasome inhibitor for the treatment of multiple myeloma and other cancers. Cancer Control 2003, 10:361-369.
    • (2003) Cancer Control , vol.10 , pp. 361-369
    • Richardson, P.G.1    Hideshima, T.2    Anderson, K.C.3
  • 108
    • 0036483890 scopus 로고    scopus 로고
    • Potentiation of tumor necrosis factor-mediated apoptosis of oral squamous cell carcinoma cells by adenovirus-mediated gene transfer of NF-kappaB inhibitor
    • Chen S., Fribley A., Wang C.Y. Potentiation of tumor necrosis factor-mediated apoptosis of oral squamous cell carcinoma cells by adenovirus-mediated gene transfer of NF-kappaB inhibitor. J Dent Res 2002, 81:98-102.
    • (2002) J Dent Res , vol.81 , pp. 98-102
    • Chen, S.1    Fribley, A.2    Wang, C.Y.3
  • 109
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-kappaB puzzle
    • Ghosh S., Karin M. Missing pieces in the NF-kappaB puzzle. Cell 2002, 109(Suppl):S81-S96.
    • (2002) Cell , vol.109 , pp. S81-S96
    • Ghosh, S.1    Karin, M.2
  • 110
    • 0026603895 scopus 로고
    • Ubiquitin-dependent protein degradation: a cellular perspective
    • Jentsch S. Ubiquitin-dependent protein degradation: a cellular perspective. Trends Cell Biol 1992, 2:98-103.
    • (1992) Trends Cell Biol , vol.2 , pp. 98-103
    • Jentsch, S.1
  • 111
    • 0032429122 scopus 로고    scopus 로고
    • Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts
    • An B., Goldfarb R.H., Siman R., Dou Q.P. Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts. Cell Death Differ 1998, 5:1062-1075.
    • (1998) Cell Death Differ , vol.5 , pp. 1062-1075
    • An, B.1    Goldfarb, R.H.2    Siman, R.3    Dou, Q.P.4
  • 112
    • 0034635952 scopus 로고    scopus 로고
    • Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progression
    • Li B., Dou Q.P. Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progression. Proc Natl Acad Sci USA 2000, 97:3850-3855.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3850-3855
    • Li, B.1    Dou, Q.P.2
  • 113
    • 0033532543 scopus 로고    scopus 로고
    • Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway
    • Dimmeler S., Breitschopf K., Haendeler J., Zeiher A.M. Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway. J Exp Med 1999, 189:1815-1822.
    • (1999) J Exp Med , vol.189 , pp. 1815-1822
    • Dimmeler, S.1    Breitschopf, K.2    Haendeler, J.3    Zeiher, A.M.4
  • 114
    • 33646128506 scopus 로고    scopus 로고
    • Epigenetics as a mechanism driving polygenic clinical drug resistance
    • Glasspool R.M., Teodoridis J.M., Brown R. Epigenetics as a mechanism driving polygenic clinical drug resistance. Br J Cancer 2006, 94:1087-1092.
    • (2006) Br J Cancer , vol.94 , pp. 1087-1092
    • Glasspool, R.M.1    Teodoridis, J.M.2    Brown, R.3
  • 115
    • 84856857494 scopus 로고    scopus 로고
    • Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cells
    • Ajabnoor G.M., Crook T., Coley H.M. Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cells. Cell Death Dis 2012, 3:e260.
    • (2012) Cell Death Dis , vol.3 , pp. e260
    • Ajabnoor, G.M.1    Crook, T.2    Coley, H.M.3
  • 116
    • 79955509238 scopus 로고    scopus 로고
    • Polo-like kinase Plk2 is an epigenetic determinant of chemosensitivity and clinical outcomes in ovarian cancer
    • Syed N., Coley H.M., Sehouli J., Koensgen D., Mustea A., Szlosarek P., et al. Polo-like kinase Plk2 is an epigenetic determinant of chemosensitivity and clinical outcomes in ovarian cancer. Cancer Res 2011, 71:3317-3327.
    • (2011) Cancer Res , vol.71 , pp. 3317-3327
    • Syed, N.1    Coley, H.M.2    Sehouli, J.3    Koensgen, D.4    Mustea, A.5    Szlosarek, P.6
  • 117
    • 33847612419 scopus 로고    scopus 로고
    • Cytostatic drug treatment causes seeding of gene promoter methylation
    • Bredberg A., Bodmer W. Cytostatic drug treatment causes seeding of gene promoter methylation. Eur J Cancer 2007, 43:947-954.
    • (2007) Eur J Cancer , vol.43 , pp. 947-954
    • Bredberg, A.1    Bodmer, W.2
  • 118
    • 74849113290 scopus 로고    scopus 로고
    • The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions
    • Matthew E.M., Hart L.S., Astrinidis A., Navaraj A., Dolloff N.G., Dicker D.T., et al. The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions. Cell Cycle (Georgetown, Tex) 2009, 8:4168-4175.
    • (2009) Cell Cycle (Georgetown, Tex) , vol.8 , pp. 4168-4175
    • Matthew, E.M.1    Hart, L.S.2    Astrinidis, A.3    Navaraj, A.4    Dolloff, N.G.5    Dicker, D.T.6
  • 119
    • 84856453540 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer
    • Coley H.M., Safuwan N.A., Chivers P., Papacharalbous E., Giannopoulos T., Butler-Manuel S., et al. The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer. Br J Cancer 2012, 106:482-489.
    • (2012) Br J Cancer , vol.106 , pp. 482-489
    • Coley, H.M.1    Safuwan, N.A.2    Chivers, P.3    Papacharalbous, E.4    Giannopoulos, T.5    Butler-Manuel, S.6
  • 120
    • 0030854026 scopus 로고    scopus 로고
    • Aberrant splicing but not mutations of TSG101 in human breast cancer
    • Lee M.P., Feinberg A.P. Aberrant splicing but not mutations of TSG101 in human breast cancer. Cancer Res 1997, 57:3131-3134.
    • (1997) Cancer Res , vol.57 , pp. 3131-3134
    • Lee, M.P.1    Feinberg, A.P.2
  • 122
    • 78149455880 scopus 로고    scopus 로고
    • Disturbed expression of splicing factors in renal cancer affects alternative splicing of apoptosis regulators, oncogenes, and tumor suppressors
    • Piekielko-Witkowska A., Wiszomirska H., Wojcicka A., Poplawski P., Boguslawska J., Tanski Z., et al. Disturbed expression of splicing factors in renal cancer affects alternative splicing of apoptosis regulators, oncogenes, and tumor suppressors. PLoS ONE 2010, 5:e13690.
    • (2010) PLoS ONE , vol.5 , pp. e13690
    • Piekielko-Witkowska, A.1    Wiszomirska, H.2    Wojcicka, A.3    Poplawski, P.4    Boguslawska, J.5    Tanski, Z.6
  • 124
    • 56349095800 scopus 로고    scopus 로고
    • E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35
    • Merdzhanova G., Edmond V., De S.S., Van den B.A., Corcos L., Brambilla C., et al. E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35. Cell Death Differ 2008, 15:1815-1823.
    • (2008) Cell Death Differ , vol.15 , pp. 1815-1823
    • Merdzhanova, G.1    Edmond, V.2    De, S.S.3    Van den, B.A.4    Corcos, L.5    Brambilla, C.6
  • 125
    • 79959215165 scopus 로고    scopus 로고
    • SRSF2 is required for sodium butyrate-mediated p21(WAF1) induction and premature senescence in human lung carcinoma cell lines
    • Edmond V., Brambilla C., Brambilla E., Gazzeri S., Eymin B. SRSF2 is required for sodium butyrate-mediated p21(WAF1) induction and premature senescence in human lung carcinoma cell lines. Cell Cycle (Georgetown, Tex) 2011, 10:1968-1977.
    • (2011) Cell Cycle (Georgetown, Tex) , vol.10 , pp. 1968-1977
    • Edmond, V.1    Brambilla, C.2    Brambilla, E.3    Gazzeri, S.4    Eymin, B.5
  • 126
    • 79551602983 scopus 로고    scopus 로고
    • Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin
    • Edmond V., Moysan E., Khochbin S., Matthias P., Brambilla C., Brambilla E., et al. Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin. EMBO J 2011, 30:510-523.
    • (2011) EMBO J , vol.30 , pp. 510-523
    • Edmond, V.1    Moysan, E.2    Khochbin, S.3    Matthias, P.4    Brambilla, C.5    Brambilla, E.6
  • 127
    • 84871435690 scopus 로고    scopus 로고
    • Evolution of intracellular compartmentalization
    • Diekmann Y., Pereira-Leal J.B. Evolution of intracellular compartmentalization. Biochem J 2013, 449:319-331.
    • (2013) Biochem J , vol.449 , pp. 319-331
    • Diekmann, Y.1    Pereira-Leal, J.B.2
  • 128
    • 84870212338 scopus 로고    scopus 로고
    • Nuclear organization and genome function
    • Van B.K., Corces V.G. Nuclear organization and genome function. Annu Rev Cell Dev Biol 2012, 28:163-187.
    • (2012) Annu Rev Cell Dev Biol , vol.28 , pp. 163-187
    • Van, B.K.1    Corces, V.G.2
  • 129
    • 36849074774 scopus 로고    scopus 로고
    • Dynamics and interplay of nuclear architecture, genome organization, and gene expression
    • Schneider R., Grosschedl R. Dynamics and interplay of nuclear architecture, genome organization, and gene expression. Genes Dev 2007, 21:3027-3043.
    • (2007) Genes Dev , vol.21 , pp. 3027-3043
    • Schneider, R.1    Grosschedl, R.2
  • 130
    • 0033786789 scopus 로고    scopus 로고
    • Nuclear envelope proteins and associated diseases
    • Nagano A., Arahata K. Nuclear envelope proteins and associated diseases. Curr Opin Neurol 2000, 13:533-539.
    • (2000) Curr Opin Neurol , vol.13 , pp. 533-539
    • Nagano, A.1    Arahata, K.2
  • 131
    • 84867786612 scopus 로고    scopus 로고
    • Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions
    • Raices M., D'Angelo M.A. Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions. Nat Rev Mol Cell Biol 2012, 13:687-699.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 687-699
    • Raices, M.1    D'Angelo, M.A.2
  • 132
    • 84861384878 scopus 로고    scopus 로고
    • Functional architecture of the nuclear pore complex
    • Grossman E., Medalia O., Zwerger M. Functional architecture of the nuclear pore complex. Annu Rev Biophys 2012, 41:557-584.
    • (2012) Annu Rev Biophys , vol.41 , pp. 557-584
    • Grossman, E.1    Medalia, O.2    Zwerger, M.3
  • 133
    • 84860450204 scopus 로고    scopus 로고
    • To the pore and through the pore: a story of mRNA export kinetics
    • Oeffinger M., Zenklusen D. To the pore and through the pore: a story of mRNA export kinetics. Biochim Biophys Acta 2012, 1819:494-506.
    • (2012) Biochim Biophys Acta , vol.1819 , pp. 494-506
    • Oeffinger, M.1    Zenklusen, D.2
  • 134
    • 77955311720 scopus 로고    scopus 로고
    • The part and the whole: functions of nucleoporins in nucleocytoplasmic transport
    • Walde S., Kehlenbach R.H. The part and the whole: functions of nucleoporins in nucleocytoplasmic transport. Trends Cell Biol 2010, 20:461-469.
    • (2010) Trends Cell Biol , vol.20 , pp. 461-469
    • Walde, S.1    Kehlenbach, R.H.2
  • 135
    • 78649650714 scopus 로고    scopus 로고
    • Recognition of nuclear targeting signals by Karyopherin-beta proteins
    • Xu D., Farmer A., Chook Y.M. Recognition of nuclear targeting signals by Karyopherin-beta proteins. Curr Opin Struct Biol 2010, 20:782-790.
    • (2010) Curr Opin Struct Biol , vol.20 , pp. 782-790
    • Xu, D.1    Farmer, A.2    Chook, Y.M.3
  • 136
    • 79960912049 scopus 로고    scopus 로고
    • Nuclear import by karyopherin-betas: recognition and inhibition
    • Chook Y.M., Suel K.E. Nuclear import by karyopherin-betas: recognition and inhibition. Biochim Biophys Acta 2011, 1813:1593-1606.
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 1593-1606
    • Chook, Y.M.1    Suel, K.E.2
  • 137
    • 0036368289 scopus 로고    scopus 로고
    • Exportin-mediated nuclear export of proteins and ribonucleoproteins
    • Fornerod M., Ohno M. Exportin-mediated nuclear export of proteins and ribonucleoproteins. Results Probl Cell Differ 2002, 35:67-91.
    • (2002) Results Probl Cell Differ , vol.35 , pp. 67-91
    • Fornerod, M.1    Ohno, M.2
  • 139
    • 0029991830 scopus 로고    scopus 로고
    • Nuclear pore-targeting complex and its role on nuclear protein transport
    • Yoneda Y. Nuclear pore-targeting complex and its role on nuclear protein transport. Arch Histol Cytol 1996, 59:97-107.
    • (1996) Arch Histol Cytol , vol.59 , pp. 97-107
    • Yoneda, Y.1
  • 140
    • 84858294567 scopus 로고    scopus 로고
    • Structural basis of high-affinity nuclear localization signal interactions with importin-alpha
    • Marfori M., Lonhienne T.G., Forwood J.K., Kobe B. Structural basis of high-affinity nuclear localization signal interactions with importin-alpha. Traffic 2012, 13:532-548.
    • (2012) Traffic , vol.13 , pp. 532-548
    • Marfori, M.1    Lonhienne, T.G.2    Forwood, J.K.3    Kobe, B.4
  • 141
    • 62449215108 scopus 로고    scopus 로고
    • The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation
    • van der Watt P.J., Maske C.P., Hendricks D.T., Parker M.I., Denny L., Govender D., et al. The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation. Int J Cancer 2009, 124:1829-1840.
    • (2009) Int J Cancer , vol.124 , pp. 1829-1840
    • van der Watt, P.J.1    Maske, C.P.2    Hendricks, D.T.3    Parker, M.I.4    Denny, L.5    Govender, D.6
  • 142
    • 33947726050 scopus 로고    scopus 로고
    • CRM1-mediated nuclear export: to the pore and beyond
    • Hutten S., Kehlenbach R.H. CRM1-mediated nuclear export: to the pore and beyond. Trends Cell Biol 2007, 17:193-201.
    • (2007) Trends Cell Biol , vol.17 , pp. 193-201
    • Hutten, S.1    Kehlenbach, R.H.2
  • 143
    • 0030831534 scopus 로고    scopus 로고
    • CRM1 is responsible for intracellular transport mediated by the nuclear export signal
    • Fukuda M., Asano S., Nakamura T., Adachi M., Yoshida M., Yanagida M., et al. CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature 1997, 390:308-311.
    • (1997) Nature , vol.390 , pp. 308-311
    • Fukuda, M.1    Asano, S.2    Nakamura, T.3    Adachi, M.4    Yoshida, M.5    Yanagida, M.6
  • 144
    • 0026046039 scopus 로고
    • Nuclear localization is essential for the activity of p53 protein
    • Shaulsky G., Goldfinger N., Tosky M.S., Levine A.J., Rotter V. Nuclear localization is essential for the activity of p53 protein. Oncogene 1991, 6:2055-2065.
    • (1991) Oncogene , vol.6 , pp. 2055-2065
    • Shaulsky, G.1    Goldfinger, N.2    Tosky, M.S.3    Levine, A.J.4    Rotter, V.5
  • 145
    • 61649105802 scopus 로고    scopus 로고
    • CRM1-mediated nuclear export of proteins and drug resistance in cancer
    • Turner J.G., Sullivan D.M. CRM1-mediated nuclear export of proteins and drug resistance in cancer. Curr Med Chem 2008, 15:2648-2655.
    • (2008) Curr Med Chem , vol.15 , pp. 2648-2655
    • Turner, J.G.1    Sullivan, D.M.2
  • 148
    • 84877791472 scopus 로고    scopus 로고
    • Targeting the nuclear transport machinery by rational drug design
    • Mao L., Yang Y. Targeting the nuclear transport machinery by rational drug design. Curr Pharm Des 2013, 19:2318-2325.
    • (2013) Curr Pharm Des , vol.19 , pp. 2318-2325
    • Mao, L.1    Yang, Y.2
  • 149
    • 0037268889 scopus 로고    scopus 로고
    • Nucleo-cytoplasmic transport of proteins as a target for therapeutic drugs
    • Yashiroda Y., Yoshida M. Nucleo-cytoplasmic transport of proteins as a target for therapeutic drugs. Curr Med Chem 2003, 10:741-748.
    • (2003) Curr Med Chem , vol.10 , pp. 741-748
    • Yashiroda, Y.1    Yoshida, M.2
  • 150
    • 0020571348 scopus 로고
    • Leptomycins A and B, new antifungal antibiotics. II. Structure elucidation
    • Hamamoto T., Seto H., Beppu T. Leptomycins A and B, new antifungal antibiotics. II. Structure elucidation. J Antibiot (Tokyo) 1983, 36:646-650.
    • (1983) J Antibiot (Tokyo) , vol.36 , pp. 646-650
    • Hamamoto, T.1    Seto, H.2    Beppu, T.3
  • 151
    • 0020606355 scopus 로고
    • Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization
    • Hamamoto T., Gunji S., Tsuji H., Beppu T. Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization. J Antibiot (Tokyo) 1983, 36:639-645.
    • (1983) J Antibiot (Tokyo) , vol.36 , pp. 639-645
    • Hamamoto, T.1    Gunji, S.2    Tsuji, H.3    Beppu, T.4
  • 152
    • 0033529866 scopus 로고    scopus 로고
    • Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region
    • Kudo N., Matsumori N., Taoka H., Fujiwara D., Schreiner E.P., Wolff B., et al. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci USA 1999, 96:9112-9117.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 9112-9117
    • Kudo, N.1    Matsumori, N.2    Taoka, H.3    Fujiwara, D.4    Schreiner, E.P.5    Wolff, B.6
  • 154
    • 80053619765 scopus 로고    scopus 로고
    • CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity
    • Sakakibara K., Saito N., Sato T., Suzuki A., Hasegawa Y., Friedman J.M., et al. CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity. Blood 2011, 118:3922-3931.
    • (2011) Blood , vol.118 , pp. 3922-3931
    • Sakakibara, K.1    Saito, N.2    Sato, T.3    Suzuki, A.4    Hasegawa, Y.5    Friedman, J.M.6
  • 155
    • 85027917385 scopus 로고    scopus 로고
    • Consensus Induced Fit Docking (cIFD): methodology, validation, and application to the discovery of novel Crm1 inhibitors
    • Kalid O., Toledo W.D., Shechter S., Sherman W., Shacham S. Consensus Induced Fit Docking (cIFD): methodology, validation, and application to the discovery of novel Crm1 inhibitors. J Comput Aided Mol Des 2012, 26:1217-1228.
    • (2012) J Comput Aided Mol Des , vol.26 , pp. 1217-1228
    • Kalid, O.1    Toledo, W.D.2    Shechter, S.3    Sherman, W.4    Shacham, S.5
  • 156
    • 84877601009 scopus 로고    scopus 로고
    • CRM1 blockade by selective inhibitors of nuclear export (SINE) attenuates kidney cancer growth
    • Inoue H., Kauffman M., Shacham S., Landesman Y., Yang J., Evans C.P., et al. CRM1 blockade by selective inhibitors of nuclear export (SINE) attenuates kidney cancer growth. J Urol 2013, 189:2317-2326.
    • (2013) J Urol , vol.189 , pp. 2317-2326
    • Inoue, H.1    Kauffman, M.2    Shacham, S.3    Landesman, Y.4    Yang, J.5    Evans, C.P.6
  • 157
    • 84873570648 scopus 로고    scopus 로고
    • Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells
    • Etchin J., Sun Q., Kentsis A., Farmer A., Zhang Z.C., Sanda T., et al. Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia 2013, 27:66-74.
    • (2013) Leukemia , vol.27 , pp. 66-74
    • Etchin, J.1    Sun, Q.2    Kentsis, A.3    Farmer, A.4    Zhang, Z.C.5    Sanda, T.6
  • 158
    • 84870887672 scopus 로고    scopus 로고
    • Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma
    • Zhang K., Wang M., Tamayo A.T., Shacham S., Kauffman M., Lee J., et al. Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma. Exp Hematol 2013, 41:67-78.
    • (2013) Exp Hematol , vol.41 , pp. 67-78
    • Zhang, K.1    Wang, M.2    Tamayo, A.T.3    Shacham, S.4    Kauffman, M.5    Lee, J.6
  • 159
    • 84879566083 scopus 로고    scopus 로고
    • Selective inhibitors of nuclear export for the treatment of non-Hodgkin's Lymphomas
    • Azmi A.S., Al-Katib A., Aboukameel A., McCauley D., Kauffman M., Shacham S., et al. Selective inhibitors of nuclear export for the treatment of non-Hodgkin's Lymphomas. Haematologica 2013, 98:1098-1106.
    • (2013) Haematologica , vol.98 , pp. 1098-1106
    • Azmi, A.S.1    Al-Katib, A.2    Aboukameel, A.3    McCauley, D.4    Kauffman, M.5    Shacham, S.6
  • 160
    • 84881323214 scopus 로고    scopus 로고
    • Selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in mice
    • Azmi A.S., Aboukameel A., Bao B., Sarkar F.H., Philip P.A., Kauffman M., et al. Selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in mice. Gastroenterology 2012, 144:447-456.
    • (2012) Gastroenterology , vol.144 , pp. 447-456
    • Azmi, A.S.1    Aboukameel, A.2    Bao, B.3    Sarkar, F.H.4    Philip, P.A.5    Kauffman, M.6
  • 161
    • 58349104143 scopus 로고    scopus 로고
    • Identification of nuclear export inhibitors with potent anticancer activity in vivo
    • Mutka S.C., Yang W.Q., Dong S.D., Ward S.L., Craig D.A., Timmermans P.B., et al. Identification of nuclear export inhibitors with potent anticancer activity in vivo. Cancer Res 2009, 69:510-517.
    • (2009) Cancer Res , vol.69 , pp. 510-517
    • Mutka, S.C.1    Yang, W.Q.2    Dong, S.D.3    Ward, S.L.4    Craig, D.A.5    Timmermans, P.B.6
  • 162
    • 84881319008 scopus 로고    scopus 로고
    • Nuclear export mediated regulation of microRNAs: potential target for drug intervention
    • Muqbil I., Bao B., bou-Samra A.B., Mohammad R.M., Azmi A.S. Nuclear export mediated regulation of microRNAs: potential target for drug intervention. Curr Drug Targets 2013, 14:1094-1100.
    • (2013) Curr Drug Targets , vol.14 , pp. 1094-1100
    • Muqbil, I.1    Bao, B.2    bou-Samra, A.B.3    Mohammad, R.M.4    Azmi, A.S.5
  • 163
    • 84890844835 scopus 로고    scopus 로고
    • Unveiling the role of nuclear transport in epithelial-to-mesenchymal transition
    • Azmi A.S. Unveiling the role of nuclear transport in epithelial-to-mesenchymal transition. Curr Cancer Drug Targets 2013, 13:906-914.
    • (2013) Curr Cancer Drug Targets , vol.13 , pp. 906-914
    • Azmi, A.S.1
  • 164
    • 51349085099 scopus 로고    scopus 로고
    • Glioblastoma multiforme: a rare manifestation of extensive liver and bone metastases
    • Robert M., Wastie M. Glioblastoma multiforme: a rare manifestation of extensive liver and bone metastases. Biomed Imaging Interv J 2008, 4:e3.
    • (2008) Biomed Imaging Interv J , vol.4 , pp. e3
    • Robert, M.1    Wastie, M.2
  • 165
    • 70350099256 scopus 로고    scopus 로고
    • Meta-analysis of glioblastoma multiforme versus anaplastic astrocytoma identifies robust gene markers
    • Dreyfuss J.M., Johnson M.D., Park P.J. Meta-analysis of glioblastoma multiforme versus anaplastic astrocytoma identifies robust gene markers. Mol Cancer 2009, 8:71.
    • (2009) Mol Cancer , vol.8 , pp. 71
    • Dreyfuss, J.M.1    Johnson, M.D.2    Park, P.J.3
  • 166
    • 68149182696 scopus 로고    scopus 로고
    • Temozolomide concomitant and adjuvant to radiotherapy in elderly patients with glioblastoma: correlation with MGMT promoter methylation status
    • Brandes A.A., Franceschi E., Tosoni A., Benevento F., Scopece L., Mazzocchi V., et al. Temozolomide concomitant and adjuvant to radiotherapy in elderly patients with glioblastoma: correlation with MGMT promoter methylation status. Cancer 2009, 115:3512-3518.
    • (2009) Cancer , vol.115 , pp. 3512-3518
    • Brandes, A.A.1    Franceschi, E.2    Tosoni, A.3    Benevento, F.4    Scopece, L.5    Mazzocchi, V.6
  • 167
    • 42649129028 scopus 로고    scopus 로고
    • Modulatory effects of acetazolomide and dexamethasone on temozolomide-mediated apoptosis in human glioblastoma T98G and U87MG cells
    • Das A., Banik N.L., Ray S.K. Modulatory effects of acetazolomide and dexamethasone on temozolomide-mediated apoptosis in human glioblastoma T98G and U87MG cells. Cancer Invest 2008, 26:352-358.
    • (2008) Cancer Invest , vol.26 , pp. 352-358
    • Das, A.1    Banik, N.L.2    Ray, S.K.3
  • 168
    • 79951984402 scopus 로고    scopus 로고
    • Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme
    • Lai A., Tran A., Nghiemphu P.L., Pope W.B., Solis O.E., Selch M., et al. Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. J Clin Oncol 2011, 29:142-148.
    • (2011) J Clin Oncol , vol.29 , pp. 142-148
    • Lai, A.1    Tran, A.2    Nghiemphu, P.L.3    Pope, W.B.4    Solis, O.E.5    Selch, M.6
  • 169
    • 77951003656 scopus 로고    scopus 로고
    • Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States
    • Grossman S.A., Ye X., Piantadosi S., Desideri S., Nabors L.B., Rosenfeld M., et al. Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States. Clin Cancer Res 2010, 16:2443-2449.
    • (2010) Clin Cancer Res , vol.16 , pp. 2443-2449
    • Grossman, S.A.1    Ye, X.2    Piantadosi, S.3    Desideri, S.4    Nabors, L.B.5    Rosenfeld, M.6
  • 170
    • 75749109750 scopus 로고    scopus 로고
    • O6-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients
    • Spiegl-Kreinecker S., Pirker C., Filipits M., Lotsch D., Buchroithner J., Pichler J., et al. O6-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients. Neuro Oncol 2010, 12:28-36.
    • (2010) Neuro Oncol , vol.12 , pp. 28-36
    • Spiegl-Kreinecker, S.1    Pirker, C.2    Filipits, M.3    Lotsch, D.4    Buchroithner, J.5    Pichler, J.6
  • 171
    • 77954341696 scopus 로고    scopus 로고
    • Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics
    • Krakstad C., Chekenya M. Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics. Mol Cancer 2010, 9:135.
    • (2010) Mol Cancer , vol.9 , pp. 135
    • Krakstad, C.1    Chekenya, M.2
  • 173
    • 0026481269 scopus 로고
    • Immunolocalization of basic fibroblast growth factor to the microvasculature of human brain tumors
    • Brem S., Tsanaclis A.M., Gately S., Gross J.L., Herblin W.F. Immunolocalization of basic fibroblast growth factor to the microvasculature of human brain tumors. Cancer 1992, 70:2673-2680.
    • (1992) Cancer , vol.70 , pp. 2673-2680
    • Brem, S.1    Tsanaclis, A.M.2    Gately, S.3    Gross, J.L.4    Herblin, W.F.5
  • 174
    • 0036141447 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling
    • Chakravarti A., Loeffler J.S., Dyson N.J. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. Cancer Res 2002, 62:200-207.
    • (2002) Cancer Res , vol.62 , pp. 200-207
    • Chakravarti, A.1    Loeffler, J.S.2    Dyson, N.J.3
  • 175
    • 35348822482 scopus 로고    scopus 로고
    • Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
    • Stommel J.M., Kimmelman A.C., Ying H., Nabioullin R., Ponugoti A.H., Wiedemeyer R., et al. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 2007, 318:287-290.
    • (2007) Science , vol.318 , pp. 287-290
    • Stommel, J.M.1    Kimmelman, A.C.2    Ying, H.3    Nabioullin, R.4    Ponugoti, A.H.5    Wiedemeyer, R.6
  • 176
    • 67649084009 scopus 로고    scopus 로고
    • Targeted therapy for malignant glioma patients: lessons learned and the road ahead
    • Huang T.T., Sarkaria S.M., Cloughesy T.F., Mischel P.S. Targeted therapy for malignant glioma patients: lessons learned and the road ahead. Neurotherapeutics 2009, 6:500-512.
    • (2009) Neurotherapeutics , vol.6 , pp. 500-512
    • Huang, T.T.1    Sarkaria, S.M.2    Cloughesy, T.F.3    Mischel, P.S.4
  • 177
    • 0035266245 scopus 로고    scopus 로고
    • P53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells
    • Hirose Y., Berger M.S., Pieper R.O. p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells. Cancer Res 2001, 61:1957-1963.
    • (2001) Cancer Res , vol.61 , pp. 1957-1963
    • Hirose, Y.1    Berger, M.S.2    Pieper, R.O.3
  • 178
    • 60849086456 scopus 로고    scopus 로고
    • Bcl-2 inhibitors: small molecules with a big impact on cancer therapy
    • Vogler M., Dinsdale D., Dyer M.J., Cohen G.M. Bcl-2 inhibitors: small molecules with a big impact on cancer therapy. Cell Death Differ 2009, 16:360-367.
    • (2009) Cell Death Differ , vol.16 , pp. 360-367
    • Vogler, M.1    Dinsdale, D.2    Dyer, M.J.3    Cohen, G.M.4
  • 179
    • 56149097601 scopus 로고    scopus 로고
    • Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins
    • Tagscherer K.E., Fassl A., Campos B., Farhadi M., Kraemer A., Bock B.C., et al. Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins. Oncogene 2008, 27:6646-6656.
    • (2008) Oncogene , vol.27 , pp. 6646-6656
    • Tagscherer, K.E.1    Fassl, A.2    Campos, B.3    Farhadi, M.4    Kraemer, A.5    Bock, B.C.6
  • 180
    • 33645059697 scopus 로고    scopus 로고
    • The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death
    • Manero F., Gautier F., Gallenne T., Cauquil N., Gree D., Cartron P.F., et al. The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death. Cancer Res 2006, 66:2757-2764.
    • (2006) Cancer Res , vol.66 , pp. 2757-2764
    • Manero, F.1    Gautier, F.2    Gallenne, T.3    Cauquil, N.4    Gree, D.5    Cartron, P.F.6
  • 182
    • 33750112776 scopus 로고    scopus 로고
    • Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins
    • Wang G., Nikolovska-Coleska Z., Yang C.Y., Wang R., Tang G., Guo J., et al. Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J Med Chem 2006, 49:6139-6142.
    • (2006) J Med Chem , vol.49 , pp. 6139-6142
    • Wang, G.1    Nikolovska-Coleska, Z.2    Yang, C.Y.3    Wang, R.4    Tang, G.5    Guo, J.6
  • 185
    • 78650121259 scopus 로고    scopus 로고
    • Survivin knockdown and concurrent 4-HPR treatment controlled human glioblastoma in vitro and in vivo
    • George J., Banik N.L., Ray S.K. Survivin knockdown and concurrent 4-HPR treatment controlled human glioblastoma in vitro and in vivo. Neuro Oncol 2010, 12:1088-1101.
    • (2010) Neuro Oncol , vol.12 , pp. 1088-1101
    • George, J.1    Banik, N.L.2    Ray, S.K.3
  • 186
    • 38749131581 scopus 로고    scopus 로고
    • Combination of all-trans retinoic acid and paclitaxel-induced differentiation and apoptosis in human glioblastoma U87MG xenografts in nude mice
    • Karmakar S., Banik N.L., Ray S.K. Combination of all-trans retinoic acid and paclitaxel-induced differentiation and apoptosis in human glioblastoma U87MG xenografts in nude mice. Cancer 2008, 112:596-607.
    • (2008) Cancer , vol.112 , pp. 596-607
    • Karmakar, S.1    Banik, N.L.2    Ray, S.K.3
  • 187
    • 38649083441 scopus 로고    scopus 로고
    • Retinoids induced astrocytic differentiation with down regulation of telomerase activity and enhanced sensitivity to taxol for apoptosis in human glioblastoma T98G and U87MG cells
    • Das A., Banik N.L., Ray S.K. Retinoids induced astrocytic differentiation with down regulation of telomerase activity and enhanced sensitivity to taxol for apoptosis in human glioblastoma T98G and U87MG cells. J Neurooncol 2008, 87:9-22.
    • (2008) J Neurooncol , vol.87 , pp. 9-22
    • Das, A.1    Banik, N.L.2    Ray, S.K.3
  • 189
    • 48749114753 scopus 로고    scopus 로고
    • Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas
    • Joo K.M., Kim S.Y., Jin X., Song S.Y., Kong D.S., Lee J.I., et al. Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas. Lab Investig: J Techn Methods Pathol 2008, 88:808-815.
    • (2008) Lab Investig: J Techn Methods Pathol , vol.88 , pp. 808-815
    • Joo, K.M.1    Kim, S.Y.2    Jin, X.3    Song, S.Y.4    Kong, D.S.5    Lee, J.I.6
  • 190
    • 67650485853 scopus 로고    scopus 로고
    • Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma
    • Vellanki S.H., Grabrucker A., Liebau S., Proepper C., Eramo A., Braun V., et al. Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma. Neoplasia 2009, 11:743-752.
    • (2009) Neoplasia , vol.11 , pp. 743-752
    • Vellanki, S.H.1    Grabrucker, A.2    Liebau, S.3    Proepper, C.4    Eramo, A.5    Braun, V.6
  • 192
    • 20444491582 scopus 로고    scopus 로고
    • Differential expression of chemokines in synovial cells exposed to different Borrelia burgdorferi isolates
    • Singh S.K., Morbach H., Nanki T., Girschick H.J. Differential expression of chemokines in synovial cells exposed to different Borrelia burgdorferi isolates. Clin Exp Rheumatol 2005, 23:311-322.
    • (2005) Clin Exp Rheumatol , vol.23 , pp. 311-322
    • Singh, S.K.1    Morbach, H.2    Nanki, T.3    Girschick, H.J.4
  • 193
    • 0022407463 scopus 로고
    • Characterization of autostimulatory and transforming growth factors from human melanoma cells
    • Richmond A., Lawson D.H., Nixon D.W., Chawla R.K. Characterization of autostimulatory and transforming growth factors from human melanoma cells. Cancer Res 1985, 45:6390-6394.
    • (1985) Cancer Res , vol.45 , pp. 6390-6394
    • Richmond, A.1    Lawson, D.H.2    Nixon, D.W.3    Chawla, R.K.4
  • 194
    • 0033021558 scopus 로고    scopus 로고
    • The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice
    • Mrowietz U., Schwenk U., Maune S., Bartels J., Kupper M., Fichtner I., et al. The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice. Br J Cancer 1999, 79:1025-1031.
    • (1999) Br J Cancer , vol.79 , pp. 1025-1031
    • Mrowietz, U.1    Schwenk, U.2    Maune, S.3    Bartels, J.4    Kupper, M.5    Fichtner, I.6
  • 195
    • 0026500980 scopus 로고
    • Monocyte chemotactic cytokine gene transfer modulates macrophage infiltration, growth, and susceptibility to IL-2 therapy of a murine melanoma
    • Bottazzi B., Walter S., Govoni D., Colotta F., Mantovani A. Monocyte chemotactic cytokine gene transfer modulates macrophage infiltration, growth, and susceptibility to IL-2 therapy of a murine melanoma. J Immunol 1992, 148:1280-1285.
    • (1992) J Immunol , vol.148 , pp. 1280-1285
    • Bottazzi, B.1    Walter, S.2    Govoni, D.3    Colotta, F.4    Mantovani, A.5
  • 196
    • 15844379405 scopus 로고    scopus 로고
    • Exchanging interleukin-8 and melanoma growth-stimulating activity receptor binding specificities
    • Lowman H.B., Slagle P.H., DeForge L.E., Wirth C.M., Gillece-Castro B.L., Bourell J.H., et al. Exchanging interleukin-8 and melanoma growth-stimulating activity receptor binding specificities. J Biol Chem 1996, 271:14344-14352.
    • (1996) J Biol Chem , vol.271 , pp. 14344-14352
    • Lowman, H.B.1    Slagle, P.H.2    DeForge, L.E.3    Wirth, C.M.4    Gillece-Castro, B.L.5    Bourell, J.H.6
  • 197
    • 0035920230 scopus 로고    scopus 로고
    • Rel/NF-kappaB transcription factors protect against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by up-regulating the TRAIL decoy receptor DcR1
    • Bernard D., Quatannens B., Vandenbunder B., Abbadie C. Rel/NF-kappaB transcription factors protect against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by up-regulating the TRAIL decoy receptor DcR1. J Biol Chem 2001, 276:27322-27328.
    • (2001) J Biol Chem , vol.276 , pp. 27322-27328
    • Bernard, D.1    Quatannens, B.2    Vandenbunder, B.3    Abbadie, C.4
  • 198
    • 0035963273 scopus 로고    scopus 로고
    • Constitutive activation of nuclear factor-kappaB prevents TRAIL-induced apoptosis in renal cancer cells
    • Oya M., Ohtsubo M., Takayanagi A., Tachibana M., Shimizu N., Murai M. Constitutive activation of nuclear factor-kappaB prevents TRAIL-induced apoptosis in renal cancer cells. Oncogene 2001, 20:3888-3896.
    • (2001) Oncogene , vol.20 , pp. 3888-3896
    • Oya, M.1    Ohtsubo, M.2    Takayanagi, A.3    Tachibana, M.4    Shimizu, N.5    Murai, M.6
  • 199
    • 0029066512 scopus 로고
    • FAP-1: a protein tyrosine phosphatase that associates with Fas
    • Sato T., Irie S., Kitada S., Reed J.C. FAP-1: a protein tyrosine phosphatase that associates with Fas. Science 1995, 268:411-415.
    • (1995) Science , vol.268 , pp. 411-415
    • Sato, T.1    Irie, S.2    Kitada, S.3    Reed, J.C.4
  • 200
    • 0038302839 scopus 로고    scopus 로고
    • FAP-1 association with Fas (Apo-1) inhibits Fas expression on the cell surface
    • Ivanov V.N., Lopez B.P., Maulit G., Sato T.A., Sassoon D., Ronai Z. FAP-1 association with Fas (Apo-1) inhibits Fas expression on the cell surface. Mol Cell Biol 2003, 23:3623-3635.
    • (2003) Mol Cell Biol , vol.23 , pp. 3623-3635
    • Ivanov, V.N.1    Lopez, B.P.2    Maulit, G.3    Sato, T.A.4    Sassoon, D.5    Ronai, Z.6
  • 201
    • 0032522738 scopus 로고    scopus 로고
    • IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
    • Deveraux Q.L., Roy N., Stennicke H.R., Van A.T., Zhou Q., Srinivasula S.M., et al. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J 1998, 17:2215-2223.
    • (1998) EMBO J , vol.17 , pp. 2215-2223
    • Deveraux, Q.L.1    Roy, N.2    Stennicke, H.R.3    Van, A.T.4    Zhou, Q.5    Srinivasula, S.M.6
  • 202
    • 0030810926 scopus 로고    scopus 로고
    • X-linked IAP is a direct inhibitor of cell-death proteases
    • Deveraux Q.L., Takahashi R., Salvesen G.S., Reed J.C. X-linked IAP is a direct inhibitor of cell-death proteases. Nature 1997, 388:300-304.
    • (1997) Nature , vol.388 , pp. 300-304
    • Deveraux, Q.L.1    Takahashi, R.2    Salvesen, G.S.3    Reed, J.C.4
  • 203
    • 0035134989 scopus 로고    scopus 로고
    • Extra c-myc oncogene copies in high risk cutaneous malignant melanoma and melanoma metastases
    • Kraehn G.M., Utikal J., Udart M., Greulich K.M., Bezold G., Kaskel P., et al. Extra c-myc oncogene copies in high risk cutaneous malignant melanoma and melanoma metastases. Br J Cancer 2001, 84:72-79.
    • (2001) Br J Cancer , vol.84 , pp. 72-79
    • Kraehn, G.M.1    Utikal, J.2    Udart, M.3    Greulich, K.M.4    Bezold, G.5    Kaskel, P.6
  • 204
  • 207
    • 27244457769 scopus 로고    scopus 로고
    • Raf: a strategic target for therapeutic development against cancer
    • Beeram M., Patnaik A., Rowinsky E.K. Raf: a strategic target for therapeutic development against cancer. J Clin Oncol 2005, 23:6771-6790.
    • (2005) J Clin Oncol , vol.23 , pp. 6771-6790
    • Beeram, M.1    Patnaik, A.2    Rowinsky, E.K.3
  • 209
    • 33847220364 scopus 로고    scopus 로고
    • Melanoma biology and new targeted therapy
    • Gray-Schopfer V., Wellbrock C., Marais R. Melanoma biology and new targeted therapy. Nature 2007, 445:851-857.
    • (2007) Nature , vol.445 , pp. 851-857
    • Gray-Schopfer, V.1    Wellbrock, C.2    Marais, R.3
  • 211
    • 0344010691 scopus 로고    scopus 로고
    • Cancer robustness: tumour tactics
    • Kitano H. Cancer robustness: tumour tactics. Nature 2003, 426:125.
    • (2003) Nature , vol.426 , pp. 125
    • Kitano, H.1
  • 212
    • 78650507860 scopus 로고    scopus 로고
    • Pancreatic intraepithelial neoplasia - can we detect early pancreatic cancer
    • Haugk B. Pancreatic intraepithelial neoplasia - can we detect early pancreatic cancer. Histopathology 2010, 57:503-514.
    • (2010) Histopathology , vol.57 , pp. 503-514
    • Haugk, B.1
  • 213
    • 77954676046 scopus 로고    scopus 로고
    • Molecular mechanism of pancreatic cancer - understanding proliferation, invasion, and metastasis
    • Mihaljevic A.L., Michalski C.W., Friess H., Kleeff J. Molecular mechanism of pancreatic cancer - understanding proliferation, invasion, and metastasis. Langenbecks Arch Surg 2010, 395:295-308.
    • (2010) Langenbecks Arch Surg , vol.395 , pp. 295-308
    • Mihaljevic, A.L.1    Michalski, C.W.2    Friess, H.3    Kleeff, J.4
  • 217
    • 66149090396 scopus 로고    scopus 로고
    • TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway
    • Wang Z., Azmi A.S., Ahmad A., Banerjee S., Wang S., Sarkar F.H., et al. TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway. Cancer Res 2009, 69:2757-2765.
    • (2009) Cancer Res , vol.69 , pp. 2757-2765
    • Wang, Z.1    Azmi, A.S.2    Ahmad, A.3    Banerjee, S.4    Wang, S.5    Sarkar, F.H.6
  • 218
    • 0033913693 scopus 로고    scopus 로고
    • Altered mechanisms of apoptosis in colon cancer: Fas resistance and counterattack in the tumor-immune conflict
    • O'Connell J., Bennett M.W., Nally K., Houston A., O'Sullivan G.C., Shanahan F. Altered mechanisms of apoptosis in colon cancer: Fas resistance and counterattack in the tumor-immune conflict. Ann N Y Acad Sci 2000, 910:178-192.
    • (2000) Ann N Y Acad Sci , vol.910 , pp. 178-192
    • O'Connell, J.1    Bennett, M.W.2    Nally, K.3    Houston, A.4    O'Sullivan, G.C.5    Shanahan, F.6
  • 219
    • 84922121997 scopus 로고    scopus 로고
    • Understanding the mechanisms of androgen deprivation resistance in prostate cancer at the molecular level
    • Karantanos T., Evans C.P., Tombal B., Thompson T.C., Montironi R., Isaacs W.B. Understanding the mechanisms of androgen deprivation resistance in prostate cancer at the molecular level. Eur Urol 2015, 67:470-479.
    • (2015) Eur Urol , vol.67 , pp. 470-479
    • Karantanos, T.1    Evans, C.P.2    Tombal, B.3    Thompson, T.C.4    Montironi, R.5    Isaacs, W.B.6
  • 221
    • 0031922434 scopus 로고    scopus 로고
    • Relation between Bcl-2, cell proliferation, and the androgen receptor status in prostate tissue and precursors of prostate cancer
    • Bonkhoff H., Fixemer T., Remberger K. Relation between Bcl-2, cell proliferation, and the androgen receptor status in prostate tissue and precursors of prostate cancer. Prostate 1998, 34:251-258.
    • (1998) Prostate , vol.34 , pp. 251-258
    • Bonkhoff, H.1    Fixemer, T.2    Remberger, K.3
  • 222
    • 77953483885 scopus 로고    scopus 로고
    • MYC activity mitigates response to rapamycin in prostate cancer through 4EBP1-mediated inhibition of autophagy
    • Balakumaran B.S., Herbert J.T., Febbo P.G. MYC activity mitigates response to rapamycin in prostate cancer through 4EBP1-mediated inhibition of autophagy. Autophagy 2010, 6:281-282.
    • (2010) Autophagy , vol.6 , pp. 281-282
    • Balakumaran, B.S.1    Herbert, J.T.2    Febbo, P.G.3
  • 223
    • 70350230219 scopus 로고    scopus 로고
    • MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy
    • Balakumaran B.S., Porrello A., Hsu D.S., Glover W., Foye A., Leung J.Y., et al. MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy. Cancer Res 2009, 69:7803-7810.
    • (2009) Cancer Res , vol.69 , pp. 7803-7810
    • Balakumaran, B.S.1    Porrello, A.2    Hsu, D.S.3    Glover, W.4    Foye, A.5    Leung, J.Y.6
  • 224
    • 84895832199 scopus 로고    scopus 로고
    • Autophagy pathway is required for IL-6 induced neuroendocrine differentiation and chemoresistance of prostate cancer LNCaP cells
    • Chang P.C., Wang T.Y., Chang Y.T., Chu C.Y., Lee C.L., Hsu H.W., et al. Autophagy pathway is required for IL-6 induced neuroendocrine differentiation and chemoresistance of prostate cancer LNCaP cells. PLoS ONE 2014, 9:e88556.
    • (2014) PLoS ONE , vol.9 , pp. e88556
    • Chang, P.C.1    Wang, T.Y.2    Chang, Y.T.3    Chu, C.Y.4    Lee, C.L.5    Hsu, H.W.6
  • 225
    • 84875874119 scopus 로고    scopus 로고
    • Does androgen-ablation therapy (AAT) associated autophagy have a pro-survival effect in LNCaP human prostate cancer cells
    • Bennett H.L., Stockley J., Fleming J.T., Mandal R., O'Prey J., Ryan K.M., et al. Does androgen-ablation therapy (AAT) associated autophagy have a pro-survival effect in LNCaP human prostate cancer cells. BJU Int 2013, 111:672-682.
    • (2013) BJU Int , vol.111 , pp. 672-682
    • Bennett, H.L.1    Stockley, J.2    Fleming, J.T.3    Mandal, R.4    O'Prey, J.5    Ryan, K.M.6
  • 227
    • 84868088934 scopus 로고    scopus 로고
    • Autophagy modulators sensitize prostate epithelial cancer cell lines to TNF-alpha-dependent apoptosis
    • Giampietri C., Petrungaro S., Padula F., D'Alessio A., Marini E.S., Facchiano A., et al. Autophagy modulators sensitize prostate epithelial cancer cell lines to TNF-alpha-dependent apoptosis. Apoptosis 2012, 17:1210-1222.
    • (2012) Apoptosis , vol.17 , pp. 1210-1222
    • Giampietri, C.1    Petrungaro, S.2    Padula, F.3    D'Alessio, A.4    Marini, E.S.5    Facchiano, A.6
  • 228
    • 84885094823 scopus 로고    scopus 로고
    • ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases antimitotic-mediated apoptosis in human prostate cancer cells
    • Parrondo R., de Las P.A., Reiner T., Perez-Stable C. ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases antimitotic-mediated apoptosis in human prostate cancer cells. Peer J 2013, 1:e144.
    • (2013) Peer J , vol.1 , pp. e144
    • Parrondo, R.1    de Las, P.A.2    Reiner, T.3    Perez-Stable, C.4
  • 229
    • 77956424866 scopus 로고    scopus 로고
    • Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro
    • Zhang X.Q., Huang X.F., Hu X.B., Zhan Y.H., An Q.X., Yang S.M., et al. Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro. Asian J Androl 2010, 12:697-708.
    • (2010) Asian J Androl , vol.12 , pp. 697-708
    • Zhang, X.Q.1    Huang, X.F.2    Hu, X.B.3    Zhan, Y.H.4    An, Q.X.5    Yang, S.M.6
  • 230
    • 84865661651 scopus 로고    scopus 로고
    • Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xenograft models of prostate cancer
    • Jackson R.S., Placzek W., Fernandez A., Ziaee S., Chu C.Y., Wei J., et al. Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xenograft models of prostate cancer. Neoplasia 2012, 14:656-665.
    • (2012) Neoplasia , vol.14 , pp. 656-665
    • Jackson, R.S.1    Placzek, W.2    Fernandez, A.3    Ziaee, S.4    Chu, C.Y.5    Wei, J.6
  • 231
    • 79959828710 scopus 로고    scopus 로고
    • GDC-0941 sensitizes breast cancer to ABT-737 in vitro and in vivo through promoting the degradation of Mcl-1
    • Zheng L., Yang W., Zhang C., Ding W.J., Zhu H., Lin N.M., et al. GDC-0941 sensitizes breast cancer to ABT-737 in vitro and in vivo through promoting the degradation of Mcl-1. Cancer Lett 2011, 309:27-36.
    • (2011) Cancer Lett , vol.309 , pp. 27-36
    • Zheng, L.1    Yang, W.2    Zhang, C.3    Ding, W.J.4    Zhu, H.5    Lin, N.M.6
  • 232
    • 79960146856 scopus 로고    scopus 로고
    • Synergistic antitumor activity of gemcitabine and ABT-737 in vitro and in vivo through disrupting the interaction of USP9X and Mcl-1
    • Zhang C., Cai T.Y., Zhu H., Yang L.Q., Jiang H., Dong X.W., et al. Synergistic antitumor activity of gemcitabine and ABT-737 in vitro and in vivo through disrupting the interaction of USP9X and Mcl-1. Mol Cancer Ther 2011, 10:1264-1275.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1264-1275
    • Zhang, C.1    Cai, T.Y.2    Zhu, H.3    Yang, L.Q.4    Jiang, H.5    Dong, X.W.6
  • 233
    • 80051694782 scopus 로고    scopus 로고
    • TRAIL-mediated signaling in prostate, bladder and renal cancer
    • Voelkel-Johnson C. TRAIL-mediated signaling in prostate, bladder and renal cancer. Nat Rev Urol 2011, 8:417-427.
    • (2011) Nat Rev Urol , vol.8 , pp. 417-427
    • Voelkel-Johnson, C.1
  • 234
    • 84906216713 scopus 로고    scopus 로고
    • Upregulation of microRNA135a-3p and death receptor 5 plays a critical role in Tanshinone I sensitized prostate cancer cells to TRAIL induced apoptosis
    • Shin E.A., Sohn E.J., Won G., Choi J.U., Jeong M., Kim B., et al. Upregulation of microRNA135a-3p and death receptor 5 plays a critical role in Tanshinone I sensitized prostate cancer cells to TRAIL induced apoptosis. Oncotarget 2014, 5:5624-5636.
    • (2014) Oncotarget , vol.5 , pp. 5624-5636
    • Shin, E.A.1    Sohn, E.J.2    Won, G.3    Choi, J.U.4    Jeong, M.5    Kim, B.6
  • 235
    • 84906515599 scopus 로고    scopus 로고
    • Deconstructing breast cancer cell biology and the mechanisms of multidrug resistance
    • Videira M., Reis R.L., Brito M.A. Deconstructing breast cancer cell biology and the mechanisms of multidrug resistance. Biochim Biophys Acta 2014, 1846:312-325.
    • (2014) Biochim Biophys Acta , vol.1846 , pp. 312-325
    • Videira, M.1    Reis, R.L.2    Brito, M.A.3
  • 237
    • 79956113945 scopus 로고    scopus 로고
    • Epidermal growth factor regulates Mcl-1 expression through the MAPK-Elk-1 signalling pathway contributing to cell survival in breast cancer
    • Booy E.P., Henson E.S., Gibson S.B. Epidermal growth factor regulates Mcl-1 expression through the MAPK-Elk-1 signalling pathway contributing to cell survival in breast cancer. Oncogene 2011, 30:2367-2378.
    • (2011) Oncogene , vol.30 , pp. 2367-2378
    • Booy, E.P.1    Henson, E.S.2    Gibson, S.B.3
  • 238
    • 84857415191 scopus 로고    scopus 로고
    • Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737
    • Oakes S.R., Vaillant F., Lim E., Lee L., Breslin K., Feleppa F., et al. Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737. Proc Natl Acad Sci USA 2012, 109:2766-2771.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 2766-2771
    • Oakes, S.R.1    Vaillant, F.2    Lim, E.3    Lee, L.4    Breslin, K.5    Feleppa, F.6
  • 239
    • 79960607503 scopus 로고    scopus 로고
    • A pilot study to investigate the role of the 26S proteasome in radiotherapy resistance and loco-regional recurrence following breast conserving therapy for early breast cancer
    • Elfadl D., Hodgkinson V.C., Long E.D., Scaife L., Drew P.J., Lind M.J., et al. A pilot study to investigate the role of the 26S proteasome in radiotherapy resistance and loco-regional recurrence following breast conserving therapy for early breast cancer. Breast 2011, 20:334-337.
    • (2011) Breast , vol.20 , pp. 334-337
    • Elfadl, D.1    Hodgkinson, V.C.2    Long, E.D.3    Scaife, L.4    Drew, P.J.5    Lind, M.J.6
  • 240
    • 80054717405 scopus 로고    scopus 로고
    • Influence of proteasome inhibitor bortezomib on the expression of multidrug resistance genes and Akt kinase activity
    • Panischeva L.A., Kakpakova E.S., Rybalkina E.Y., Stavrovskaya A.A. Influence of proteasome inhibitor bortezomib on the expression of multidrug resistance genes and Akt kinase activity. Biochemistry (Mosc) 2011, 76:1009-1016.
    • (2011) Biochemistry (Mosc) , vol.76 , pp. 1009-1016
    • Panischeva, L.A.1    Kakpakova, E.S.2    Rybalkina, E.Y.3    Stavrovskaya, A.A.4
  • 241
    • 0029990349 scopus 로고    scopus 로고
    • B-chronic lymphocytic leukemia: a malignancy of anti-self B cells
    • Caligaris-Cappio F. B-chronic lymphocytic leukemia: a malignancy of anti-self B cells. Blood 1996, 87:2615-2620.
    • (1996) Blood , vol.87 , pp. 2615-2620
    • Caligaris-Cappio, F.1
  • 242
    • 77956646833 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia: a disease of activated monoclonal B cells
    • Damle R.N., Calissano C., Chiorazzi N. Chronic lymphocytic leukaemia: a disease of activated monoclonal B cells. Best Pract Res Clin Haematol 2010, 23:33-45.
    • (2010) Best Pract Res Clin Haematol , vol.23 , pp. 33-45
    • Damle, R.N.1    Calissano, C.2    Chiorazzi, N.3
  • 243
    • 20044372326 scopus 로고    scopus 로고
    • In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells
    • Messmer B.T., Messmer D., Allen S.L., Kolitz J.E., Kudalkar P., Cesar D., et al. In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J Clin Invest 2005, 115:755-764.
    • (2005) J Clin Invest , vol.115 , pp. 755-764
    • Messmer, B.T.1    Messmer, D.2    Allen, S.L.3    Kolitz, J.E.4    Kudalkar, P.5    Cesar, D.6
  • 244
    • 0032101593 scopus 로고    scopus 로고
    • Differential sensitivity of CD4+ and CD8+ T lymphocytes to the killing efficacy of Fas (Apo-1/CD95) ligand+ tumor cells in B chronic lymphocytic leukemia
    • Tinhofer I., Marschitz I., Kos M., Henn T., Egle A., Villunger A., et al. Differential sensitivity of CD4+ and CD8+ T lymphocytes to the killing efficacy of Fas (Apo-1/CD95) ligand+ tumor cells in B chronic lymphocytic leukemia. Blood 1998, 91:4273-4281.
    • (1998) Blood , vol.91 , pp. 4273-4281
    • Tinhofer, I.1    Marschitz, I.2    Kos, M.3    Henn, T.4    Egle, A.5    Villunger, A.6
  • 246
    • 0036716281 scopus 로고    scopus 로고
    • The Bcl2 family: regulators of the cellular life-or-death switch
    • Cory S., Adams J.M. The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2002, 2:647-656.
    • (2002) Nat Rev Cancer , vol.2 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 247
    • 77952952903 scopus 로고    scopus 로고
    • The role of Bcl-2 family proteins in chronic lymphocytic leukaemia
    • Buggins A.G., Pepper C.J. The role of Bcl-2 family proteins in chronic lymphocytic leukaemia. Leuk Res 2010, 34:837-842.
    • (2010) Leuk Res , vol.34 , pp. 837-842
    • Buggins, A.G.1    Pepper, C.J.2
  • 248
    • 0030752756 scopus 로고    scopus 로고
    • Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance
    • Pepper C., Hoy T., Bentley D.P. Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance. Br J Cancer 1997, 76:935-938.
    • (1997) Br J Cancer , vol.76 , pp. 935-938
    • Pepper, C.1    Hoy, T.2    Bentley, D.P.3
  • 249
    • 0029871942 scopus 로고    scopus 로고
    • Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome
    • Robertson L.E., Plunkett W., McConnell K., Keating M.J., McDonnell T.J. Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome. Leukemia 1996, 10:456-459.
    • (1996) Leukemia , vol.10 , pp. 456-459
    • Robertson, L.E.1    Plunkett, W.2    McConnell, K.3    Keating, M.J.4    McDonnell, T.J.5
  • 250
    • 55749105701 scopus 로고    scopus 로고
    • Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers
    • Pepper C., Lin T.T., Pratt G., Hewamana S., Brennan P., Hiller L., et al. Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers. Blood 2008, 112:3807-3817.
    • (2008) Blood , vol.112 , pp. 3807-3817
    • Pepper, C.1    Lin, T.T.2    Pratt, G.3    Hewamana, S.4    Brennan, P.5    Hiller, L.6
  • 251
    • 60249088881 scopus 로고    scopus 로고
    • Mcl-1 expression predicts progression-free survival in chronic lymphocytic leukemia patients treated with pentostatin, cyclophosphamide, and rituximab
    • Awan F.T., Kay N.E., Davis M.E., Wu W., Geyer S.M., Leung N., et al. Mcl-1 expression predicts progression-free survival in chronic lymphocytic leukemia patients treated with pentostatin, cyclophosphamide, and rituximab. Blood 2009, 113:535-537.
    • (2009) Blood , vol.113 , pp. 535-537
    • Awan, F.T.1    Kay, N.E.2    Davis, M.E.3    Wu, W.4    Geyer, S.M.5    Leung, N.6
  • 252
    • 45149111564 scopus 로고    scopus 로고
    • Low MCL-1 mRNA expression correlates with prolonged survival in B-cell chronic lymphocytic leukemia
    • Veronese L., Tournilhac O., Verrelle P., Davi F., Dighiero G., Chautard E., et al. Low MCL-1 mRNA expression correlates with prolonged survival in B-cell chronic lymphocytic leukemia. Leukemia 2008, 22:1291-1293.
    • (2008) Leukemia , vol.22 , pp. 1291-1293
    • Veronese, L.1    Tournilhac, O.2    Verrelle, P.3    Davi, F.4    Dighiero, G.5    Chautard, E.6
  • 253
    • 58149378361 scopus 로고    scopus 로고
    • C-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches
    • Hallaert D.Y., Jaspers A., van Noesel C.J., van Oers M.H., Kater A.P., Eldering E. c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches. Blood 2008, 112:5141-5149.
    • (2008) Blood , vol.112 , pp. 5141-5149
    • Hallaert, D.Y.1    Jaspers, A.2    van Noesel, C.J.3    van Oers, M.H.4    Kater, A.P.5    Eldering, E.6
  • 254
    • 33846944718 scopus 로고    scopus 로고
    • Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity
    • Smit L.A., Hallaert D.Y., Spijker R., de G.B., Jaspers A., Kater A.P., et al. Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity. Blood 2007, 109:1660-1668.
    • (2007) Blood , vol.109 , pp. 1660-1668
    • Smit, L.A.1    Hallaert, D.Y.2    Spijker, R.3    de, G.B.4    Jaspers, A.5    Kater, A.P.6
  • 255
    • 38349107623 scopus 로고    scopus 로고
    • The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells
    • Longo P.G., Laurenti L., Gobessi S., Sica S., Leone G., Efremov D.G. The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells. Blood 2008, 111:846-855.
    • (2008) Blood , vol.111 , pp. 846-855
    • Longo, P.G.1    Laurenti, L.2    Gobessi, S.3    Sica, S.4    Leone, G.5    Efremov, D.G.6
  • 256
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997, 91:231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6
  • 257
    • 33644865025 scopus 로고    scopus 로고
    • Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function
    • Qi X.J., Wildey G.M., Howe P.H. Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function. J Biol Chem 2006, 281:813-823.
    • (2006) J Biol Chem , vol.281 , pp. 813-823
    • Qi, X.J.1    Wildey, G.M.2    Howe, P.H.3
  • 258
    • 79954438975 scopus 로고    scopus 로고
    • The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia
    • Durig J., Duhrsen U., Klein-Hitpass L., Worm J., Hansen J.B., Orum H., et al. The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia. Leukemia 2011, 25:638-647.
    • (2011) Leukemia , vol.25 , pp. 638-647
    • Durig, J.1    Duhrsen, U.2    Klein-Hitpass, L.3    Worm, J.4    Hansen, J.B.5    Orum, H.6
  • 259
    • 84865861478 scopus 로고    scopus 로고
    • Design of novel BH3 mimetics for the treatment of chronic lymphocytic leukemia
    • Billard C. Design of novel BH3 mimetics for the treatment of chronic lymphocytic leukemia. Leukemia 2012, 26:2032-2038.
    • (2012) Leukemia , vol.26 , pp. 2032-2038
    • Billard, C.1
  • 260
    • 78650006103 scopus 로고    scopus 로고
    • MicroRNA in chronic lymphocytic leukemia: transitioning from laboratory-based investigation to clinical application
    • Nana-Sinkam S.P., Croce C.M. MicroRNA in chronic lymphocytic leukemia: transitioning from laboratory-based investigation to clinical application. Cancer Genet Cytogenet 2010, 203:127-133.
    • (2010) Cancer Genet Cytogenet , vol.203 , pp. 127-133
    • Nana-Sinkam, S.P.1    Croce, C.M.2
  • 261
    • 77956627474 scopus 로고    scopus 로고
    • Therapy of chronic lymphocytic leukaemia
    • Hallek M. Therapy of chronic lymphocytic leukaemia. Best Pract Res Clin Haematol 2010, 23:85-96.
    • (2010) Best Pract Res Clin Haematol , vol.23 , pp. 85-96
    • Hallek, M.1
  • 262
    • 40749132494 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia
    • Dighiero G., Hamblin T.J. Chronic lymphocytic leukaemia. Lancet 2008, 371:1017-1029.
    • (2008) Lancet , vol.371 , pp. 1017-1029
    • Dighiero, G.1    Hamblin, T.J.2
  • 263
    • 82555169679 scopus 로고    scopus 로고
    • Fludarabine plus alemtuzumab versus fludarabine alone in patients with previously treated chronic lymphocytic leukaemia: a randomised phase 3 trial
    • Elter T., Gercheva-Kyuchukova L., Pylylpenko H., Robak T., Jaksic B., Rekhtman G., et al. Fludarabine plus alemtuzumab versus fludarabine alone in patients with previously treated chronic lymphocytic leukaemia: a randomised phase 3 trial. Lancet Oncol 2011, 12:1204-1213.
    • (2011) Lancet Oncol , vol.12 , pp. 1204-1213
    • Elter, T.1    Gercheva-Kyuchukova, L.2    Pylylpenko, H.3    Robak, T.4    Jaksic, B.5    Rekhtman, G.6
  • 264
    • 78651251536 scopus 로고    scopus 로고
    • Novel agents for the treatment of chronic lymphocytic leukemia
    • bou-Nassar K., Brown J.R. Novel agents for the treatment of chronic lymphocytic leukemia. Clin Adv Hematol Oncol 2010, 8:886-895.
    • (2010) Clin Adv Hematol Oncol , vol.8 , pp. 886-895
    • bou-Nassar, K.1    Brown, J.R.2
  • 265
    • 52649179285 scopus 로고    scopus 로고
    • Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells
    • Balakrishnan K., Wierda W.G., Keating M.J., Gandhi V. Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells. Blood 2008, 112:1971-1980.
    • (2008) Blood , vol.112 , pp. 1971-1980
    • Balakrishnan, K.1    Wierda, W.G.2    Keating, M.J.3    Gandhi, V.4
  • 266
    • 59449095496 scopus 로고    scopus 로고
    • AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance
    • Balakrishnan K., Burger J.A., Wierda W.G., Gandhi V. AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Blood 2009, 113:149-153.
    • (2009) Blood , vol.113 , pp. 149-153
    • Balakrishnan, K.1    Burger, J.A.2    Wierda, W.G.3    Gandhi, V.4
  • 267
    • 56149092147 scopus 로고    scopus 로고
    • Regulation of antiapoptotic MCL-1 function by gossypol: mechanistic insights from in vitro reconstituted systems
    • Etxebarria A., Landeta O., Antonsson B., Basanez G. Regulation of antiapoptotic MCL-1 function by gossypol: mechanistic insights from in vitro reconstituted systems. Biochem Pharmacol 2008, 76:1563-1576.
    • (2008) Biochem Pharmacol , vol.76 , pp. 1563-1576
    • Etxebarria, A.1    Landeta, O.2    Antonsson, B.3    Basanez, G.4
  • 268
    • 79952096877 scopus 로고    scopus 로고
    • Phytochemicals in cancer prevention and therapy: truth or dare?
    • Russo M., Spagnuolo C., Tedesco I., Russo G.L. Phytochemicals in cancer prevention and therapy: truth or dare?. Toxins (Basel) 2010, 2:517-551.
    • (2010) Toxins (Basel) , vol.2 , pp. 517-551
    • Russo, M.1    Spagnuolo, C.2    Tedesco, I.3    Russo, G.L.4
  • 269
    • 0031570776 scopus 로고    scopus 로고
    • Altered sensitivity to retinoid-induced apoptosis associated with changes in the subcellular distribution of Bcl-2
    • Bruel A., Karsenty E., Schmid M., McDonnell T.J., Lanotte M. Altered sensitivity to retinoid-induced apoptosis associated with changes in the subcellular distribution of Bcl-2. Exp Cell Res 1997, 233:281-287.
    • (1997) Exp Cell Res , vol.233 , pp. 281-287
    • Bruel, A.1    Karsenty, E.2    Schmid, M.3    McDonnell, T.J.4    Lanotte, M.5
  • 271
    • 43049176634 scopus 로고    scopus 로고
    • Health effects of quercetin: from antioxidant to nutraceutical
    • Boots A.W., Haenen G.R., Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 2008, 585:325-337.
    • (2008) Eur J Pharmacol , vol.585 , pp. 325-337
    • Boots, A.W.1    Haenen, G.R.2    Bast, A.3
  • 272
    • 84892369382 scopus 로고    scopus 로고
    • How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo
    • Forman H.J., Davies K.J., Ursini F. How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo. Free Radic Biol Med 2014, 66:24-35.
    • (2014) Free Radic Biol Med , vol.66 , pp. 24-35
    • Forman, H.J.1    Davies, K.J.2    Ursini, F.3
  • 273
    • 84906509849 scopus 로고    scopus 로고
    • Hydroxychavicol, a betel leaf component, inhibits prostate cancer through ROS-driven DNA damage and apoptosis
    • Gundala S.R., Yang C., Mukkavilli R., Paranjpe R., Brahmbhatt M., Pannu V., et al. Hydroxychavicol, a betel leaf component, inhibits prostate cancer through ROS-driven DNA damage and apoptosis. Toxicol Appl Pharmacol 2014, 280:86-96.
    • (2014) Toxicol Appl Pharmacol , vol.280 , pp. 86-96
    • Gundala, S.R.1    Yang, C.2    Mukkavilli, R.3    Paranjpe, R.4    Brahmbhatt, M.5    Pannu, V.6
  • 274
    • 80555129638 scopus 로고    scopus 로고
    • Grape proanthocyanidins induce apoptosis by loss of mitochondrial membrane potential of human non-small cell lung cancer cells in vitro and in vivo
    • Singh T., Sharma S.D., Katiyar S.K. Grape proanthocyanidins induce apoptosis by loss of mitochondrial membrane potential of human non-small cell lung cancer cells in vitro and in vivo. PLoS ONE 2011, 6:e27444.
    • (2011) PLoS ONE , vol.6 , pp. e27444
    • Singh, T.1    Sharma, S.D.2    Katiyar, S.K.3
  • 275
    • 84882575961 scopus 로고    scopus 로고
    • Targeting the ubiquitin-proteasome system for cancer therapy
    • Shen M., Schmitt S., Buac D., Dou Q.P. Targeting the ubiquitin-proteasome system for cancer therapy. Expert Opin Ther Targets 2013, 17:1091-1108.
    • (2013) Expert Opin Ther Targets , vol.17 , pp. 1091-1108
    • Shen, M.1    Schmitt, S.2    Buac, D.3    Dou, Q.P.4
  • 276
    • 84994535439 scopus 로고    scopus 로고
    • Prostate Cancer Chemoprevention Targeting Men with High-Grade Prostatic Intraepithelial Neoplasia (HGPIN) and Atypical Small Acinar Proliferation (ASAP): Model for Trial Design and Outcome Measures
    • Kumar N., Crocker T., Smith T., Connors S., Pow-Sang J., Spiess P.E., et al. Prostate Cancer Chemoprevention Targeting Men with High-Grade Prostatic Intraepithelial Neoplasia (HGPIN) and Atypical Small Acinar Proliferation (ASAP): Model for Trial Design and Outcome Measures. J Clin Trials 2012, 2.
    • (2012) J Clin Trials , pp. 2
    • Kumar, N.1    Crocker, T.2    Smith, T.3    Connors, S.4    Pow-Sang, J.5    Spiess, P.E.6
  • 277
    • 0035918278 scopus 로고    scopus 로고
    • Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo
    • Nam S., Smith D.M., Dou Q.P. Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo. J Biol Chem 2001, 276:13322-13330.
    • (2001) J Biol Chem , vol.276 , pp. 13322-13330
    • Nam, S.1    Smith, D.M.2    Dou, Q.P.3
  • 279
    • 2442541377 scopus 로고    scopus 로고
    • Structure-activity relationships of synthetic analogs of (-)-epigallocatechin-3-gallate as proteasome inhibitors
    • Kazi A., Wang Z., Kumar N., Falsetti S.C., Chan T.H., Dou Q.P. Structure-activity relationships of synthetic analogs of (-)-epigallocatechin-3-gallate as proteasome inhibitors. Anticancer Res 2004, 24:943-954.
    • (2004) Anticancer Res , vol.24 , pp. 943-954
    • Kazi, A.1    Wang, Z.2    Kumar, N.3    Falsetti, S.C.4    Chan, T.H.5    Dou, Q.P.6
  • 280
    • 0036428820 scopus 로고    scopus 로고
    • Synthetic analogs of green tea polyphenols as proteasome inhibitors
    • Smith D.M., Wang Z., Kazi A., Li L.H., Chan T.H., Dou Q.P. Synthetic analogs of green tea polyphenols as proteasome inhibitors. Mol Med 2002, 8:382-392.
    • (2002) Mol Med , vol.8 , pp. 382-392
    • Smith, D.M.1    Wang, Z.2    Kazi, A.3    Li, L.H.4    Chan, T.H.5    Dou, Q.P.6
  • 281
    • 0038000122 scopus 로고    scopus 로고
    • Molecular targets for green tea in prostate cancer prevention
    • 2417S-24S
    • Adhami V.M., Ahmad N., Mukhtar H. Molecular targets for green tea in prostate cancer prevention. J Nutr 2003, 133. 2417S-24S.
    • (2003) J Nutr , vol.133
    • Adhami, V.M.1    Ahmad, N.2    Mukhtar, H.3
  • 282
    • 0030930265 scopus 로고    scopus 로고
    • Suppression of extracellular signals and cell proliferation through EGF receptor binding by (-)-epigallocatechin gallate in human A431 epidermoid carcinoma cells
    • Liang Y.C., Lin-Shiau S.Y., Chen C.F., Lin J.K. Suppression of extracellular signals and cell proliferation through EGF receptor binding by (-)-epigallocatechin gallate in human A431 epidermoid carcinoma cells. J Cell Biochem 1997, 67:55-65.
    • (1997) J Cell Biochem , vol.67 , pp. 55-65
    • Liang, Y.C.1    Lin-Shiau, S.Y.2    Chen, C.F.3    Lin, J.K.4
  • 283
    • 0033568515 scopus 로고    scopus 로고
    • Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved
    • Chung J.Y., Huang C., Meng X., Dong Z., Yang C.S. Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved. Cancer Res 1999, 59:4610-4617.
    • (1999) Cancer Res , vol.59 , pp. 4610-4617
    • Chung, J.Y.1    Huang, C.2    Meng, X.3    Dong, Z.4    Yang, C.S.5
  • 284
    • 0033213758 scopus 로고    scopus 로고
    • Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of Cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (-)-epigallocatechin-3-gallate
    • Liang Y.C., Lin-Shiau S.Y., Chen C.F., Lin J.K. Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of Cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (-)-epigallocatechin-3-gallate. J Cell Biochem 1999, 75:1-12.
    • (1999) J Cell Biochem , vol.75 , pp. 1-12
    • Liang, Y.C.1    Lin-Shiau, S.Y.2    Chen, C.F.3    Lin, J.K.4
  • 285
    • 33947404063 scopus 로고    scopus 로고
    • Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo
    • Adhami V.M., Malik A., Zaman N., Sarfaraz S., Siddiqui I.A., Syed D.N., et al. Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo. Clin Cancer Res 2007, 13:1611-1619.
    • (2007) Clin Cancer Res , vol.13 , pp. 1611-1619
    • Adhami, V.M.1    Malik, A.2    Zaman, N.3    Sarfaraz, S.4    Siddiqui, I.A.5    Syed, D.N.6
  • 286
    • 0042261670 scopus 로고    scopus 로고
    • Inhibition of the proteasome activity, a novel mechanism associated with the tumor cell apoptosis-inducing ability of genistein
    • Kazi A., Daniel K.G., Smith D.M., Kumar N.B., Dou Q.P. Inhibition of the proteasome activity, a novel mechanism associated with the tumor cell apoptosis-inducing ability of genistein. Biochem Pharmacol 2003, 66:965-976.
    • (2003) Biochem Pharmacol , vol.66 , pp. 965-976
    • Kazi, A.1    Daniel, K.G.2    Smith, D.M.3    Kumar, N.B.4    Dou, Q.P.5
  • 287
    • 84961972020 scopus 로고    scopus 로고
    • Molecular targeted therapies using botanicals for prostate cancer chemoprevention
    • Kumar N., Chornokur G. Molecular targeted therapies using botanicals for prostate cancer chemoprevention. Transl Med (Sunnyvale) 2012, (Suppl. 2):005.
    • (2012) Transl Med (Sunnyvale) , pp. 005
    • Kumar, N.1    Chornokur, G.2
  • 288
    • 84872058507 scopus 로고    scopus 로고
    • Phase 2 trial of daily, oral Polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia
    • Shanafelt T.D., Call T.G., Zent C.S., Leis J.F., LaPlant B., Bowen D.A., et al. Phase 2 trial of daily, oral Polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia. Cancer 2013, 119:363-370.
    • (2013) Cancer , vol.119 , pp. 363-370
    • Shanafelt, T.D.1    Call, T.G.2    Zent, C.S.3    Leis, J.F.4    LaPlant, B.5    Bowen, D.A.6
  • 289
    • 68949110352 scopus 로고    scopus 로고
    • Phase I trial of daily oral Polyphenon E in patients with asymptomatic Rai stage 0 to II chronic lymphocytic leukemia
    • Shanafelt T.D., Call T.G., Zent C.S., LaPlant B., Bowen D.A., Roos M., et al. Phase I trial of daily oral Polyphenon E in patients with asymptomatic Rai stage 0 to II chronic lymphocytic leukemia. J Clin Oncol 2009, 27:3808-3814.
    • (2009) J Clin Oncol , vol.27 , pp. 3808-3814
    • Shanafelt, T.D.1    Call, T.G.2    Zent, C.S.3    LaPlant, B.4    Bowen, D.A.5    Roos, M.6
  • 290
    • 73349096649 scopus 로고    scopus 로고
    • Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease
    • Lin T.S., Ruppert A.S., Johnson A.J., Fischer B., Heerema N.A., Andritsos L.A., et al. Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease. J Clin Oncol 2009, 27:6012-6018.
    • (2009) J Clin Oncol , vol.27 , pp. 6012-6018
    • Lin, T.S.1    Ruppert, A.S.2    Johnson, A.J.3    Fischer, B.4    Heerema, N.A.5    Andritsos, L.A.6
  • 291
    • 63849246351 scopus 로고    scopus 로고
    • Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia
    • Phelps M.A., Lin T.S., Johnson A.J., Hurh E., Rozewski D.M., Farley K.L., et al. Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia. Blood 2009, 113:2637-2645.
    • (2009) Blood , vol.113 , pp. 2637-2645
    • Phelps, M.A.1    Lin, T.S.2    Johnson, A.J.3    Hurh, E.4    Rozewski, D.M.5    Farley, K.L.6
  • 292
    • 33845473093 scopus 로고    scopus 로고
    • Acute liver failure induced by green tea extracts: case report and review of the literature
    • Molinari M., Watt K.D., Kruszyna T., Nelson R., Walsh M., Huang W.Y., et al. Acute liver failure induced by green tea extracts: case report and review of the literature. Liver Transpl 2006, 12:1892-1895.
    • (2006) Liver Transpl , vol.12 , pp. 1892-1895
    • Molinari, M.1    Watt, K.D.2    Kruszyna, T.3    Nelson, R.4    Walsh, M.5    Huang, W.Y.6
  • 293
    • 0345275780 scopus 로고    scopus 로고
    • Liver toxicity of Camellia sinensis dried etanolic extract
    • Pedros C., Cereza G., Garcia N., Laporte J.R. Liver toxicity of Camellia sinensis dried etanolic extract. Med Clin (Barc) 2003, 121:598-599.
    • (2003) Med Clin (Barc) , vol.121 , pp. 598-599
    • Pedros, C.1    Cereza, G.2    Garcia, N.3    Laporte, J.R.4
  • 295
    • 3442882798 scopus 로고    scopus 로고
    • Bortezomib as a potential treatment for prostate cancer
    • Papandreou C.N., Logothetis C.J. Bortezomib as a potential treatment for prostate cancer. Cancer Res 2004, 64:5036-5043.
    • (2004) Cancer Res , vol.64 , pp. 5036-5043
    • Papandreou, C.N.1    Logothetis, C.J.2
  • 296
    • 2642551603 scopus 로고    scopus 로고
    • Development of the proteasome inhibitor Velcade (Bortezomib)
    • Adams J., Kauffman M. Development of the proteasome inhibitor Velcade (Bortezomib). Cancer Invest 2004, 22:304-311.
    • (2004) Cancer Invest , vol.22 , pp. 304-311
    • Adams, J.1    Kauffman, M.2
  • 297
    • 0042334847 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals
    • Chow H.H., Cai Y., Hakim I.A., Crowell J.A., Shahi F., Brooks C.A., et al. Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. Clin Cancer Res 2003, 9:3312-3319.
    • (2003) Clin Cancer Res , vol.9 , pp. 3312-3319
    • Chow, H.H.1    Cai, Y.2    Hakim, I.A.3    Crowell, J.A.4    Shahi, F.5    Brooks, C.A.6
  • 298
    • 65249101693 scopus 로고    scopus 로고
    • Homology modeling and docking analysis of the interaction between polyphenols and mammalian 20S proteasomes
    • Mozzicafreddo M., Cuccioloni M., Cecarini V., Eleuteri A.M., Angeletti M. Homology modeling and docking analysis of the interaction between polyphenols and mammalian 20S proteasomes. J Chem Inf Model 2009, 49:401-409.
    • (2009) J Chem Inf Model , vol.49 , pp. 401-409
    • Mozzicafreddo, M.1    Cuccioloni, M.2    Cecarini, V.3    Eleuteri, A.M.4    Angeletti, M.5
  • 299
    • 4344602767 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein function by tea catechins in KB-C2 cells
    • Kitagawa S., Nabekura T., Kamiyama S. Inhibition of P-glycoprotein function by tea catechins in KB-C2 cells. J Pharm Pharmacol 2004, 56:1001-1005.
    • (2004) J Pharm Pharmacol , vol.56 , pp. 1001-1005
    • Kitagawa, S.1    Nabekura, T.2    Kamiyama, S.3
  • 300
    • 0037196568 scopus 로고    scopus 로고
    • Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols
    • Jodoin J., Demeule M., Beliveau R. Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols. Biochim Biophys Acta 2002, 1542:149-159.
    • (2002) Biochim Biophys Acta , vol.1542 , pp. 149-159
    • Jodoin, J.1    Demeule, M.2    Beliveau, R.3
  • 301
    • 76749101143 scopus 로고    scopus 로고
    • (-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line
    • Farabegoli F., Papi A., Bartolini G., Ostan R., Orlandi M. (-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line. Phytomedicine 2010, 17:356-362.
    • (2010) Phytomedicine , vol.17 , pp. 356-362
    • Farabegoli, F.1    Papi, A.2    Bartolini, G.3    Ostan, R.4    Orlandi, M.5
  • 302
    • 5644297293 scopus 로고    scopus 로고
    • Reversal of cancer multidrug resistance by green tea polyphenols
    • Mei Y., Qian F., Wei D., Liu J. Reversal of cancer multidrug resistance by green tea polyphenols. J Pharm Pharmacol 2004, 56:1307-1314.
    • (2004) J Pharm Pharmacol , vol.56 , pp. 1307-1314
    • Mei, Y.1    Qian, F.2    Wei, D.3    Liu, J.4
  • 303
    • 77953188130 scopus 로고    scopus 로고
    • Green tea catechins augment the antitumor activity of doxorubicin in an in vivo mouse model for chemoresistant liver cancer
    • Liang G., Tang A., Lin X., Li L., Zhang S., Huang Z., et al. Green tea catechins augment the antitumor activity of doxorubicin in an in vivo mouse model for chemoresistant liver cancer. Int J Oncol 2010, 37:111-123.
    • (2010) Int J Oncol , vol.37 , pp. 111-123
    • Liang, G.1    Tang, A.2    Lin, X.3    Li, L.4    Zhang, S.5    Huang, Z.6
  • 304
    • 79951577565 scopus 로고    scopus 로고
    • Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models
    • Chen T.C., Wang W., Golden E.B., Thomas S., Sivakumar W., Hofman F.M., et al. Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models. Cancer Lett 2011, 302:100-108.
    • (2011) Cancer Lett , vol.302 , pp. 100-108
    • Chen, T.C.1    Wang, W.2    Golden, E.B.3    Thomas, S.4    Sivakumar, W.5    Hofman, F.M.6
  • 305
    • 78650217504 scopus 로고    scopus 로고
    • Combination therapy with epigallocatechin-3-gallate and doxorubicin in human prostate tumor modeling studies: inhibition of metastatic tumor growth in severe combined immunodeficiency mice
    • Stearns M.E., Amatangelo M.D., Varma D., Sell C., Goodyear S.M. Combination therapy with epigallocatechin-3-gallate and doxorubicin in human prostate tumor modeling studies: inhibition of metastatic tumor growth in severe combined immunodeficiency mice. Am J Pathol 2010, 177:3169-3179.
    • (2010) Am J Pathol , vol.177 , pp. 3169-3179
    • Stearns, M.E.1    Amatangelo, M.D.2    Varma, D.3    Sell, C.4    Goodyear, S.M.5
  • 306
    • 77956038678 scopus 로고    scopus 로고
    • (-)-Epigallocatechin gallate sensitizes breast cancer cells to paclitaxel in a murine model of breast carcinoma
    • Luo T., Wang J., Yin Y., Hua H., Jing J., Sun X., et al. (-)-Epigallocatechin gallate sensitizes breast cancer cells to paclitaxel in a murine model of breast carcinoma. Breast Cancer Res 2010, 12:R8.
    • (2010) Breast Cancer Res , vol.12 , pp. R8
    • Luo, T.1    Wang, J.2    Yin, Y.3    Hua, H.4    Jing, J.5    Sun, X.6
  • 307
    • 76949108486 scopus 로고    scopus 로고
    • Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells
    • Davenport A., Frezza M., Shen M., Ge Y., Huo C., Chan T.H., et al. Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells. Int J Mol Med 2010, 25:465-470.
    • (2010) Int J Mol Med , vol.25 , pp. 465-470
    • Davenport, A.1    Frezza, M.2    Shen, M.3    Ge, Y.4    Huo, C.5    Chan, T.H.6
  • 308
    • 84857096093 scopus 로고    scopus 로고
    • Enhancement of cancer chemosensitization potential of cisplatin by tea polyphenols poly(lactide-co-glycolide) nanoparticles
    • Singh M., Bhatnagar P., Srivastava A.K., Kumar P., Shukla Y., Gupta K.C. Enhancement of cancer chemosensitization potential of cisplatin by tea polyphenols poly(lactide-co-glycolide) nanoparticles. J Biomed Nanotechnol 2011, 7:202.
    • (2011) J Biomed Nanotechnol , vol.7 , pp. 202
    • Singh, M.1    Bhatnagar, P.2    Srivastava, A.K.3    Kumar, P.4    Shukla, Y.5    Gupta, K.C.6
  • 310
    • 0037443797 scopus 로고    scopus 로고
    • A phase II trial of green tea in the treatment of patients with androgen independent metastatic prostate carcinoma
    • Jatoi A., Ellison N., Burch P.A., Sloan J.A., Dakhil S.R., Novotny P., et al. A phase II trial of green tea in the treatment of patients with androgen independent metastatic prostate carcinoma. Cancer 2003, 97:1442-1446.
    • (2003) Cancer , vol.97 , pp. 1442-1446
    • Jatoi, A.1    Ellison, N.2    Burch, P.A.3    Sloan, J.A.4    Dakhil, S.R.5    Novotny, P.6
  • 311
    • 18144410567 scopus 로고    scopus 로고
    • A prospective clinical trial of green tea for hormone refractory prostate cancer: an evaluation of the complementary/alternative therapy approach
    • Choan E., Segal R., Jonker D., Malone S., Reaume N., Eapen L., et al. A prospective clinical trial of green tea for hormone refractory prostate cancer: an evaluation of the complementary/alternative therapy approach. Urol Oncol 2005, 23:108-113.
    • (2005) Urol Oncol , vol.23 , pp. 108-113
    • Choan, E.1    Segal, R.2    Jonker, D.3    Malone, S.4    Reaume, N.5    Eapen, L.6
  • 312
    • 84917744524 scopus 로고    scopus 로고
    • Resveratrol augments paclitaxel treatment in MDA-MB-231 and paclitaxel-resistant MDA-MB-231 breast cancer cells
    • Sprouse A.A., Herbert B.S. Resveratrol augments paclitaxel treatment in MDA-MB-231 and paclitaxel-resistant MDA-MB-231 breast cancer cells. Anticancer Res 2014, 34:5363-5374.
    • (2014) Anticancer Res , vol.34 , pp. 5363-5374
    • Sprouse, A.A.1    Herbert, B.S.2
  • 313
    • 84897026499 scopus 로고    scopus 로고
    • Combinations of platinums and selected phytochemicals as a means of overcoming resistance in ovarian cancer
    • Huq F., Yu J.Q., Beale P., Chan C., Arzuman L., Nessa M.U., et al. Combinations of platinums and selected phytochemicals as a means of overcoming resistance in ovarian cancer. Anticancer Res 2014, 34:541-545.
    • (2014) Anticancer Res , vol.34 , pp. 541-545
    • Huq, F.1    Yu, J.Q.2    Beale, P.3    Chan, C.4    Arzuman, L.5    Nessa, M.U.6
  • 314
    • 84894464496 scopus 로고    scopus 로고
    • Resveratrol induced ER expansion and ER caspase-mediated apoptosis in human nasopharyngeal carcinoma cells
    • Chow S.E., Kao C.H., Liu Y.T., Cheng M.L., Yang Y.W., Huang Y.K., et al. Resveratrol induced ER expansion and ER caspase-mediated apoptosis in human nasopharyngeal carcinoma cells. Apoptosis 2014, 19:527-541.
    • (2014) Apoptosis , vol.19 , pp. 527-541
    • Chow, S.E.1    Kao, C.H.2    Liu, Y.T.3    Cheng, M.L.4    Yang, Y.W.5    Huang, Y.K.6
  • 315
    • 84881062200 scopus 로고    scopus 로고
    • Resveratrol sensitizes tamoxifen in antiestrogen-resistant breast cancer cells with epithelial-mesenchymal transition features
    • Shi X.P., Miao S., Wu Y., Zhang W., Zhang X.F., Ma H.Z., et al. Resveratrol sensitizes tamoxifen in antiestrogen-resistant breast cancer cells with epithelial-mesenchymal transition features. Int J Mol Sci 2013, 14:15655-15668.
    • (2013) Int J Mol Sci , vol.14 , pp. 15655-15668
    • Shi, X.P.1    Miao, S.2    Wu, Y.3    Zhang, W.4    Zhang, X.F.5    Ma, H.Z.6
  • 318
    • 84882440944 scopus 로고    scopus 로고
    • Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission
    • Farrand L., Byun S., Kim J.Y., Im-aram A., Lee J., Lim S., et al. Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission. J Biol Chem 2013, 288:23740-23750.
    • (2013) J Biol Chem , vol.288 , pp. 23740-23750
    • Farrand, L.1    Byun, S.2    Kim, J.Y.3    Im-aram, A.4    Lee, J.5    Lim, S.6
  • 320
    • 0036784966 scopus 로고    scopus 로고
    • Comparative antiproliferative and apoptotic effects of resveratrol, epsilon-viniferin and vine-shots derived polyphenols (vineatrols) on chronic B lymphocytic leukemia cells and normal human lymphocytes
    • Billard C., Izard J.C., Roman V., Kern C., Mathiot C., Mentz F., et al. Comparative antiproliferative and apoptotic effects of resveratrol, epsilon-viniferin and vine-shots derived polyphenols (vineatrols) on chronic B lymphocytic leukemia cells and normal human lymphocytes. Leuk Lymphoma 2002, 43:1991-2002.
    • (2002) Leuk Lymphoma , vol.43 , pp. 1991-2002
    • Billard, C.1    Izard, J.C.2    Roman, V.3    Kern, C.4    Mathiot, C.5    Mentz, F.6
  • 321
    • 84880746717 scopus 로고    scopus 로고
    • Resveratrol has anti-leukemic activity associated with decreased O-GlcNAcylated proteins
    • Tomic J., McCaw L., Li Y., Hough M.R., Ben-David Y., Moffat J., et al. Resveratrol has anti-leukemic activity associated with decreased O-GlcNAcylated proteins. Exp Hematol 2013, 41:675-686.
    • (2013) Exp Hematol , vol.41 , pp. 675-686
    • Tomic, J.1    McCaw, L.2    Li, Y.3    Hough, M.R.4    Ben-David, Y.5    Moffat, J.6
  • 322
    • 84877912111 scopus 로고    scopus 로고
    • Resveratrol and quercetin-induced apoptosis of human 232B4 chronic lymphocytic leukemia cells by activation of caspase-3 and cell cycle arrest
    • Gokbulut A.A., Apohan E., Baran Y. Resveratrol and quercetin-induced apoptosis of human 232B4 chronic lymphocytic leukemia cells by activation of caspase-3 and cell cycle arrest. Hematology 2013, 18:144-150.
    • (2013) Hematology , vol.18 , pp. 144-150
    • Gokbulut, A.A.1    Apohan, E.2    Baran, Y.3
  • 323
    • 0022357855 scopus 로고
    • Potential anticancer activity of turmeric (Curcuma longa)
    • Kuttan R., Bhanumathy P., Nirmala K., George M.C. Potential anticancer activity of turmeric (Curcuma longa). Cancer Lett 1985, 29:197-202.
    • (1985) Cancer Lett , vol.29 , pp. 197-202
    • Kuttan, R.1    Bhanumathy, P.2    Nirmala, K.3    George, M.C.4
  • 324
    • 84874110026 scopus 로고    scopus 로고
    • Curcumin, a component of turmeric: from farm to pharmacy
    • Gupta S.C., Kismali G., Aggarwal B.B. Curcumin, a component of turmeric: from farm to pharmacy. Biofactors 2013, 39:2-13.
    • (2013) Biofactors , vol.39 , pp. 2-13
    • Gupta, S.C.1    Kismali, G.2    Aggarwal, B.B.3
  • 325
  • 326
    • 68449098158 scopus 로고    scopus 로고
    • Rapamycin and curcumin induce apoptosis in primary resting B chronic lymphocytic leukemia cells
    • Hayun R., Okun E., Berrebi A., Shvidel L., Bassous L., Sredni B., et al. Rapamycin and curcumin induce apoptosis in primary resting B chronic lymphocytic leukemia cells. Leuk Lymphoma 2009, 50:625-632.
    • (2009) Leuk Lymphoma , vol.50 , pp. 625-632
    • Hayun, R.1    Okun, E.2    Berrebi, A.3    Shvidel, L.4    Bassous, L.5    Sredni, B.6
  • 327
    • 63149189848 scopus 로고    scopus 로고
    • Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG
    • Ghosh A.K., Kay N.E., Secreto C.R., Shanafelt T.D. Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG. Clin Cancer Res 2009, 15:1250-1258.
    • (2009) Clin Cancer Res , vol.15 , pp. 1250-1258
    • Ghosh, A.K.1    Kay, N.E.2    Secreto, C.R.3    Shanafelt, T.D.4
  • 328
    • 63149100975 scopus 로고    scopus 로고
    • Turmeric and green tea: a recipe for the treatment of B-chronic lymphocytic leukemia
    • Angelo L.S., Kurzrock R. Turmeric and green tea: a recipe for the treatment of B-chronic lymphocytic leukemia. Clin Cancer Res 2009, 15:1123-1125.
    • (2009) Clin Cancer Res , vol.15 , pp. 1123-1125
    • Angelo, L.S.1    Kurzrock, R.2
  • 329
    • 81855164783 scopus 로고    scopus 로고
    • The flavonoid quercetin in disease prevention and therapy: facts and fancies
    • Russo M., Spagnuolo C., Tedesco I., Bilotto S., Russo G.L. The flavonoid quercetin in disease prevention and therapy: facts and fancies. Biochem Pharmacol 2012, 83:6-15.
    • (2012) Biochem Pharmacol , vol.83 , pp. 6-15
    • Russo, M.1    Spagnuolo, C.2    Tedesco, I.3    Bilotto, S.4    Russo, G.L.5
  • 330
    • 84863514720 scopus 로고    scopus 로고
    • Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia
    • Spagnuolo C., Russo M., Bilotto S., Tedesco I., Laratta B., Russo G.L. Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia. Ann NY Acad Sci 2012, 1259:95-103.
    • (2012) Ann NY Acad Sci , vol.1259 , pp. 95-103
    • Spagnuolo, C.1    Russo, M.2    Bilotto, S.3    Tedesco, I.4    Laratta, B.5    Russo, G.L.6
  • 331
    • 77955982848 scopus 로고    scopus 로고
    • Quercetin induced apoptosis in association with death receptors and fludarabine in cells isolated from chronic lymphocytic leukaemia patients
    • Russo M., Spagnuolo C., Volpe S., Mupo A., Tedesco I., Russo G.L. Quercetin induced apoptosis in association with death receptors and fludarabine in cells isolated from chronic lymphocytic leukaemia patients. Br J Cancer 2010, 103:642-648.
    • (2010) Br J Cancer , vol.103 , pp. 642-648
    • Russo, M.1    Spagnuolo, C.2    Volpe, S.3    Mupo, A.4    Tedesco, I.5    Russo, G.L.6
  • 332
    • 84874657510 scopus 로고    scopus 로고
    • ABT-737 resistance in B-cells isolated from chronic lymphocytic leukemia patients and leukemia cell lines is overcome by the pleiotropic kinase inhibitor quercetin through Mcl-1 down-regulation
    • Russo M., Spagnuolo C., Volpe S., Tedesco I., Bilotto S., Russo G.L. ABT-737 resistance in B-cells isolated from chronic lymphocytic leukemia patients and leukemia cell lines is overcome by the pleiotropic kinase inhibitor quercetin through Mcl-1 down-regulation. Biochem Pharmacol 2013, 85:927-936.
    • (2013) Biochem Pharmacol , vol.85 , pp. 927-936
    • Russo, M.1    Spagnuolo, C.2    Volpe, S.3    Tedesco, I.4    Bilotto, S.5    Russo, G.L.6
  • 333
    • 79956152511 scopus 로고    scopus 로고
    • Effects of combination of notch inhibitor plus hedgehog inhibitor or Wnt inhibitor on growth of leukemia cells
    • Okuhashi Y., Itoh M., Nara N., Tohda S. Effects of combination of notch inhibitor plus hedgehog inhibitor or Wnt inhibitor on growth of leukemia cells. Anticancer Res 2011, 31:893-896.
    • (2011) Anticancer Res , vol.31 , pp. 893-896
    • Okuhashi, Y.1    Itoh, M.2    Nara, N.3    Tohda, S.4
  • 334
    • 84859102919 scopus 로고    scopus 로고
    • Natural isothiocyanates: genotoxic potential versus chemoprevention
    • Fimognari C., Turrini E., Ferruzzi L., Lenzi M., Hrelia P. Natural isothiocyanates: genotoxic potential versus chemoprevention. Mutat Res 2012, 750:107-131.
    • (2012) Mutat Res , vol.750 , pp. 107-131
    • Fimognari, C.1    Turrini, E.2    Ferruzzi, L.3    Lenzi, M.4    Hrelia, P.5
  • 335
    • 33749526461 scopus 로고    scopus 로고
    • Sulforaphane increases the efficacy of doxorubicin in mouse fibroblasts characterized by p53 mutations
    • Fimognari C., Nusse M., Lenzi M., Sciuscio D., Cantelli-Forti G., Hrelia P. Sulforaphane increases the efficacy of doxorubicin in mouse fibroblasts characterized by p53 mutations. Mutat Res 2006, 601:92-101.
    • (2006) Mutat Res , vol.601 , pp. 92-101
    • Fimognari, C.1    Nusse, M.2    Lenzi, M.3    Sciuscio, D.4    Cantelli-Forti, G.5    Hrelia, P.6
  • 336
    • 0035866772 scopus 로고    scopus 로고
    • Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer
    • Geisler S., Lonning P.E., Aas T., Johnsen H., Fluge O., Haugen D.F., et al. Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer. Cancer Res 2001, 61:2505-2512.
    • (2001) Cancer Res , vol.61 , pp. 2505-2512
    • Geisler, S.1    Lonning, P.E.2    Aas, T.3    Johnsen, H.4    Fluge, O.5    Haugen, D.F.6
  • 337
    • 84861325625 scopus 로고    scopus 로고
    • Anthracycline cardiotoxicity: prevalence, pathogenesis and treatment
    • Volkova M., Russell R. Anthracycline cardiotoxicity: prevalence, pathogenesis and treatment. Curr Cardiol Rev 2011, 7:214-220.
    • (2011) Curr Cardiol Rev , vol.7 , pp. 214-220
    • Volkova, M.1    Russell, R.2
  • 338
    • 84867888901 scopus 로고    scopus 로고
    • Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models
    • Gupta P., Srivastava S.K. Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models. BMC Med 2012, 10:80.
    • (2012) BMC Med , vol.10 , pp. 80
    • Gupta, P.1    Srivastava, S.K.2
  • 339
    • 0031443156 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells
    • Garcia R., Yu C.L., Hudnall A., Catlett R., Nelson K.L., Smithgall T., et al. Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ 1997, 8:1267-1276.
    • (1997) Cell Growth Differ , vol.8 , pp. 1267-1276
    • Garcia, R.1    Yu, C.L.2    Hudnall, A.3    Catlett, R.4    Nelson, K.L.5    Smithgall, T.6
  • 340
    • 79955559726 scopus 로고    scopus 로고
    • Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death
    • Kaminski B.M., Weigert A., Brune B., Schumacher M., Wenzel U., Steinhilber D., et al. Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death. Cancer Chemother Pharmacol 2011, 67:1167-1178.
    • (2011) Cancer Chemother Pharmacol , vol.67 , pp. 1167-1178
    • Kaminski, B.M.1    Weigert, A.2    Brune, B.3    Schumacher, M.4    Wenzel, U.5    Steinhilber, D.6
  • 341
    • 80053931057 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin
    • Wang X., Govind S., Sajankila S.P., Mi L., Roy R., Chung F.L. Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin. Mol Nutr Food Res 2011, 55:1572-1581.
    • (2011) Mol Nutr Food Res , vol.55 , pp. 1572-1581
    • Wang, X.1    Govind, S.2    Sajankila, S.P.3    Mi, L.4    Roy, R.5    Chung, F.L.6
  • 342
    • 84861433397 scopus 로고    scopus 로고
    • Enhancement of cisplatin cytotoxicity by benzyl isothiocyanate in HL-60 cells
    • Lee Y., Kim Y.J., Choi Y.J., Lee J.W., Lee S., Chung H.W. Enhancement of cisplatin cytotoxicity by benzyl isothiocyanate in HL-60 cells. Food Chem Toxicol 2012, 50:2397-2406.
    • (2012) Food Chem Toxicol , vol.50 , pp. 2397-2406
    • Lee, Y.1    Kim, Y.J.2    Choi, Y.J.3    Lee, J.W.4    Lee, S.5    Chung, H.W.6
  • 343
    • 34447120145 scopus 로고    scopus 로고
    • The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells
    • Mi L., Wang X., Govind S., Hood B.L., Veenstra T.D., Conrads T.P., et al. The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells. Cancer Res 2007, 67:6409-6416.
    • (2007) Cancer Res , vol.67 , pp. 6409-6416
    • Mi, L.1    Wang, X.2    Govind, S.3    Hood, B.L.4    Veenstra, T.D.5    Conrads, T.P.6
  • 344
    • 67650547972 scopus 로고    scopus 로고
    • Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes
    • Mi L., Gan N., Cheema A., Dakshanamurthy S., Wang X., Yang D.C., et al. Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes. J Biol Chem 2009, 284:17039-17051.
    • (2009) J Biol Chem , vol.284 , pp. 17039-17051
    • Mi, L.1    Gan, N.2    Cheema, A.3    Dakshanamurthy, S.4    Wang, X.5    Yang, D.C.6
  • 346
    • 77954664504 scopus 로고    scopus 로고
    • Putative chemopreventive molecules can increase Nrf2-regulated cell defense in some human cancer cell lines, resulting in resistance to common cytotoxic therapies
    • Hu L., Miao W., Loignon M., Kandouz M., Batist G. Putative chemopreventive molecules can increase Nrf2-regulated cell defense in some human cancer cell lines, resulting in resistance to common cytotoxic therapies. Cancer Chemother Pharmacol 2010, 66:467-474.
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 467-474
    • Hu, L.1    Miao, W.2    Loignon, M.3    Kandouz, M.4    Batist, G.5
  • 347
    • 77956357506 scopus 로고    scopus 로고
    • Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells
    • Nair S., Barve A., Khor T.O., Shen G.X., Lin W., Chan J.Y., et al. Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells. Acta Pharmacol Sin 2010, 31:1223-1240.
    • (2010) Acta Pharmacol Sin , vol.31 , pp. 1223-1240
    • Nair, S.1    Barve, A.2    Khor, T.O.3    Shen, G.X.4    Lin, W.5    Chan, J.Y.6
  • 348
    • 79954424076 scopus 로고    scopus 로고
    • Nrf2: control of sensitivity to carcinogens
    • Slocum S.L., Kensler T.W. Nrf2: control of sensitivity to carcinogens. Arch Toxicol 2011, 85:273-284.
    • (2011) Arch Toxicol , vol.85 , pp. 273-284
    • Slocum, S.L.1    Kensler, T.W.2
  • 350
    • 84889768148 scopus 로고    scopus 로고
    • Cancer preventive efficacy of marine carotenoid fucoxanthin: cell cycle arrest and apoptosis
    • Rengarajan T., Rajendran P., Nandakumar N., Balasubramanian M.P., Nishigaki I. Cancer preventive efficacy of marine carotenoid fucoxanthin: cell cycle arrest and apoptosis. Nutrients 2013, 5:4978-4989.
    • (2013) Nutrients , vol.5 , pp. 4978-4989
    • Rengarajan, T.1    Rajendran, P.2    Nandakumar, N.3    Balasubramanian, M.P.4    Nishigaki, I.5
  • 351
    • 84893153896 scopus 로고    scopus 로고
    • Napyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis
    • Farnaes L., Coufal N.G., Kauffman C.A., Rheingold A.L., DiPasquale A.G., Jensen P.R., et al. Napyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis. J Nat Prod 2014, 77:15-21.
    • (2014) J Nat Prod , vol.77 , pp. 15-21
    • Farnaes, L.1    Coufal, N.G.2    Kauffman, C.A.3    Rheingold, A.L.4    DiPasquale, A.G.5    Jensen, P.R.6
  • 352
    • 84890290307 scopus 로고    scopus 로고
    • Napyradiomycins CNQ525.510B and A80915C target the Hsp90 paralogue Grp94
    • Farnaes L., La Clair J.J., Fenical W. Napyradiomycins CNQ525.510B and A80915C target the Hsp90 paralogue Grp94. Org Biomol Chem 2014, 12:418-423.
    • (2014) Org Biomol Chem , vol.12 , pp. 418-423
    • Farnaes, L.1    La Clair, J.J.2    Fenical, W.3
  • 353
    • 79955615962 scopus 로고    scopus 로고
    • Bactericidal kinetics of marine-derived napyradiomycins against contemporary methicillin-resistant Staphylococcus aureus
    • Haste N.M., Farnaes L., Perera V.R., Fenical W., Nizet V., Hensler M.E. Bactericidal kinetics of marine-derived napyradiomycins against contemporary methicillin-resistant Staphylococcus aureus. Mar Drugs 2011, 9:680-689.
    • (2011) Mar Drugs , vol.9 , pp. 680-689
    • Haste, N.M.1    Farnaes, L.2    Perera, V.R.3    Fenical, W.4    Nizet, V.5    Hensler, M.E.6
  • 354
    • 84892419887 scopus 로고    scopus 로고
    • Fucoxanthin: a marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms
    • Kumar S.R., Hosokawa M., Miyashita K. Fucoxanthin: a marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms. Mar Drugs 2013, 11:5130-5147.
    • (2013) Mar Drugs , vol.11 , pp. 5130-5147
    • Kumar, S.R.1    Hosokawa, M.2    Miyashita, K.3
  • 355
    • 84892894049 scopus 로고    scopus 로고
    • Gliotoxin isolated from marine fungus Aspergillus sp. induces apoptosis of human cervical cancer and chondrosarcoma cells
    • Nguyen V.T., Lee J.S., Qian Z.J., Li Y.X., Kim K.N., Heo S.J., et al. Gliotoxin isolated from marine fungus Aspergillus sp. induces apoptosis of human cervical cancer and chondrosarcoma cells. Mar Drugs 2014, 12:69-87.
    • (2014) Mar Drugs , vol.12 , pp. 69-87
    • Nguyen, V.T.1    Lee, J.S.2    Qian, Z.J.3    Li, Y.X.4    Kim, K.N.5    Heo, S.J.6
  • 356
    • 84892841374 scopus 로고    scopus 로고
    • The marine fungal metabolite, AD0157, inhibits angiogenesis by targeting the Akt signaling pathway
    • Garcia-Caballero M., Canedo L., Fernandez-Medarde A., Medina M.A., Quesada A.R. The marine fungal metabolite, AD0157, inhibits angiogenesis by targeting the Akt signaling pathway. Mar Drugs 2014, 12:279-299.
    • (2014) Mar Drugs , vol.12 , pp. 279-299
    • Garcia-Caballero, M.1    Canedo, L.2    Fernandez-Medarde, A.3    Medina, M.A.4    Quesada, A.R.5
  • 357
    • 84878840937 scopus 로고    scopus 로고
    • Toluquinol, a marine fungus metabolite, is a new angiosuppresor that interferes with the Akt pathway
    • Garcia-Caballero M., Mari-Beffa M., Canedo L., Medina M.A., Quesada A.R. Toluquinol, a marine fungus metabolite, is a new angiosuppresor that interferes with the Akt pathway. Biochem Pharmacol 2013, 85:1727-1740.
    • (2013) Biochem Pharmacol , vol.85 , pp. 1727-1740
    • Garcia-Caballero, M.1    Mari-Beffa, M.2    Canedo, L.3    Medina, M.A.4    Quesada, A.R.5
  • 358
    • 84908093917 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of novel 3-alkylpyridine marine alkaloid analogs with promising anticancer activity
    • Goncalves A.M., de Lima A.B., da Silva Barbosa M.C., de Camargos L.F., de Oliveira J.T., de Souza B.C., et al. Synthesis and biological evaluation of novel 3-alkylpyridine marine alkaloid analogs with promising anticancer activity. Mar Drugs 2014, 12:4361-4378.
    • (2014) Mar Drugs , vol.12 , pp. 4361-4378
    • Goncalves, A.M.1    de Lima, A.B.2    da Silva Barbosa, M.C.3    de Camargos, L.F.4    de Oliveira, J.T.5    de Souza, B.C.6
  • 359
    • 84897364000 scopus 로고    scopus 로고
    • Apoptosis inducing lead compounds isolated from marine organisms of potential relevance in cancer treatment
    • Beesoo R., Neergheen-Bhujun V., Bhagooli R., Bahorun T. Apoptosis inducing lead compounds isolated from marine organisms of potential relevance in cancer treatment. Mutat Res Fundam Mol Mech Mutagen 2014, 10.1016/j.mrfmmm.2014.03.005.
    • (2014) Mutat Res Fundam Mol Mech Mutagen
    • Beesoo, R.1    Neergheen-Bhujun, V.2    Bhagooli, R.3    Bahorun, T.4
  • 360
    • 84873661833 scopus 로고    scopus 로고
    • Asymmetric siRNA targeting the bcl2 gene inhibits the proliferation of cancer cells in vitro and in vivo
    • Yin Y., Chen X., Zhang C.D., Liu P.F., Duan Y.R., Fan Y.R., et al. Asymmetric siRNA targeting the bcl2 gene inhibits the proliferation of cancer cells in vitro and in vivo. Int J Oncol 2013, 42:253-260.
    • (2013) Int J Oncol , vol.42 , pp. 253-260
    • Yin, Y.1    Chen, X.2    Zhang, C.D.3    Liu, P.F.4    Duan, Y.R.5    Fan, Y.R.6
  • 361
    • 84887420799 scopus 로고    scopus 로고
    • Tumor suppressor PDCD4 modulates miR-184-mediated direct suppression of C-MYC and BCL2 blocking cell growth and survival in nasopharyngeal carcinoma
    • Zhen Y., Liu Z., Yang H., Yu X., Wu Q., Hua S., et al. Tumor suppressor PDCD4 modulates miR-184-mediated direct suppression of C-MYC and BCL2 blocking cell growth and survival in nasopharyngeal carcinoma. Cell Death Dis 2013, 4:e872.
    • (2013) Cell Death Dis , vol.4 , pp. e872
    • Zhen, Y.1    Liu, Z.2    Yang, H.3    Yu, X.4    Wu, Q.5    Hua, S.6
  • 362
    • 84861372976 scopus 로고    scopus 로고
    • Inhibition of Mcl-1 promotes senescence in cancer cells: implications for preventing tumor growth and chemotherapy resistance
    • Bolesta E., Pfannenstiel L.W., Demelash A., Lesniewski M.L., Tobin M., Schlanger S.E., et al. Inhibition of Mcl-1 promotes senescence in cancer cells: implications for preventing tumor growth and chemotherapy resistance. Mol Cell Biol 2012, 32:1879-1892.
    • (2012) Mol Cell Biol , vol.32 , pp. 1879-1892
    • Bolesta, E.1    Pfannenstiel, L.W.2    Demelash, A.3    Lesniewski, M.L.4    Tobin, M.5    Schlanger, S.E.6
  • 363
    • 84878015338 scopus 로고    scopus 로고
    • Autophagy restricts proliferation driven by oncogenic phosphatidylinositol 3-kinase in three-dimensional culture
    • Chen N., Eritja N., Lock R., Debnath J. Autophagy restricts proliferation driven by oncogenic phosphatidylinositol 3-kinase in three-dimensional culture. Oncogene 2013, 32:2543-2554.
    • (2013) Oncogene , vol.32 , pp. 2543-2554
    • Chen, N.1    Eritja, N.2    Lock, R.3    Debnath, J.4
  • 364
    • 84866121636 scopus 로고    scopus 로고
    • Suppression of basal autophagy reduces lung cancer cell proliferation and enhances caspase-dependent and -independent apoptosis by stimulating ROS formation
    • Kaminskyy V.O., Piskunova T., Zborovskaya I.B., Tchevkina E.M., Zhivotovsky B. Suppression of basal autophagy reduces lung cancer cell proliferation and enhances caspase-dependent and -independent apoptosis by stimulating ROS formation. Autophagy 2012, 8:1032-1044.
    • (2012) Autophagy , vol.8 , pp. 1032-1044
    • Kaminskyy, V.O.1    Piskunova, T.2    Zborovskaya, I.B.3    Tchevkina, E.M.4    Zhivotovsky, B.5
  • 365
    • 84880308008 scopus 로고    scopus 로고
    • Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE2 to promote tumor growth and to inhibit T cell activation
    • Sha W., Olesch C., Hanaka H., Radmark O., Weigert A., Brune B. Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE2 to promote tumor growth and to inhibit T cell activation. Int J Cancer 2013, 133:1578-1588.
    • (2013) Int J Cancer , vol.133 , pp. 1578-1588
    • Sha, W.1    Olesch, C.2    Hanaka, H.3    Radmark, O.4    Weigert, A.5    Brune, B.6
  • 366
    • 84856823318 scopus 로고    scopus 로고
    • The relationship between tumour necrosis, tumour proliferation, local and systemic inflammation, microvessel density and survival in patients undergoing potentially curative resection of oesophageal adenocarcinoma
    • Dutta S., Going J.J., Crumley A.B., Mohammed Z., Orange C., Edwards J., et al. The relationship between tumour necrosis, tumour proliferation, local and systemic inflammation, microvessel density and survival in patients undergoing potentially curative resection of oesophageal adenocarcinoma. Br J Cancer 2012, 106:702-710.
    • (2012) Br J Cancer , vol.106 , pp. 702-710
    • Dutta, S.1    Going, J.J.2    Crumley, A.B.3    Mohammed, Z.4    Orange, C.5    Edwards, J.6
  • 367
    • 84871647827 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis
    • Chang D.J., An H., Kim K.S., Kim H.H., Jung J., Lee J.M., et al. Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis. J Med Chem 2012, 55:10863-10884.
    • (2012) J Med Chem , vol.55 , pp. 10863-10884
    • Chang, D.J.1    An, H.2    Kim, K.S.3    Kim, H.H.4    Jung, J.5    Lee, J.M.6
  • 368
    • 80052023055 scopus 로고    scopus 로고
    • Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90
    • Zhao M., Ma J., Zhu H.Y., Zhang X.H., Du Z.Y., Xu Y.J., et al. Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90. Mol Cancer 2011, 10:104.
    • (2011) Mol Cancer , vol.10 , pp. 104
    • Zhao, M.1    Ma, J.2    Zhu, H.Y.3    Zhang, X.H.4    Du, Z.Y.5    Xu, Y.J.6
  • 369
    • 84868203239 scopus 로고    scopus 로고
    • Proteasome inhibitor interacts synergistically with autophagy inhibitor to suppress proliferation and induce apoptosis in hepatocellular carcinoma
    • Hui B., Shi Y.H., Ding Z.B., Zhou J., Gu C.Y., Peng Y.F., et al. Proteasome inhibitor interacts synergistically with autophagy inhibitor to suppress proliferation and induce apoptosis in hepatocellular carcinoma. Cancer 2012, 118:5560-5571.
    • (2012) Cancer , vol.118 , pp. 5560-5571
    • Hui, B.1    Shi, Y.H.2    Ding, Z.B.3    Zhou, J.4    Gu, C.Y.5    Peng, Y.F.6
  • 370
    • 84863927725 scopus 로고    scopus 로고
    • The human immunodeficiency virus-1 protease inhibitor nelfinavir impairs proteasome activity and inhibits the proliferation of multiple myeloma cells in vitro and in vivo
    • Bono C., Karlin L., Harel S., Mouly E., Labaume S., Galicier L., et al. The human immunodeficiency virus-1 protease inhibitor nelfinavir impairs proteasome activity and inhibits the proliferation of multiple myeloma cells in vitro and in vivo. Haematologica 2012, 97:1101-1109.
    • (2012) Haematologica , vol.97 , pp. 1101-1109
    • Bono, C.1    Karlin, L.2    Harel, S.3    Mouly, E.4    Labaume, S.5    Galicier, L.6
  • 371
    • 84856698334 scopus 로고    scopus 로고
    • BCL2A1: the underdog in the BCL2 family
    • Vogler M. BCL2A1: the underdog in the BCL2 family. Cell Death Differ 2012, 19:67-74.
    • (2012) Cell Death Differ , vol.19 , pp. 67-74
    • Vogler, M.1
  • 372
    • 79954619217 scopus 로고    scopus 로고
    • Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFkappaB pathway in the Noble rat model
    • Hsu A., Bruno R.S., Lohr C.V., Taylor A.W., Dashwood R.H., Bray T.M., et al. Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFkappaB pathway in the Noble rat model. J Nutr Biochem 2011, 22:502-510.
    • (2011) J Nutr Biochem , vol.22 , pp. 502-510
    • Hsu, A.1    Bruno, R.S.2    Lohr, C.V.3    Taylor, A.W.4    Dashwood, R.H.5    Bray, T.M.6
  • 373
    • 79954543947 scopus 로고    scopus 로고
    • Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells
    • Zhang H.Y., Zhang Q., Zhang X., Yu C., Huo X., Cheng E., et al. Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells. Am J Physiol Gastrointest Liver Physiol 2011, 300:G454-G460.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.300 , pp. G454-G460
    • Zhang, H.Y.1    Zhang, Q.2    Zhang, X.3    Yu, C.4    Huo, X.5    Cheng, E.6
  • 374
    • 78049426652 scopus 로고    scopus 로고
    • Inflammation and survival pathways: chronic lymphocytic leukemia as a model system
    • Chen L.S., Balakrishnan K., Gandhi V. Inflammation and survival pathways: chronic lymphocytic leukemia as a model system. Biochem Pharmacol 2010, 80:1936-1945.
    • (2010) Biochem Pharmacol , vol.80 , pp. 1936-1945
    • Chen, L.S.1    Balakrishnan, K.2    Gandhi, V.3
  • 375
    • 84877332455 scopus 로고    scopus 로고
    • Targeting NFKB by autophagy to polarize hepatoma-associated macrophage differentiation
    • Chang C.P., Su Y.C., Lee P.H., Lei H.Y. Targeting NFKB by autophagy to polarize hepatoma-associated macrophage differentiation. Autophagy 2013, 9:619-621.
    • (2013) Autophagy , vol.9 , pp. 619-621
    • Chang, C.P.1    Su, Y.C.2    Lee, P.H.3    Lei, H.Y.4
  • 376
    • 84864805916 scopus 로고    scopus 로고
    • Autophagy and cancer - issues we need to digest
    • Liu E.Y., Ryan K.M. Autophagy and cancer - issues we need to digest. J Cell Sci 2012, 125:2349-2358.
    • (2012) J Cell Sci , vol.125 , pp. 2349-2358
    • Liu, E.Y.1    Ryan, K.M.2
  • 377
    • 84884791665 scopus 로고    scopus 로고
    • Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1
    • Chopra M., Lang I., Salzmann S., Pachel C., Kraus S., Bauerlein C.A., et al. Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1. PLoS ONE 2013, 8:e75737.
    • (2013) PLoS ONE , vol.8 , pp. e75737
    • Chopra, M.1    Lang, I.2    Salzmann, S.3    Pachel, C.4    Kraus, S.5    Bauerlein, C.A.6
  • 378
    • 0025076232 scopus 로고
    • Positron emission tomographic scanning demonstrates a presynaptic dopaminergic lesion in Lytico-Bodig. The amyotrophic lateral sclerosis-parkinsonism-dementia complex of Guam
    • Snow B.J., Peppard R.F., Guttman M., Okada J., Martin W.R., Steele J., et al. Positron emission tomographic scanning demonstrates a presynaptic dopaminergic lesion in Lytico-Bodig. The amyotrophic lateral sclerosis-parkinsonism-dementia complex of Guam. Arch Neurol 1990, 47:870-874.
    • (1990) Arch Neurol , vol.47 , pp. 870-874
    • Snow, B.J.1    Peppard, R.F.2    Guttman, M.3    Okada, J.4    Martin, W.R.5    Steele, J.6
  • 379
    • 35148849219 scopus 로고    scopus 로고
    • High-throughput screening fluorescence polarization assay for tumor-specific Hsp90
    • Du Y., Moulick K., Rodina A., Aguirre J., Felts S., Dingledine R., et al. High-throughput screening fluorescence polarization assay for tumor-specific Hsp90. J Biomol Screen 2007, 12:915-924.
    • (2007) J Biomol Screen , vol.12 , pp. 915-924
    • Du, Y.1    Moulick, K.2    Rodina, A.3    Aguirre, J.4    Felts, S.5    Dingledine, R.6
  • 380
    • 38449087767 scopus 로고    scopus 로고
    • Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase
    • Arthur J.C., Lich J.D., Aziz R.K., Kotb M., Ting J.P. Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase. J Immunol 2007, 179:6291-6296.
    • (2007) J Immunol , vol.179 , pp. 6291-6296
    • Arthur, J.C.1    Lich, J.D.2    Aziz, R.K.3    Kotb, M.4    Ting, J.P.5
  • 382
    • 84858683642 scopus 로고    scopus 로고
    • Targeting the ubiquitin-proteasome pathway with inorganic compounds to fight cancer: a challenge for the future
    • Dalla Via L., Nardon C., Fregona D. Targeting the ubiquitin-proteasome pathway with inorganic compounds to fight cancer: a challenge for the future. Fut Med Chem 2012, 4:525-543.
    • (2012) Fut Med Chem , vol.4 , pp. 525-543
    • Dalla Via, L.1    Nardon, C.2    Fregona, D.3
  • 383
    • 84858003660 scopus 로고    scopus 로고
    • Pre-cachexia in patients with stages I-III non-small cell lung cancer: systemic inflammation and functional impairment without activation of skeletal muscle ubiquitin proteasome system
    • Op den Kamp C.M., Langen R.C., Minnaard R., Kelders M.C., Snepvangers F.J., Hesselink M.K., et al. Pre-cachexia in patients with stages I-III non-small cell lung cancer: systemic inflammation and functional impairment without activation of skeletal muscle ubiquitin proteasome system. Lung Cancer 2012, 76:112-117.
    • (2012) Lung Cancer , vol.76 , pp. 112-117
    • Op den Kamp, C.M.1    Langen, R.C.2    Minnaard, R.3    Kelders, M.C.4    Snepvangers, F.J.5    Hesselink, M.K.6
  • 384
    • 37549001026 scopus 로고    scopus 로고
    • Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion
    • Deng J., Shimamura T., Perera S., Carlson N.E., Cai D., Shapiro G.I., et al. Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion. Cancer Res 2007, 67:11867-11875.
    • (2007) Cancer Res , vol.67 , pp. 11867-11875
    • Deng, J.1    Shimamura, T.2    Perera, S.3    Carlson, N.E.4    Cai, D.5    Shapiro, G.I.6
  • 385
    • 0344844410 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells
    • Cai J., Ahmad S., Jiang W.G., Huang J., Kontos C.D., Boulton M., et al. Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells. Diabetes 2003, 52:2959-2968.
    • (2003) Diabetes , vol.52 , pp. 2959-2968
    • Cai, J.1    Ahmad, S.2    Jiang, W.G.3    Huang, J.4    Kontos, C.D.5    Boulton, M.6
  • 386
    • 24344458927 scopus 로고    scopus 로고
    • Involvement of PI3K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells
    • Trisciuoglio D., Iervolino A., Zupi G., Del Bufalo D. Involvement of PI3K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells. Mol Biol Cell 2005, 16:4153-4162.
    • (2005) Mol Biol Cell , vol.16 , pp. 4153-4162
    • Trisciuoglio, D.1    Iervolino, A.2    Zupi, G.3    Del Bufalo, D.4
  • 387
    • 84880053827 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) signaling promotes proliferation and survival in osteoprogenitors by increasing early growth response 2 (EGR2) expression
    • Chandra A., Lan S., Zhu J., Siclari V.A., Qin L. Epidermal growth factor receptor (EGFR) signaling promotes proliferation and survival in osteoprogenitors by increasing early growth response 2 (EGR2) expression. J Biol Chem 2013, 288:20488-20498.
    • (2013) J Biol Chem , vol.288 , pp. 20488-20498
    • Chandra, A.1    Lan, S.2    Zhu, J.3    Siclari, V.A.4    Qin, L.5
  • 388
    • 84887478940 scopus 로고    scopus 로고
    • IBP-mediated suppression of autophagy promotes growth and metastasis of breast cancer cells via activating mTORC2/Akt/FOXO3a signaling pathway
    • Chen S., Han Q., Wang X., Yang M., Zhang Z., Li P., et al. IBP-mediated suppression of autophagy promotes growth and metastasis of breast cancer cells via activating mTORC2/Akt/FOXO3a signaling pathway. Cell Death Dis 2013, 4:e842.
    • (2013) Cell Death Dis , vol.4 , pp. e842
    • Chen, S.1    Han, Q.2    Wang, X.3    Yang, M.4    Zhang, Z.5    Li, P.6
  • 389
    • 0036164502 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha inhibits growth factor-mediated cell proliferation through SHP-1 activation in endothelial cells
    • Nakagami H., Cui T.X., Iwai M., Shiuchi T., Takeda-Matsubara Y., Wu L., et al. Tumor necrosis factor-alpha inhibits growth factor-mediated cell proliferation through SHP-1 activation in endothelial cells. Arterioscler Thromb Vasc Biol 2002, 22:238-242.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 238-242
    • Nakagami, H.1    Cui, T.X.2    Iwai, M.3    Shiuchi, T.4    Takeda-Matsubara, Y.5    Wu, L.6
  • 390
    • 75149123144 scopus 로고    scopus 로고
    • Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth
    • Chandarlapaty S., Scaltriti M., Angelini P., Ye Q., Guzman M., Hudis C.A., et al. Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth. Oncogene 2010, 29:325-334.
    • (2010) Oncogene , vol.29 , pp. 325-334
    • Chandarlapaty, S.1    Scaltriti, M.2    Angelini, P.3    Ye, Q.4    Guzman, M.5    Hudis, C.A.6
  • 391
    • 35848929277 scopus 로고    scopus 로고
    • Src-mediated phosphorylation of Hsp90 in response to vascular endothelial growth factor (VEGF) is required for VEGF receptor-2 signaling to endothelial NO synthase
    • Duval M., Le Boeuf F., Huot J., Gratton J.P. Src-mediated phosphorylation of Hsp90 in response to vascular endothelial growth factor (VEGF) is required for VEGF receptor-2 signaling to endothelial NO synthase. Mol Biol Cell 2007, 18:4659-4668.
    • (2007) Mol Biol Cell , vol.18 , pp. 4659-4668
    • Duval, M.1    Le Boeuf, F.2    Huot, J.3    Gratton, J.P.4
  • 392
    • 1642486367 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/c-Jun/AP-1 signaling
    • Yang Y., Ikezoe T., Saito T., Kobayashi M., Koeffler H.P., Taguchi H. Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/c-Jun/AP-1 signaling. Cancer Sci 2004, 95:176-180.
    • (2004) Cancer Sci , vol.95 , pp. 176-180
    • Yang, Y.1    Ikezoe, T.2    Saito, T.3    Kobayashi, M.4    Koeffler, H.P.5    Taguchi, H.6
  • 393
    • 48749110809 scopus 로고    scopus 로고
    • Synergistic anti-proliferative and pro-apoptotic activity of combined therapy with bortezomib, a proteasome inhibitor, with anti-epidermal growth factor receptor (EGFR) drugs in human cancer cells
    • Cascone T., Morelli M.P., Morgillo F., Kim W.Y., Rodolico G., Pepe S., et al. Synergistic anti-proliferative and pro-apoptotic activity of combined therapy with bortezomib, a proteasome inhibitor, with anti-epidermal growth factor receptor (EGFR) drugs in human cancer cells. J Cell Physiol 2008, 216:698-707.
    • (2008) J Cell Physiol , vol.216 , pp. 698-707
    • Cascone, T.1    Morelli, M.P.2    Morgillo, F.3    Kim, W.Y.4    Rodolico, G.5    Pepe, S.6
  • 394
    • 0034671768 scopus 로고    scopus 로고
    • Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation
    • Alt J.R., Cleveland J.L., Hannink M., Diehl J.A. Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Genes Dev 2000, 14:3102-3114.
    • (2000) Genes Dev , vol.14 , pp. 3102-3114
    • Alt, J.R.1    Cleveland, J.L.2    Hannink, M.3    Diehl, J.A.4
  • 395
    • 0033603847 scopus 로고    scopus 로고
    • Effects of differential overexpression of Bcl-2 on apoptosis, proliferation, and telomerase activity in Jurkat T cells
    • Johnson V.L., Cooper I.R., Jenkins J.R., Chow S.C. Effects of differential overexpression of Bcl-2 on apoptosis, proliferation, and telomerase activity in Jurkat T cells. Exp Cell Res 1999, 251:175-184.
    • (1999) Exp Cell Res , vol.251 , pp. 175-184
    • Johnson, V.L.1    Cooper, I.R.2    Jenkins, J.R.3    Chow, S.C.4
  • 396
    • 0031006856 scopus 로고    scopus 로고
    • Bcl-2 modulates telomerase activity
    • Mandal M., Kumar R. Bcl-2 modulates telomerase activity. J Biol Chem 1997, 272:14183-14187.
    • (1997) J Biol Chem , vol.272 , pp. 14183-14187
    • Mandal, M.1    Kumar, R.2
  • 397
    • 34548497874 scopus 로고    scopus 로고
    • Telomere 3' overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cells
    • Aoki H., Iwado E., Eller M.S., Kondo Y., Fujiwara K., Li G.Z., et al. Telomere 3' overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cells. FASEB J 2007, 21:2918-2930.
    • (2007) FASEB J , vol.21 , pp. 2918-2930
    • Aoki, H.1    Iwado, E.2    Eller, M.S.3    Kondo, Y.4    Fujiwara, K.5    Li, G.Z.6
  • 398
    • 38449091201 scopus 로고    scopus 로고
    • Combined effect of 2-5A-linked antisense against telomerase RNA and conventional therapies on human malignant glioma cells in vitro and in vivo
    • Iwado E., Daido S., Kondo Y., Kondo S. Combined effect of 2-5A-linked antisense against telomerase RNA and conventional therapies on human malignant glioma cells in vitro and in vivo. Int J Oncol 2007, 31:1087-1095.
    • (2007) Int J Oncol , vol.31 , pp. 1087-1095
    • Iwado, E.1    Daido, S.2    Kondo, Y.3    Kondo, S.4
  • 399
    • 84862886876 scopus 로고    scopus 로고
    • Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production
    • Capparelli C., Guido C., Whitaker-Menezes D., Bonuccelli G., Balliet R., Pestell T.G., et al. Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production. Cell Cycle (Georgetown, Tex) 2012, 11:2285-2302.
    • (2012) Cell Cycle (Georgetown, Tex) , vol.11 , pp. 2285-2302
    • Capparelli, C.1    Guido, C.2    Whitaker-Menezes, D.3    Bonuccelli, G.4    Balliet, R.5    Pestell, T.G.6
  • 400
    • 84873109651 scopus 로고    scopus 로고
    • Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development
    • Jain M.V., Paczulla A.M., Klonisch T., Dimgba F.N., Rao S.B., Roberg K., et al. Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development. J Cell Mol Med 2013, 17:12-29.
    • (2013) J Cell Mol Med , vol.17 , pp. 12-29
    • Jain, M.V.1    Paczulla, A.M.2    Klonisch, T.3    Dimgba, F.N.4    Rao, S.B.5    Roberg, K.6
  • 401
    • 77956193668 scopus 로고    scopus 로고
    • Induction of premature senescence by hsp90 inhibition in small cell lung cancer
    • Restall I.J., Lorimer I.A. Induction of premature senescence by hsp90 inhibition in small cell lung cancer. PLoS ONE 2010, 5:e11076.
    • (2010) PLoS ONE , vol.5 , pp. e11076
    • Restall, I.J.1    Lorimer, I.A.2
  • 402
    • 84886739871 scopus 로고    scopus 로고
    • A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation
    • Chan K.C., Ting C.M., Chan P.S., Lo M.C., Lo K.W., Curry J.E., et al. A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation. Mol Cancer 2013, 12:128.
    • (2013) Mol Cancer , vol.12 , pp. 128
    • Chan, K.C.1    Ting, C.M.2    Chan, P.S.3    Lo, M.C.4    Lo, K.W.5    Curry, J.E.6
  • 403
    • 38349050179 scopus 로고    scopus 로고
    • Proteasome modulates mitochondrial function during cellular senescence
    • Torres C.A., Perez V.I. Proteasome modulates mitochondrial function during cellular senescence. Free Radic Biol Med 2008, 44:403-414.
    • (2008) Free Radic Biol Med , vol.44 , pp. 403-414
    • Torres, C.A.1    Perez, V.I.2
  • 404
    • 0042346327 scopus 로고    scopus 로고
    • Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation
    • Chondrogianni N., Stratford F.L., Trougakos I.P., Friguet B., Rivett A.J., Gonos E.S. Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation. J Biol Chem 2003, 278:28026-28037.
    • (2003) J Biol Chem , vol.278 , pp. 28026-28037
    • Chondrogianni, N.1    Stratford, F.L.2    Trougakos, I.P.3    Friguet, B.4    Rivett, A.J.5    Gonos, E.S.6
  • 405
    • 84878005738 scopus 로고    scopus 로고
    • Variant G6PD levels promote tumor cell proliferation or apoptosis via the STAT3/5 pathway in the human melanoma xenograft mouse model
    • Hu T., Zhang C., Tang Q., Su Y., Li B., Chen L., et al. Variant G6PD levels promote tumor cell proliferation or apoptosis via the STAT3/5 pathway in the human melanoma xenograft mouse model. BMC Cancer 2013, 13:251.
    • (2013) BMC Cancer , vol.13 , pp. 251
    • Hu, T.1    Zhang, C.2    Tang, Q.3    Su, Y.4    Li, B.5    Chen, L.6
  • 406
    • 84878845628 scopus 로고    scopus 로고
    • MicroRNA-210 targets antiapoptotic Bcl-2 expression and mediates hypoxia-induced apoptosis of neuroblastoma cells
    • Chio C.C., Lin J.W., Cheng H.A., Chiu W.T., Wang Y.H., Wang J.J., et al. MicroRNA-210 targets antiapoptotic Bcl-2 expression and mediates hypoxia-induced apoptosis of neuroblastoma cells. Arch Toxicol 2013, 87:459-468.
    • (2013) Arch Toxicol , vol.87 , pp. 459-468
    • Chio, C.C.1    Lin, J.W.2    Cheng, H.A.3    Chiu, W.T.4    Wang, Y.H.5    Wang, J.J.6
  • 407
    • 84869445913 scopus 로고    scopus 로고
    • Glucose - a sweet way to die: metabolic switching modulates tumor cell death
    • MacFarlane M., Robinson G.L., Cain K. Glucose - a sweet way to die: metabolic switching modulates tumor cell death. Cell Cycle (Georgetown, Tex) 2012, 11:3919-3925.
    • (2012) Cell Cycle (Georgetown, Tex) , vol.11 , pp. 3919-3925
    • MacFarlane, M.1    Robinson, G.L.2    Cain, K.3
  • 408
    • 84885619223 scopus 로고    scopus 로고
    • Glycolysis inhibition sensitizes non-small cell lung cancer with T790M mutation to irreversible EGFR inhibitors via translational suppression of Mcl-1 by AMPK activation
    • Kim S.M., Yun M.R., Hong Y.K., Solca F., Kim J.H., Kim H.J., et al. Glycolysis inhibition sensitizes non-small cell lung cancer with T790M mutation to irreversible EGFR inhibitors via translational suppression of Mcl-1 by AMPK activation. Mol Cancer Ther 2013, 12:2145-2156.
    • (2013) Mol Cancer Ther , vol.12 , pp. 2145-2156
    • Kim, S.M.1    Yun, M.R.2    Hong, Y.K.3    Solca, F.4    Kim, J.H.5    Kim, H.J.6
  • 409
    • 84875366769 scopus 로고    scopus 로고
    • Inhibition of S6K1 enhances glucose deprivation-induced cell death via downregulation of anti-apoptotic proteins in MCF-7 breast cancer cells
    • Choi H.N., Jin H.O., Kim J.H., Hong S.E., Kim H.A., Kim E.K., et al. Inhibition of S6K1 enhances glucose deprivation-induced cell death via downregulation of anti-apoptotic proteins in MCF-7 breast cancer cells. Biochem Biophys Res Commun 2013, 432:123-128.
    • (2013) Biochem Biophys Res Commun , vol.432 , pp. 123-128
    • Choi, H.N.1    Jin, H.O.2    Kim, J.H.3    Hong, S.E.4    Kim, H.A.5    Kim, E.K.6
  • 410
    • 84861215287 scopus 로고    scopus 로고
    • Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy
    • McBrayer S.K., Cheng J.C., Singhal S., Krett N.L., Rosen S.T., Shanmugam M. Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy. Blood 2012, 119:4686-4697.
    • (2012) Blood , vol.119 , pp. 4686-4697
    • McBrayer, S.K.1    Cheng, J.C.2    Singhal, S.3    Krett, N.L.4    Rosen, S.T.5    Shanmugam, M.6
  • 411
    • 84894218696 scopus 로고    scopus 로고
    • Inhibition of GSK-3 induces differentiation and impaired glucose metabolism in renal cancer
    • Pal K., Cao Y., Gaisina I.N., Bhattacharya S., Dutta S.K., Wang E., et al. Inhibition of GSK-3 induces differentiation and impaired glucose metabolism in renal cancer. Mol Cancer Ther 2014, 13:285-296.
    • (2014) Mol Cancer Ther , vol.13 , pp. 285-296
    • Pal, K.1    Cao, Y.2    Gaisina, I.N.3    Bhattacharya, S.4    Dutta, S.K.5    Wang, E.6
  • 412
    • 84890432985 scopus 로고    scopus 로고
    • P53 status determines the role of autophagy in pancreatic tumour development
    • Rosenfeldt M.T., O'Prey J., Morton J.P., Nixon C., MacKay G., Mrowinska A., et al. p53 status determines the role of autophagy in pancreatic tumour development. Nature 2013, 504:296-300.
    • (2013) Nature , vol.504 , pp. 296-300
    • Rosenfeldt, M.T.1    O'Prey, J.2    Morton, J.P.3    Nixon, C.4    MacKay, G.5    Mrowinska, A.6
  • 413
    • 85069238538 scopus 로고    scopus 로고
    • Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism
    • Klarer A.C., O'Neal J., Imbert-Fernandez Y., Clem A., Ellis S.R., Clark J., et al. Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism. Cancer Metab 2014, 2:2.
    • (2014) Cancer Metab , vol.2 , pp. 2
    • Klarer, A.C.1    O'Neal, J.2    Imbert-Fernandez, Y.3    Clem, A.4    Ellis, S.R.5    Clark, J.6
  • 414
    • 84865276622 scopus 로고    scopus 로고
    • Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death
    • Wanka C., Brucker D.P., Bahr O., Ronellenfitsch M., Weller M., Steinbach J.P., et al. Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death. Oncogene 2012, 31:3764-3776.
    • (2012) Oncogene , vol.31 , pp. 3764-3776
    • Wanka, C.1    Brucker, D.P.2    Bahr, O.3    Ronellenfitsch, M.4    Weller, M.5    Steinbach, J.P.6
  • 415
    • 77957777599 scopus 로고    scopus 로고
    • 2-deoxyglucose sensitizes melanoma cells to TRAIL-induced apoptosis which is reduced by mannose
    • Qin J.Z., Xin H., Nickoloff B.J. 2-deoxyglucose sensitizes melanoma cells to TRAIL-induced apoptosis which is reduced by mannose. Biochem Biophys Res Commun 2010, 401:293-299.
    • (2010) Biochem Biophys Res Commun , vol.401 , pp. 293-299
    • Qin, J.Z.1    Xin, H.2    Nickoloff, B.J.3
  • 416
    • 77949653043 scopus 로고    scopus 로고
    • Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation
    • Pradelli L.A., Beneteau M., Chauvin C., Jacquin M.A., Marchetti S., Munoz-Pinedo C., et al. Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation. Oncogene 2010, 29:1641-1652.
    • (2010) Oncogene , vol.29 , pp. 1641-1652
    • Pradelli, L.A.1    Beneteau, M.2    Chauvin, C.3    Jacquin, M.A.4    Marchetti, S.5    Munoz-Pinedo, C.6
  • 417
    • 56249134557 scopus 로고    scopus 로고
    • A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death
    • Wood T.E., Dalili S., Simpson C.D., Hurren R., Mao X., Saiz F.S., et al. A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol Cancer Ther 2008, 7:3546-3555.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3546-3555
    • Wood, T.E.1    Dalili, S.2    Simpson, C.D.3    Hurren, R.4    Mao, X.5    Saiz, F.S.6
  • 418
    • 84862638382 scopus 로고    scopus 로고
    • Expression and therapeutic relevance of heat-shock protein 90 in pancreatic endocrine tumors
    • Mayer P., Harjung A., Breinig M., Fischer L., Ehemann V., Malz M., et al. Expression and therapeutic relevance of heat-shock protein 90 in pancreatic endocrine tumors. Endocr Relat Cancer 2012, 19:217-232.
    • (2012) Endocr Relat Cancer , vol.19 , pp. 217-232
    • Mayer, P.1    Harjung, A.2    Breinig, M.3    Fischer, L.4    Ehemann, V.5    Malz, M.6
  • 419
    • 58649121962 scopus 로고    scopus 로고
    • Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death
    • Beck R., Verrax J., Gonze T., Zappone M., Pedrosa R.C., Taper H., et al. Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death. Biochem Pharmacol 2009, 77:375-383.
    • (2009) Biochem Pharmacol , vol.77 , pp. 375-383
    • Beck, R.1    Verrax, J.2    Gonze, T.3    Zappone, M.4    Pedrosa, R.C.5    Taper, H.6
  • 420
    • 0037648896 scopus 로고    scopus 로고
    • Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal
    • Tsuruo T., Naito M., Tomida A., Fujita N., Mashima T., Sakamoto H., et al. Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal. Cancer Sci 2003, 94:15-21.
    • (2003) Cancer Sci , vol.94 , pp. 15-21
    • Tsuruo, T.1    Naito, M.2    Tomida, A.3    Fujita, N.4    Mashima, T.5    Sakamoto, H.6
  • 421
    • 84878768307 scopus 로고    scopus 로고
    • BAK and NOXA are critical determinants of mitochondrial apoptosis induced by bortezomib in mesothelioma
    • Busacca S., Chacko A.D., Klabatsa A., Arthur K., Sheaff M., Barbone D., et al. BAK and NOXA are critical determinants of mitochondrial apoptosis induced by bortezomib in mesothelioma. PLoS ONE 2013, 8:e65489.
    • (2013) PLoS ONE , vol.8 , pp. e65489
    • Busacca, S.1    Chacko, A.D.2    Klabatsa, A.3    Arthur, K.4    Sheaff, M.5    Barbone, D.6
  • 422
    • 34548525940 scopus 로고    scopus 로고
    • Bcl-2 expression in small cell lung cancer: a mechanism for apoptosis antagonism and immune evasion
    • Zheng J.M., Wang D.K., Jiang H.M. bcl-2 expression in small cell lung cancer: a mechanism for apoptosis antagonism and immune evasion. Di 1 Jun Yi Da Xue Xue Bao = Acad J First Med Coll PLA 2005, 25:1537-1539.
    • (2005) Di 1 Jun Yi Da Xue Xue Bao = Acad J First Med Coll PLA , vol.25 , pp. 1537-1539
    • Zheng, J.M.1    Wang, D.K.2    Jiang, H.M.3
  • 423
    • 5444237088 scopus 로고    scopus 로고
    • STAT proteins as novel targets for cancer drug discovery
    • Turkson J. STAT proteins as novel targets for cancer drug discovery. Expert Opin Ther Targets 2004, 8:409-422.
    • (2004) Expert Opin Ther Targets , vol.8 , pp. 409-422
    • Turkson, J.1
  • 424
    • 84877728919 scopus 로고    scopus 로고
    • The emerging hallmarks of metabolic reprogramming and immune evasion: distinct or linked
    • Kareva I., Hahnfeldt P. The emerging hallmarks of metabolic reprogramming and immune evasion: distinct or linked. Cancer Res 2013, 73:2737-2742.
    • (2013) Cancer Res , vol.73 , pp. 2737-2742
    • Kareva, I.1    Hahnfeldt, P.2
  • 425
    • 84883368914 scopus 로고    scopus 로고
    • Post-translational control of IL-1beta via the human papillomavirus type 16 E6 oncoprotein: a novel mechanism of innate immune escape mediated by the E3-ubiquitin ligase E6-AP and p53
    • Niebler M., Qian X., Hofler D., Kogosov V., Kaewprag J., Kaufmann A.M., et al. Post-translational control of IL-1beta via the human papillomavirus type 16 E6 oncoprotein: a novel mechanism of innate immune escape mediated by the E3-ubiquitin ligase E6-AP and p53. PLoS Pathogens 2013, 9:e1003536.
    • (2013) PLoS Pathogens , vol.9 , pp. e1003536
    • Niebler, M.1    Qian, X.2    Hofler, D.3    Kogosov, V.4    Kaewprag, J.5    Kaufmann, A.M.6
  • 426
    • 83655182735 scopus 로고    scopus 로고
    • Immune evasion strategies of the human gamma-herpesviruses: implications for viral tumorigenesis
    • Zhang X., Dawson C.W., He Z., Huang P. Immune evasion strategies of the human gamma-herpesviruses: implications for viral tumorigenesis. J Med Virol 2012, 84:272-281.
    • (2012) J Med Virol , vol.84 , pp. 272-281
    • Zhang, X.1    Dawson, C.W.2    He, Z.3    Huang, P.4
  • 427
    • 79551702601 scopus 로고    scopus 로고
    • Association of defective HLA-I expression with antigen processing machinery and their association with clinicopathological characteristics in Kazak patients with esophageal cancer
    • Ayshamgul H., Ma H., Ilyar S., Zhang L.W., Abulizi A. Association of defective HLA-I expression with antigen processing machinery and their association with clinicopathological characteristics in Kazak patients with esophageal cancer. Chin Med J (Engl) 2011, 124:341-346.
    • (2011) Chin Med J (Engl) , vol.124 , pp. 341-346
    • Ayshamgul, H.1    Ma, H.2    Ilyar, S.3    Zhang, L.W.4    Abulizi, A.5
  • 428
    • 0035266313 scopus 로고    scopus 로고
    • Up-Regulation of Bcl-2 in microvascular endothelial cells enhances intratumoral angiogenesis and accelerates tumor growth
    • Nor J.E., Christensen J., Liu J., Peters M., Mooney D.J., Strieter R.M., et al. Up-Regulation of Bcl-2 in microvascular endothelial cells enhances intratumoral angiogenesis and accelerates tumor growth. Cancer Res 2001, 61:2183-2188.
    • (2001) Cancer Res , vol.61 , pp. 2183-2188
    • Nor, J.E.1    Christensen, J.2    Liu, J.3    Peters, M.4    Mooney, D.J.5    Strieter, R.M.6
  • 429
    • 74549210540 scopus 로고    scopus 로고
    • Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways
    • Pignochino Y., Grignani G., Cavalloni G., Motta M., Tapparo M., Bruno S., et al. Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways. Mol Cancer 2009, 8:118.
    • (2009) Mol Cancer , vol.8 , pp. 118
    • Pignochino, Y.1    Grignani, G.2    Cavalloni, G.3    Motta, M.4    Tapparo, M.5    Bruno, S.6
  • 430
    • 33750284176 scopus 로고    scopus 로고
    • Autophagy in cancer: good, bad, or both
    • Hippert M.M., O'Toole P.S., Thorburn A. Autophagy in cancer: good, bad, or both. Cancer Res 2006, 66:9349-9351.
    • (2006) Cancer Res , vol.66 , pp. 9349-9351
    • Hippert, M.M.1    O'Toole, P.S.2    Thorburn, A.3
  • 431
    • 0242636948 scopus 로고    scopus 로고
    • Tumor necrosis correlates with angiogenesis and is a predictor of poor prognosis in malignant mesothelioma
    • Edwards J.G., Swinson D.E., Jones J.L., Muller S., Waller D.A., O'Byrne K.J. Tumor necrosis correlates with angiogenesis and is a predictor of poor prognosis in malignant mesothelioma. Chest 2003, 124:1916-1923.
    • (2003) Chest , vol.124 , pp. 1916-1923
    • Edwards, J.G.1    Swinson, D.E.2    Jones, J.L.3    Muller, S.4    Waller, D.A.5    O'Byrne, K.J.6
  • 432
    • 10644261537 scopus 로고    scopus 로고
    • Induction of angiogenesis by heat shock protein 90 mediated by protein kinase Akt and endothelial nitric oxide synthase
    • Sun J., Liao J.K. Induction of angiogenesis by heat shock protein 90 mediated by protein kinase Akt and endothelial nitric oxide synthase. Arterioscler Thromb Vasc Biol 2004, 24:2238-2244.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 2238-2244
    • Sun, J.1    Liao, J.K.2
  • 434
    • 33845971510 scopus 로고    scopus 로고
    • Nuclear export is essential for the tumor-promoting activity of survivin
    • Knauer S.K., Kramer O.H., Knosel T., Engels K., Rodel F., Kovacs A.F., et al. Nuclear export is essential for the tumor-promoting activity of survivin. FASEB J 2007, 21:207-216.
    • (2007) FASEB J , vol.21 , pp. 207-216
    • Knauer, S.K.1    Kramer, O.H.2    Knosel, T.3    Engels, K.4    Rodel, F.5    Kovacs, A.F.6
  • 435
    • 77249169359 scopus 로고    scopus 로고
    • Bcl-2 overexpression induces a partial epithelial to mesenchymal transition and promotes squamous carcinoma cell invasion and metastasis
    • Zuo J., Ishikawa T., Boutros S., Xiao Z., Humtsoe J.O., Kramer R.H. Bcl-2 overexpression induces a partial epithelial to mesenchymal transition and promotes squamous carcinoma cell invasion and metastasis. Mol Cancer Res: MCR 2010, 8:170-182.
    • (2010) Mol Cancer Res: MCR , vol.8 , pp. 170-182
    • Zuo, J.1    Ishikawa, T.2    Boutros, S.3    Xiao, Z.4    Humtsoe, J.O.5    Kramer, R.H.6
  • 436
    • 70349246434 scopus 로고    scopus 로고
    • Prognostic role of myeloid cell leukemia-1 protein (Mcl-1) expression in human gastric cancer
    • Likui W., Qun L., Wanqing Z., Haifeng S., Fangqiu L., Xiaojun L. Prognostic role of myeloid cell leukemia-1 protein (Mcl-1) expression in human gastric cancer. J Surg Oncol 2009, 100:396-400.
    • (2009) J Surg Oncol , vol.100 , pp. 396-400
    • Likui, W.1    Qun, L.2    Wanqing, Z.3    Haifeng, S.4    Fangqiu, L.5    Xiaojun, L.6
  • 437
    • 84863578884 scopus 로고    scopus 로고
    • DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer
    • Lv Q., Wang W., Xue J., Hua F., Mu R., Lin H., et al. DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer. Cancer Res 2012, 72:3238-3250.
    • (2012) Cancer Res , vol.72 , pp. 3238-3250
    • Lv, Q.1    Wang, W.2    Xue, J.3    Hua, F.4    Mu, R.5    Lin, H.6
  • 438
    • 33745713171 scopus 로고    scopus 로고
    • Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
    • Degenhardt K., Mathew R., Beaudoin B., Bray K., Anderson D., Chen G., et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006, 10:51-64.
    • (2006) Cancer Cell , vol.10 , pp. 51-64
    • Degenhardt, K.1    Mathew, R.2    Beaudoin, B.3    Bray, K.4    Anderson, D.5    Chen, G.6
  • 439
    • 0037226644 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer
    • Seki N., Hayakawa Y., Brooks A.D., Wine J., Wiltrout R.H., Yagita H., et al. Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer. Cancer Res 2003, 63:207-213.
    • (2003) Cancer Res , vol.63 , pp. 207-213
    • Seki, N.1    Hayakawa, Y.2    Brooks, A.D.3    Wine, J.4    Wiltrout, R.H.5    Yagita, H.6
  • 440
    • 64949083563 scopus 로고    scopus 로고
    • Inhibition of cancer invasion and metastasis by targeting the molecular chaperone heat-shock protein 90
    • Koga F., Kihara K., Neckers L. Inhibition of cancer invasion and metastasis by targeting the molecular chaperone heat-shock protein 90. Anticancer Res 2009, 29:797-807.
    • (2009) Anticancer Res , vol.29 , pp. 797-807
    • Koga, F.1    Kihara, K.2    Neckers, L.3
  • 441
    • 84878677607 scopus 로고    scopus 로고
    • The effects of Hsp90 expression alteration on spinal metastases of breast carcinoma
    • Yan W., Xiao J., Liu T., Huang W., Yang X., Wu Z., et al. The effects of Hsp90 expression alteration on spinal metastases of breast carcinoma. Tumour Biol 2013, 34:1391-1397.
    • (2013) Tumour Biol , vol.34 , pp. 1391-1397
    • Yan, W.1    Xiao, J.2    Liu, T.3    Huang, W.4    Yang, X.5    Wu, Z.6
  • 442
    • 84890447252 scopus 로고    scopus 로고
    • PKC?-dependent activation of the ubiquitin proteasome system is responsible for high glucose-induced human breast cancer MCF-7 cell proliferation, migration and invasion
    • Zhu S., Yao F., Li W.H., Wan J.N., Zhang Y.M., Tang Z., et al. PKC?-dependent activation of the ubiquitin proteasome system is responsible for high glucose-induced human breast cancer MCF-7 cell proliferation, migration and invasion. Asian Pac J Cancer Prevent: APJCP 2013, 14:5687-5692.
    • (2013) Asian Pac J Cancer Prevent: APJCP , vol.14 , pp. 5687-5692
    • Zhu, S.1    Yao, F.2    Li, W.H.3    Wan, J.N.4    Zhang, Y.M.5    Tang, Z.6
  • 443
    • 84877601009 scopus 로고    scopus 로고
    • CRM1 blockade by selective inhibitors of nuclear export attenuates kidney cancer growth
    • Inoue H., Kauffman M., Shacham S., Landesman Y., Yang J., Evans C.P., et al. CRM1 blockade by selective inhibitors of nuclear export attenuates kidney cancer growth. J Urol 2013, 189:2317-2326.
    • (2013) J Urol , vol.189 , pp. 2317-2326
    • Inoue, H.1    Kauffman, M.2    Shacham, S.3    Landesman, Y.4    Yang, J.5    Evans, C.P.6
  • 444
    • 77957366071 scopus 로고    scopus 로고
    • Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-kappaB activation and de novo gene transcription
    • Buggins A.G., Pepper C., Patten P.E., Hewamana S., Gohil S., Moorhead J., et al. Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-kappaB activation and de novo gene transcription. Cancer Res 2010, 70:7523-7533.
    • (2010) Cancer Res , vol.70 , pp. 7523-7533
    • Buggins, A.G.1    Pepper, C.2    Patten, P.E.3    Hewamana, S.4    Gohil, S.5    Moorhead, J.6
  • 445
    • 79959879734 scopus 로고    scopus 로고
    • Dual targeting of Bcl-2 and VEGF: a potential strategy to improve therapy for prostate cancer
    • Anai S., Sakamoto N., Sakai Y., Tanaka M., Porvasnik S., Urbanek C., et al. Dual targeting of Bcl-2 and VEGF: a potential strategy to improve therapy for prostate cancer. Urol Oncol 2011, 29:421-429.
    • (2011) Urol Oncol , vol.29 , pp. 421-429
    • Anai, S.1    Sakamoto, N.2    Sakai, Y.3    Tanaka, M.4    Porvasnik, S.5    Urbanek, C.6
  • 446
    • 66449099090 scopus 로고    scopus 로고
    • Autophagy suppresses tumorigenesis through elimination of p62
    • Mathew R., Karp C.M., Beaudoin B., Vuong N., Chen G., Chen H.Y., et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009, 137:1062-1075.
    • (2009) Cell , vol.137 , pp. 1062-1075
    • Mathew, R.1    Karp, C.M.2    Beaudoin, B.3    Vuong, N.4    Chen, G.5    Chen, H.Y.6
  • 447
    • 84889012246 scopus 로고    scopus 로고
    • Role of the Hypoxia-inducible factor-1 alpha induced autophagy in the conversion of non-stem pancreatic cancer cells into CD133+ pancreatic cancer stem-like cells
    • Zhu H., Wang D., Liu Y., Su Z., Zhang L., Chen F., et al. Role of the Hypoxia-inducible factor-1 alpha induced autophagy in the conversion of non-stem pancreatic cancer cells into CD133+ pancreatic cancer stem-like cells. Cancer Cell Int 2013, 13:119.
    • (2013) Cancer Cell Int , vol.13 , pp. 119
    • Zhu, H.1    Wang, D.2    Liu, Y.3    Su, Z.4    Zhang, L.5    Chen, F.6
  • 448
    • 84885850772 scopus 로고    scopus 로고
    • Hypoxia-induced senescence contributes to the regulation of microenvironment in melanomas
    • Mo J., Sun B., Zhao X., Gu Q., Dong X., Liu Z., et al. Hypoxia-induced senescence contributes to the regulation of microenvironment in melanomas. Pathol Res Pract 2013, 209:640-647.
    • (2013) Pathol Res Pract , vol.209 , pp. 640-647
    • Mo, J.1    Sun, B.2    Zhao, X.3    Gu, Q.4    Dong, X.5    Liu, Z.6
  • 449
    • 84867289621 scopus 로고    scopus 로고
    • The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-kappaB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells
    • Walsby E., Pearce L., Burnett A.K., Fegan C., Pepper C. The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-kappaB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells. Oncotarget 2012, 3:525-534.
    • (2012) Oncotarget , vol.3 , pp. 525-534
    • Walsby, E.1    Pearce, L.2    Burnett, A.K.3    Fegan, C.4    Pepper, C.5
  • 450
    • 84866564405 scopus 로고    scopus 로고
    • Targeting the tumor proteasome as a mechanism to control the synthesis and bioactivity of matrix macromolecules
    • Skandalis S.S., Aletras A.J., Gialeli C., Theocharis A.D., Afratis N., Tzanakakis G.N., et al. Targeting the tumor proteasome as a mechanism to control the synthesis and bioactivity of matrix macromolecules. Curr Mol Med 2012, 12:1068-1082.
    • (2012) Curr Mol Med , vol.12 , pp. 1068-1082
    • Skandalis, S.S.1    Aletras, A.J.2    Gialeli, C.3    Theocharis, A.D.4    Afratis, N.5    Tzanakakis, G.N.6
  • 451
    • 84891847971 scopus 로고    scopus 로고
    • CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications
    • Tai Y.T., Landesman Y., Acharya C., Calle Y., Zhong M.Y., Cea M., et al. CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications. Leukemia 2014, 28:155-165.
    • (2014) Leukemia , vol.28 , pp. 155-165
    • Tai, Y.T.1    Landesman, Y.2    Acharya, C.3    Calle, Y.4    Zhong, M.Y.5    Cea, M.6
  • 452
    • 84883289236 scopus 로고    scopus 로고
    • Negative modulation of mitochondrial oxidative phosphorylation by epigallocatechin-3 gallate leads to growth arrest and apoptosis in human malignant pleural mesothelioma cells
    • Valenti D., de Bari L., Manente G.A., Rossi L., Mutti L., Moro L., et al. Negative modulation of mitochondrial oxidative phosphorylation by epigallocatechin-3 gallate leads to growth arrest and apoptosis in human malignant pleural mesothelioma cells. Biochim Biophys Acta 2013, 1832:2085-2096.
    • (2013) Biochim Biophys Acta , vol.1832 , pp. 2085-2096
    • Valenti, D.1    de Bari, L.2    Manente, G.A.3    Rossi, L.4    Mutti, L.5    Moro, L.6
  • 453
    • 77953232664 scopus 로고    scopus 로고
    • Effect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice
    • Zhang Q., Fu H., Pan J., He J., Ryota S., Hara Y., et al. Effect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice. Pharm Res 2010, 27:1066-1071.
    • (2010) Pharm Res , vol.27 , pp. 1066-1071
    • Zhang, Q.1    Fu, H.2    Pan, J.3    He, J.4    Ryota, S.5    Hara, Y.6
  • 454
    • 79956046608 scopus 로고    scopus 로고
    • (-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis
    • Pang X., Wu Y., Wu Y., Lu B., Chen J., Wang J., et al. (-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis. Mol Cancer Ther 2011, 10:795-805.
    • (2011) Mol Cancer Ther , vol.10 , pp. 795-805
    • Pang, X.1    Wu, Y.2    Wu, Y.3    Lu, B.4    Chen, J.5    Wang, J.6
  • 455
    • 77952025257 scopus 로고    scopus 로고
    • Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in vivo using (-)-gossypol
    • Zhang X.Q., Huang X.F., Mu S.J., An Q.X., Xia A.J., Chen R., et al. Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in vivo using (-)-gossypol. Asian J Androl 2010, 12:390-399.
    • (2010) Asian J Androl , vol.12 , pp. 390-399
    • Zhang, X.Q.1    Huang, X.F.2    Mu, S.J.3    An, Q.X.4    Xia, A.J.5    Chen, R.6
  • 456
    • 84255186213 scopus 로고    scopus 로고
    • EGCG inhibits the invasion of highly invasive CL1-5 lung cancer cells through suppressing MMP-2 expression via JNK signaling and induces G2/M arrest
    • Deng Y.T., Lin J.K. EGCG inhibits the invasion of highly invasive CL1-5 lung cancer cells through suppressing MMP-2 expression via JNK signaling and induces G2/M arrest. J Agric Food Chem 2011, 59:13318-13327.
    • (2011) J Agric Food Chem , vol.59 , pp. 13318-13327
    • Deng, Y.T.1    Lin, J.K.2
  • 457
    • 81855206547 scopus 로고    scopus 로고
    • Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1alpha
    • Wang H., Bian S., Yang C.S. Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1alpha. Carcinogenesis 2011, 32:1881-1889.
    • (2011) Carcinogenesis , vol.32 , pp. 1881-1889
    • Wang, H.1    Bian, S.2    Yang, C.S.3
  • 458
    • 84862796331 scopus 로고    scopus 로고
    • Triptolide inhibits colon-rectal cancer cells proliferation by induction of G1 phase arrest through upregulation of p21
    • Liu J., Shen M., Yue Z., Yang Z., Wang M., Li C., et al. Triptolide inhibits colon-rectal cancer cells proliferation by induction of G1 phase arrest through upregulation of p21. Phytomedicine 2012, 19:756-762.
    • (2012) Phytomedicine , vol.19 , pp. 756-762
    • Liu, J.1    Shen, M.2    Yue, Z.3    Yang, Z.4    Wang, M.5    Li, C.6
  • 459
    • 84893529503 scopus 로고    scopus 로고
    • Triptolide induces growth inhibition and apoptosis of human laryngocarcinoma cells by enhancing p53 activities and suppressing E6-mediated p53 degradation
    • Zhao F., Huang W., Ousman T., Zhang B., Han Y., Clotaire D.Z., et al. Triptolide induces growth inhibition and apoptosis of human laryngocarcinoma cells by enhancing p53 activities and suppressing E6-mediated p53 degradation. PLoS ONE 2013, 8:e80784.
    • (2013) PLoS ONE , vol.8 , pp. e80784
    • Zhao, F.1    Huang, W.2    Ousman, T.3    Zhang, B.4    Han, Y.5    Clotaire, D.Z.6
  • 460
    • 84877730312 scopus 로고    scopus 로고
    • Gossypol induces apoptosis in ovarian cancer cells through oxidative stress
    • Wang J., Jin L., Li X., Deng H., Chen Y., Lian Q., et al. Gossypol induces apoptosis in ovarian cancer cells through oxidative stress. Mol BioSyst 2013, 9:1489-1497.
    • (2013) Mol BioSyst , vol.9 , pp. 1489-1497
    • Wang, J.1    Jin, L.2    Li, X.3    Deng, H.4    Chen, Y.5    Lian, Q.6
  • 461
    • 84887318592 scopus 로고    scopus 로고
    • Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo
    • Soderquist R., Bates D.J., Danilov A.V., Eastman A. Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo. Leukemia 2013, 27:2262-2264.
    • (2013) Leukemia , vol.27 , pp. 2262-2264
    • Soderquist, R.1    Bates, D.J.2    Danilov, A.V.3    Eastman, A.4
  • 462
    • 84860835752 scopus 로고    scopus 로고
    • (-)-Epigallocatechin-3-gallate, a green tea-derived catechin, synergizes with celecoxib to inhibit IL-1-induced tumorigenic mediators by human pancreatic adenocarcinoma cells Colo357
    • Hardtner C., Multhoff G., Falk W., Radons J. (-)-Epigallocatechin-3-gallate, a green tea-derived catechin, synergizes with celecoxib to inhibit IL-1-induced tumorigenic mediators by human pancreatic adenocarcinoma cells Colo357. Eur J Pharmacol 2012, 684:36-43.
    • (2012) Eur J Pharmacol , vol.684 , pp. 36-43
    • Hardtner, C.1    Multhoff, G.2    Falk, W.3    Radons, J.4
  • 463
    • 80053942696 scopus 로고    scopus 로고
    • EGCG downregulates IL-1RI expression and suppresses IL-1-induced tumorigenic factors in human pancreatic adenocarcinoma cells
    • Hoffmann J., Junker H., Schmieder A., Venz S., Brandt R., Multhoff G., et al. EGCG downregulates IL-1RI expression and suppresses IL-1-induced tumorigenic factors in human pancreatic adenocarcinoma cells. Biochem Pharmacol 2011, 82:1153-1162.
    • (2011) Biochem Pharmacol , vol.82 , pp. 1153-1162
    • Hoffmann, J.1    Junker, H.2    Schmieder, A.3    Venz, S.4    Brandt, R.5    Multhoff, G.6
  • 464
    • 80053938368 scopus 로고    scopus 로고
    • Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway
    • Park B., Sung B., Yadav V.R., Chaturvedi M.M., Aggarwal B.B. Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway. Biochem Pharmacol 2011, 82:1134-1144.
    • (2011) Biochem Pharmacol , vol.82 , pp. 1134-1144
    • Park, B.1    Sung, B.2    Yadav, V.R.3    Chaturvedi, M.M.4    Aggarwal, B.B.5
  • 465
    • 77951932747 scopus 로고    scopus 로고
    • RNA polymerase - an important molecular target of triptolide in cancer cells
    • Pan J. RNA polymerase - an important molecular target of triptolide in cancer cells. Cancer Lett 2010, 292:149-152.
    • (2010) Cancer Lett , vol.292 , pp. 149-152
    • Pan, J.1
  • 466
    • 67649559317 scopus 로고    scopus 로고
    • Gossypol inhibits the growth of MAT-LyLu prostate cancer cells by modulation of TGFbeta/Akt signaling
    • Jiang J., Ye W., Lin Y.C. Gossypol inhibits the growth of MAT-LyLu prostate cancer cells by modulation of TGFbeta/Akt signaling. Int J Mol Med 2009, 24:69-75.
    • (2009) Int J Mol Med , vol.24 , pp. 69-75
    • Jiang, J.1    Ye, W.2    Lin, Y.C.3
  • 467
    • 1442301661 scopus 로고    scopus 로고
    • The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta1 (TGFbeta1) signal transduction pathway
    • Jiang J., Sugimoto Y., Liu S., Chang H.L., Park K.Y., Kulp S.K., et al. The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta1 (TGFbeta1) signal transduction pathway. Anticancer Res 2004, 24:91-100.
    • (2004) Anticancer Res , vol.24 , pp. 91-100
    • Jiang, J.1    Sugimoto, Y.2    Liu, S.3    Chang, H.L.4    Park, K.Y.5    Kulp, S.K.6
  • 468
    • 84866436804 scopus 로고    scopus 로고
    • Epigallocatechin gallate sensitizes CAL-27 human oral squamous cell carcinoma cells to the anti-metastatic effects of gefitinib (Iressa) via synergistic suppression of epidermal growth factor receptor and matrix metalloproteinase-2
    • Chang C.M., Chang P.Y., Tu M.G., Lu C.C., Kuo S.C., Amagaya S., et al. Epigallocatechin gallate sensitizes CAL-27 human oral squamous cell carcinoma cells to the anti-metastatic effects of gefitinib (Iressa) via synergistic suppression of epidermal growth factor receptor and matrix metalloproteinase-2. Oncol Rep 2012, 28:1799-1807.
    • (2012) Oncol Rep , vol.28 , pp. 1799-1807
    • Chang, C.M.1    Chang, P.Y.2    Tu, M.G.3    Lu, C.C.4    Kuo, S.C.5    Amagaya, S.6
  • 469
    • 79960693011 scopus 로고    scopus 로고
    • The anti-cancer effects of (-)-epigallocatechin-3-gallate on the signaling pathways associated with membrane receptors in MCF-7 cells
    • Hsu Y.C., Liou Y.M. The anti-cancer effects of (-)-epigallocatechin-3-gallate on the signaling pathways associated with membrane receptors in MCF-7 cells. J Cell Physiol 2011, 226:2721-2730.
    • (2011) J Cell Physiol , vol.226 , pp. 2721-2730
    • Hsu, Y.C.1    Liou, Y.M.2
  • 470
    • 0036146830 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate inhibits basic fibroblast growth factor-induced intracellular signaling transduction pathway in rat aortic smooth muscle cells
    • Hwang K.C., Lee K.H., Jang Y., Yun Y.P., Chung K.H. Epigallocatechin-3-gallate inhibits basic fibroblast growth factor-induced intracellular signaling transduction pathway in rat aortic smooth muscle cells. J Cardiovasc Pharmacol 2002, 39:271-277.
    • (2002) J Cardiovasc Pharmacol , vol.39 , pp. 271-277
    • Hwang, K.C.1    Lee, K.H.2    Jang, Y.3    Yun, Y.P.4    Chung, K.H.5
  • 471
    • 84861590032 scopus 로고    scopus 로고
    • Triptolide inhibits the proliferation of prostate cancer cells and down-regulates SUMO-specific protease 1 expression
    • Huang W., He T., Chai C., Yang Y., Zheng Y., Zhou P., et al. Triptolide inhibits the proliferation of prostate cancer cells and down-regulates SUMO-specific protease 1 expression. PLoS ONE 2012, 7:e37693.
    • (2012) PLoS ONE , vol.7 , pp. e37693
    • Huang, W.1    He, T.2    Chai, C.3    Yang, Y.4    Zheng, Y.5    Zhou, P.6
  • 472
    • 77953591515 scopus 로고    scopus 로고
    • Gossypol exerts its cytotoxic effect on HL-60 leukemic cell line via decreasing activity of protein phosphatase 2A and interacting with human telomerase reverse transcriptase activity
    • Sahin F., Avci C.B., Gunduz C., Sezgin C., Simsir I.Y., Saydam G. Gossypol exerts its cytotoxic effect on HL-60 leukemic cell line via decreasing activity of protein phosphatase 2A and interacting with human telomerase reverse transcriptase activity. Hematology 2010, 15:144-150.
    • (2010) Hematology , vol.15 , pp. 144-150
    • Sahin, F.1    Avci, C.B.2    Gunduz, C.3    Sezgin, C.4    Simsir, I.Y.5    Saydam, G.6
  • 473
    • 53049083722 scopus 로고    scopus 로고
    • Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT
    • Moon D.O., Kim M.O., Choi Y.H., Lee H.G., Kim N.D., Kim G.Y. Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT. FEBS Lett 2008, 582:3367-3373.
    • (2008) FEBS Lett , vol.582 , pp. 3367-3373
    • Moon, D.O.1    Kim, M.O.2    Choi, Y.H.3    Lee, H.G.4    Kim, N.D.5    Kim, G.Y.6
  • 474
    • 70349558298 scopus 로고    scopus 로고
    • Apoptosis induction effects of EGCG in laryngeal squamous cell carcinoma cells through telomerase repression
    • Wang X., Hao M.W., Dong K., Lin F., Ren J.H., Zhang H.Z. Apoptosis induction effects of EGCG in laryngeal squamous cell carcinoma cells through telomerase repression. Arch Pharmacal Res 2009, 32:1263-1269.
    • (2009) Arch Pharmacal Res , vol.32 , pp. 1263-1269
    • Wang, X.1    Hao, M.W.2    Dong, K.3    Lin, F.4    Ren, J.H.5    Zhang, H.Z.6
  • 476
    • 0036023433 scopus 로고    scopus 로고
    • Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells
    • Kiviharju T.M., Lecane P.S., Sellers R.G., Peehl D.M. Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells. Clin Cancer Res 2002, 8:2666-2674.
    • (2002) Clin Cancer Res , vol.8 , pp. 2666-2674
    • Kiviharju, T.M.1    Lecane, P.S.2    Sellers, R.G.3    Peehl, D.M.4
  • 478
    • 84863346573 scopus 로고    scopus 로고
    • Down-regulation of glucose-regulated protein (GRP) 78 potentiates cytotoxic effect of celecoxib in human urothelial carcinoma cells
    • Huang K.H., Kuo K.L., Chen S.C., Weng T.I., Chuang Y.T., Tsai Y.C., et al. Down-regulation of glucose-regulated protein (GRP) 78 potentiates cytotoxic effect of celecoxib in human urothelial carcinoma cells. PLoS ONE 2012, 7:e33615.
    • (2012) PLoS ONE , vol.7 , pp. e33615
    • Huang, K.H.1    Kuo, K.L.2    Chen, S.C.3    Weng, T.I.4    Chuang, Y.T.5    Tsai, Y.C.6
  • 479
    • 84875994002 scopus 로고    scopus 로고
    • Role of oxidative stress, endoplasmic reticulum stress and ERK activation in triptolide-induced apoptosis
    • Tan B.J., Chiu G.N. Role of oxidative stress, endoplasmic reticulum stress and ERK activation in triptolide-induced apoptosis. Int J Oncol 2013, 42:1605-1612.
    • (2013) Int J Oncol , vol.42 , pp. 1605-1612
    • Tan, B.J.1    Chiu, G.N.2
  • 480
    • 84863356225 scopus 로고    scopus 로고
    • Tripchlorolide induces cell death in lung cancer cells by autophagy
    • Chen L., Liu Q., Huang Z., Wu F., Li Z., Chen X., et al. Tripchlorolide induces cell death in lung cancer cells by autophagy. Int J Oncol 2012, 40:1066-1070.
    • (2012) Int J Oncol , vol.40 , pp. 1066-1070
    • Chen, L.1    Liu, Q.2    Huang, Z.3    Wu, F.4    Li, Z.5    Chen, X.6
  • 481
    • 78651359258 scopus 로고    scopus 로고
    • Triptolide induces apoptosis in human adrenal cancer NCI-H295 cells through a mitochondrial-dependent pathway
    • Wu P.P., Liu K.C., Huang W.W., Ma C.Y., Lin H., Yang J.S., et al. Triptolide induces apoptosis in human adrenal cancer NCI-H295 cells through a mitochondrial-dependent pathway. Oncol Rep 2011, 25:551-557.
    • (2011) Oncol Rep , vol.25 , pp. 551-557
    • Wu, P.P.1    Liu, K.C.2    Huang, W.W.3    Ma, C.Y.4    Lin, H.5    Yang, J.S.6
  • 482
  • 483
    • 84883887202 scopus 로고    scopus 로고
    • Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization
    • Jang J.Y., Lee J.K., Jeon Y.K., Kim C.W. Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization. BMC Cancer 2013, 13:421.
    • (2013) BMC Cancer , vol.13 , pp. 421
    • Jang, J.Y.1    Lee, J.K.2    Jeon, Y.K.3    Kim, C.W.4
  • 484
    • 52149116029 scopus 로고    scopus 로고
    • Triptolide inhibits interferon-gamma-induced programmed death-1-ligand 1 surface expression in breast cancer cells
    • Liang M., Fu J. Triptolide inhibits interferon-gamma-induced programmed death-1-ligand 1 surface expression in breast cancer cells. Cancer Lett 2008, 270:337-341.
    • (2008) Cancer Lett , vol.270 , pp. 337-341
    • Liang, M.1    Fu, J.2
  • 485
    • 36448962451 scopus 로고    scopus 로고
    • EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer
    • Shankar S., Ganapathy S., Hingorani S.R., Srivastava R.K. EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer. Front Biosci 2008, 13:440-452.
    • (2008) Front Biosci , vol.13 , pp. 440-452
    • Shankar, S.1    Ganapathy, S.2    Hingorani, S.R.3    Srivastava, R.K.4
  • 486
    • 84879670401 scopus 로고    scopus 로고
    • Triptolide induces apoptosis and inhibits the growth and angiogenesis of human pancreatic cancer cells by downregulating COX-2 and VEGF
    • Ma J.X., Sun Y.L., Wang Y.Q., Wu H.Y., Jin J., Yu X.F. Triptolide induces apoptosis and inhibits the growth and angiogenesis of human pancreatic cancer cells by downregulating COX-2 and VEGF. Oncol Res 2013, 20:359-368.
    • (2013) Oncol Res , vol.20 , pp. 359-368
    • Ma, J.X.1    Sun, Y.L.2    Wang, Y.Q.3    Wu, H.Y.4    Jin, J.5    Yu, X.F.6
  • 487
    • 33646375977 scopus 로고    scopus 로고
    • (-)-gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo
    • Wolter K.G., Wang S.J., Henson B.S., Wang S., Griffith K.A., Kumar B., et al. (-)-gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo. Neoplasia 2006, 8:163-172.
    • (2006) Neoplasia , vol.8 , pp. 163-172
    • Wolter, K.G.1    Wang, S.J.2    Henson, B.S.3    Wang, S.4    Griffith, K.A.5    Kumar, B.6
  • 489
    • 0141576565 scopus 로고    scopus 로고
    • Triptolide inhibits the growth and metastasis of solid tumors
    • Yang S., Chen J., Guo Z., Xu X.M., Wang L., Pei X.F., et al. Triptolide inhibits the growth and metastasis of solid tumors. Mol Cancer Ther 2003, 2:65-72.
    • (2003) Mol Cancer Ther , vol.2 , pp. 65-72
    • Yang, S.1    Chen, J.2    Guo, Z.3    Xu, X.M.4    Wang, L.5    Pei, X.F.6
  • 490
    • 84867070588 scopus 로고    scopus 로고
    • NF-kappaB inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model
    • Pacak K., Sirova M., Giubellino A., Lencesova L., Csaderova L., Laukova M., et al. NF-kappaB inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model. Int J Cancer 2012, 131:2445-2455.
    • (2012) Int J Cancer , vol.131 , pp. 2445-2455
    • Pacak, K.1    Sirova, M.2    Giubellino, A.3    Lencesova, L.4    Csaderova, L.5    Laukova, M.6
  • 491
    • 84896284216 scopus 로고    scopus 로고
    • XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer
    • Cheng Y., Holloway M.P., Nguyen K., McCauley D., Landesman Y., Kauffman M.G., et al. XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer. Mol Cancer Ther 2014, 13:675-686.
    • (2014) Mol Cancer Ther , vol.13 , pp. 675-686
    • Cheng, Y.1    Holloway, M.P.2    Nguyen, K.3    McCauley, D.4    Landesman, Y.5    Kauffman, M.G.6
  • 492
    • 84875052270 scopus 로고    scopus 로고
    • KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia
    • Etchin J., Sanda T., Mansour M.R., Kentsis A., Montero J., Le B.T., et al. KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. Br J Haematol 2013, 161:117-127.
    • (2013) Br J Haematol , vol.161 , pp. 117-127
    • Etchin, J.1    Sanda, T.2    Mansour, M.R.3    Kentsis, A.4    Montero, J.5    Le, B.T.6
  • 494
    • 84877702897 scopus 로고    scopus 로고
    • Epigallocatechin gallate targeting of membrane type 1 matrix metalloproteinase-mediated Src and Janus kinase/signal transducers and activators of transcription 3 signaling inhibits transcription of colony-stimulating factors 2 and 3 in mesenchymal stromal cells
    • Zgheib A., Lamy S., Annabi B. Epigallocatechin gallate targeting of membrane type 1 matrix metalloproteinase-mediated Src and Janus kinase/signal transducers and activators of transcription 3 signaling inhibits transcription of colony-stimulating factors 2 and 3 in mesenchymal stromal cells. J Biol Chem 2013, 288:13378-13386.
    • (2013) J Biol Chem , vol.288 , pp. 13378-13386
    • Zgheib, A.1    Lamy, S.2    Annabi, B.3
  • 495
    • 84872824063 scopus 로고    scopus 로고
    • Triptolide induces S phase arrest via the inhibition of cyclin E and CDC25A and triggers apoptosis via caspase- and mitochondrial-dependent signaling pathways in A375.S2 human melanoma cells
    • Hung F.M., Chen Y.L., Huang A.C., Hsiao Y.P., Yang J.S., Chung M.T., et al. Triptolide induces S phase arrest via the inhibition of cyclin E and CDC25A and triggers apoptosis via caspase- and mitochondrial-dependent signaling pathways in A375.S2 human melanoma cells. Oncol Rep 2013, 29:1053-1060.
    • (2013) Oncol Rep , vol.29 , pp. 1053-1060
    • Hung, F.M.1    Chen, Y.L.2    Huang, A.C.3    Hsiao, Y.P.4    Yang, J.S.5    Chung, M.T.6
  • 496
    • 84857995858 scopus 로고    scopus 로고
    • MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML
    • Carter B.Z., Mak D.H., Shi Y., Fidler J.M., Chen R., Ling X., et al. MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML. Leukemia 2012, 26:443-450.
    • (2012) Leukemia , vol.26 , pp. 443-450
    • Carter, B.Z.1    Mak, D.H.2    Shi, Y.3    Fidler, J.M.4    Chen, R.5    Ling, X.6
  • 497
    • 84899920472 scopus 로고    scopus 로고
    • Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells
    • Zhong Y., El-Gamal D., Dubovsky J.A., Beckwith K.A., Harrington B.K., Williams K.E., et al. Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells. Leukemia 2014, 28:1158-1163.
    • (2014) Leukemia , vol.28 , pp. 1158-1163
    • Zhong, Y.1    El-Gamal, D.2    Dubovsky, J.A.3    Beckwith, K.A.4    Harrington, B.K.5    Williams, K.E.6


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