Effects of differential overexpression of Bcl-2 on apoptosis, proliferation, and telomerase activity in Jurkat T cells

Experimental Cell Research

Volumn 251, Issue 1, 1999, Pages 175-184

  Johnson, Victoria L ^a   Cooper, Ian R ^a   Jenkins, John R ^a   Chow, Sek C ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; FAS ANTIGEN; PROTEIN BCL 2; STAUROSPORINE; TELOMERASE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESTRICTION FRAGMENT;

EID: 0033603847     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1999.4557     Document Type: Article

References (44)

1. Oltvai Z. N., Korsmeyer S. J. Checkpoints of dueling dimers foil death wishes. Cell. 79:1994;189-192.
2. Kroemer G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat. Med. 3:1997;614-620.
3. Thompson C. B. Apoptosis and the pathogenesis and treatment of disease. Science. 267:1995;1456-1462.
4. Oltvai Z. N., Milliman C., Korsmeyer S. J. Bcl-2 heterdimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell. 74:1993;609-619.
5. Estoppey S., Rodriguez I., Sadoul R., Martinou J. C. Bcl-2 prevents activation of cpp32 cysteine protease and cleavage of poly (adp-ribose) polymerase and ul-70 kd proteins in staurosporine-mediated apoptosis. Cell Death Different. 4:1997;34-38.
6. Armstrong R. C., Aja T., Xiang J., Gaur S., Krebs J. F., Hoang K., Bai X., Korsmeyer S. J., Karanewsky D. S., Fritz L. C., Tomaselli K. J. Fas-induced activation of the cell death-related protease cpp32 is inhibited by bcl-2 and by ICE family protease inhibitors. J. Biol. Chem. 271:1996;16850-16855.
7. Jaattela M., Benedict M., Tewari M., Shayman J. A., Dixit V. M. Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. Oncogene. 10:1995;2297-2305.
8. Itoh N., Tsujimoto Y., Nagata S. Effect of bcl-2 on Fas antigen-mediated cell death. J. Immunol. 151:1993;621-627.
9. Strasser A., Harris A. W., Huang D. C. S., Krammer P. H., Cory S. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J. 14:1995;6136-6147.
10. Memon S. A., Moreno M. B., Petrak D., Zacharchuk C. M. Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma. J. Immunol. 155:1995;4644-4652.
11. Hengartner M. O., Ellis R. E., Horvitz H. R. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature. 356:1992;494-499.
12. Yuan J., Shaham S., Ledoux S., Ellis H. M., Horvitz H. R. The C. Elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1b-converting enzyme. Cell. 75:1993;641-652.
13. Zou H., Henzel W. J., Liu X., Lutschg A., Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell. 90:1997;405-413.
14. Hengartner M. O., Horvitz H. R. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene Bcl-2. Cell. 76:1994;665-676.
15. Orth K., Chinnaiyan A. M., Gang M., Froelich C. J., Dixit V. M. The ced-3/ice-like protease mch2 is activated during apoptosis and cleaves the death substrate lamin a. J. Biol. Chem. 271:1996;16443-16446.
16. Chinnaiyan A. M., Orourke K., Lane B. R., Dixit V. M. Interaction of ced-4 with ced-3 and ced-9: A molecular framework for cell death. Science. 275:1997;1122-1126.
17. Wu D., Wallen H. D., Nunez G. Interaction and regulation of subcellular localization of CED-4 by CED-9. Science. 275:1997;1126-1129.
18. L) interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc. Natl. Acad. Sci. USA. 95:1998;4386-4391.
19. Pan G., O'Rourke K., Dixit V. M. Caspase-9, Bcl-X(L), and Apaf-1 form a ternary complex. J. Biol. Chem. 273:1998;5841-5845.
20. Huang D. C. S., O'Reilly L. A., Strasser A., Cory S. The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry. EMBO J. 16:1997;4628-4638.
21. O'Reilly L. A., Huang D. C. S., Strasser A. The cell death inhibitor BCl-2 and its homologues influence control of cell cycle entry. EMBO J. 15:1996;6979-6990.
22. Borner C. Diminished cell proliferation associated with the death-protective activity of Bcl-2. J. Biol. Chem. 271:1996;12695-12698.
23. Brady H. J. M., Gil-Gomez G., Kirberg J., Berns A. J. M. Baxalpha perturbs T cell development and affects cell cycle entry of T cells. EMBO J. 15:1996;6991-7001.
24. Antonsson B., Conti F., Ciavatta A., Montessuit S., Lewis S., Martinou I., Bernasconi L., Bernard A., Mermod J., Mazzei G., Maundrell K., Gambale F., Sadoul R., Martinou J. Inhibition of Bax channel-forming activity by Bcl-2. Science. 277:1997;370-372.
25. Mandal M., Kumar R. Bcl-2 modulates telomerase activity. J. Biol. Chem. 272:1997;14183-14187.
26. Blackburn E. H. Structure and function of telomeres. Nature. 350:1991;569-573.
27. Morin G. B. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell. 59:1989;521-529.
28. Harley C. B., Vaziri H., Counter C. M., Allsopp R. C. The telomere hypothesis of cellular aging. Exp. Gerontol. 27:1992;375-382.
29. Holt S. E., Shay J. W., Wright W. E. Refining the telomere-telomerase hypothesis of aging and cancer. Nat. Biotechnol. 14:1996;836-839.
30. Broccoli D., Young J. W., De Lange T. Telomerase activity in normal and malignant hematopoietic cells. Proc. Natl. Acad. Sci. USA. 92:1995;9082-9086.
31. Shay J. W., Bacchetti S. A survey of telomerase activity in human cancer. Eur. J. Cancer. 33:1997;787-791.
32. Wong G. H. W., Goeddel D. V. Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways. J. Immunol. 152:1994;1751-1755.
33. Church G. M., Gilbert W. Genomic sequencing. Proc. Natl. Acad. Sci. USA. 81:1984;1991-1995.
34. Weng N., Levine B. L., June C. H., Hodes R. J. Human naive and memory T lymphocytes differ in telomeric length and replicative potential. Proc. Natl. Acad. Sci. USA. 92:1995;11091-11094.
35. Chinnaiyan A. M., Orth K., O'Rourke K., Duan H., Poirier G. G., Dixit V. M. Molecular ordering of the cell death pathway. Bcl-2 and Bcl-x(L) function upstream of the CED-3-like apoptotic proteases. J. Biol. Chem. 271:1996;4573-4576.
36. Weis M., Schlegel J., Kass G. E. N., Holmström T. H., Peters I., Eriksson J. E., Orrenius S., Chow S. C. Cellular events in Fas/APO-1-mediated apoptosis in JURKAT T lymphocytes. Exp. Cell Res. 219:1995;699-708.
37. Medema J. P., Scaffidi C., Kischkel F. C., Shevchenko A., Mann M., Krammer P. H., Peter M. E. Flice is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J. 16:1997;2794-2804.
38. Muzio M., Chinnaiyan A. M., Kischkel F. C., Orourke K., Shevchenko A., Ni J., Scaffidi C., Bretz J. D., Zhang M., Gentz R., Mann M., Krammer P. H., Peter M. E., Dixit V. M. Flice, a novel FADD-homologous ICE/ced-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell. 85:1996;817-827.
39. Chen J., Flannery J. G., LaVail M. M., Steinberg R. H., Xu J., Simon M. I. Bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations. Proc. Natl. Acad. Sci. USA. 93:1996;7042-7047.
40. Shibasaki F., Kondo E., Akagi T., McKeon F. Suppression of signalling through transcription factor NFAT by interactions between calcineurin and bcl-2. Nature. 386:1997;728-731.
41. Jain J., McCaffrey P. G., Miner Z., Kerppola T. K., Lambert J. N., Verdine G. L., Curran T., Rao A. The T-cell transcription factor NFAT(p) is a substrate for calcineurin and interacts with fos and jun. Nature. 365:1993;352-355.
42. Luo C., Burgeon E., Carew J. A., McCaffrey P. G., Badalian T. M., Lane W. S., Hogan P. G., Rao A. Recombinant NFAT1 (NFATp) is regulated by calcineurin in t cells and mediates transcription of several cytokine genes. Mol. Cell. Biol. 16:1996;3955-3966.
43. Chiu C., Harley C. B. Replicative senescence and cell immortality: The role of telomeres and telomerase. Proc. Soc. Exp. Biol. Med. 214:1997;99-106.
44. Bodnar A. G., Ouellette M., Frolkis M., Holt S. E., Chiu C., Morin G. B., Harley C. B., Shay J. W., Lichtsteiner S., Wright W. E. Extension of life span by introduction of telomerase into normal human cells. Science. 279:1998;349-352.