메뉴 건너뛰기




Volumn 72, Issue 13, 2012, Pages 3238-3250

DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; DEATH EFFECTOR DOMAIN CONTAINING DNA BINDING PROTEIN; DNA BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; UNCLASSIFIED DRUG;

EID: 84863578884     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-3832     Document Type: Article
Times cited : (146)

References (48)
  • 1
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer CL, Weinberg RA. A perspective on cancer cell metastasis. Science 2011;331:1559-64.
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 2
    • 77955497101 scopus 로고    scopus 로고
    • Current and emerging concepts in tumour metastasis
    • Coghlin C, Murray GI. Current and emerging concepts in tumour metastasis. J Pathol 2010;222:1-15.
    • (2010) J Pathol , vol.222 , pp. 1-15
    • Coghlin, C.1    Murray, G.I.2
  • 3
    • 52949124048 scopus 로고    scopus 로고
    • Cancer: The metastasis cascade
    • Klein CA. Cancer: the metastasis cascade. Science 2008;321:1785-87.
    • (2008) Science , vol.321 , pp. 1785-1787
    • Klein, C.A.1
  • 4
    • 79955420293 scopus 로고    scopus 로고
    • Cancer theory faces doubts
    • Ledford H. Cancer theory faces doubts. Nature 2011;472:273.
    • (2011) Nature , vol.472 , pp. 273
    • Ledford, H.1
  • 5
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009;139:871-90.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 6
    • 77951058591 scopus 로고    scopus 로고
    • Immune promotion of epithelial-mesenchymal transition and generation of breast cancer stem cells
    • Reiman JM, Knutson KL, Radisky DC. Immune promotion of epithelial-mesenchymal transition and generation of breast cancer stem cells. Cancer Res 2010;70:3005-8.
    • (2010) Cancer Res , vol.70 , pp. 3005-3008
    • Reiman, J.M.1    Knutson, K.L.2    Radisky, D.C.3
  • 7
    • 79958265710 scopus 로고    scopus 로고
    • Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
    • Scheel C, Eaton EN, Li SH, Chaffer CL, Reinhardt F, Kah KJ, et al. Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell 2011;145:926-40.
    • (2011) Cell , vol.145 , pp. 926-940
    • Scheel, C.1    Eaton, E.N.2    Li, S.H.3    Chaffer, C.L.4    Reinhardt, F.5    Kah, K.J.6
  • 9
    • 77956215419 scopus 로고    scopus 로고
    • Cancer cell of origin: Spotlight on luminal progenitors
    • Chaffer CL, Weinberg RA. Cancer cell of origin: spotlight on luminal progenitors. Cell Stem Cell 2010;7:271-2.
    • (2010) Cell Stem Cell , vol.7 , pp. 271-272
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 10
  • 11
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer
    • Singh A, Settleman J. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 2010;29:4741-51.
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 12
    • 33746851956 scopus 로고    scopus 로고
    • Tumor metastasis: Mechanistic insights and clinical challenges
    • DOI 10.1038/nm1469, PII NM1469
    • Steeg PS. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 2006;12:895-904. (Pubitemid 44175140)
    • (2006) Nature Medicine , vol.12 , Issue.8 , pp. 895-904
    • Steeg, P.S.1
  • 13
    • 0038393124 scopus 로고    scopus 로고
    • The death effector domain protein family: Regulators of cellular homeostasis
    • DOI 10.1038/ni0503-404
    • Tibbetts MD, Zheng L, Lenardo MJ. The death effector domain protein family: regulators of cellular homeostasis. Nat Immunol 2003;4:404-9. (Pubitemid 36592429)
    • (2003) Nature Immunology , vol.4 , Issue.5 , pp. 404-409
    • Tibbetts, M.D.1    Zheng, L.2    Lenardo, M.J.3
  • 14
    • 63049089877 scopus 로고    scopus 로고
    • Death effector domain-containing proteins
    • Valmiki MG, Ramos JW. Death effector domain-containing proteins. Cell Mol Life Sci 2009;66:814-30.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 814-830
    • Valmiki, M.G.1    Ramos, J.W.2
  • 15
    • 64149084526 scopus 로고    scopus 로고
    • The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation
    • Kurabe N, Arai S, Nishijima A, Kubota N, Suizu F, Mori M, et al. The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation. J Biol Chem 2009;284:5050-5.
    • (2009) J Biol Chem , vol.284 , pp. 5050-5055
    • Kurabe, N.1    Arai, S.2    Nishijima, A.3    Kubota, N.4    Suizu, F.5    Mori, M.6
  • 16
    • 38349161010 scopus 로고    scopus 로고
    • Two distinct controls of mitotic cdk1/cyclin B1 activity requisite for cell growth prior to cell division
    • Miyazaki T, Arai S. Two distinct controls of mitotic cdk1/cyclin B1 activity requisite for cell growth prior to cell division. Cell Cycle 2007;6:1419-25.
    • (2007) Cell Cycle , vol.6 , pp. 1419-1425
    • Miyazaki, T.1    Arai, S.2
  • 18
    • 0346880485 scopus 로고    scopus 로고
    • The death effector domain protein family
    • DOI 10.1038/sj.onc.1207103
    • Barnhart BC, Lee JC, Alappat EC, Peter ME. The death effector domain protein family. Oncogene 2003;22:8634-44. (Pubitemid 38019199)
    • (2003) Oncogene , vol.22 , Issue.53 REV. ISS. 7 , pp. 8634-8644
    • Barnhart, B.C.1    Lee, J.C.2    Alappat, E.C.3    Peter, M.E.4
  • 19
    • 77954173919 scopus 로고    scopus 로고
    • DEDD negatively regulates transforming growth factor-beta1 signaling by interacting with Smad3
    • Xue JF, Hua F, Lv Q, Lin H, Wang ZY, Yan J, et al. DEDD negatively regulates transforming growth factor-beta1 signaling by interacting with Smad3. FEBS Lett 2010;584:3028-34.
    • (2010) FEBS Lett , vol.584 , pp. 3028-3034
    • Xue, J.F.1    Hua, F.2    Lv, Q.3    Lin, H.4    Wang, Z.Y.5    Yan, J.6
  • 20
    • 80054027591 scopus 로고    scopus 로고
    • TRB3 interacts with SMAD3 promoting tumor cell migration and invasion
    • Hua F, Mu R, Liu J, Xue J, Wang Z, Lin H, et al. TRB3 interacts with SMAD3 promoting tumor cell migration and invasion. J Cell Sci 2011;124:3235-46.
    • (2011) J Cell Sci , vol.124 , pp. 3235-3246
    • Hua, F.1    Mu, R.2    Liu, J.3    Xue, J.4    Wang, Z.5    Lin, H.6
  • 24
    • 41649119370 scopus 로고    scopus 로고
    • Snail is a repressor of RKIP transcription in metastatic prostate cancer cells
    • Beach S, Tang H, Park S, Dhillon AS, Keller ET, Kolch W, et al. Snail is a repressor of RKIP transcription in metastatic prostate cancer cells. Oncogene 2007;27:2243-48.
    • (2007) Oncogene , vol.27 , pp. 2243-2248
    • Beach, S.1    Tang, H.2    Park, S.3    Dhillon, A.S.4    Keller, E.T.5    Kolch, W.6
  • 26
    • 18444369940 scopus 로고    scopus 로고
    • Alterations of Fas-pathway genes associated with nodal metastasis in non-small cell lung cancer
    • Shin MS, Kim HS, Lee SH, Lee JW, Song YH, KimYS, et al. Alterations of Fas-pathway genes associated with nodal metastasis in non-small cell lung cancer. Oncogene 2002;21:4129-36.
    • (2002) Oncogene , vol.21 , pp. 4129-4136
    • Shin, M.S.1    Kim, H.S.2    Lee, S.H.3    Lee, J.W.4    Song, Y.H.5    Kim, Y.S.6
  • 27
    • 47249145558 scopus 로고    scopus 로고
    • Bacillus Calmette-Guvrin and TLR4 agonist prevent cardiovascular hypertrophy and fibrosis by regulating immune microenvironment
    • Liu YY, Cai WF, Yang HZ, Cui B, Chen ZR, Liu HZ, et al. Bacillus Calmette-Guvrin and TLR4 agonist prevent cardiovascular hypertrophy and fibrosis by regulating immune microenvironment. J Immunol 2008;180:7349-57.
    • (2008) J Immunol , vol.180 , pp. 7349-7357
    • Liu, Y.Y.1    Cai, W.F.2    Yang, H.Z.3    Cui, B.4    Chen, Z.R.5    Liu, H.Z.6
  • 28
    • 68349130145 scopus 로고    scopus 로고
    • Blocking TLR2 activity attenuates pulmonary metastases of tumor
    • Yang HZ, Cui B, Liu HZ, Mi S, Yan J, Yan HM, et al. Blocking TLR2 activity attenuates pulmonary metastases of tumor. PLoS One 2009;4:e6520.
    • (2009) PLoS One , vol.4
    • Yang, H.Z.1    Cui, B.2    Liu, H.Z.3    Mi, S.4    Yan, J.5    Yan, H.M.6
  • 29
    • 40749094918 scopus 로고    scopus 로고
    • SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis
    • DOI 10.1038/nature06781, PII NATURE06781
    • Han HJ, Russo J, Kohwi Y, Kohwi-Shigematsu T. SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. Nature 2008;452:187-93. (Pubitemid 351380252)
    • (2008) Nature , vol.452 , Issue.7184 , pp. 187-193
    • Han, H.-J.1    Russo, J.2    Kohwi, Y.3    Kohwi-Shigematsu, T.4
  • 30
    • 80052731707 scopus 로고    scopus 로고
    • Timing is critical for an effective anti-metastatic immunotherapy: The decisive role of IFNγ/STAT1-mediated activation of autophagy
    • Yan J, Wang ZY, Yang HZ, Liu HZ, Mi S, Lv XX, et al. Timing is critical for an effective anti-metastatic immunotherapy: the decisive role of IFNγ/STAT1-mediated activation of autophagy. PLoS One 2011;6:e24705.
    • (2011) PLoS One , vol.6
    • Yan, J.1    Wang, Z.Y.2    Yang, H.Z.3    Liu, H.Z.4    Mi, S.5    Lv, X.X.6
  • 31
    • 78149485367 scopus 로고    scopus 로고
    • Key signalling nodes in mammary gland development and cancer. The Snail1-Twist1 conspiracy in malignant breast cancer progression
    • Foubert E, De Craene B, Berx G. Key signalling nodes in mammary gland development and cancer. The Snail1-Twist1 conspiracy in malignant breast cancer progression. Breast Cancer Res 2010;12:206.
    • (2010) Breast Cancer Res , vol.12 , pp. 206
    • Foubert, E.1    De Craene, B.2    Berx, G.3
  • 32
    • 84055216937 scopus 로고    scopus 로고
    • Temporal and spatial cooperation of Snail1 and Twist1 during epithelial-mesenchymal transition predicts for human breast cancer recurrence
    • Tran DD, Corsa CA, Biswas H, Aft R, Longmore GD. Temporal and spatial cooperation of Snail1 and Twist1 during epithelial-mesenchymal transition predicts for human breast cancer recurrence. Mol Cancer Res 2011;9:1644-57.
    • (2011) Mol Cancer Res , vol.9 , pp. 1644-1657
    • Tran, D.D.1    Corsa, C.A.2    Biswas, H.3    Aft, R.4    Longmore, G.D.5
  • 33
    • 34249289041 scopus 로고    scopus 로고
    • Snail, ZEB and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • DOI 10.1038/nrc2131, PII NRC2131
    • Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 2007;7:415-28. (Pubitemid 46809165)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.6 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 35
    • 5444269904 scopus 로고    scopus 로고
    • Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
    • DOI 10.1038/ncb1173
    • Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M, et al. Dual regulation of Snail by GSK-3[beta]-mediated phosphorylation in control of epithelial- mesenchymal transition. Nat Cell Biol 2004;6: 931-40. (Pubitemid 39359846)
    • (2004) Nature Cell Biology , vol.6 , Issue.10 , pp. 931-940
    • Zhou, B.P.1    Deng, J.2    Xia, W.3    Xu, J.4    Li, Y.M.5    Gunduz, M.6    Hung, M.-C.7
  • 37
    • 74949090299 scopus 로고    scopus 로고
    • An overview of the molecular mechanism of autophagy
    • Yang Z, Klionsky DJ. An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol 2009;335:1-32.
    • (2009) Curr Top Microbiol Immunol , vol.335 , pp. 1-32
    • Yang, Z.1    Klionsky, D.J.2
  • 38
    • 79953153832 scopus 로고    scopus 로고
    • Autophagy and tumorigenesis
    • Roy S, Debnath J. Autophagy and tumorigenesis. Semin Immunopathol 2010;32:383-96.
    • (2010) Semin Immunopathol , vol.32 , pp. 383-396
    • Roy, S.1    Debnath, J.2
  • 39
    • 77953543377 scopus 로고    scopus 로고
    • The Beclin 1-VPS34 complex-at the crossroads of autophagy and beyond
    • Funderburk SF, Wang QJ, Yue Z. The Beclin 1-VPS34 complex-at the crossroads of autophagy and beyond. Trends Cell Biol 2010;20:355-62.
    • (2010) Trends Cell Biol , vol.20 , pp. 355-362
    • Funderburk, S.F.1    Wang, Q.J.2    Yue, Z.3
  • 40
    • 39749141485 scopus 로고    scopus 로고
    • The regulation and function of Class III PI3Ks: Novel roles for Vps34
    • DOI 10.1042/BJ20071427
    • Backer JM. The regulation and function of class III PI3Ks: novel roles for Vps34. Biochem J 2008;410:1-17. (Pubitemid 351300321)
    • (2008) Biochemical Journal , vol.410 , Issue.1 , pp. 1-17
    • Backer, J.M.1
  • 41
    • 64049113909 scopus 로고    scopus 로고
    • Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin1-phosphatidylinositol-3-kinase complex
    • Zhong Y, Wang QJ, Li X, Yan Y, Backer JM, Chait BT, et al. Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin1-phosphatidylinositol-3-kinase complex. Nat Cell Biol 2009;11:468-76.
    • (2009) Nat Cell Biol , vol.11 , pp. 468-476
    • Zhong, Y.1    Wang, Q.J.2    Li, X.3    Yan, Y.4    Backer, J.M.5    Chait, B.T.6
  • 42
    • 75649151387 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer development and its clinical significance
    • Iwatsuki M, Mimori K, Yokobori T, Ishi H, Beppu T, Nakamori S, et al. Epithelial-mesenchymal transition in cancer development and its clinical significance. Cancer Sci 2010;101:293-9.
    • (2010) Cancer Sci , vol.101 , pp. 293-299
    • Iwatsuki, M.1    Mimori, K.2    Yokobori, T.3    Ishi, H.4    Beppu, T.5    Nakamori, S.6
  • 43
    • 78650954694 scopus 로고    scopus 로고
    • Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice
    • Mori M, Kitazume M, Ose R, Kurokawa J, Koga K, Osuga Y, et al. Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice. J Clin Invest 2011;121:318-27.
    • (2011) J Clin Invest , vol.121 , pp. 318-327
    • Mori, M.1    Kitazume, M.2    Ose, R.3    Kurokawa, J.4    Koga, K.5    Osuga, Y.6
  • 44
    • 30944447303 scopus 로고    scopus 로고
    • Fusing DEDD with ubiquitin changes its intracellular localization and apoptotic potential
    • DOI 10.1007/s10495-005-1833-z
    • Lee JC, Wang GX, Schickling O, Peter ME. Fusing DEDD with ubiquitin changes its intracellular localization and apoptotic potential. Apoptosis 2005;10:1483-95. (Pubitemid 43117690)
    • (2005) Apoptosis , vol.10 , Issue.6 , pp. 1483-1495
    • Lee, J.C.1    Wang, G.X.2    Schickling, O.3    Peter, M.E.4
  • 45
    • 0037448684 scopus 로고    scopus 로고
    • DEDD and DEDD2 associate with caspase-8/10 and signal cell death
    • DOI 10.1038/sj.onc.1206099
    • Alcivar A, Hu S, Tang J, Yang X. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene 2003;22:291-7. (Pubitemid 36174186)
    • (2003) Oncogene , vol.22 , Issue.2 , pp. 291-297
    • Alcivar, A.1    Hu, S.2    Tang, J.3    Yang, X.4
  • 46
    • 74449091175 scopus 로고    scopus 로고
    • The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability
    • Kurabe N, Mori M, Kurokawa J, Taniguchi K, Aoyama H, Atsuda K, et al. The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability. Biochem Biophys Res Commun 2010;391:1708-13.
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 1708-1713
    • Kurabe, N.1    Mori, M.2    Kurokawa, J.3    Taniguchi, K.4    Aoyama, H.5    Atsuda, K.6
  • 47
    • 77950212231 scopus 로고    scopus 로고
    • Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34
    • Miller S, Tavshanjian B, Oleksy A, Perisic O, Houseman BT, Shokat KM, et al. Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34. Science 2010;327:1638-42.
    • (2010) Science , vol.327 , pp. 1638-1642
    • Miller, S.1    Tavshanjian, B.2    Oleksy, A.3    Perisic, O.4    Houseman, B.T.5    Shokat, K.M.6
  • 48
    • 80053501671 scopus 로고    scopus 로고
    • Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13
    • Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L, et al. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 2011;147:223-34.
    • (2011) Cell , vol.147 , pp. 223-234
    • Liu, J.1    Xia, H.2    Kim, M.3    Xu, L.4    Li, Y.5    Zhang, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.