메뉴 건너뛰기




Volumn 66, Issue 8, 2009, Pages 1326-1336

Mcl-1 is a potential therapeutic target in multiple types of cancer

Author keywords

Apoptosis; Bcl 2 family; Cancer; Mcl 1; Therapeutic

Indexed keywords

2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID; 4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; 6 (2,6 DICHLOROPHENYL) 2 (4 FLUORO 3 METHYLANILINO) 8 METHYL 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; ALPHA INTERFERON; ANTINEOPLASTIC AGENT; BH3 PROTEIN; BIM PROTEIN; CYTOCHROME C; DASATINIB; DEXAMETHASONE; EPIGALLOCATECHIN GALLATE; ETODOLAC; FLAVOPIRIDOL; HOMOHARRINGTONINE; IBUPROFEN; IMATINIB; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL X; PROTEIN BID; PROTEIN MCL 1; PSEUDOMONAS EXOTOXIN; PUMA PROTEIN; RESVERATROL; ROSCOVITINE; SDX 101; SORAFENIB; STAT3 PROTEIN; STAT5 PROTEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 67349136004     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-008-8637-6     Document Type: Review
Times cited : (289)

References (98)
  • 1
    • 0015383455 scopus 로고
    • Apoptosis : A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J. F., Wyllie, A. H. and Currie, A. R. (1972) Apoptosis : A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 2
    • 1442359848 scopus 로고    scopus 로고
    • The interplay between the Bcl-2 family and death receptor-mediated apoptosis
    • Sprick, M. R. and Walczak, H. (2004) The interplay between the Bcl-2 family and death receptor-mediated apoptosis. Biochim. Biophys. Acta 1644, 125-132.
    • (2004) Biochim. Biophys. Acta , vol.1644 , pp. 125-132
    • Sprick, M.R.1    Walczak, H.2
  • 3
    • 0032575688 scopus 로고    scopus 로고
    • The Bcl-2 protein family: Arbiters of cell survival
    • Adams, J. M, and Cory, S. (1998) The Bcl-2 protein family: Arbiters of cell survival. Science 281, 1322-1326.
    • (1998) Science , vol.281 , pp. 1322-1326
    • Adams, J.M.1    Cory, S.2
  • 4
    • 0035146929 scopus 로고    scopus 로고
    • Life-or-death decisions by the Bcl-2 protein family
    • Adams, J. M. and Cory, S. (2001) Life-or-death decisions by the Bcl-2 protein family. Trends Biochem. Sci. 26, 61-66.
    • (2001) Trends Biochem. Sci , vol.26 , pp. 61-66
    • Adams, J.M.1    Cory, S.2
  • 6
    • 34748924281 scopus 로고    scopus 로고
    • Bcl-2-regulated apoptosis: Mechanism and therapeutic potential
    • Adams, J. M. and Cory, S. (2007) Bcl-2-regulated apoptosis: Mechanism and therapeutic potential. Curr. Opin. Immunol. 19, 488-496.
    • (2007) Curr. Opin. Immunol , vol.19 , pp. 488-496
    • Adams, J.M.1    Cory, S.2
  • 7
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green, D. R. and Reed, J. C. (1998) Mitochondria and apoptosis. Science 281, 1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 8
    • 0027480450 scopus 로고
    • MCLl, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2
    • Kozopas, K. M., Yang, T., Buchan, H. L., Zhou, P. and Craig, R. W. (1993) MCLl, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc. Natl. Acad. Sci. USA 90, 3516-3520.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3516-3520
    • Kozopas, K.M.1    Yang, T.2    Buchan, H.L.3    Zhou, P.4    Craig, R.W.5
  • 9
    • 0029043811 scopus 로고
    • Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo
    • Krajewski, S., Bodrug, S., Krajewska, M., Shabaik, A., Gascoyne, R., Berean, K. and Reed, J. C. (1995) Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo. Am. J. Pathol. 146, 1309-1319.
    • (1995) Am. J. Pathol , vol.146 , pp. 1309-1319
    • Krajewski, S.1    Bodrug, S.2    Krajewska, M.3    Shabaik, A.4    Gascoyne, R.5    Berean, K.6    Reed, J.C.7
  • 10
    • 33947598446 scopus 로고    scopus 로고
    • Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma
    • Zhuang, L., Lee, C. S., Scolyer, R. A., McCarthy, S. W., Zhang, X. D., Thompson, J. F. and Hersey, P. (2007) Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma. Mod. Pathol, 20, 416-426.
    • (2007) Mod. Pathol , vol.20 , pp. 416-426
    • Zhuang, L.1    Lee, C.S.2    Scolyer, R.A.3    McCarthy, S.W.4    Zhang, X.D.5    Thompson, J.F.6    Hersey, P.7
  • 11
    • 0038810258 scopus 로고    scopus 로고
    • Bcl-2-related protein family gene expression during oligodendroglial differentiation
    • Itoh, T, Itoh, A. and Pleasure D. (2003) Bcl-2-related protein family gene expression during oligodendroglial differentiation. J. Neurochem. 85,1500-1512.
    • (2003) J. Neurochem , vol.85 , pp. 1500-1512
    • Itoh, T.1    Itoh, A.2    Pleasure, D.3
  • 12
    • 0034698122 scopus 로고    scopus 로고
    • Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death
    • Bingle, C. D., Craig, R. W., Swales, B. M., Singleton, V., Zhou, P. and Whyte, M. K. (2000) Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death. J. Biol. Chem. 275,22136-22146.
    • (2000) J. Biol. Chem , vol.275 , pp. 22136-22146
    • Bingle, C.D.1    Craig, R.W.2    Swales, B.M.3    Singleton, V.4    Zhou, P.5    Whyte, M.K.6
  • 13
    • 0034726071 scopus 로고    scopus 로고
    • In vivo localisation and stability of human Mcl-1 using green fluorescent protein (GFP) fusion proteins
    • Akgul, C., Moulding, D. A., White, M. R. and Edwards, S. W. (2000) In vivo localisation and stability of human Mcl-1 using green fluorescent protein (GFP) fusion proteins. FEBS Lett. 478, 72-76.
    • (2000) FEBS Lett , vol.478 , pp. 72-76
    • Akgul, C.1    Moulding, D.A.2    White, M.R.3    Edwards, S.W.4
  • 14
    • 15444373128 scopus 로고    scopus 로고
    • Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells
    • Weng, C., Li, Y., Xu, D., Shi, Y and Tang, H. (2005) Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells. J. Biol. Chem. 280, 10491-10500.
    • (2005) J. Biol. Chem , vol.280 , pp. 10491-10500
    • Weng, C.1    Li, Y.2    Xu, D.3    Shi, Y.4    Tang, H.5
  • 16
    • 34347350211 scopus 로고    scopus 로고
    • Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization
    • Ding, Q., He, X., Hsu, J. M., Xia, W., Chen, C. T., Li, L. Y., Lee, D. F., Liu, J. G., Zhong, Q., Wang, X. and Hung, M. C. (2007) Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Mol. Cell. Biol. 27,4006-4017.
    • (2007) Mol. Cell. Biol , vol.27 , pp. 4006-4017
    • Ding, Q.1    He, X.2    Hsu, J.M.3    Xia, W.4    Chen, C.T.5    Li, L.Y.6    Lee, D.F.7    Liu, J.G.8    Zhong, Q.9    Wang, X.10    Hung, M.C.11
  • 18
    • 34247254266 scopus 로고    scopus 로고
    • NBK/BIK antagonizes MCL-I and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition
    • Shimazu, T., Degenhardt, K., Nur-E-Kamal, A., Zhang, J., Yoshida, T., Zhang, Y., Mathew, R., White, E. and Inouye, M. (2007) NBK/BIK antagonizes MCL-I and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition. Genes Dev. 21, 929-941.
    • (2007) Genes Dev , vol.21 , pp. 929-941
    • Shimazu, T.1    Degenhardt, K.2    Nur-E-Kamal, A.3    Zhang, J.4    Yoshida, T.5    Zhang, Y.6    Mathew, R.7    White, E.8    Inouye, M.9
  • 19
    • 34447515353 scopus 로고    scopus 로고
    • Functional linkage between NOXA and Bim in mitochondrial apoptotic events
    • Han, J., Goldstein, L. A., Hou, W. and Rabinowich, H. (2007) Functional linkage between NOXA and Bim in mitochondrial apoptotic events. J. Biol. Chem. 282, 16223-16231.
    • (2007) J. Biol. Chem , vol.282 , pp. 16223-16231
    • Han, J.1    Goldstein, L.A.2    Hou, W.3    Rabinowich, H.4
  • 20
    • 33646846666 scopus 로고    scopus 로고
    • Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis
    • Clohessy, J. G., Zhuang, J., de Boer, J., Gil-Gómez, G. and Brady, H. J. (2006) Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis. J. Biol. Chem. 281, 5750-5759.
    • (2006) J. Biol. Chem , vol.281 , pp. 5750-5759
    • Clohessy, J.G.1    Zhuang, J.2    de Boer, J.3    Gil-Gómez, G.4    Brady, H.J.5
  • 22
    • 22244464818 scopus 로고    scopus 로고
    • Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
    • Willis, S. N., Chen, L.,Dewson,G.,Wei, A., Naik, E., Fletcher, J. I.,Adams, J. M. and Huang,D. C. (2005) Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev. 19, 1294-1305.
    • (2005) Genes Dev , vol.19 , pp. 1294-1305
    • Willis, S.N.1    Chen, L.2    Dewson, G.3    Wei, A.4    Naik, E.5    Fletcher, J.I.6    Adams, J.M.7    Huang, D.C.8
  • 24
    • 32944479992 scopus 로고    scopus 로고
    • Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells
    • Isomoto, H., Kobayashi, S., Werneburg, N. W., Bronk, S. F., Guicciardi, M. E., Frank, D. A. and Gores, G. J. (2005) Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells. Hepatology 42, 1329-1338.
    • (2005) Hepatology , vol.42 , pp. 1329-1338
    • Isomoto, H.1    Kobayashi, S.2    Werneburg, N.W.3    Bronk, S.F.4    Guicciardi, M.E.5    Frank, D.A.6    Gores, G.J.7
  • 26
    • 0032772367 scopus 로고    scopus 로고
    • The antiapoptotic gene mcl-1 is upregulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB
    • Wang, J. M., Chao, J. R., Chen, W., Kuo, M. L., Yen, J. J. and Yang-Yen, H. F. (1999) The antiapoptotic gene mcl-1 is upregulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB. Mol. Cell Biol. 19, 6195-6206.
    • (1999) Mol. Cell Biol , vol.19 , pp. 6195-6206
    • Wang, J.M.1    Chao, J.R.2    Chen, W.3    Kuo, M.L.4    Yen, J.J.5    Yang-Yen, H.F.6
  • 27
    • 0037370472 scopus 로고    scopus 로고
    • Interleukin-3 stimulation of mcl-1 gene transcription involves activation of the PU.1 transcription factor through a p38 mitogen-activated protein kinase-dependent pathway
    • Wang, J. M., Lai, M. Z. andYang-Yen, H. F. (2003) Interleukin-3 stimulation of mcl-1 gene transcription involves activation of the PU.1 transcription factor through a p38 mitogen-activated protein kinase-dependent pathway. Mol. Cell Biol. 23, 1896-1909.
    • (2003) Mol. Cell Biol , vol.23 , pp. 1896-1909
    • Wang, J.M.1    Lai, M.Z.2    andYang-Yen, H.F.3
  • 29
    • 15744369062 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-dependent overexpression of myeloid cell factor-1 protects hypoxic cells against tert-butyl hydroperoxide-induced apoptosis
    • Piret, J. P.,Minet, E.,Cosse, J. P., Ninane,N., Debacq,C.,Raes, M. and Michiels,C. (2005) Hypoxia-inducible factor-1-dependent overexpression of myeloid cell factor-1 protects hypoxic cells against tert-butyl hydroperoxide-induced apoptosis. J. Biol. Chem. 280, 9336-9344.
    • (2005) J. Biol. Chem , vol.280 , pp. 9336-9344
    • Piret, J.P.1    Minet, E.2    Cosse, J.P.3    Ninane, N.4    Debacq, C.5    Raes, M.6    Michiels, C.7
  • 30
    • 8644243021 scopus 로고    scopus 로고
    • Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death
    • Vickers,E.R., Kazsa, A.,Kurnaz, I. A., Seifert, A.,Zeef, L.A., O'Donnell, A., Hayes, A. and Sharrocks, A. D. (2004) Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death. Mol. Cell Biol. 24, 10340-10351.
    • (2004) Mol. Cell Biol , vol.24 , pp. 10340-10351
    • Vickers, E.R.1    Kazsa, A.2    Kurnaz, I.A.3    Seifert, A.4    Zeef, L.A.5    O'Donnell, A.6    Hayes, A.7    Sharrocks, A.D.8
  • 32
    • 0035213274 scopus 로고    scopus 로고
    • BCL-2 family expression in human neutrophils during delayed and accelerated apoptosis
    • Moulding, D. A., Akgul, C., Derouet, M., White, M. R. and Edwards, S. W. (2001) BCL-2 family expression in human neutrophils during delayed and accelerated apoptosis. J. Leukoc. Biol. 70, 783-792.
    • (2001) J. Leukoc. Biol , vol.70 , pp. 783-792
    • Moulding, D.A.1    Akgul, C.2    Derouet, M.3    White, M.R.4    Edwards, S.W.5
  • 33
    • 34548687035 scopus 로고    scopus 로고
    • mir-29 regulates Mcl-1 protein expression and apoptosis
    • Mott, J. L., Kobayashi, S., Bronk, S. F. and Gores, G. J. (2007) mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene 26, 6133-6140.
    • (2007) Oncogene , vol.26 , pp. 6133-6140
    • Mott, J.L.1    Kobayashi, S.2    Bronk, S.F.3    Gores, G.J.4
  • 36
    • 3142683869 scopus 로고    scopus 로고
    • MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol
    • Domina, A.M., Vrana, J. A., Gregory,M. A., Hann, S. R. and Craig, R. W. (2004) MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol. Oncogene 23, 5301-5315.
    • (2004) Oncogene , vol.23 , pp. 5301-5315
    • Domina, A.M.1    Vrana, J.A.2    Gregory, M.A.3    Hann, S.R.4    Craig, R.W.5
  • 37
    • 33644855216 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
    • Maurer, U., Charvet, C., Wagman, A. S., Dejardin, E. and Gren, D. R. (2006) Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol. Cell 21, 749-760.
    • (2006) Mol. Cell , vol.21 , pp. 749-760
    • Maurer, U.1    Charvet, C.2    Wagman, A.S.3    Dejardin, E.4    Gren, D.R.5
  • 38
    • 0037113878 scopus 로고    scopus 로고
    • Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress
    • Inoshita, S., Takeda, K., Hatai, T., Terada, Y., Sano,M., Hata, J., Umezawa, A. and Ichijo, H. (2002) Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress. J. Biol. Chem. 277, 43730-43734.
    • (2002) J. Biol. Chem , vol.277 , pp. 43730-43734
    • Inoshita, S.1    Takeda, K.2    Hatai, T.3    Terada, Y.4    Sano, M.5    Hata, J.6    Umezawa, A.7    Ichijo, H.8
  • 39
    • 3042686666 scopus 로고    scopus 로고
    • Granulocyte macrophage colony-stimulating factor signaling and proteasome inhibition delay neutrophil apoptosis by increasing the stability of Mcl-1
    • Derouet, M., Thomas, L., Cross,A., Moots, R. J. and Edwards, S. W. (2004) Granulocyte macrophage colony-stimulating factor signaling and proteasome inhibition delay neutrophil apoptosis by increasing the stability of Mcl-1. J. Biol. Chem. 279, 26915-26921.
    • (2004) J. Biol. Chem , vol.279 , pp. 26915-26921
    • Derouet, M.1    Thomas, L.2    Cross, A.3    Moots, R.J.4    Edwards, S.W.5
  • 40
    • 21244472965 scopus 로고    scopus 로고
    • Mule/ARFBP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis
    • Zhong, Q., Gao, W., Du, F. and Wang, X. (2005) Mule/ARFBP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell 121, 1085-1095.
    • (2005) Cell , vol.121 , pp. 1085-1095
    • Zhong, Q.1    Gao, W.2    Du, F.3    Wang, X.4
  • 42
    • 0036659905 scopus 로고    scopus 로고
    • Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells
    • Derenne, S., Monia, B.,Dean,N. M., Taylor, J. K., Rapp,M. J., Harousseau, J. L., Bataille, R. and Amiot, M. (2002) Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells. Blood 100, 194-199.
    • (2002) Blood , vol.100 , pp. 194-199
    • Derenne, S.1    Monia, B.2    Dean, N.M.3    Taylor, J.K.4    Rapp, M.J.5    Harousseau, J.L.6    Bataille, R.7    Amiot, M.8
  • 46
    • 34247511009 scopus 로고    scopus 로고
    • Mcl-1 is a relevant therapeutic target in acute and chronic lymphoid malignancies: Down-regulation enhances rituximab-mediated apoptosis and complement-dependent cytotoxicity
    • Hussain, S. R.,Cheney,C.M., Johnson, A. J., Lin,T. S.,Grever, M. R.,Caligiuri, M. A., Lucas,D.M. and Byrd, J.C. (2007) Mcl-1 is a relevant therapeutic target in acute and chronic lymphoid malignancies: Down-regulation enhances rituximab-mediated apoptosis and complement-dependent cytotoxicity. Clin. Cancer Res. 13, 2144-2150.
    • (2007) Clin. Cancer Res , vol.13 , pp. 2144-2150
    • Hussain, S.R.1    Cheney, C.M.2    Johnson, A.J.3    Lin, T.S.4    Grever, M.R.5    Caligiuri, M.A.6    Lucas, D.M.7    Byrd, J.C.8
  • 47
    • 45949094910 scopus 로고    scopus 로고
    • Targeting Bcl-2 family members with the BH3 mimeticAT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma
    • Paoluzzi, L.,Gonen, M.,Gardner, J.R., Mastrella, J.,Yang,D., Holmlund, J., Sorensen, M., Leopold, L., Manova, K., Marcucci, G., Heaney, M. L. and O'Connor, O. A. (2008) Targeting Bcl-2 family members with the BH3 mimeticAT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma. Blood 111, 5350-5358.
    • (2008) Blood , vol.111 , pp. 5350-5358
    • Paoluzzi, L.1    Gonen, M.2    Gardner, J.R.3    Mastrella, J.4    Yang, D.5    Holmlund, J.6    Sorensen, M.7    Leopold, L.8    Manova, K.9    Marcucci, G.10    Heaney, M.L.11    O'Connor, O.A.12
  • 48
    • 6344289534 scopus 로고    scopus 로고
    • Downregulation of the antiapoptotic MCL-1 protein and apoptosis in MA-11 breast cancer cells induced by an anti-epidermal growth factor receptor-Pseudomonas exotoxin a immunotoxin
    • Andersson, Y., Juell, S. and Fodstad, Ø. (2004) Downregulation of the antiapoptotic MCL-1 protein and apoptosis in MA-11 breast cancer cells induced by an anti-epidermal growth factor receptor-Pseudomonas exotoxin a immunotoxin. Int. J. Cancer 112, 475-483.
    • (2004) Int. J. Cancer , vol.112 , pp. 475-483
    • Andersson, Y.1    Juell, S.2    Fodstad, Ø.3
  • 50
    • 51849157031 scopus 로고    scopus 로고
    • Inducing apoptosis and enhancing chemosensitivity to Gemcitabine via RNA interference targeting Mcl-1 gene in pancreatic carcinoma cell
    • Wei, S. H., Dong, K., Lin, F., Wang, X., Li, B., Shen, J. J., Zhang, Q., Wang, R. and Zhang, H. Z. (2008) Inducing apoptosis and enhancing chemosensitivity to Gemcitabine via RNA interference targeting Mcl-1 gene in pancreatic carcinoma cell. Cancer Chemother. Pharmacol. 62, 1055-1064.
    • (2008) Cancer Chemother. Pharmacol , vol.62 , pp. 1055-1064
    • Wei, S.H.1    Dong, K.2    Lin, F.3    Wang, X.4    Li, B.5    Shen, J.J.6    Zhang, Q.7    Wang, R.8    Zhang, H.Z.9
  • 51
    • 33750715718 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of lipidic nano-particles in cancer. Anticancer Agents
    • Allen, T. M., Cheng, W. W., Hare, J. I. and Laginha, K. M. (2006) Pharmacokinetics and pharmacodynamics of lipidic nano-particles in cancer. Anticancer Agents Med. Chem. 6, 513-523.
    • (2006) Med. Chem , vol.6 , pp. 513-523
    • Allen, T.M.1    Cheng, W.W.2    Hare, J.I.3    Laginha, K.M.4
  • 53
    • 67349135580 scopus 로고    scopus 로고
    • CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multidrug resistant ovarian cancer cells. Cancer Chemother
    • Epub ahead of print
    • Duan, Z., Ames, R. Y., Ryan, M., Hornicek, F. J., Mankin, H. and Seiden, M. V. (2008) CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multidrug resistant ovarian cancer cells. Cancer Chemother. Pharmacol. (Epub ahead of print).
    • (2008) Pharmacol
    • Duan, Z.1    Ames, R.Y.2    Ryan, M.3    Hornicek, F.J.4    Mankin, H.5    Seiden, M.V.6
  • 54
    • 33645471372 scopus 로고    scopus 로고
    • Semisynthetic homoharringtonine induces apoptosis via inhibition of protein synthesis and triggers rapid myeloid cell leukemia-1 down-regulation in myeloid leukemia cells
    • Tang, R., Faussat, A. M.,Majdak, P.,Marzac, C., Dubrulle, S., Marjanovic, Z., Legrand, O. and Marie, J. P. (2006) Semisynthetic homoharringtonine induces apoptosis via inhibition of protein synthesis and triggers rapid myeloid cell leukemia-1 down-regulation in myeloid leukemia cells. Mol. Cancer Ther. 5, 723-731.
    • (2006) Mol. Cancer Ther , vol.5 , pp. 723-731
    • Tang, R.1    Faussat, A.M.2    Majdak, P.3    Marzac, C.4    Dubrulle, S.5    Marjanovic, Z.6    Legrand, O.7    Marie, J.P.8
  • 55
    • 5444237088 scopus 로고    scopus 로고
    • STAT proteins as novel targets for cancer drug discovery
    • Turkson, J. (2004) STAT proteins as novel targets for cancer drug discovery. Expert Opin. Ther. Targets 8, 409-422.
    • (2004) Expert Opin. Ther. Targets , vol.8 , pp. 409-422
    • Turkson, J.1
  • 56
    • 33645464650 scopus 로고    scopus 로고
    • Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis ofmalignant cells containing activated Stat3 protein
    • Kotha, A., Sekharam, M., Cilenti, L., Siddiquee, K., Khaled, A., Zervos, A. S., Carter, B., Turkson, J. and Jove R. (2006) Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis ofmalignant cells containing activated Stat3 protein. Mol. Cancer Ther. 5, 621-629.
    • (2006) Mol. Cancer Ther , vol.5 , pp. 621-629
    • Kotha, A.1    Sekharam, M.2    Cilenti, L.3    Siddiquee, K.4    Khaled, A.5    Zervos, A.S.6    Carter, B.7    Turkson, J.8    Jove, R.9
  • 57
    • 35448979972 scopus 로고    scopus 로고
    • Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity
    • Thyrell, L., Arulampalam, V., Hjortsberg, L., Farnebo, M., Grandér, D. and Pokrovskaja Tamm, K. (2007) Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity. Exp.Cell Res. 313, 4015-4024.
    • (2007) Exp.Cell Res , vol.313 , pp. 4015-4024
    • Thyrell, L.1    Arulampalam, V.2    Hjortsberg, L.3    Farnebo, M.4    Grandér, D.5    Pokrovskaja Tamm, K.6
  • 58
    • 34248166041 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells
    • Nam, S., Williams, A., Vultur, A., List, A., Bhalla, K., Smith, D., Lee, F. Y. and Jove, R. (2007) Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells. Mol. Cancer Ther. 6, 1400-1405.
    • (2007) Mol. Cancer Ther , vol.6 , pp. 1400-1405
    • Nam, S.1    Williams, A.2    Vultur, A.3    List, A.4    Bhalla, K.5    Smith, D.6    Lee, F.Y.7    Jove, R.8
  • 61
    • 20444477948 scopus 로고    scopus 로고
    • Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase IIdependent transcription and down-regulation of Mcl-1
    • MacCallum, D. E., Melville, J., Frame, S.,Watt, K., Anderson, S., Gianella-Borradori, A., Lane, D. P. and Gren, S. R. (2005) Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase IIdependent transcription and down-regulation of Mcl-1. Cancer Res. 65, 5399-5407.
    • (2005) Cancer Res , vol.65 , pp. 5399-5407
    • MacCallum, D.E.1    Melville, J.2    Frame, S.3    Watt, K.4    Anderson, S.5    Gianella-Borradori, A.6    Lane, D.P.7    Gren, S.R.8
  • 62
    • 0036850211 scopus 로고    scopus 로고
    • The cyclindependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1
    • Gojo, I., Zhang, B. and Fenton, R. G. (2002) The cyclindependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1. Clin. Cancer Res. 8, 3527-3538.
    • (2002) Clin. Cancer Res , vol.8 , pp. 3527-3538
    • Gojo, I.1    Zhang, B.2    Fenton, R.G.3
  • 63
    • 27444436166 scopus 로고    scopus 로고
    • Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation
    • Rahmani, M., Davis, E. M., Bauer, C., Dent, P. and Grant, S. (2005) Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation. J. Biol. Chem. 280, 35217-35227.
    • (2005) J. Biol. Chem , vol.280 , pp. 35217-35227
    • Rahmani, M.1    Davis, E.M.2    Bauer, C.3    Dent, P.4    Grant, S.5
  • 64
    • 11144356134 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells
    • Maggio, S. C., Rosato, R. R., Kramer, L, B., Dai, Y., Rahmani, M., Paik, D. S., Czarnik, A. C., Payne, S. G., Spiegel, S. and Grant, S. (2004) The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells. Cancer Res. 64, 2590-2600.
    • (2004) Cancer Res , vol.64 , pp. 2590-2600
    • Maggio, S.C.1    Rosato, R.R.2    Kramer, L.B.3    Dai, Y.4    Rahmani, M.5    Paik, D.S.6    Czarnik, A.C.7    Payne, S.G.8    Spiegel, S.9    Grant, S.10
  • 65
    • 33646533106 scopus 로고    scopus 로고
    • Ryu, J. K., Lee, W. J., Lee, K. H., Hwang, J. H., Kim, Y. T., Yoon, Y. B. and Kim, C. Y. (2006) SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines.Cancer Lett. 237, 143-154.
    • Ryu, J. K., Lee, W. J., Lee, K. H., Hwang, J. H., Kim, Y. T., Yoon, Y. B. and Kim, C. Y. (2006) SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines.Cancer Lett. 237, 143-154.
  • 66
    • 46949097093 scopus 로고    scopus 로고
    • Protein phosphatase 1 activation and alternative splicing of Bcl-X and Mcl-1 by EGCG+ ibuprofen
    • Kim, M. H. (2008) Protein phosphatase 1 activation and alternative splicing of Bcl-X and Mcl-1 by EGCG+ ibuprofen. J. Cell Biochem. 104, 1491-1499.
    • (2008) J. Cell Biochem , vol.104 , pp. 1491-1499
    • Kim, M.H.1
  • 68
    • 0035844238 scopus 로고    scopus 로고
    • Mercatante,D.R., Bortner, C.D., Cidlowski, J. A. andKole,R. (2001) Modification of alternative splicing of Bcl-x pre-mRNA in prostate and breast cancer cells. analysis of apoptosis and cell death. J. Biol. Chem. 276, 16411-16417.
    • Mercatante,D.R., Bortner, C.D., Cidlowski, J. A. andKole,R. (2001) Modification of alternative splicing of Bcl-x pre-mRNA in prostate and breast cancer cells. analysis of apoptosis and cell death. J. Biol. Chem. 276, 16411-16417.
  • 69
    • 0035502474 scopus 로고    scopus 로고
    • Modification of alternative splicing by antisense oligonucleotides as a potential chemotherapy for cancer and other diseases
    • Mercatante, D. R., Sazani, P. and Kole, R. (2001) Modification of alternative splicing by antisense oligonucleotides as a potential chemotherapy for cancer and other diseases. Curr. Cancer Drug Targets 1, 211-230.
    • (2001) Curr. Cancer Drug Targets , vol.1 , pp. 211-230
    • Mercatante, D.R.1    Sazani, P.2    Kole, R.3
  • 70
    • 4644299291 scopus 로고    scopus 로고
    • Alternative splicing of Bcl-2-related genes: Functional consequences and potential therapeutic applications
    • Akgul, C., Moulding, D. A. and Edwards, S. W. (2004) Alternative splicing of Bcl-2-related genes: Functional consequences and potential therapeutic applications. Cell. Mol. Life Sci. 61, 2189-2199.
    • (2004) Cell. Mol. Life Sci , vol.61 , pp. 2189-2199
    • Akgul, C.1    Moulding, D.A.2    Edwards, S.W.3
  • 71
    • 34548096400 scopus 로고    scopus 로고
    • Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1
    • Wang,Y. F., Jiang, C. C., Kiejda, K. A.,Gillespie, S., Zhang, X. D. and Hersey, P. (2007) Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1. Clin. Cancer Res. 13, 4934-4942.
    • (2007) Clin. Cancer Res , vol.13 , pp. 4934-4942
    • Wang, Y.F.1    Jiang, C.C.2    Kiejda, K.A.3    Gillespie, S.4    Zhang, X.D.5    Hersey, P.6
  • 72
    • 34250740869 scopus 로고    scopus 로고
    • The novel tyrosine kinase inhibitor EXEL-0862 induces apoptosis in human FIP1L1-PDGFR-alpha-expressing cells through caspase-3-mediated cleavage of Mcl-1
    • Pan, J., Quintás-Cardama, A., Manshouri, T., Giles, F. J., Lamb, P., Tefferi, A., Cortes, J., Kantarjian,H. andVerstovsek, S. (2007) The novel tyrosine kinase inhibitor EXEL-0862 induces apoptosis in human FIP1L1-PDGFR-alpha-expressing cells through caspase-3-mediated cleavage of Mcl-1. Leukemia 21, 1395-1404.
    • (2007) Leukemia , vol.21 , pp. 1395-1404
    • Pan, J.1    Quintás-Cardama, A.2    Manshouri, T.3    Giles, F.J.4    Lamb, P.5    Tefferi, A.6    Cortes, J.7    Kantarjian, H.8    andVerstovsek, S.9
  • 73
    • 0000015743 scopus 로고    scopus 로고
    • Antisense oligonucleotides: Basic concepts and mechanisms
    • Dias, N. and Stein, C. A. (2002) Antisense oligonucleotides: Basic concepts and mechanisms. Mol. Cancer Ther. 1, 347-355.
    • (2002) Mol. Cancer Ther , vol.1 , pp. 347-355
    • Dias, N.1    Stein, C.A.2
  • 74
    • 33748792048 scopus 로고    scopus 로고
    • RNA interference for the treatment of cancer
    • Putral, L. N., Gu, W. and McMillan, N. A. (2006) RNA interference for the treatment of cancer. Drug News Perspect. 19, 317-324.
    • (2006) Drug News Perspect , vol.19 , pp. 317-324
    • Putral, L.N.1    Gu, W.2    McMillan, N.A.3
  • 75
    • 0034283981 scopus 로고    scopus 로고
    • Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells
    • Moulding,D.A., Giles,R.V., Spiller,D.G.,White,M.R.,Tidd, D. M. and Edwards, S.W. (2000) Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells. Blood 96, 1756-1763.
    • (2000) Blood , vol.96 , pp. 1756-1763
    • Moulding, D.A.1    Giles, R.V.2    Spiller, D.G.3    White, M.R.4    Tidd, D.M.5    Edwards, S.W.6
  • 76
    • 33947579975 scopus 로고    scopus 로고
    • Identification of MCL1 as a novel target in neoplastic mast cells in systemic mastocytosis: Inhibition of mast cell survival by MCL1 antisense oligonucleotides and synergism with PKC412
    • Aichberger, K. J.,Mayerhofer,M., Gleixner,K. V., Krauth, M. T., Gruze, A., Pickl, W. F., Wacheck, V., Selzer, E., Mllauer, L., Agis, H., Sillaber, C. and Valent, P. (2007) Identification of MCL1 as a novel target in neoplastic mast cells in systemic mastocytosis: Inhibition of mast cell survival by MCL1 antisense oligonucleotides and synergism with PKC412. Blood 109, 3031-3041.
    • (2007) Blood , vol.109 , pp. 3031-3041
    • Aichberger, K.J.1    Mayerhofer, M.2    Gleixner, K.V.3    Krauth, M.T.4    Gruze, A.5    Pickl, W.F.6    Wacheck, V.7    Selzer, E.8    Mllauer, L.9    Agis, H.10    Sillaber, C.11    Valent, P.12
  • 77
    • 44049083639 scopus 로고    scopus 로고
    • Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: A breakthrough in anticancer therapy
    • Labi, V., Grespi, F., Baumgartner, F. and Villunger, A. (2008) Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: A breakthrough in anticancer therapy. Cell Death Differ. 15, 977-987.
    • (2008) Cell Death Differ , vol.15 , pp. 977-987
    • Labi, V.1    Grespi, F.2    Baumgartner, F.3    Villunger, A.4
  • 78
    • 38949123709 scopus 로고    scopus 로고
    • Smallmolecule inhibitors of Bcl-2 family proteins as therapeutic agents in cancer
    • Mohammad, R., Giri, A. and Goustin, A. S. (2008) Smallmolecule inhibitors of Bcl-2 family proteins as therapeutic agents in cancer. Recent Patents Anticancer Drug Discov. 3, 20-30.
    • (2008) Recent Patents Anticancer Drug Discov , vol.3 , pp. 20-30
    • Mohammad, R.1    Giri, A.2    Goustin, A.S.3
  • 80
    • 33846674886 scopus 로고    scopus 로고
    • Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation
    • Chen, S., Dai, Y., Harada, H., Dent, P. and Grant, S. (2007) Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation. Cancer Res. 67, 782-791.
    • (2007) Cancer Res , vol.67 , pp. 782-791
    • Chen, S.1    Dai, Y.2    Harada, H.3    Dent, P.4    Grant, S.5
  • 81
    • 34249996230 scopus 로고    scopus 로고
    • Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737
    • Lin, X., Morgan-Lappe, S., Huang, X., Li, L., Zakula, D. M., Vernetti, L. A., Fesik, S.W. and Shen, Y. (2007) 'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737. Oncogene 26, 3972-3979.
    • (2007) Oncogene , vol.26 , pp. 3972-3979
    • Lin, X.1    Morgan-Lappe, S.2    Huang, X.3    Li, L.4    Zakula, D.M.5    Vernetti, L.A.6    Fesik, S.W.7    Shen, Y.8
  • 82
    • 43149117910 scopus 로고    scopus 로고
    • Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation
    • Kang,M.H.,Wan, Z.,Kang,Y.H., Sposto,R. and Reynolds,C. P. (2008) Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation. J. Natl. Cancer Inst. 100, 580-595.
    • (2008) J. Natl. Cancer Inst , vol.100 , pp. 580-595
    • Kang, M.H.1    Wan, Z.2    Kang, Y.H.3    Sposto, R.4    Reynolds, C.P.5
  • 84
    • 48649091081 scopus 로고    scopus 로고
    • The discovery of small molecule chemical probes of Bcl-X(L) and Mcl-1
    • Prakesch, M.,Denisov,A.Y., Naim,M., Gehring,K. and Arya, P. (2008) The discovery of small molecule chemical probes of Bcl-X(L) and Mcl-1. Bioorg. Med. Chem. 16, 7443-7449.
    • (2008) Bioorg. Med. Chem , vol.16 , pp. 7443-7449
    • Prakesch, M.1    Denisov, A.Y.2    Naim, M.3    Gehring, K.4    Arya, P.5
  • 85
    • 34247276084 scopus 로고    scopus 로고
    • Tang,G.,Yang,C.Y.,Nikolovska-Coleska, Z.,Guo, J., Qiu, S., Wang, R.,Gao,W.,Wang,G., Stuckey, J., Krajewski, K., Jiang, S.,Roller, P. P. andWang, S. (2007) Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins. J.Med. Chem. 50, 1723-1726.
    • Tang,G.,Yang,C.Y.,Nikolovska-Coleska, Z.,Guo, J., Qiu, S., Wang, R.,Gao,W.,Wang,G., Stuckey, J., Krajewski, K., Jiang, S.,Roller, P. P. andWang, S. (2007) Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins. J.Med. Chem. 50, 1723-1726.
  • 87
    • 56149092147 scopus 로고    scopus 로고
    • Regulation of antiapoptotic MCL-1 function by gossypol: Mechanistic insights from in vitro reconstituted systems
    • Etxebarria, A., Landeta, O., Antonsson, B. and Basañez, G. (2008) Regulation of antiapoptotic MCL-1 function by gossypol: Mechanistic insights from in vitro reconstituted systems. Biochem Pharmacol. 76, 1563-1576.
    • (2008) Biochem Pharmacol , vol.76 , pp. 1563-1576
    • Etxebarria, A.1    Landeta, O.2    Antonsson, B.3    Basañez, G.4
  • 88
    • 40549146581 scopus 로고    scopus 로고
    • Preclinical studies of Apogossypolone: A new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in follicular small cleaved cell lymphoma model
    • Arnold, A. A., Aboukameel, A., Chen, J., Yang, D.,Wang, S., Al-Katib, A. and Mohammad, R. M. (2008) Preclinical studies of Apogossypolone: A new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in follicular small cleaved cell lymphoma model. Mol. Cancer 7, 20.
    • (2008) Mol. Cancer , vol.7 , pp. 20
    • Arnold, A.A.1    Aboukameel, A.2    Chen, J.3    Yang, D.4    Wang, S.5    Al-Katib, A.6    Mohammad, R.M.7
  • 89
    • 34249982915 scopus 로고    scopus 로고
    • Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma
    • Trudel, S., Li, Z. H., Rauw, J., Tiedemann, R. E., Wen, X. Y. and Stewart, A. K. (2007) Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma. Blood 109, 5430-5438.
    • (2007) Blood , vol.109 , pp. 5430-5438
    • Trudel, S.1    Li, Z.H.2    Rauw, J.3    Tiedemann, R.E.4    Wen, X.Y.5    Stewart, A.K.6
  • 91
    • 47349099502 scopus 로고    scopus 로고
    • Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells
    • Lasithiotakis, K. G., Sinnberg, T.W., Schittek, B., Flaherty, K. T., Kulms, D., Maczey, E., Garbe, C. and Meier, F. E. (2008) Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells. J. Invest. Dermatol. 128, 2013-2023.
    • (2008) J. Invest. Dermatol , vol.128 , pp. 2013-2023
    • Lasithiotakis, K.G.1    Sinnberg, T.W.2    Schittek, B.3    Flaherty, K.T.4    Kulms, D.5    Maczey, E.6    Garbe, C.7    Meier, F.E.8
  • 92
    • 15944394073 scopus 로고    scopus 로고
    • Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways
    • Hahn, M., Li,W., Yu, C., Rahmani, M., Dent, P. and Grant, S. (2005) Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways. Mol. Cancer Ther. 4, 457-470.
    • (2005) Mol. Cancer Ther , vol.4 , pp. 457-470
    • Hahn, M.1    Li, W.2    Yu, C.3    Rahmani, M.4    Dent, P.5    Grant, S.6
  • 93
    • 33750312678 scopus 로고    scopus 로고
    • Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA
    • Qin, J. Z., Xin, H., Sitailo, L.A., Denning,M. F. and Nickoloff, B. J. (2006) Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA. Cancer Res. 66, 9636-9645.
    • (2006) Cancer Res , vol.66 , pp. 9636-9645
    • Qin, J.Z.1    Xin, H.2    Sitailo, L.A.3    Denning, M.F.4    Nickoloff, B.J.5
  • 95
    • 0034618369 scopus 로고    scopus 로고
    • MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells
    • Boucher, M. J., Morisset, J., Vachon, P. H., Reed, J. C., Lainé, J. and Rivard, N. (2000) MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells. J. Cell. Biochem. 79, 355-369.
    • (2000) J. Cell. Biochem , vol.79 , pp. 355-369
    • Boucher, M.J.1    Morisset, J.2    Vachon, P.H.3    Reed, J.C.4    Lainé, J.5    Rivard, N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.