Selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in mice

Gastroenterology

Volumn 144, Issue 2, 2013, Pages 447-456

  Azmi, Asfar S ^a   Aboukameel, Amro ^b   Bao, Bin ^a   Sarkar, Fazlul H ^a   Philip, Philip A ^b   Kauffman, Michael ^c   Shacham, Sharon ^c   Mohammad, Ramzi M ^a,b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Karyopharm Therapeutics   (United States)

^c KARMANOS CANCER INSTITUTE   (United States)

Author keywords

CRM1; Exportin; Nucleus; Small molecule inhibitor; Translocation

Indexed keywords

ANTINEOPLASTIC AGENT; CALYCULIN A; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOTOXIC AGENT; GEMCITABINE; KARYOPHERIN; KPT 127; KPT 185; KPT 205; KPT 227; KPT 330; PROTEIN P27; PROTEIN P53; PROTEIN P73; PROTEINASE ACTIVATED RECEPTOR 4; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CELL RECEPTOR; EXPORTIN 1 PROTEIN; RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOPLASM; DRUG CYTOTOXICITY; FEMALE; HUMAN; HUMAN CELL; IC 50; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEAR IMPORT; NUCLEAR LOCALIZATION SIGNAL; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TREATMENT DURATION; WEIGHT REDUCTION; WESTERN BLOTTING; ACTIVE TRANSPORT; ANIMAL; COMPARATIVE STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL NEOPLASM; FLUORESCENCE MICROSCOPY; GENETICS; IMMUNOPRECIPITATION; METABOLISM; PANCREAS TUMOR; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOPRECIPITATION; KARYOPHERINS; MICE; MICROSCOPY, FLUORESCENCE; NEOPLASMS, EXPERIMENTAL; PANCREATIC NEOPLASMS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, NEOPLASM;

EID: 84881323214     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2012.10.036     Document Type: Article

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