Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals

Clinical Cancer Research

Volumn 9, Issue 9, 2003, Pages 3312-3319

  Chow, H H Sherry ^a,b   Cai, Yan ^a,b   Hakim, Iman A ^a   Crowell, James A ^c   Shahi, Farah ^a   Brooks, Chris A ^a   Dorr, Robert T ^a   Hara, Yukihiko ^d   Alberts, David S ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPICATECHIN; EPIGALLOCATECHIN GALLATE; PLACEBO; POLYPHENOL DERIVATIVE; POLYPHENON E; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD CELL COUNT; BLOOD CHEMISTRY; CANCER PREVENTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG SAFETY; ERYTHEMA; FEMALE; GASTROINTESTINAL SYMPTOM; HEADACHE; HEARTBURN; HUMAN; HUMAN EXPERIMENT; MALE; MYALGIA; NAUSEA; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH PAIN; TEA; ULTRAVIOLET RADIATION; VERTIGO;

ADULT; CATECHIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHEMA; FEMALE; FLAVONOIDS; FREE RADICAL SCAVENGERS; HUMANS; MALE; MIDDLE AGED; PHENOLS; PLACEBOS; TEA; TIME FACTORS; ULTRAVIOLET RAYS;

EID: 0042334847     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Katiyar, S. K., and Mukhtar, H. Tea in chemoprevention of cancer: epidemiologic and experimental studies. Int. J. Oncol., 8: 221-238, 1996.
2. Dreosti, I. E., Wargovich, M. J., and Yang, C. S. Inhibition of cancinogenesis by tea: the evidence from experimental studies. Crit. Rev. Food Sci. Nutr., 37: 761-770, 1997.
3. Scott, B. C., Butler, J., Halliwell, B., and Aruoma, O. I. Evaluation of the antioxidant actions of ferulic acid and catechins. Free Radic. Res. Comm., 19: 241-253, 1993.
4. Laughton, M. J., Evans, P. J., Moroney, M. A., Hoult, J. R., and Halliwell, B. Inhibition of mammalian 5-lipoxygenase and cyclooxygenase by flavonoids and phenolic dietary additives. Relationship to antioxidant activity and to iron ion-reducing ability. Biochem. Pharmacol., 42: 1673-1681, 1991.
5. Yang, C. S., Chung, J. Y., Yang, G., Chhabra, S. K., and Lee, M. J. Tea and tea polyphenols in cancer prevention. J. Nutr., 130: 472S-478S, 2000.
6. Khan, S. G., Katiyar, S. K., Agarwal, R., and Mukhtar, H. Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention. Cancer Res., 52: 4050-4052, 1992.
7. Katiyar, S. K., Agarwal, R., Zaim, M. T., and Mukhtar, H. Protection against N-nitrosodiethylamine and benzo (α) pyrene-induced forestomach and lung tumorigenesis in A/J mice by green tea. Carcinogenesis (Lond.), 14: 849-855, 1993.
8. Chow, H. H., Cai, Y., Alberts, D. S., Hakim, I., Dorr, R., Shahi, F., Crowell, J. A., Yang, C. S., and Hara, Y. Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. Cancer Epidemiol. Biomark. Prev., 10: 53-58, 2001.
9. Lee, M. J., Wang, Z. Y., Li, H., Chen, L., Sun, Y., Gobbo, S., Balentine, D. A., and Yang, C. S. Analysis of plasma and urinary tea polyphenols in human subjects. Cancer Epidemiol. Biomark. Prev., 4: 393-399, 1995.
10. nd Ed., pp. 409-416, New York: Dekker, 1982.
11. Pisters, K. M. W., Newman, R. A., Coldman, B., Shin, D. M., Khuri, F. R., Hong, W. K., Glisson, B. S., and Lee, J. S. Phase I trial of oral green tea extract in adult patients with solid tumors. J. Clin. Oncol., 19: 1830-1838, 2001.
12. rd Ed., pp. 83-105, Media, PA: William and Wilkins, 1995.
13. Lu, Y. P., Lou, Y. R., Lin, Y., Shih, W. J., Huang, M. T., Yang, C. S., and Conney, A. H. Inhibitory effects of orally administered green tea, black tea, and caffeine on skin carcinogenesis in mice previously treated with ultraviolet B light (high-risk mice): relationship to decreased tissue fat. Cancer Res., 61: 5002-5009, 2001.
14. Lou, Y. R., Lu, Y. P., Xie, J. G., Huang, M. T., and Conney, A. H. Effects of oral administration of tea, decaffeinated tea, and caffeine on the formation and growth of tumors in high-risk SKH-1 mice previously treated with ultraviolet B light. Nutr. Cancer, 33: 146-153, 1999.
15. Agarwal, R., Katiyar, S. K., Khan, S. G., and Mukhtar, H. Protection against ultraviolet B radiation-induced effects in the skin of SKH-1 hairless mice by a polyphenolic fraction isolated from green tea. Photochem. Photobiol., 58: 695-700, 1993.
16. Katiyar, S. K., Perez, A., and Mukhtar, H. Green tea polyphenol treatment to human skin prevents formation of ultraviolet light B-induced pyrimidine dimmers in DNA. Clin. Cancer Res., 6: 3864-3869, 2000.
17. Katiyar, S. K., Afaq, F., Perez, A., and Mukhtar, H. Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress. Carcinogenesis (Lond.), 22: 287-294, 2001.
18. Stahl, W., Heinrich, U., Jungmann, H., Sies, H., and Tronnier, H. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans. Am. J. Clin. Nutr., 71: 795-798, 2000.
19. Huang, M. T., Xie, J. G., Wang, Z. Y., Ho, C. T., Lou, Y. R., Wang, C. X., Hard, G. C., and Conney, A. H. Effects of tea, decaffeinated tea, and caffeine on UVB light-induced complete carcinogenesis in SKH-1 mice: demonstration of caffeine as a biologically important constituent of tea. Cancer Res., 57: 2623-2629, 1997.