메뉴 건너뛰기




Volumn 6, Issue 3, 2009, Pages 500-512

Targeted Therapy for Malignant Glioma Patients: Lessons Learned and the Road Ahead

Author keywords

coactivation; Glioma; growth factors; microenvironment; molecular targeted therapy

Indexed keywords

3 [1 (2,6 DICHLORO 3 FLUOROPHENYL)ETHOXY] 5 [1 (4 PIPERIDINYL) 1H PYRAZOL 4 YL] 2 PYRIDINYLAMINE; 5 (2,6 DICHLOROBENZYLSULFONYL) 3 [3,5 DIMETHYL 4 [2 (1 PYRROLIDINYLMETHYL) 1 PYRROLIDINYLCARBONYL] 1H PYRROL 2 YLMETHYLENE] 1,3 DIHYDRO 2H INDOL 2 ONE; AFLIBERCEPT; AM 7; AMG 102; ANTINEOPLASTIC AGENT; ARQ 197; BEVACIZUMAB; CE 355621; CEDIRANIB; CETUXIMAB; DASATINIB; DN 30; ERLOTINIB; GEFITINIB; HYDROXYUREA; IMATINIB; IMC A12; JNJ 38877605; LAPATINIB; MK 2461; MONOCLONAL ANTIBODY 806; MP 470; NIMOTUZUMAB; PAZOPANIB; SORAFENIB; SUNITINIB; TANDUTINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; VATALANIB; XL 184;

EID: 67649084009     PISSN: 19337213     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nurt.2009.04.008     Document Type: Article
Times cited : (82)

References (125)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0026010995 scopus 로고
    • Molecular themes in oncogenesis
    • Bishop J.M. Molecular themes in oncogenesis. Cell 64 (1991) 235-248
    • (1991) Cell , vol.64 , pp. 235-248
    • Bishop, J.M.1
  • 3
    • 33846821916 scopus 로고    scopus 로고
    • High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene
    • Bruna A., Darken R.S., Rojo F., et al. High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell 11 (2007) 147-160
    • (2007) Cancer Cell , vol.11 , pp. 147-160
    • Bruna, A.1    Darken, R.S.2    Rojo, F.3
  • 4
    • 30944442620 scopus 로고    scopus 로고
    • Hypoxia inducible factor 1-alpha regulates of platelet derived growth factor-B in human glioblastoma cells
    • Yoshida D., Kim K., Noha M., and Teramoto A. Hypoxia inducible factor 1-alpha regulates of platelet derived growth factor-B in human glioblastoma cells. J Neurooncol 76 (2006) 13-21
    • (2006) J Neurooncol , vol.76 , pp. 13-21
    • Yoshida, D.1    Kim, K.2    Noha, M.3    Teramoto, A.4
  • 5
    • 0037096867 scopus 로고    scopus 로고
    • Hepatocyte growth factor is associated with poor prognosis of malignant gliomas and is a predictor for recurrence of meningioma
    • Arrieta O., Garcia E., Guevara P., et al. Hepatocyte growth factor is associated with poor prognosis of malignant gliomas and is a predictor for recurrence of meningioma. Cancer 94 (2002) 3210-3218
    • (2002) Cancer , vol.94 , pp. 3210-3218
    • Arrieta, O.1    Garcia, E.2    Guevara, P.3
  • 6
    • 0030690583 scopus 로고    scopus 로고
    • Met and hepatocyte growth factor/scatter factor expression in human gliomas
    • Koochekpour S., Jeffers M., Rulong S., et al. Met and hepatocyte growth factor/scatter factor expression in human gliomas. Cancer Res 57 (1997) 5391-5398
    • (1997) Cancer Res , vol.57 , pp. 5391-5398
    • Koochekpour, S.1    Jeffers, M.2    Rulong, S.3
  • 7
    • 30444437590 scopus 로고    scopus 로고
    • Role of hepatocyte growth factor activator (HGF activator) in invasive growth of human glioblastoma cells in vivo
    • Uchinokura S., Miyata S., Fukushima T., et al. Role of hepatocyte growth factor activator (HGF activator) in invasive growth of human glioblastoma cells in vivo. Int J Cancer 118 (2006) 583-592
    • (2006) Int J Cancer , vol.118 , pp. 583-592
    • Uchinokura, S.1    Miyata, S.2    Fukushima, T.3
  • 8
    • 40749101512 scopus 로고    scopus 로고
    • Transcription-dependent epidermal growth factor receptor activation by hepatocyte growth factor
    • Reznik T.E., Sang Y., Ma Y., et al. Transcription-dependent epidermal growth factor receptor activation by hepatocyte growth factor. Mol Cancer Res 6 (2008) 139-150
    • (2008) Mol Cancer Res , vol.6 , pp. 139-150
    • Reznik, T.E.1    Sang, Y.2    Ma, Y.3
  • 9
  • 10
    • 0346690262 scopus 로고    scopus 로고
    • Adenosine 5′-triphosphate-sensitive potassium channel-mediated blood-brain tumor barrier permeability increase in a rat brain tumor model
    • Ningaraj N.S., Rao M.K., and Black K.L. Adenosine 5′-triphosphate-sensitive potassium channel-mediated blood-brain tumor barrier permeability increase in a rat brain tumor model. Cancer Res 63 (2003) 8899-8911
    • (2003) Cancer Res , vol.63 , pp. 8899-8911
    • Ningaraj, N.S.1    Rao, M.K.2    Black, K.L.3
  • 11
    • 0034454980 scopus 로고    scopus 로고
    • Endocytosis and transcytosis of an immunoliposome-based brain drug delivery system
    • Cerletti A., Drewe J., Fricker G., Eberle A.N., and Huwyler J. Endocytosis and transcytosis of an immunoliposome-based brain drug delivery system. J Drug Target 8 (2000) 435-446
    • (2000) J Drug Target , vol.8 , pp. 435-446
    • Cerletti, A.1    Drewe, J.2    Fricker, G.3    Eberle, A.N.4    Huwyler, J.5
  • 12
    • 0032894155 scopus 로고    scopus 로고
    • Retention of biologic activity of human epidermal growth factor following conjugation to a blood-brain barrier drug delivery vector via an extended poly(ethylene glycol) linker
    • Deguchi Y., Kurihara A., and Pardridge W.M. Retention of biologic activity of human epidermal growth factor following conjugation to a blood-brain barrier drug delivery vector via an extended poly(ethylene glycol) linker. Bioconjug Chem 10 (1999) 32-37
    • (1999) Bioconjug Chem , vol.10 , pp. 32-37
    • Deguchi, Y.1    Kurihara, A.2    Pardridge, W.M.3
  • 13
    • 32844458760 scopus 로고    scopus 로고
    • Improving the delivery of therapeutic agents to CNS neoplasms: a clinical review
    • Badruddoja M.A., and Black K.L. Improving the delivery of therapeutic agents to CNS neoplasms: a clinical review. Front Biosci 11 (2006) 1466-1478
    • (2006) Front Biosci , vol.11 , pp. 1466-1478
    • Badruddoja, M.A.1    Black, K.L.2
  • 14
    • 62349110027 scopus 로고    scopus 로고
    • EGFR signals to mTOR through PKC and independently of Akt in glioma [Erratum in: Sci Signal 2009;2(60):er4]
    • Fan Q.W., Cheng C., Knight Z.A., et al. EGFR signals to mTOR through PKC and independently of Akt in glioma [Erratum in: Sci Signal 2009;2(60):er4]. Sci Signal 2 55 (2009) ra4
    • (2009) Sci Signal , vol.2 , Issue.55
    • Fan, Q.W.1    Cheng, C.2    Knight, Z.A.3
  • 15
    • 61449191698 scopus 로고    scopus 로고
    • EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors
    • Li L., Dutra A., Pak E., et al. EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors. Neuro Oncol 11 (2009) 9-21
    • (2009) Neuro Oncol , vol.11 , pp. 9-21
    • Li, L.1    Dutra, A.2    Pak, E.3
  • 16
    • 0037228960 scopus 로고    scopus 로고
    • PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter
    • Pore N., Liu S., Haas-Kogan D.A., O'Rourke D.M., and Maity A. PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter. Cancer Res 63 (2003) 236-241
    • (2003) Cancer Res , vol.63 , pp. 236-241
    • Pore, N.1    Liu, S.2    Haas-Kogan, D.A.3    O'Rourke, D.M.4    Maity, A.5
  • 17
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455 (2008) 1061-1068
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 18
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons D.W., Jones S., Zhang X., et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321 (2008) 1807-1812
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 19
    • 19044397160 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
    • Bachoo R.M., Maher E.A., Ligon K.L., et al. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 1 (2002) 269-277
    • (2002) Cancer Cell , vol.1 , pp. 269-277
    • Bachoo, R.M.1    Maher, E.A.2    Ligon, K.L.3
  • 20
    • 0035256772 scopus 로고    scopus 로고
    • Gliomagenesis: genetic alterations and mouse models
    • Holland E.C. Gliomagenesis: genetic alterations and mouse models. Nat Rev Genet 2 (2001) 120-129
    • (2001) Nat Rev Genet , vol.2 , pp. 120-129
    • Holland, E.C.1
  • 21
    • 24044492207 scopus 로고    scopus 로고
    • Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model
    • Shannon P., Sabha N., Lau N., et al. Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model. Am J Pathol 167 (2005) 859-867
    • (2005) Am J Pathol , vol.167 , pp. 859-867
    • Shannon, P.1    Sabha, N.2    Lau, N.3
  • 22
    • 33747885901 scopus 로고    scopus 로고
    • High-grade glioma formation results from postnatal Pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model
    • Wei Q., Clarke L., Scheidenhelm D.K., et al. High-grade glioma formation results from postnatal Pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model. Cancer Res 66 (2006) 7429-7437
    • (2006) Cancer Res , vol.66 , pp. 7429-7437
    • Wei, Q.1    Clarke, L.2    Scheidenhelm, D.K.3
  • 23
    • 0037382205 scopus 로고    scopus 로고
    • Genetic determinants of malignancy in a mouse model for oligodendroglioma
    • Weiss W.A., Burns M.J., Hackett C., et al. Genetic determinants of malignancy in a mouse model for oligodendroglioma. Cancer Res 63 (2003) 1589-1595
    • (2003) Cancer Res , vol.63 , pp. 1589-1595
    • Weiss, W.A.1    Burns, M.J.2    Hackett, C.3
  • 24
    • 0036490954 scopus 로고    scopus 로고
    • Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation
    • Xiao A., Wu H., Pandolfi P.P., Louis D.N., and Van Dyke T. Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell 1 (2002) 157-168
    • (2002) Cancer Cell , vol.1 , pp. 157-168
    • Xiao, A.1    Wu, H.2    Pandolfi, P.P.3    Louis, D.N.4    Van Dyke, T.5
  • 25
    • 54549095950 scopus 로고    scopus 로고
    • p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
    • Zheng H., Ying H., Yan H., et al. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature 455 (2008) 1129-1133
    • (2008) Nature , vol.455 , pp. 1129-1133
    • Zheng, H.1    Ying, H.2    Yan, H.3
  • 26
    • 23644443053 scopus 로고    scopus 로고
    • Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
    • Zhu Y., Guignard F., Zhao D., et al. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 8 (2005) 119-130
    • (2005) Cancer Cell , vol.8 , pp. 119-130
    • Zhu, Y.1    Guignard, F.2    Zhao, D.3
  • 27
    • 44849089702 scopus 로고    scopus 로고
    • Pten haploinsufficiency accelerates formation of high-grade astrocytomas
    • Kwon C.H., Zhao D., Chen J., et al. Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res 68 (2008) 3286-3294
    • (2008) Cancer Res , vol.68 , pp. 3286-3294
    • Kwon, C.H.1    Zhao, D.2    Chen, J.3
  • 28
    • 34147184365 scopus 로고    scopus 로고
    • Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel
    • Sarkaria J.N., Yang L., Grogan P.T., et al. Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel. Mol Cancer Ther 6 (2007) 1167-1174
    • (2007) Mol Cancer Ther , vol.6 , pp. 1167-1174
    • Sarkaria, J.N.1    Yang, L.2    Grogan, P.T.3
  • 29
    • 0038615946 scopus 로고    scopus 로고
    • Analysis of the phosphatidylinositol 3′-kinase signaling pathway in glioblastoma patients in vivo
    • Choe G., Horvath S., Cloughesy T.F., et al. Analysis of the phosphatidylinositol 3′-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res 63 (2003) 2742-2746
    • (2003) Cancer Res , vol.63 , pp. 2742-2746
    • Choe, G.1    Horvath, S.2    Cloughesy, T.F.3
  • 30
    • 0036094711 scopus 로고    scopus 로고
    • Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival
    • Ermoian R.P., Furniss C.S., Lamborn K.R., et al. Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival. Clin Cancer Res 8 (2002) 1100-1106
    • (2002) Clin Cancer Res , vol.8 , pp. 1100-1106
    • Ermoian, R.P.1    Furniss, C.S.2    Lamborn, K.R.3
  • 31
    • 33745260930 scopus 로고    scopus 로고
    • AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling
    • Riemenschneider M.J., Betensky R.A., Pasedag S.M., and Louis D.N. AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling. Cancer Res 66 (2006) 5618-5623
    • (2006) Cancer Res , vol.66 , pp. 5618-5623
    • Riemenschneider, M.J.1    Betensky, R.A.2    Pasedag, S.M.3    Louis, D.N.4
  • 32
    • 14444288522 scopus 로고    scopus 로고
    • The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling
    • Huang H.S., Nagane M., Klingbeil C.K., et al. The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J Biol Chem 272 (1997) 2927-2935
    • (1997) J Biol Chem , vol.272 , pp. 2927-2935
    • Huang, H.S.1    Nagane, M.2    Klingbeil, C.K.3
  • 33
    • 0026350664 scopus 로고
    • Transforming growth factor-alpha, epidermal growth factor receptor, and proliferating potential in benign and malignant gliomas
    • Maruno M., Kovach J.S., Kelly P.J., and Yanagihara T. Transforming growth factor-alpha, epidermal growth factor receptor, and proliferating potential in benign and malignant gliomas. J Neurosurg 75 (1991) 97-102
    • (1991) J Neurosurg , vol.75 , pp. 97-102
    • Maruno, M.1    Kovach, J.S.2    Kelly, P.J.3    Yanagihara, T.4
  • 34
    • 0029591402 scopus 로고
    • Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor
    • Montgomery R.B., Moscatello D.K., Wong A.J., Cooper J.A., and Stahl W.L. Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor. J Biol Chem 270 (1995) 30562-30566
    • (1995) J Biol Chem , vol.270 , pp. 30562-30566
    • Montgomery, R.B.1    Moscatello, D.K.2    Wong, A.J.3    Cooper, J.A.4    Stahl, W.L.5
  • 35
    • 0024654697 scopus 로고
    • Immunocytochemical study of transforming growth factor expression in benign and malignant gliomas
    • Samuels V., Barrett J.M., Bockman S., Pantazis C.G., and Allen Jr. M.B. Immunocytochemical study of transforming growth factor expression in benign and malignant gliomas. Am J Pathol 134 (1989) 894-902
    • (1989) Am J Pathol , vol.134 , pp. 894-902
    • Samuels, V.1    Barrett, J.M.2    Bockman, S.3    Pantazis, C.G.4    Allen Jr., M.B.5
  • 36
    • 0030832167 scopus 로고    scopus 로고
    • Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII
    • Wikstrand C.J., McLendon R.E., Friedman A.H., and Bigner D.D. Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII. Cancer Res 57 (1997) 4130-4140
    • (1997) Cancer Res , vol.57 , pp. 4130-4140
    • Wikstrand, C.J.1    McLendon, R.E.2    Friedman, A.H.3    Bigner, D.D.4
  • 37
    • 0025193732 scopus 로고
    • Differential amplification of the TGF-alpha gene in human gliomas
    • Yung W.K., Zhang X., Steck P.A., and Hung M.C. Differential amplification of the TGF-alpha gene in human gliomas. Cancer Commun 2 (1990) 201-205
    • (1990) Cancer Commun , vol.2 , pp. 201-205
    • Yung, W.K.1    Zhang, X.2    Steck, P.A.3    Hung, M.C.4
  • 38
    • 38949117993 scopus 로고    scopus 로고
    • Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples
    • Yoshimoto K., Dang J., Zhu S., et al. Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples. Clin Cancer Res 14 (2008) 488-493
    • (2008) Clin Cancer Res , vol.14 , pp. 488-493
    • Yoshimoto, K.1    Dang, J.2    Zhu, S.3
  • 39
    • 34547881522 scopus 로고    scopus 로고
    • Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
    • Huang P.H., Mukasa A., Bonavia R., et al. Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma. Proc Natl Acad Sci U S A 104 (2007) 12867-12872
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 12867-12872
    • Huang, P.H.1    Mukasa, A.2    Bonavia, R.3
  • 40
    • 0034231944 scopus 로고    scopus 로고
    • Analysis of genomic rearrangements associated with EGRFvIII expression suggests involvement of Alu repeat elements
    • Frederick L., Eley G., Wang X.Y., and James C.D. Analysis of genomic rearrangements associated with EGRFvIII expression suggests involvement of Alu repeat elements. Neuro Oncol 2 (2000) 159-163
    • (2000) Neuro Oncol , vol.2 , pp. 159-163
    • Frederick, L.1    Eley, G.2    Wang, X.Y.3    James, C.D.4
  • 41
    • 0034163550 scopus 로고    scopus 로고
    • Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas
    • Frederick L., Wang X.Y., Eley G., and James C.D. Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. Cancer Res 60 (2000) 1383-1387
    • (2000) Cancer Res , vol.60 , pp. 1383-1387
    • Frederick, L.1    Wang, X.Y.2    Eley, G.3    James, C.D.4
  • 42
    • 33845926387 scopus 로고    scopus 로고
    • Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain
    • Lee J.C., Vivanco I., Beroukhim R., et al. Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. PLoS Med 3 (2006) e485
    • (2006) PLoS Med , vol.3
    • Lee, J.C.1    Vivanco, I.2    Beroukhim, R.3
  • 43
    • 0026687707 scopus 로고
    • Oncogenes: cause or consequence in the development of glial tumors
    • Akbasak A., and Sunar-Akbasak B. Oncogenes: cause or consequence in the development of glial tumors. J Neurol Sci 111 (1992) 119-133
    • (1992) J Neurol Sci , vol.111 , pp. 119-133
    • Akbasak, A.1    Sunar-Akbasak, B.2
  • 44
    • 0035878746 scopus 로고    scopus 로고
    • Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor
    • Mishima K., Johns T.G., Luwor R.B., et al. Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor. Cancer Res 61 (2001) 5349-5354
    • (2001) Cancer Res , vol.61 , pp. 5349-5354
    • Mishima, K.1    Johns, T.G.2    Luwor, R.B.3
  • 45
    • 56249114865 scopus 로고    scopus 로고
    • Gene silencing for epidermal growth factor receptor variant III induces cell-specific cytotoxicity
    • Yamoutpour F., Bodempudi V., Park S.E., et al. Gene silencing for epidermal growth factor receptor variant III induces cell-specific cytotoxicity. Mol Cancer Ther 7 (2008) 3586-3597
    • (2008) Mol Cancer Ther , vol.7 , pp. 3586-3597
    • Yamoutpour, F.1    Bodempudi, V.2    Park, S.E.3
  • 46
    • 53049092916 scopus 로고    scopus 로고
    • Inhibition of glioblastoma growth in a highly invasive nude mouse model can be achieved by targeting epidermal growth factor receptor but not vascular endothelial growth factor receptor-2
    • Martens T., Laabs Y., Gunther H.S., et al. Inhibition of glioblastoma growth in a highly invasive nude mouse model can be achieved by targeting epidermal growth factor receptor but not vascular endothelial growth factor receptor-2. Clin Cancer Res 14 (2008) 5447-5458
    • (2008) Clin Cancer Res , vol.14 , pp. 5447-5458
    • Martens, T.1    Laabs, Y.2    Gunther, H.S.3
  • 47
    • 21444450373 scopus 로고    scopus 로고
    • Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib
    • Haas-Kogan D.A., Prados M.D., Tihan T., et al. Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib. J Natl Cancer Inst 97 (2005) 880-887
    • (2005) J Natl Cancer Inst , vol.97 , pp. 880-887
    • Haas-Kogan, D.A.1    Prados, M.D.2    Tihan, T.3
  • 48
    • 33746807790 scopus 로고    scopus 로고
    • Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas
    • Doherty L., Gigas D.C., Kesari S., et al. Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas. Neurology 67 (2006) 156-158
    • (2006) Neurology , vol.67 , pp. 156-158
    • Doherty, L.1    Gigas, D.C.2    Kesari, S.3
  • 49
    • 27744606737 scopus 로고    scopus 로고
    • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
    • Mellinghoff I.K., Wang M.Y., Vivanco I., et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med 353 (2005) 2012-2024
    • (2005) N Engl J Med , vol.353 , pp. 2012-2024
    • Mellinghoff, I.K.1    Wang, M.Y.2    Vivanco, I.3
  • 50
    • 34548596728 scopus 로고    scopus 로고
    • A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma
    • Fan Q.W., Cheng C.K., Nicolaides T.P., et al. A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Res 67 (2007) 7960-7965
    • (2007) Cancer Res , vol.67 , pp. 7960-7965
    • Fan, Q.W.1    Cheng, C.K.2    Nicolaides, T.P.3
  • 51
    • 33748058820 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells
    • Wang M.Y., Lu K.V., Zhu S., et al. Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells. Cancer Res 66 (2006) 7864-7869
    • (2006) Cancer Res , vol.66 , pp. 7864-7869
    • Wang, M.Y.1    Lu, K.V.2    Zhu, S.3
  • 52
    • 21044431575 scopus 로고    scopus 로고
    • Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme
    • Chang S.M., Wen P., Cloughesy T., et al. Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme. Invest New Drugs 23 (2005) 357-361
    • (2005) Invest New Drugs , vol.23 , pp. 357-361
    • Chang, S.M.1    Wen, P.2    Cloughesy, T.3
  • 53
    • 38849208347 scopus 로고    scopus 로고
    • Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma
    • Cloughesy T.F., Yoshimoto K., Nghiemphu P., et al. Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med 5 (2008) e8
    • (2008) PLoS Med , vol.5
    • Cloughesy, T.F.1    Yoshimoto, K.2    Nghiemphu, P.3
  • 54
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin D.A., and Sabatini D.M. Defining the role of mTOR in cancer. Cancer Cell 12 (2007) 9-22
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 55
    • 53049084191 scopus 로고    scopus 로고
    • S6K1 plays a key role in glial transformation
    • Nakamura J.L., Garcia E., and Pieper R.O. S6K1 plays a key role in glial transformation. Cancer Res 68 (2008) 6516-6523
    • (2008) Cancer Res , vol.68 , pp. 6516-6523
    • Nakamura, J.L.1    Garcia, E.2    Pieper, R.O.3
  • 56
    • 58049200573 scopus 로고    scopus 로고
    • Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors
    • Carracedo A., Baselga J., and Pandolfi P.P. Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors. Cell Cycle 7 (2008) 3805-3809
    • (2008) Cell Cycle , vol.7 , pp. 3805-3809
    • Carracedo, A.1    Baselga, J.2    Pandolfi, P.P.3
  • 57
    • 51349164790 scopus 로고    scopus 로고
    • Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
    • Carracedo A., Ma L., Teruya-Feldstein J., et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest 118 (2008) 3065-3074
    • (2008) J Clin Invest , vol.118 , pp. 3065-3074
    • Carracedo, A.1    Ma, L.2    Teruya-Feldstein, J.3
  • 58
    • 35348822482 scopus 로고    scopus 로고
    • Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
    • Stommel J.M., Kimmelman A.C., Ying H., et al. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 318 (2007) 287-290
    • (2007) Science , vol.318 , pp. 287-290
    • Stommel, J.M.1    Kimmelman, A.C.2    Ying, H.3
  • 59
    • 39449135834 scopus 로고    scopus 로고
    • PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
    • Hambardzumyan D., Becher O.J., Rosenblum M.K., et al. PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev 22 (2008) 436-448
    • (2008) Genes Dev , vol.22 , pp. 436-448
    • Hambardzumyan, D.1    Becher, O.J.2    Rosenblum, M.K.3
  • 60
    • 50849086732 scopus 로고    scopus 로고
    • DNA repair and cancer stem-like cells: potential partners in glioma drug resistance?
    • Johannessen T.C., Bjerkvig R., and Tysnes B.B. DNA repair and cancer stem-like cells: potential partners in glioma drug resistance?. Cancer Treat Rev 34 (2008) 558-567
    • (2008) Cancer Treat Rev , vol.34 , pp. 558-567
    • Johannessen, T.C.1    Bjerkvig, R.2    Tysnes, B.B.3
  • 61
    • 67649118749 scopus 로고    scopus 로고
    • Turning cancer stem cells inside-out: an exploration of glioma stem cell signaling pathways
    • Li Z., Wang H., Eyler C.E., and Rich J.N. Turning cancer stem cells inside-out: an exploration of glioma stem cell signaling pathways. J Biol Chem (2009)
    • (2009) J Biol Chem
    • Li, Z.1    Wang, H.2    Eyler, C.E.3    Rich, J.N.4
  • 62
    • 64549155723 scopus 로고    scopus 로고
    • Cancer stem cells from human glioma cell line are resistant to Fas-induced apoptosis
    • Bertrand J., Begaud-Grimaud G., Bessette B., et al. Cancer stem cells from human glioma cell line are resistant to Fas-induced apoptosis. Int J Oncol 34 (2009) 717-727
    • (2009) Int J Oncol , vol.34 , pp. 717-727
    • Bertrand, J.1    Begaud-Grimaud, G.2    Bessette, B.3
  • 63
    • 42349115400 scopus 로고    scopus 로고
    • INK4c as a tumor suppressor gene in glioblastoma multiforme
    • INK4c as a tumor suppressor gene in glioblastoma multiforme. Cancer Res 68 (2008) 2564-2569
    • (2008) Cancer Res , vol.68 , pp. 2564-2569
    • Solomon, D.A.1    Kim, J.S.2    Jenkins, S.3
  • 64
    • 33846457387 scopus 로고    scopus 로고
    • Aberrant splicing of cyclin-dependent kinase-associated protein phosphatase KAP increases proliferation and migration in glioblastoma
    • Yu Y., Jiang X., Schoch B.S., et al. Aberrant splicing of cyclin-dependent kinase-associated protein phosphatase KAP increases proliferation and migration in glioblastoma. Cancer Res 67 (2007) 130-138
    • (2007) Cancer Res , vol.67 , pp. 130-138
    • Yu, Y.1    Jiang, X.2    Schoch, B.S.3
  • 65
    • 0035833368 scopus 로고    scopus 로고
    • Identification of p21 as a target of cycloheximide-mediated facilitation of CD95-mediated apoptosis in human malignant glioma cells
    • Glaser T., Wagenknecht B., and Weller M. Identification of p21 as a target of cycloheximide-mediated facilitation of CD95-mediated apoptosis in human malignant glioma cells. Oncogene 20 (2001) 4757-4767
    • (2001) Oncogene , vol.20 , pp. 4757-4767
    • Glaser, T.1    Wagenknecht, B.2    Weller, M.3
  • 66
    • 57749090260 scopus 로고    scopus 로고
    • p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts
    • Dinca E.B., Lu K.V., Sarkaria J.N., et al. p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts. Cancer Res 68 (2008) 10034-10039
    • (2008) Cancer Res , vol.68 , pp. 10034-10039
    • Dinca, E.B.1    Lu, K.V.2    Sarkaria, J.N.3
  • 67
    • 33846118474 scopus 로고    scopus 로고
    • Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
    • Parsa A.T., Waldron J.S., Panner A., et al. Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. Nat Med 13 (2007) 84-88
    • (2007) Nat Med , vol.13 , pp. 84-88
    • Parsa, A.T.1    Waldron, J.S.2    Panner, A.3
  • 68
    • 34648821254 scopus 로고    scopus 로고
    • Making a tumour's bed: glioblastoma stem cells and the vascular niche
    • Gilbertson R.J., and Rich J.N. Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nat Rev Cancer 7 (2007) 733-736
    • (2007) Nat Rev Cancer , vol.7 , pp. 733-736
    • Gilbertson, R.J.1    Rich, J.N.2
  • 69
    • 1842500007 scopus 로고    scopus 로고
    • Phase II trial of gefitinib in recurrent glioblastoma
    • Rich J.N., Reardon D.A., Peery T., et al. Phase II trial of gefitinib in recurrent glioblastoma. J Clin Oncol 22 (2004) 133-142
    • (2004) J Clin Oncol , vol.22 , pp. 133-142
    • Rich, J.N.1    Reardon, D.A.2    Peery, T.3
  • 70
    • 57149118473 scopus 로고    scopus 로고
    • Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177
    • Brown P.D., Krishnan S., Sarkaria J.N., et al. Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177. J Clin Oncol 26 (2008) 5603-5609
    • (2008) J Clin Oncol , vol.26 , pp. 5603-5609
    • Brown, P.D.1    Krishnan, S.2    Sarkaria, J.N.3
  • 71
    • 39749169093 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitors in neuro-oncology: hopes and disappointments
    • Brandes A.A., Franceschi E., Tosoni A., Hegi M.E., and Stupp R. Epidermal growth factor receptor inhibitors in neuro-oncology: hopes and disappointments. Clin Cancer Res 14 (2008) 957-960
    • (2008) Clin Cancer Res , vol.14 , pp. 957-960
    • Brandes, A.A.1    Franceschi, E.2    Tosoni, A.3    Hegi, M.E.4    Stupp, R.5
  • 72
    • 33750708563 scopus 로고    scopus 로고
    • Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling
    • Wong T.W., Lee F.Y., Yu C., et al. Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin Cancer Res 12 (2006) 6186-6193
    • (2006) Clin Cancer Res , vol.12 , pp. 6186-6193
    • Wong, T.W.1    Lee, F.Y.2    Yu, C.3
  • 73
    • 60749105959 scopus 로고    scopus 로고
    • A multicenter stratified phase II study of cetuximab for the treatment of patients with recurrent high-grade glioma
    • (abstract)
    • Neyns B., Sadones J., Joosens E., et al. A multicenter stratified phase II study of cetuximab for the treatment of patients with recurrent high-grade glioma. J Clin Oncol Meet Abstr 26 (2008) 2017 (abstract)
    • (2008) J Clin Oncol Meet Abstr , vol.26 , pp. 2017
    • Neyns, B.1    Sadones, J.2    Joosens, E.3
  • 74
    • 33845674883 scopus 로고    scopus 로고
    • Panitumumab the first fully human monoclonal antibody: from the bench to the clinic
    • Cohenuram M., and Saif M.W. Panitumumab the first fully human monoclonal antibody: from the bench to the clinic. Anticancer Drugs 18 (2007) 7-15
    • (2007) Anticancer Drugs , vol.18 , pp. 7-15
    • Cohenuram, M.1    Saif, M.W.2
  • 75
    • 34147092140 scopus 로고    scopus 로고
    • Results of a phase II trial of h-R3 monoclonal antibody (nimotuzumab) in the treatment of resistant or relapsed high-grade gliomas in children and adolescents
    • (abstract)
    • Bode U., Buchen S., Janssen G., et al. Results of a phase II trial of h-R3 monoclonal antibody (nimotuzumab) in the treatment of resistant or relapsed high-grade gliomas in children and adolescents. J Clin Oncol Meet Abstr 24 (2006) 1522 (abstract)
    • (2006) J Clin Oncol Meet Abstr , vol.24 , pp. 1522
    • Bode, U.1    Buchen, S.2    Janssen, G.3
  • 76
    • 57049158226 scopus 로고    scopus 로고
    • Final report of a phase II trial of nimotuzumab in the treatment of refractory and relapsed high-grade gliomas in children and adolescents
    • (abstract)
    • Bode U., Buchen S., Warmuth-Metz M., et al. Final report of a phase II trial of nimotuzumab in the treatment of refractory and relapsed high-grade gliomas in children and adolescents. J Clin Oncol Meet Abstr 25 (2007) 2006 (abstract)
    • (2007) J Clin Oncol Meet Abstr , vol.25 , pp. 2006
    • Bode, U.1    Buchen, S.2    Warmuth-Metz, M.3
  • 77
    • 41249094559 scopus 로고    scopus 로고
    • Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization
    • Schmiedel J., Blaukat A., Li S., Knochel T., and Ferguson K.M. Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization. Cancer Cell 13 (2008) 365-373
    • (2008) Cancer Cell , vol.13 , pp. 365-373
    • Schmiedel, J.1    Blaukat, A.2    Li, S.3    Knochel, T.4    Ferguson, K.M.5
  • 78
    • 43149102957 scopus 로고    scopus 로고
    • The antibody zalutumumab inhibits epidermal growth factor receptor signaling by limiting intra- and intermolecular flexibility
    • Lammerts van Bueren J.J., Bleeker W.K., Brannstrom A., et al. The antibody zalutumumab inhibits epidermal growth factor receptor signaling by limiting intra- and intermolecular flexibility. Proc Natl Acad Sci U S A 105 (2008) 6109-6114
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 6109-6114
    • Lammerts van Bueren, J.J.1    Bleeker, W.K.2    Brannstrom, A.3
  • 79
    • 38949190157 scopus 로고    scopus 로고
    • A phase I study of IMC-11F8, a fully human anti-epidermal growth factor receptor (EGFR) IgG1 monoclonal antibody in patients with solid tumors: interim results
    • (abstract)
    • Kuenen B., Witteveen E., Ruijter R., et al. A phase I study of IMC-11F8, a fully human anti-epidermal growth factor receptor (EGFR) IgG1 monoclonal antibody in patients with solid tumors: interim results. ASCO Meet Abstr 24 (2006) 3024 (abstract)
    • (2006) ASCO Meet Abstr , vol.24 , pp. 3024
    • Kuenen, B.1    Witteveen, E.2    Ruijter, R.3
  • 80
    • 59349095589 scopus 로고    scopus 로고
    • A phase II multicenter study evaluating the efficacy and safety of IMC-11F8, a recombinant human IgG1 anti-epidermal growth factor receptor (EGFR) monoclonal antibody (Mab), combined with 5-FU/FA and oxaliplatin (mFOLFOX-6) as first-line therapy
    • (abstract)
    • Tabernero J., Sastre Valera J., Delaunoit T., et al. A phase II multicenter study evaluating the efficacy and safety of IMC-11F8, a recombinant human IgG1 anti-epidermal growth factor receptor (EGFR) monoclonal antibody (Mab), combined with 5-FU/FA and oxaliplatin (mFOLFOX-6) as first-line therapy. ASCO Meet Abstr 26 (2008) 4066 (abstract)
    • (2008) ASCO Meet Abstr , vol.26 , pp. 4066
    • Tabernero, J.1    Sastre Valera, J.2    Delaunoit, T.3
  • 81
    • 34250193662 scopus 로고    scopus 로고
    • The efficacy of epidermal growth factor receptor-specific antibodies against glioma xenografts is influenced by receptor levels, activation status, and heterodimerization
    • Johns T.G., Perera R.M., Vernes S.C., et al. The efficacy of epidermal growth factor receptor-specific antibodies against glioma xenografts is influenced by receptor levels, activation status, and heterodimerization. Clin Cancer Res 13 (2007) 1911-1925
    • (2007) Clin Cancer Res , vol.13 , pp. 1911-1925
    • Johns, T.G.1    Perera, R.M.2    Vernes, S.C.3
  • 82
    • 5044220734 scopus 로고    scopus 로고
    • Recombinant humanised anti-HER2/neu antibody (Herceptin) induces cellular death of glioblastomas
    • Mineo J.F., Bordron A., Quintin-Roue I., et al. Recombinant humanised anti-HER2/neu antibody (Herceptin) induces cellular death of glioblastomas. Br J Cancer 91 (2004) 1195-1199
    • (2004) Br J Cancer , vol.91 , pp. 1195-1199
    • Mineo, J.F.1    Bordron, A.2    Quintin-Roue, I.3
  • 83
    • 51749083686 scopus 로고    scopus 로고
    • Effect of AMG 479 on anti-tumor effects of gemcitabine and erlotinib against pancreatic carcinoma xenograft models
    • (abstract)
    • Beltran P.J., Mitchell P., Moody G., et al. Effect of AMG 479 on anti-tumor effects of gemcitabine and erlotinib against pancreatic carcinoma xenograft models. ASCO Meet Abstr 26 (2008) 4617 (abstract)
    • (2008) ASCO Meet Abstr , vol.26 , pp. 4617
    • Beltran, P.J.1    Mitchell, P.2    Moody, G.3
  • 84
    • 34848903049 scopus 로고    scopus 로고
    • IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor
    • Rowinsky E.K., Youssoufian H., Tonra J.R., et al. IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor. Clin Cancer Res 13 (2007) 5549s-5555s
    • (2007) Clin Cancer Res , vol.13
    • Rowinsky, E.K.1    Youssoufian, H.2    Tonra, J.R.3
  • 85
    • 35148889523 scopus 로고    scopus 로고
    • A phase I, first in man study of weekly IMC-A12, a fully human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors
    • (abstract)
    • Higano C.S., Yu E.Y., Whiting S.H., et al. A phase I, first in man study of weekly IMC-A12, a fully human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors. J Clin Oncol Meet Abstr 25 (2007) 3505 (abstract)
    • (2007) J Clin Oncol Meet Abstr , vol.25 , pp. 3505
    • Higano, C.S.1    Yu, E.Y.2    Whiting, S.H.3
  • 86
    • 54349107362 scopus 로고    scopus 로고
    • High activity of the anti-IGF-IR antibody CP-751,871 in combination with paclitaxel and carboplatin in squamous NSCLC
    • (abstract)
    • Karp D.D., Paz-Ares L.G., Novello S., et al. High activity of the anti-IGF-IR antibody CP-751,871 in combination with paclitaxel and carboplatin in squamous NSCLC. ASCO Meet Abstr 26 (2008) 8015 (abstract)
    • (2008) ASCO Meet Abstr , vol.26 , pp. 8015
    • Karp, D.D.1    Paz-Ares, L.G.2    Novello, S.3
  • 87
    • 20144386856 scopus 로고    scopus 로고
    • Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871
    • Cohen B.D., Baker D.A., Soderstrom C., et al. Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871. Clin Cancer Res 11 (2005) 2063-2073
    • (2005) Clin Cancer Res , vol.11 , pp. 2063-2073
    • Cohen, B.D.1    Baker, D.A.2    Soderstrom, C.3
  • 88
    • 50449087162 scopus 로고    scopus 로고
    • Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4
    • Matsumoto K., Nakamura T., and Sakai K. Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4. Proteomics 8 (2008) 3360-3370
    • (2008) Proteomics , vol.8 , pp. 3360-3370
    • Matsumoto, K.1    Nakamura, T.2    Sakai, K.3
  • 89
    • 85047689927 scopus 로고    scopus 로고
    • An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice
    • Mazzone M., Basilico C., Cavassa S., et al. An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice. J Clin Invest 114 (2004) 1418-1432
    • (2004) J Clin Invest , vol.114 , pp. 1418-1432
    • Mazzone, M.1    Basilico, C.2    Cavassa, S.3
  • 90
    • 3142619403 scopus 로고    scopus 로고
    • The Sema domain of Met is necessary for receptor dimerization and activation
    • Kong-Beltran M., Stamos J., and Wickramasinghe D. The Sema domain of Met is necessary for receptor dimerization and activation. Cancer Cell 6 (2004) 75-84
    • (2004) Cancer Cell , vol.6 , pp. 75-84
    • Kong-Beltran, M.1    Stamos, J.2    Wickramasinghe, D.3
  • 91
    • 3142512610 scopus 로고    scopus 로고
    • Targeting the tumor and its microenvironment by a dual-function decoy Met receptor
    • Michieli P., Mazzone M., Basilico C., et al. Targeting the tumor and its microenvironment by a dual-function decoy Met receptor. Cancer Cell 6 (2004) 61-73
    • (2004) Cancer Cell , vol.6 , pp. 61-73
    • Michieli, P.1    Mazzone, M.2    Basilico, C.3
  • 92
    • 67649106160 scopus 로고    scopus 로고
    • Available at:, Accessed May 29, 2009
    • Compugen. CGEN-241: soluble variants of MET. Available at: http://www.cgen.com/data/uploads/Pdf/CGEN-241%20update%20September%204%2008.pdf. Accessed May 29, 2009.
    • CGEN-241: Soluble variants of MET
    • Compugen1
  • 93
    • 33644769210 scopus 로고    scopus 로고
    • Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts
    • Kim K.J., Wang L., Su Y.C., et al. Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts. Clin Cancer Res 12 (2006) 1292-1298
    • (2006) Clin Cancer Res , vol.12 , pp. 1292-1298
    • Kim, K.J.1    Wang, L.2    Su, Y.C.3
  • 94
    • 36749042647 scopus 로고    scopus 로고
    • AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts
    • Jun H.T., Sun J., Rex K., et al. AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts. Clin Cancer Res 13 (2007) 6735-6742
    • (2007) Clin Cancer Res , vol.13 , pp. 6735-6742
    • Jun, H.T.1    Sun, J.2    Rex, K.3
  • 95
    • 33750683969 scopus 로고    scopus 로고
    • A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo
    • Martens T., Schmidt N.O., Eckerich C., et al. A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo. Clin Cancer Res 12 (2006) 6144-6152
    • (2006) Clin Cancer Res , vol.12 , pp. 6144-6152
    • Martens, T.1    Schmidt, N.O.2    Eckerich, C.3
  • 97
    • 33645518840 scopus 로고    scopus 로고
    • Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity
    • Petrelli A., Circosta P., Granziero L., et al. Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity. Proc Natl Acad Sci U S A 103 (2006) 5090-5095
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 5090-5095
    • Petrelli, A.1    Circosta, P.2    Granziero, L.3
  • 98
    • 41449107739 scopus 로고    scopus 로고
    • c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations
    • Bellon S.F., Kaplan-Lefko P., Yang Y., et al. c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations. J Biol Chem 283 (2008) 2675-2683
    • (2008) J Biol Chem , vol.283 , pp. 2675-2683
    • Bellon, S.F.1    Kaplan-Lefko, P.2    Yang, Y.3
  • 99
    • 34948882975 scopus 로고    scopus 로고
    • Phase 1 study of ARQ 197, a selective inhibitor of the c-Met RTK in patients with metastatic solid tumors reaches recommended phase 2 dose
    • (abstract)
    • Garcia A., Rosen L., Cunningham C.C., et al. Phase 1 study of ARQ 197, a selective inhibitor of the c-Met RTK in patients with metastatic solid tumors reaches recommended phase 2 dose. J Clin Oncol Meet Abstr 25 (2007) 3525 (abstract)
    • (2007) J Clin Oncol Meet Abstr , vol.25 , pp. 3525
    • Garcia, A.1    Rosen, L.2    Cunningham, C.C.3
  • 100
    • 67349243424 scopus 로고    scopus 로고
    • Phase I trial to determine the dose range for the c-Met inhibitor ARQ 197 that inhibits c-Met and FAK phosphorylation, when administered by an oral twice-a-day schedule
    • (abstract)
    • Yap T.A., Harris D., Barriuso J., et al. Phase I trial to determine the dose range for the c-Met inhibitor ARQ 197 that inhibits c-Met and FAK phosphorylation, when administered by an oral twice-a-day schedule. J Clin Oncol Meet Abstr 26 (2008) 3584 (abstract)
    • (2008) J Clin Oncol Meet Abstr , vol.26 , pp. 3584
    • Yap, T.A.1    Harris, D.2    Barriuso, J.3
  • 101
    • 67349288561 scopus 로고    scopus 로고
    • First in human phase I study of MK-2461, a small molecule inhibitor of c-Met, for patients with advanced solid tumors
    • (abstract)
    • Camacho L.H., Moulder S.L., LoRusso P.M., et al. First in human phase I study of MK-2461, a small molecule inhibitor of c-Met, for patients with advanced solid tumors. J Clin Oncol Meet Abstr 26 (2008) 14657 (abstract)
    • (2008) J Clin Oncol Meet Abstr , vol.26 , pp. 14657
    • Camacho, L.H.1    Moulder, S.L.2    LoRusso, P.M.3
  • 102
    • 67649120450 scopus 로고    scopus 로고
    • Sensitization of a glioblastoma multiforme (GBM) cell line by MP470: a novel c-Met antagonist
    • (abstract)
    • Welsh J., Mahadevan D., Bearss D., and Stea B. Sensitization of a glioblastoma multiforme (GBM) cell line by MP470: a novel c-Met antagonist. Int J Radiat Oncol Biol Phys 69 (2007) S100 (abstract)
    • (2007) Int J Radiat Oncol Biol Phys , vol.69
    • Welsh, J.1    Mahadevan, D.2    Bearss, D.3    Stea, B.4
  • 103
    • 34249324494 scopus 로고    scopus 로고
    • An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms
    • Zou H.Y., Li Q., Lee J.H., et al. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res 67 (2007) 4408-4417
    • (2007) Cancer Res , vol.67 , pp. 4408-4417
    • Zou, H.Y.1    Li, Q.2    Lee, J.H.3
  • 104
    • 10744228765 scopus 로고    scopus 로고
    • A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo
    • Christensen J.G., Schreck R., Burrows J., et al. A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo. Cancer Res 63 (2003) 7345-7355
    • (2003) Cancer Res , vol.63 , pp. 7345-7355
    • Christensen, J.G.1    Schreck, R.2    Burrows, J.3
  • 105
    • 3142691273 scopus 로고    scopus 로고
    • The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants
    • Berthou S., Aebersold D.M., Schmidt L.S., et al. The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants. Oncogene 23 (2004) 5387-5393
    • (2004) Oncogene , vol.23 , pp. 5387-5393
    • Berthou, S.1    Aebersold, D.M.2    Schmidt, L.S.3
  • 106
    • 0141481285 scopus 로고    scopus 로고
    • A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase
    • Sattler M., Pride Y.B., Ma P., et al. A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Cancer Res 63 (2003) 5462-5469
    • (2003) Cancer Res , vol.63 , pp. 5462-5469
    • Sattler, M.1    Pride, Y.B.2    Ma, P.3
  • 107
    • 37149032108 scopus 로고    scopus 로고
    • A phase II study of the c-Met RTK inhibitor XL880 in patients (pts) with papillary renal-cell carcinoma (PRC)
    • (abstract)
    • Ross R.W., Stein M., Sarantopoulos J., et al. A phase II study of the c-Met RTK inhibitor XL880 in patients (pts) with papillary renal-cell carcinoma (PRC). J Clin Oncol Meet Abstr 25 (2007) 15601 (abstract)
    • (2007) J Clin Oncol Meet Abstr , vol.25 , pp. 15601
    • Ross, R.W.1    Stein, M.2    Sarantopoulos, J.3
  • 108
    • 56849132326 scopus 로고    scopus 로고
    • A phase I study of XL184, a RET, VEGFR2, and MET kinase inhibitor, in patients (pts) with advanced malignancies, including pts with medullary thyroid cancer (MTC)
    • (abstract)
    • Salgia R., Sherman S., Hong D.S., et al. A phase I study of XL184, a RET, VEGFR2, and MET kinase inhibitor, in patients (pts) with advanced malignancies, including pts with medullary thyroid cancer (MTC). J Clin Oncol Meet Abstr 26 (2008) 3522 (abstract)
    • (2008) J Clin Oncol Meet Abstr , vol.26 , pp. 3522
    • Salgia, R.1    Sherman, S.2    Hong, D.S.3
  • 109
    • 60149089005 scopus 로고    scopus 로고
    • Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy
    • Du J., Bernasconi P., Clauser K.R., et al. Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy. Nat Biotechnol 27 (2009) 77-83
    • (2009) Nat Biotechnol , vol.27 , pp. 77-83
    • Du, J.1    Bernasconi, P.2    Clauser, K.R.3
  • 110
    • 53749096014 scopus 로고    scopus 로고
    • Phase II study of imatinib in patients with recurrent gliomas of various histologies: a European Organisation for Research and Treatment of Cancer Brain Tumor Group study
    • Raymond E., Brandes A.A., Dittrich C., et al. Phase II study of imatinib in patients with recurrent gliomas of various histologies: a European Organisation for Research and Treatment of Cancer Brain Tumor Group study. J Clin Oncol 26 (2008) 4659-4665
    • (2008) J Clin Oncol , vol.26 , pp. 4659-4665
    • Raymond, E.1    Brandes, A.A.2    Dittrich, C.3
  • 111
    • 33644830094 scopus 로고    scopus 로고
    • Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme
    • Reardon D.A., Egorin M.J., Quinn J.A., et al. Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme. J Clin Oncol 23 (2005) 9359-9368
    • (2005) J Clin Oncol , vol.23 , pp. 9359-9368
    • Reardon, D.A.1    Egorin, M.J.2    Quinn, J.A.3
  • 112
    • 33748376520 scopus 로고    scopus 로고
    • Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08
    • Wen P.Y., Yung W.K., Lamborn K.R., et al. Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08. Clin Cancer Res 12 (2006) 4899-4907
    • (2006) Clin Cancer Res , vol.12 , pp. 4899-4907
    • Wen, P.Y.1    Yung, W.K.2    Lamborn, K.R.3
  • 113
    • 65649146868 scopus 로고    scopus 로고
    • Phase I pharmacokinetic study of the vascular endothelial growth factor receptor tyrosine kinase inhibitor vatalanib (PTK787) plus imatinib and hydroxyurea for malignant glioma
    • Reardon D.A., Egorin M.J., Desjardins A., et al. Phase I pharmacokinetic study of the vascular endothelial growth factor receptor tyrosine kinase inhibitor vatalanib (PTK787) plus imatinib and hydroxyurea for malignant glioma. Cancer (2009)
    • (2009) Cancer
    • Reardon, D.A.1    Egorin, M.J.2    Desjardins, A.3
  • 114
    • 36049037819 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan in recurrent glioblastoma multiforme
    • Vredenburgh J.J., Desjardins A., Herndon II J.E., et al. Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol 25 (2007) 4722-4729
    • (2007) J Clin Oncol , vol.25 , pp. 4722-4729
    • Vredenburgh, J.J.1    Desjardins, A.2    Herndon II, J.E.3
  • 115
    • 59949083263 scopus 로고    scopus 로고
    • Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
    • Kreisl T.N., Kim L., Moore K., et al. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol 27 (2009) 740-745
    • (2009) J Clin Oncol , vol.27 , pp. 740-745
    • Kreisl, T.N.1    Kim, L.2    Moore, K.3
  • 116
    • 60549106878 scopus 로고    scopus 로고
    • VEGF Trap induces antiglioma effect at different stages of disease
    • Gomez-Manzano C., Holash J., Fueyo J., et al. VEGF Trap induces antiglioma effect at different stages of disease. Neuro Oncol 10 (2008) 940-945
    • (2008) Neuro Oncol , vol.10 , pp. 940-945
    • Gomez-Manzano, C.1    Holash, J.2    Fueyo, J.3
  • 117
    • 55749102152 scopus 로고    scopus 로고
    • Phase II single arm trial of aflibercept in patients with recurrent temozolomide-resistant glioblastoma: NABTC 0601
    • (abstract)
    • De Groot J.F., Wen P.Y., Lamborn K., et al. Phase II single arm trial of aflibercept in patients with recurrent temozolomide-resistant glioblastoma: NABTC 0601. J Clin Oncol Meet Abstr 26 (2008) 2020 (abstract)
    • (2008) J Clin Oncol Meet Abstr , vol.26 , pp. 2020
    • De Groot, J.F.1    Wen, P.Y.2    Lamborn, K.3
  • 118
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
    • Wedge S.R., Kendrew J., Hennequin L.F., et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 65 (2005) 4389-4400
    • (2005) Cancer Res , vol.65 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Hennequin, L.F.3
  • 119
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • Batchelor T.T., Sorensen A.G., di Tomaso E., et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11 (2007) 83-95
    • (2007) Cancer Cell , vol.11 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    di Tomaso, E.3
  • 120
    • 33845882259 scopus 로고    scopus 로고
    • The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma
    • Podar K., Tonon G., Sattler M., et al. The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma. Proc Natl Acad Sci U S A 103 (2006) 19478-19483
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 19478-19483
    • Podar, K.1    Tonon, G.2    Sattler, M.3
  • 121
    • 33744513575 scopus 로고    scopus 로고
    • Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature
    • Adnane L., Trail P.A., Taylor I., et al. Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature. Methods Enzymol 407 (2006) 597-612
    • (2006) Methods Enzymol , vol.407 , pp. 597-612
    • Adnane, L.1    Trail, P.A.2    Taylor, I.3
  • 122
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • Wedge S.R., Ogilvie D.J., Dukes M., et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res 62 (2002) 4645-4655
    • (2002) Cancer Res , vol.62 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 123
    • 56749102822 scopus 로고    scopus 로고
    • Randomized Phase II Study of Vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer
    • Heymach J.V., Paz-Ares L., De Braud F., et al. Randomized Phase II Study of Vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer. J Clin Oncol 26 (2008) 5407-5415
    • (2008) J Clin Oncol , vol.26 , pp. 5407-5415
    • Heymach, J.V.1    Paz-Ares, L.2    De Braud, F.3
  • 124
    • 40849118632 scopus 로고    scopus 로고
    • Vandetanib in metastatic hereditary medullary thyroid cancer: follow-up results of an open-label phase II trial
    • Wells Jr. S.A., Gosnell J.E., Gagel R.F., et al. Vandetanib in metastatic hereditary medullary thyroid cancer: follow-up results of an open-label phase II trial. ASCO Meet Abstr 25 (2007) 6018
    • (2007) ASCO Meet Abstr , vol.25 , pp. 6018
    • Wells Jr., S.A.1    Gosnell, J.E.2    Gagel, R.F.3
  • 125
    • 55749091026 scopus 로고    scopus 로고
    • Final report: Phase I trial of imatinib mesylate, hydroxyurea, and vatalanib for patients with recurrent malignant glioma (MG)
    • (abstract)
    • Kirkpatrick J.P., Rich J.N., Vredenburgh J.J., et al. Final report: Phase I trial of imatinib mesylate, hydroxyurea, and vatalanib for patients with recurrent malignant glioma (MG). ASCO Meet Abstr 26 (2008) 2057 (abstract)
    • (2008) ASCO Meet Abstr , vol.26 , pp. 2057
    • Kirkpatrick, J.P.1    Rich, J.N.2    Vredenburgh, J.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.