Necroptosis: Molecular signalling and translational implications

International Journal of Cell Biology

Volumn , Issue , 2014, Pages

  Giampietri, Claudia ^a   Starace, Donatella ^a   Petrungaro, Simonetta ^a   Filippini, Antonio ^a   Ziparo, Elio ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84893867149     PISSN: 16878876     EISSN: 16878884     Source Type: Journal    
DOI: 10.1155/2014/490275     Document Type: Review

References (71)

1. Vercammen D., Beyaert R., Denecker G., Goossens V., Van Loo G., Declercq W., Grooten J., Fiers W., Vandenabeele P., Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. The Journal of Experimental Medicine 1998 187 9 1477 1485 2-s2.0-0032482169 10.1084/jem.187.9.1477 (Pubitemid 28215406)
2. Holler N., Zaru R., Micheau O., Thome M., Attinger A., Valitutti S., Bodmer J.-L., Schneider P., Seed B., Tschopp J., Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nature Immunology 2000 1 6 489 495 2-s2.0-5944233768
3. Kawahara A., Ohsawa Y., Matsumura H., Uchiyama Y., Nagata S., Caspase-independent cell killing by Fas-associated protein with death domain. Journal of Cell Biology 1998 143 5 1353 1360 2-s2.0-0032583164 10.1083/jcb.143.5.1353 (Pubitemid 28559835)
4. van Raam B. J., Salvesen G. S., Proliferative versus apoptotic functions of caspase-8: Hetero or homo: the caspase-8 dimer controls cell fate. Biochimica et Biophysica Acta 2012 1824 1 113 122 2-s2.0-82755198022 10.1016/j.bbapap. 2011.06.005
5. Festjens N., Vanden Berghe T., Vandenabeele P., Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. Biochimica et Biophysica Acta 2006 1757 9-10 1371 1387 2-s2.0-33749178260 10.1016/j.bbabio.2006.06.014 (Pubitemid 44472550)
6. Wu W., Liu P., Li J., Necroptosis: an emerging form of programmed cell death. Critical Reviews in Oncology/Hematology 2012 82 249 258
7. Chan F. K.-M., Shisler J., Bixby J. G., Felices M., Zheng L., Appel M., Orenstein J., Moss B., Lenardo M. J., A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. The Journal of Biological Chemistry 2003 278 51 51613 51621 2-s2.0-0347065342 10.1074/jbc.M305633200 (Pubitemid 38020406)
8. Matsumura H., Shimizu Y., Ohsawa Y., Kawahara A., Uchiyama Y., Nagata S., Necrotic death pathway in Fas receptor signaling. Journal of Cell Biology 2000 151 6 1247 1256 2-s2.0-0034638827 10.1083/jcb.151.6.1247
9. Vercammen D., Brouckaert G., Denecker G., Van De Craen M., Declercq W., Fiers W., Vandenabeele P., Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways. The Journal of Experimental Medicine 1998 188 5 919 930 2-s2.0-0032494143 10.1084/jem.188.5.919 (Pubitemid 28433418)
10. Fulda S., The mechanism of necroptosis in normal and cancer cells. Cancer Biology & Therapy 2013 14 11 999 1004
11. Christofferson D. E., Yuan J., Necroptosis as an alternative form of programmed cell death. Current Opinion in Cell Biology 2010 22 2 263 268 2-s2.0-77951251430 10.1016/j.ceb.2009.12.003
12. Moujalled D. M., Cook W. D., Okamoto T., Murphy J., Lawlor K. E., Vince J. E., Vaux D. L., TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1. Cell Death & Disease 2013 4, article e465
13. Cho Y. S., Challa S., Moquin D., Genga R., Ray T. D., Guildford M., Chan F. K.-M., Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 2009 137 6 1112 1123 2-s2.0-66449133280 10.1016/j.cell.2009.05.037
14. Vanlangenakker N., Vanden Berghe T., Bogaert P., Laukens B., Zobel K., Deshayes K., Vucic D., Fulda S., Vandenabeele P., Bertrand M. J. M., cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death and Differentiation 2011 18 4 656 665 2-s2.0-79952623655 10.1038/cdd.2010.138
15. Zhang D.-W., Shao J., Lin J., Zhang N., Lu B.-J., Lin S.-C., Dong M.-Q., Han J., RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009 325 5938 332 336 2-s2.0-67650812332 10.1126/science.1172308
16. He S., Wang L., Miao L., Wang T., Du F., Zhao L., Wang X., Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 2009 137 6 1100 1111 2-s2.0-66749183275 10.1016/j.cell.2009.05.021
17. Feng S., Yang Y., Mei Y., Ma L., Zhu D.-E., Hoti N., Castanares M., Wu M., Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. Cellular Signalling 2007 19 10 2056 2067 2-s2.0-34548437549 10.1016/j.cellsig.2007.05.016 (Pubitemid 47353808)
18. Lin Y., Devin A., Cook A., Keane M. M., Kelliher M., Lipkowitz S., Liu Z.-G., The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of I B kinase and c-Jun N-terminal kinase. Molecular and Cellular Biology 2000 20 18 6638 6645 2-s2.0-0033821215 10.1128/MCB.20.18.6638-6645.2000
19. Martinon F., Holler N., Richard C., Tschopp J., Activation of a pro-apoptotic amplification loop through inhibition of NF- B-dependent survival signals by caspase-mediated inactivation of RIP. FEBS Letters 2000 468 2-3 134 136 2-s2.0-0033955634 10.1016/S0014-5793(00)01212-6 (Pubitemid 30110782)
20. Narayan N., Lee I. H., Borenstein R., The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature 2012 492 199 204
21. Irrinki K. M., Mallilankaraman K., Thapa R. J., Chandramoorthy H. C., Smith F. J., Jog N. R., Gandhirajan R. K., Kelsen S. G., Houser S. R., May M. J., Balachandran S., Madesh M., Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis. Molecular and Cellular Biology 2011 31 18 3745 3758 2-s2.0-80052583012 10.1128/MCB.05303-11
22. Sun L., Wang H., Wang Z., He S., Chen S., Liao D., Wang L., Yan J., Liu W., Lei X., Wang X., Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 2012 148 1-2 213 227 2-s2.0-84856090067 10.1016/j.cell.2011.11.031
23. Murphy J. M., Czabotar P. E., Hildebrand J. M., The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity 2013 39 443 453
24. Kaczmarek A., Vandenabeele P., Krysko D. V., Necroptosis: the release of damage-associated molecular patterns and its physiological relevance. Immunity 2013 38 209 223
25. Irmler M., Thome M., Hahne M., Schneider P., Hofmann K., Steiner V., Bodmer J.-L., Schröter M., Burns K., Mattmann C., Rimoldi D., French L. E., Tschopp J., Inhibition of death receptor signals by cellular FLIP. Nature 1997 388 6638 190 195 2-s2.0-0030800070 10.1038/40657 (Pubitemid 27297457)
26. Giampietri C., Petrungaro S., Musumeci M., Coluccia P., Antonangeli F., De Cesaris P., Filippini A., Marano G., Ziparo E., c-Flip overexpression reduces cardiac hypertrophy in response to pressure overload. Journal of Hypertension 2008 26 5 1008 1016 2-s2.0-42049095914 10.1097/HJH.0b013e3282f6a179 (Pubitemid 351520989)
27. Giampietri C., Petrungaro S., Coluccia P., Antonangeli F., Giannakakis K., Faraggiana T., Filippini A., Cossu G., Ziparo E., c-Flip overexpression affects satellite cell proliferation and promotes skeletal muscle aging. Cell Death and Disease 2010 1 4, article e38 2-s2.0-79959947323 10.1038/cddis.2010.17
28. Giampietri C., Petrungaro S., Padula F., 'Alessio A D., Marini E. S., Facchiano A., Filippini A., Ziparo E., Autophagy modulators sensitize prostate epithelial cancer cell lines to TNF-alpha-dependent. Apoptosis 2012 17 11 1210 1222
29. Giampietri C., Petrungaro S., Facchiano A., Filippini A., Ziparo E., Therapeutic implications of autophagy modulation in prostate cancer. Journal of Endocrinological Investigation 2012 35 10 945
30. Quintavalle C., Incoronato M., Puca L., Acunzo M., Zanca C., Romano G., Garofalo M., Iaboni M., Croce C. M., Condorelli G., C-FLIPL enhances anti-apoptotic Akt functions by modulation of Gsk3 Β activity. Cell Death and Differentiation 2010 17 12 1908 1916 2-s2.0-78349305676 10.1038/cdd.2010.65
31. Varfolomeev E. E., Schuchmann M., Luria V., Chiannilkulchai N., Beckmann J. S., Mett I. L., Rebrikov D., Brodianski V. M., Kemper O. C., Kollet O., Lapidot T., Soffer D., Sobe T., Avraham K. B., Goncharov T., Holtmann H., Lonai P., Wallach D., Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 1998 9 2 267 276 2-s2.0-0032143986 (Pubitemid 28400040)
32. Yeh W.-C., de la Pompa J. L., McCurrach M. E., Shu H.-B., Elia A. J., Shahinian A., Ng M., Wakeham A., Khoo W., Mitchell K., El-Deiry W. S., Lowe S. W., Goeddel D. V., Mak T. W., FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science 1998 279 5358 1954 1958 2-s2.0-7144263731 10.1126/science.279.5358.1954 (Pubitemid 28168653)
33. Yeh W.-C., Itie A., Elia A. J., Ng M., Shu H.-B., Wakeham A., Mirtsos C., Suzuki N., Bonnard M., Goeddel D. V., Mak T. W., Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development. Immunity 2000 12 6 633 642 2-s2.0-0033662341
34. Dillon C., Oberst A., Weinlich R., Janke L., Kang T.-B., Ben-Moshe T., Mak T., Wallach D., Green D., Survival function of the FADD-CASPASE-8-cFLIPL complex. Cell Reports 2012 1 401 407 2-s2.0-84860139251 10.1016/j.celrep.2012. 03.010
35. Tenev T., Bianchi K., Darding M., Broemer M., Langlais C., Wallberg F., Zachariou A., Lopez J., MacFarlane M., Cain K., Meier P., The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Molecular Cell 2011 43 3 432 448 2-s2.0-79960921946 10.1016/j.molcel.2011. 06.006
36. Oberst A., Dillon C. P., Weinlich R., McCormick L. L., Fitzgerald P., Pop C., Hakem R., Salvesen G. S., Green D. R., Catalytic activity of the caspase-8-FLIP L complex inhibits RIPK3-dependent necrosis. Nature 2011 471 7338 363 367 2-s2.0-79952810024 10.1038/nature09852
37. Vanlangenakker N., Vanden Berghe T., Vandenabeele P., Many stimuli pull the necrotic trigger, an overview. Cell Death and Differentiation 2012 19 1 75 86 2-s2.0-84856759660 10.1038/cdd.2011.164
38. Srinivasula S. M., Ashwell J. D., IAPs: what's in a name? Molecular Cell 2008 30 2 123 135 2-s2.0-43049091895 10.1016/j.molcel.2008.03.008 (Pubitemid 351626688)
39. Wang L., Du F., Wang X., TNF-alpha induces two distinct caspase-8 activation pathways. Cell 2008 133 4 693 703 2-s2.0-43049152912 10.1016/j.cell.2008.03.036 (Pubitemid 351636305)
40. He W., Wang Q., Srinivasan B., A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy. Oncogene 2013 10.1038/onc.2013.256
41. Feoktistova M., Geserick P., Kellert B., Dimitrova D. P., Langlais C., Hupe M., Cain K., MacFarlane M., Häcker G., Leverkus M., CIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Molecular Cell 2011 43 3 449 463 2-s2.0-79960922705 10.1016/j.molcel.2011.06.011
42. Roach H. I., Clarke N. M. P., Physiological cell death of chondrocytes in vivo is not confined to apoptosis: new observations on the mammalian growth plate. Journal of Bone and Joint Surgery B 2000 82 4 601 613 2-s2.0-0034068977 (Pubitemid 30312832)
43. Chautan M., Chazal G., Cecconi F., Gruss P., Golstein P., Interdigital cell death can occur through a necrotic and caspase-independent pathway. Current Biology 1999 9 17 967 970 2-s2.0-0033539141 10.1016/S0960-9822(99)80425-4 (Pubitemid 29442482)
44. Bonnet M. C., Preukschat D., Welz P.-S., Van Loo G., Ermolaeva M. A., Bloch W., Haase I., Pasparakis M., The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity 2011 35 4 572 582 2-s2.0-80755132824 10.1016/j.immuni.2011.08.014
45. Golstein P., Kroemer G., Redundant cell death mechanisms as relics and backups. Cell Death and Differentiation 2005 12 supplement 2 1490 1496 2-s2.0-27644585945 10.1038/sj.cdd.4401607 (Pubitemid 41553985)
46. Wilson N. S., Dixit V., Ashkenazi A., Death receptor signal transducers: nodes of coordination in immune signaling networks. Nature Immunology 2009 10 4 348 355 2-s2.0-62849093368 10.1038/ni.1714
47. Kang T.-B., Ben-Moshe T., Varfolomeev E. E., Pewzner-Jung Y., Yogev N., Jurewicz A., Waisman A., Brenner O., Haffner R., Gustafsson E., Ramakrishnan P., Lapidot T., Wallach D., Caspase-8 serves both apoptotic and nonapoptotic roles. Journal of Immunology 2004 173 5 2976 2984 2-s2.0-4344560197 (Pubitemid 39142002)
48. Salmena L., Lemmers B., Hakem A., Matysiak-Zablocki E., Murakami K., Billie Au P. Y., Berry D. M., Tamblyn L., Shehabeldin A., Migon E., Wakeham A., Bouchard D., Yeh W. C., McGlade J. C., Ohashi P. S., Hakem R., Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes and Development 2003 17 7 883 895 2-s2.0-0037380628 10.1101/gad.1063703 (Pubitemid 36397376)
49. Ch'en I. L., Tsau J. S., Molkentin J. D., Komatsu M., Hedrick S. M., Mechanisms of necroptosis in T cells. The Journal of Experimental Medicine 2011 208 4 633 641 2-s2.0-79955484750 10.1084/jem.20110251
50. Degterev A., Hitomi J., Germscheid M., Ch'en I. L., Korkina O., Teng X., Abbott D., Cuny G. D., Yuan C., Wagner G., Hedrick S. M., Gerber S. A., Lugovskoy A., Yuan J., Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature Chemical Biology 2008 4 5 313 321 2-s2.0-42249102086 10.1038/nchembio.83 (Pubitemid 351550892)
51. Kaiser W. J., Upton J. W., Long A. B., Livingston-Rosanoff D., Daley-Bauer L. P., Hakem R., Caspary T., Mocarski E. S., RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 2011 471 7338 368 372 2-s2.0-79952811804 10.1038/nature09857
52. Imtiyaz H. Z., Rosenberg S., Zhang Y., Rahman Z. S. M., Hou Y.-J., Manser T., Zhang J., The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells. Journal of Immunology 2006 176 11 6852 6861 2-s2.0-33646879040 (Pubitemid 43787866)
53. Osborn S. L., Diehl G., Han S.-J., Xue L., Kurd N., Hsieh K., Cado D., Robey E. A., Winoto A., Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis. Proceedings of the National Academy of Sciences of the United States of America 2010 107 29 13034 13039 2-s2.0-77955609495 10.1073/pnas.1005997107
54. Zhang Y., Rosenberg S., Wang H., Imtiyaz H. Z., Hou Y.-J., Zhang J., Conditional Fas-associated death domain protein (FADD): GFP knockout mice reveal FADD is dispensable in thymic development but essential in peripheral T cell homeostasis. Journal of Immunology 2005 175 5 3033 3044 2-s2.0-23844548539 (Pubitemid 41170522)
55. Zhang H., Zhou X., McQuade T., Li J., Chan F. K., Zhang J., Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 2011 471 373 376
56. Zhang J., Cado D., Chen A., Kabra N. H., Winoto A., Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature 1998 392 6673 296 300 2-s2.0-0032546387 10.1038/32681 (Pubitemid 28155104)
57. Bohgaki T., Mozo J., Salmena L., Matysiak-Zablocki E., Bohgaki M., Sanchez O., Strasser A., Hakem A., Hakem R., Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice. Journal of Cell Biology 2011 195 2 277 291 2-s2.0-80155206809 10.1083/jcb.201103053
58. Strasser A., The role of BH3-only proteins in the immune system. Nature Reviews Immunology 2005 5 3 189 200 2-s2.0-14944348965 10.1038/nri1568 (Pubitemid 40364821)
59. Bouillet P., Metcalf D., Huang D. C. S., Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 1999 286 5445 1735 1738 2-s2.0-0033607506 10.1126/science.286.5445.1735 (Pubitemid 129515880)
60. Upton J. W., Kaiser W. J., Mocarski E. S., Virus inhibition of RIP3-dependent necrosis. Cell Host and Microbe 2010 7 4 302 313 2-s2.0-77954593965 10.1016/j.chom.2010.03.006
61. Trichonas G., Manola A., Morizane Y., Thanos A., Koufomichali X., Papakostas T. D., Montezuma S., Young L., Miller J. W., Gragoudas E., Vavvas D., A novel nonradioactive method to evaluate vascular barrier breakdown and leakage. Investigative Ophthalmology and Visual Science 2010 51 3 1677 1682 2-s2.0-77949888782 10.1167/iovs.09-4193
62. Smith C. C. T., Davidson S. M., Lim S. Y., Simpkin J. C., Hothersall J. S., Yellon D. M., Necrostatin: a potentially novel cardioprotective agent? Cardiovascular Drugs and Therapy 2007 21 4 227 233 2-s2.0-34548564715 10.1007/s10557-007-6035-1 (Pubitemid 47387468)
63. François M., Le Cabec V., Dupont M.-A., Sansonetti P. J., Maridonneau-Parini I., Induction of necrosis in human neutrophils by Shigella flexneri requires type III secretion, IpaB and IpaC invasins, and actin polymerization. Infection and Immunity 2000 68 3 1289 1296 2-s2.0-0342614919 10.1128/IAI.68.3.1289-1296.2000 (Pubitemid 30108524)
64. Koterski J. F., Nahvi M., Venkatesan M. M., Haimovich B., Virulent Shigella flexneri causes damage to mitochondria and triggers necrosis in infected human monocyte-derived macrophages. Infection and Immunity 2005 73 1 504 513 2-s2.0-11144307785 10.1128/IAI.73.1.504-513.2005 (Pubitemid 40041145)
65. Ma Y., Temkin V., Liu H., Pope R. M., NF- B protects macrophages from lipopolysaccharide-induced cell death: the role of caspase 8 and receptor-interacting protein. The Journal of Biological Chemistry 2005 280 51 41827 41834 2-s2.0-29644433629 10.1074/jbc.M510849200 (Pubitemid 43023151)
66. Bamias G., Jia L. G., Cominelli F., The tumor necrosis factor-like cytokine 1A/death receptor 3 cytokine system in intestinal inflammation. Current Opinion in Gastroenterology 2013 29 597 602
67. Welz P.-S., Wullaert A., Vlantis K., Kondylis V., Fernández-Majada V., Ermolaeva M., Kirsch P., Sterner-Kock A., Van Loo G., Pasparakis M., FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature 2011 477 7364 330 334 2-s2.0-80052850704 10.1038/nature10273
68. Liu P., Xu B., Shen W., Zhu H., Wu W., Fu Y., Chen H., Dong H., Zhu Y., Miao K., Xu W., Li J., Dysregulation of TNF α -induced necroptotic signaling in chronic lymphocytic leukemia: suppression of CYLD gene by LEF1. Leukemia 2012 26 1293 1300 2-s2.0-83155168280 10.1038/leu.2011.357
69. Alameda J. P., Moreno-Maldonado R., Navarro M., Bravo A., Ramírez A., Page A., Jorcano J. L., Fernández-Acero M. J., Casanova M. L., An inactivating CYLD mutation promotes skin tumor progression by conferring enhanced proliferative, survival and angiogenic properties to epidermal cancer cells. Oncogene 2010 29 50 6522 6532 2-s2.0-78650305124 10.1038/onc.2010.378
70. Han W., Li L., Qiu S., Lu Q., Pan Q., Gu Y., Luo J., Hu X., Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Molecular Cancer Therapeutics 2007 6 5 1641 1649 2-s2.0-34250748014 10.1158/1535-7163.MCT-06-0511 (Pubitemid 46954031)
71. Wu M., Jiang Z., Duan H., Deoxypodophyllotoxin triggers necroptosis in human non-small cell lung cancer NCI-H460 cells. Biomedicine & Pharmacotherapy 2013 67 701 706