-
1
-
-
84887131202
-
EMT in developmental morphogenesis
-
pii: S0304-3835(13)00163-8
-
Nakaya, Y.; Sheng, G. EMT in developmental morphogenesis. Cancer Lett. 2013, pii: S0304-3835(13)00163-8.
-
(2013)
Cancer Lett.
-
-
Nakaya, Y.1
Sheng, G.2
-
2
-
-
84873050284
-
Regulatory networks defining EMT during cancer initiation and progression
-
De, C. B.; Berx, G. Regulatory networks defining EMT during cancer initiation and progression. Nat. Rev. Cancer 2013, 13, 97-110.
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 97-110
-
-
De, C.B.1
Berx, G.2
-
3
-
-
0034798707
-
Leaving the neighborhood: Molecular mechanisms involved during epithelial-mesenchymal transition
-
Savagner, P. Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition. Bioessays 2001, 23, 912-923.
-
(2001)
Bioessays
, vol.23
, pp. 912-923
-
-
Savagner, P.1
-
4
-
-
84867578091
-
EMT-activating transcription factors in cancer: Beyond EMT and tumor invasiveness
-
Sanchez-Tillo, E.; Liu, Y.; de, B. O.; Siles, L.; Fanlo, L.; Cuatrecasas, M.; Darling, D. S.; Dean, D. C.; Castells, A.; Postigo, A. EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness. Cell Mol. Life Sci. 2012, 69, 3429-3456.
-
(2012)
Cell Mol. Life Sci.
, vol.69
, pp. 3429-3456
-
-
Sanchez-Tillo, E.1
Liu, Y.2
de, B.O.3
Siles, L.4
Fanlo, L.5
Cuatrecasas, M.6
Darling, D.S.7
Dean, D.C.8
Castells, A.9
Postigo, A.10
-
5
-
-
0035542552
-
Signalling from the cell surface to the nucleus
-
Lee, M.; Goodbourn, S. Signalling from the cell surface to the nucleus. Essays Biochem. 2001, 37, 71-85.
-
(2001)
Essays Biochem.
, vol.37
, pp. 71-85
-
-
Lee, M.1
Goodbourn, S.2
-
7
-
-
0029984570
-
Nucleocytoplasmic transport
-
Gorlich, D.; Mattaj, I. W. Nucleocytoplasmic transport. Science 1996, 271, 1513-1518.
-
(1996)
Science
, vol.271
, pp. 1513-1518
-
-
Gorlich, D.1
Mattaj, I.W.2
-
8
-
-
0040182590
-
Nuclear protein import
-
Gorlich, D. Nuclear protein import. Curr. Opin. Cell Biol. 1997, 9, 412-419.
-
(1997)
Curr. Opin. Cell Biol.
, vol.9
, pp. 412-419
-
-
Gorlich, D.1
-
9
-
-
0039115156
-
Transport into and out of the cell nucleus
-
Gorlich, D. Transport into and out of the cell nucleus. EMBO J. 1998, 17, 2721-2727.
-
(1998)
EMBO J.
, vol.17
, pp. 2721-2727
-
-
Gorlich, D.1
-
10
-
-
0033279841
-
Transport between the cell nucleus and the cytoplasm
-
Gorlich, D.; Kutay, U. Transport between the cell nucleus and the cytoplasm. Annu. Rev. Cell Dev. Biol. 1999, 15, 607-660.
-
(1999)
Annu. Rev. Cell Dev. Biol.
, vol.15
, pp. 607-660
-
-
Gorlich, D.1
Kutay, U.2
-
11
-
-
84858005605
-
Nuclear export of proteins and drug resistance in cancer
-
Turner, J. G.; Dawson, J.; Sullivan, D. M. Nuclear export of proteins and drug resistance in cancer. Biochem. Pharmacol. 2012, 83, 1021-1032.
-
(2012)
Biochem. Pharmacol.
, vol.83
, pp. 1021-1032
-
-
Turner, J.G.1
Dawson, J.2
Sullivan, D.M.3
-
12
-
-
61649105802
-
CRM1-mediated nuclear export of proteins and drug resistance in cancer
-
Turner, J. G.; Sullivan, D. M. CRM1-mediated nuclear export of proteins and drug resistance in cancer. Curr. Med. Chem. 2008, 15, 2648-2655.
-
(2008)
Curr. Med. Chem.
, vol.15
, pp. 2648-2655
-
-
Turner, J.G.1
Sullivan, D.M.2
-
13
-
-
56749095797
-
Transcriptional regulation of cell polarity in EMT and cancer
-
Moreno-Bueno, G.; Portillo, F.; Cano, A. Transcriptional regulation of cell polarity in EMT and cancer. Oncogene 2008, 27, 6958-6969.
-
(2008)
Oncogene
, vol.27
, pp. 6958-6969
-
-
Moreno-Bueno, G.1
Portillo, F.2
Cano, A.3
-
14
-
-
77953571622
-
Snail: More than EMT
-
Wu, Y.; Zhou, B. P. Snail: More than EMT. Cell Adh. Migr. 2010, 4, 199-203.
-
(2010)
Cell Adh. Migr.
, vol.4
, pp. 199-203
-
-
Wu, Y.1
Zhou, B.P.2
-
15
-
-
34249289041
-
Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
-
Peinado, H.; Olmeda, D.; Cano, A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat. Rev. Cancer 2007, 7, 415-428.
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 415-428
-
-
Peinado, H.1
Olmeda, D.2
Cano, A.3
-
16
-
-
84869045299
-
Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2
-
Chakrabarti, R.; Hwang, J.; Andres, B. M.; Wei, Y.; Lukacisin, M.; Romano, R. A.; Smalley, K.; Liu, S.; Yang, Q.; Ibrahim, T.; Mercatali, L.; Amadori, D.; Haffty, B. G.; Sinha, S.; Kang, Y. Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. Nat. Cell Biol. 2012, 14, 1212-1222.
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 1212-1222
-
-
Chakrabarti, R.1
Hwang, J.2
Andres, B.M.3
Wei, Y.4
Lukacisin, M.5
Romano, R.A.6
Smalley, K.7
Liu, S.8
Yang, Q.9
Ibrahim, T.10
Mercatali, L.11
Amadori, D.12
Haffty, B.G.13
Sinha, S.14
Kang, Y.15
-
17
-
-
84859416889
-
Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells
-
Mulholland, D. J.; Kobayashi, N.; Ruscetti, M.; Zhi, A.; Tran, L. M.; Huang, J.; Gleave, M.; Wu, H. Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells. Cancer Res. 2012, 72, 1878-1889.
-
(2012)
Cancer Res.
, vol.72
, pp. 1878-1889
-
-
Mulholland, D.J.1
Kobayashi, N.2
Ruscetti, M.3
Zhi, A.4
Tran, L.M.5
Huang, J.6
Gleave, M.7
Wu, H.8
-
18
-
-
63849130585
-
Role of the epithelial-mesenchymal transition regulator Slug in primary human cancers
-
Alves, C. C.; Carneiro, F.; Hoefler, H.; Becker, K. F. Role of the epithelial-mesenchymal transition regulator Slug in primary human cancers. Front Biosci. 2009, 14, 3035-3050.
-
(2009)
Front Biosci.
, vol.14
, pp. 3035-3050
-
-
Alves, C.C.1
Carneiro, F.2
Hoefler, H.3
Becker, K.F.4
-
19
-
-
77950571925
-
Regulation of p63 isoforms by Snail and slug transcription factors in human squamous cell carcinoma
-
Herfs, M.; Hubert, P.; Suarez-Carmona, M.; Reschner, A.; Saussez, S.; Berx, G.; Savagner, P.; Boniver, J.; Delvenne, P. Regulation of p63 isoforms by Snail and slug transcription factors in human squamous cell carcinoma. Am. J. Pathol. 2010, 176, 1941-1949.
-
(2010)
Am. J. Pathol.
, vol.176
, pp. 1941-1949
-
-
Herfs, M.1
Hubert, P.2
Suarez-Carmona, M.3
Reschner, A.4
Saussez, S.5
Berx, G.6
Savagner, P.7
Boniver, J.8
Delvenne, P.9
-
20
-
-
34247843997
-
Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review)
-
Katoh, Y.; Katoh, M. Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). Int. J. Mol. Med. 2006, 18, 1019-1023.
-
(2006)
Int. J. Mol. Med.
, vol.18
, pp. 1019-1023
-
-
Katoh, Y.1
Katoh, M.2
-
21
-
-
53049097596
-
Hedgehog signaling, epithelial-tomesenchymal transition and miRNA (review)
-
Katoh, Y.; Katoh, M. Hedgehog signaling, epithelial-tomesenchymal transition and miRNA (review). Int. J. Mol. Med. 2008, 22, 271-275.
-
(2008)
Int. J. Mol. Med.
, vol.22
, pp. 271-275
-
-
Katoh, Y.1
Katoh, M.2
-
22
-
-
77954030498
-
NF-kappaB promotes epithelialmesenchymal transition, migration and invasion of pancreatic carcinoma cells
-
Maier, H. J.; Schmidt-Strassburger, U.; Huber, M. A.; Wiedemann, E. M.; Beug, H.; Wirth, T. NF-kappaB promotes epithelialmesenchymal transition, migration and invasion of pancreatic carcinoma cells. Cancer Lett. 2010, 295, 214-228.
-
(2010)
Cancer Lett.
, vol.295
, pp. 214-228
-
-
Maier, H.J.1
Schmidt-Strassburger, U.2
Huber, M.A.3
Wiedemann, E.M.4
Beug, H.5
Wirth, T.6
-
23
-
-
17144386589
-
Epithelial-mesenchymal transition: NF-kappaB takes center stage
-
Huber, M. A.; Beug, H.; Wirth, T. Epithelial-mesenchymal transition: NF-kappaB takes center stage. Cell Cycle 2004, 3, 1477-1480.
-
(2004)
Cell Cycle
, vol.3
, pp. 1477-1480
-
-
Huber, M.A.1
Beug, H.2
Wirth, T.3
-
24
-
-
4344612243
-
NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
-
Huber, M. A.; Azoitei, N.; Baumann, B.; Grunert, S.; Sommer, A.; Pehamberger, H.; Kraut, N.; Beug, H.; Wirth, T. NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J. Clin. Invest. 2004, 114, 569-581.
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 569-581
-
-
Huber, M.A.1
Azoitei, N.2
Baumann, B.3
Grunert, S.4
Sommer, A.5
Pehamberger, H.6
Kraut, N.7
Beug, H.8
Wirth, T.9
-
25
-
-
41649111688
-
The role of ATF-2 in oncogenesis
-
Vlahopoulos, S. A.; Logotheti, S.; Mikas, D.; Giarika, A, Gorgoulis, V.; Zoumpourlis, V. The role of ATF-2 in oncogenesis. Bioessays, 2008, 30, 314-327.
-
(2008)
Bioessays
, vol.30
, pp. 314-327
-
-
Vlahopoulos, S.A.1
Logotheti, S.2
Mikas, D.3
Giarika, A.4
Gorgoulis, V.5
Zoumpourlis, V.6
-
26
-
-
84871846692
-
WNT signalling pathways as therapeutic targets in cancer
-
Anastas, J. N.; Moon, R. T. WNT signalling pathways as therapeutic targets in cancer. Nat. Rev. Cancer 2013, 13, 11-26.
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 11-26
-
-
Anastas, J.N.1
Moon, R.T.2
-
27
-
-
84862495767
-
Epithelialmesenchymal transition, the tumor microenvironment, and metastatic behavior of epithelial malignancies
-
Talbot, L. J.; Bhattacharya, S. D.; Kuo, P. C. Epithelialmesenchymal transition, the tumor microenvironment, and metastatic behavior of epithelial malignancies. Int. J. Biochem. Mol. Biol. 2012, 3, 117-136.
-
(2012)
Int. J. Biochem. Mol. Biol.
, vol.3
, pp. 117-136
-
-
Talbot, L.J.1
Bhattacharya, S.D.2
Kuo, P.C.3
-
28
-
-
44049090235
-
Notch signaling mediates hypoxia-induced tumor cell migration and invasion
-
Sahlgren, C.; Gustafsson, M. V.; Jin, S.; Poellinger, L.; Lendahl, U. Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc. Natl. Acad. Sci. USA 2008, 105, 6392-6397.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 6392-6397
-
-
Sahlgren, C.1
Gustafsson, M.V.2
Jin, S.3
Poellinger, L.4
Lendahl, U.5
-
29
-
-
79952283482
-
p53 regulates epithelialmesenchymal transition and stem cell properties through modulating miRNAs
-
Chang, C. J.; Chao, C. H.; Xia, W.; Yang, J. Y.; Xiong, Y.; Li, C. W.; Yu, W. H.; Rehman, S. K.; Hsu, J. L.; Lee, H. H.; Liu, M.; Chen, C. T.; Yu, D.; Hung, M. C. p53 regulates epithelialmesenchymal transition and stem cell properties through modulating miRNAs. Nat. Cell Biol. 2011, 13, 317-323.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 317-323
-
-
Chang, C.J.1
Chao, C.H.2
Xia, W.3
Yang, J.Y.4
Xiong, Y.5
Li, C.W.6
Yu, W.H.7
Rehman, S.K.8
Hsu, J.L.9
Lee, H.H.10
Liu, M.11
Chen, C.T.12
Yu, D.13
Hung, M.C.14
-
30
-
-
78649650714
-
Recognition of nuclear targeting signals by Karyopherin-beta proteins
-
Xu, D.; Farmer, A.; Chook, Y. M. Recognition of nuclear targeting signals by Karyopherin-beta proteins. Curr. Opin. Struct. Biol. 2010, 20, 782-790.
-
(2010)
Curr. Opin. Struct. Biol.
, vol.20
, pp. 782-790
-
-
Xu, D.1
Farmer, A.2
Chook, Y.M.3
-
31
-
-
79960912049
-
Nuclear import by karyopherin-betas: Recognition and inhibition
-
Chook, Y. M.; Suel, K. E. Nuclear import by karyopherin-betas: recognition and inhibition. Biochim. Biophys. Acta 2011, 1813, 1593-1606.
-
(2011)
Biochim. Biophys. Acta
, vol.1813
, pp. 1593-1606
-
-
Chook, Y.M.1
Suel, K.E.2
-
32
-
-
0036368289
-
Exportin-mediated nuclear export of proteins and ribonucleoproteins
-
Fornerod, M.; Ohno, M. Exportin-mediated nuclear export of proteins and ribonucleoproteins. Results Probl. Cell Differ. 2002, 35, 67-91.
-
(2002)
Results Probl. Cell Differ.
, vol.35
, pp. 67-91
-
-
Fornerod, M.1
Ohno, M.2
-
33
-
-
77951299111
-
Nuclear export complexes in the frame
-
Cook, A. G.; Conti, E. Nuclear export complexes in the frame. Curr. Opin. Struct. Biol. 2010, 20, 247-252.
-
(2010)
Curr. Opin. Struct. Biol.
, vol.20
, pp. 247-252
-
-
Cook, A.G.1
Conti, E.2
-
34
-
-
85047683135
-
The dynamics of karyopherin-mediated nuclear transport
-
Marelli, M.; Dilworth, D. J.; Wozniak, R. W.; Aitchison, J. D. The dynamics of karyopherin-mediated nuclear transport. Biochem. Cell Biol. 2001, 79, 603-612.
-
(2001)
Biochem. Cell Biol.
, vol.79
, pp. 603-612
-
-
Marelli, M.1
Dilworth, D.J.2
Wozniak, R.W.3
Aitchison, J.D.4
-
35
-
-
0029991830
-
Nuclear pore-targeting complex and its role on nuclear protein transport
-
Yoneda, Y. Nuclear pore-targeting complex and its role on nuclear protein transport. Arch. Histol. Cytol. 1996, 59, 97-107.
-
(1996)
Arch. Histol. Cytol.
, vol.59
, pp. 97-107
-
-
Yoneda, Y.1
-
36
-
-
84858294567
-
Structural basis of high-affinity nuclear localization signal interactions with importin-alpha
-
Marfori, M.; Lonhienne, T. G.; Forwood, J. K.; Kobe, B. Structural basis of high-affinity nuclear localization signal interactions with importin-alpha. Traffic 2012, 13, 532-548.
-
(2012)
Traffic
, vol.13
, pp. 532-548
-
-
Marfori, M.1
Lonhienne, T.G.2
Forwood, J.K.3
Kobe, B.4
-
37
-
-
77956331754
-
Quantitative structural analysis of importin-beta flexibility: Paradigm for solenoid protein structures
-
Forwood, J. K.; Lange, A.; Zachariae, U.; Marfori, M.; Preast, C.; Grubmuller, H.; Stewart, M.; Corbett, A. H.; Kobe, B. Quantitative structural analysis of importin-beta flexibility: paradigm for solenoid protein structures. Structure 2010, 18, 1171-1183.
-
(2010)
Structure
, vol.18
, pp. 1171-1183
-
-
Forwood, J.K.1
Lange, A.2
Zachariae, U.3
Marfori, M.4
Preast, C.5
Grubmuller, H.6
Stewart, M.7
Corbett, A.H.8
Kobe, B.9
-
38
-
-
14744301997
-
Leucine-rich nuclear-export signals: Born to be weak
-
Kutay, U.; Guttinger, S. Leucine-rich nuclear-export signals: born to be weak. Trends Cell Biol. 2005, 15, 121-124.
-
(2005)
Trends Cell Biol.
, vol.15
, pp. 121-124
-
-
Kutay, U.1
Guttinger, S.2
-
39
-
-
80052230265
-
Ran-dependent nuclear export mediators: A structural perspective
-
Guttler, T.; Gorlich, D. Ran-dependent nuclear export mediators: a structural perspective. EMBO J. 2011, 30, 3457-3474.
-
(2011)
EMBO J.
, vol.30
, pp. 3457-3474
-
-
Guttler, T.1
Gorlich, D.2
-
40
-
-
62449215108
-
The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation
-
van der Watt, P. J.; Maske, C. P.; Hendricks, D. T.; Parker, M. I.; Denny, L.; Govender, D.; Birrer, M. J.; Leaner, V. D. The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation. Int. J. Cancer 2009, 124, 1829-1840.
-
(2009)
Int. J. Cancer
, vol.124
, pp. 1829-1840
-
-
van der Watt, P.J.1
Maske, C.P.2
Hendricks, D.T.3
Parker, M.I.4
Denny, L.5
Govender, D.6
Birrer, M.J.7
Leaner, V.D.8
-
41
-
-
34250698315
-
Analysis of the E-cadherin repressor Snail in primary human cancers
-
Becker, K. F.; Rosivatz, E.; Blechschmidt, K.; Kremmer, E.; Sarbia, M.; Hofler, H. Analysis of the E-cadherin repressor Snail in primary human cancers. Cells Tissues Organs 2007, 185, 204-212.
-
(2007)
Cells Tissues Organs
, vol.185
, pp. 204-212
-
-
Becker, K.F.1
Rosivatz, E.2
Blechschmidt, K.3
Kremmer, E.4
Sarbia, M.5
Hofler, H.6
-
42
-
-
0038450250
-
Phosphorylation regulates the subcellular location and activity of the Snail transcriptional repressor
-
Dominguez, D.; Montserrat-Sentis, B.; Virgos-Soler, A.; Guaita, S.; Grueso, J.; Porta, M.; Puig, I.; Baulida, J.; Franci, C.; Garcia de, H. A. Phosphorylation regulates the subcellular location and activity of the Snail transcriptional repressor. Mol. Cell Biol. 2003, 23, 5078-5089.
-
(2003)
Mol. Cell Biol.
, vol.23
, pp. 5078-5089
-
-
Dominguez, D.1
Montserrat-Sentis, B.2
Virgos-Soler, A.3
Guaita, S.4
Grueso, J.5
Porta, M.6
Puig, I.7
Baulida, J.8
Franci, C.9
de Garcia, H.A.10
-
43
-
-
17844383692
-
Zinc finger domain of Snail functions as a nuclear localization signal for importin beta-mediated nuclear import pathway
-
Yamasaki, H.; Sekimoto, T.; Ohkubo, T.; Douchi, T.; Nagata, Y.; Ozawa, M.; Yoneda, Y. Zinc finger domain of Snail functions as a nuclear localization signal for importin beta-mediated nuclear import pathway. Genes Cells 2005, 10, 455-464.
-
(2005)
Genes Cells
, vol.10
, pp. 455-464
-
-
Yamasaki, H.1
Sekimoto, T.2
Ohkubo, T.3
Douchi, T.4
Nagata, Y.5
Ozawa, M.6
Yoneda, Y.7
-
44
-
-
84887138387
-
The relevance of the TGF-beta Paradox to EMT-MET programs
-
pii: S0304-3835(13)00211-5
-
Morrison, C. D.; Parvani, J. G.; Schiemann, W. P. The relevance of the TGF-beta Paradox to EMT-MET programs. Cancer Lett. 2013, pii: S0304-3835(13)00211-5.
-
(2013)
Cancer Lett.
-
-
Morrison, C.D.1
Parvani, J.G.2
Schiemann, W.P.3
-
45
-
-
79951797048
-
The transforming growth factor-beta (TGF-beta) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells
-
Caja, L.; Bertran, E.; Campbell, J.; Fausto, N.; Fabregat, I. The transforming growth factor-beta (TGF-beta) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells. J. Cell Physiol. 2011, 226, 1214-1223.
-
(2011)
J. Cell Physiol.
, vol.226
, pp. 1214-1223
-
-
Caja, L.1
Bertran, E.2
Campbell, J.3
Fausto, N.4
Fabregat, I.5
-
46
-
-
77953365784
-
Extrinsic regulation of pluripotent stem cells
-
Pera, M. F.; Tam, P. P. Extrinsic regulation of pluripotent stem cells. Nature 2010, 465, 713-720.
-
(2010)
Nature
, vol.465
, pp. 713-720
-
-
Pera, M.F.1
Tam, P.P.2
-
47
-
-
49849103199
-
Decoding the quantitative nature of TGFbeta/ Smad signaling
-
Clarke, D. C.; Liu, X. Decoding the quantitative nature of TGFbeta/ Smad signaling. Trends Cell Biol. 2008, 18, 430-442.
-
(2008)
Trends Cell Biol.
, vol.18
, pp. 430-442
-
-
Clarke, D.C.1
Liu, X.2
-
48
-
-
0031438047
-
TGF-beta signalling from cell membrane to nucleus through SMAD proteins
-
Heldin, C. H.; Miyazono, K.; Ten, D. P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 1997, 390, 465-471.
-
(1997)
Nature
, vol.390
, pp. 465-471
-
-
Heldin, C.H.1
Miyazono, K.2
Ten, D.P.3
-
49
-
-
0347664883
-
Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals
-
Xiao, Z.; Watson, N.; Rodriguez, C.; Lodish, H. F. Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals. J. Biol. Chem. 2001, 276, 39404-39410.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 39404-39410
-
-
Xiao, Z.1
Watson, N.2
Rodriguez, C.3
Lodish, H.F.4
-
50
-
-
0141706697
-
A novel nuclear export signal in Smad1 is essential for its signaling activity
-
Xiao, Z.; Brownawell, A. M.; Macara, I. G.; Lodish, H. F. A novel nuclear export signal in Smad1 is essential for its signaling activity. J. Biol. Chem. 2003, 278, 34245-34252.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 34245-34252
-
-
Xiao, Z.1
Brownawell, A.M.2
McAra, I.G.3
Lodish, H.F.4
-
51
-
-
0034604343
-
Importin beta mediates nuclear translocation of Smad 3
-
Xiao, Z.; Liu, X.; Lodish, H. F. Importin beta mediates nuclear translocation of Smad 3. J. Biol. Chem. 2000, 275, 23425-23428.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 23425-23428
-
-
Xiao, Z.1
Liu, X.2
Lodish, H.F.3
-
52
-
-
0034608799
-
A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation
-
Xiao, Z.; Liu, X.; Henis, Y. I.; Lodish, H. F. A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation. Proc. Natl. Acad. Sci. USA 2000, 97, 7853-7858.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 7853-7858
-
-
Xiao, Z.1
Liu, X.2
Henis, Y.I.3
Lodish, H.F.4
-
53
-
-
0034252221
-
Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal
-
Watanabe, M.; Masuyama, N.; Fukuda, M.; Nishida, E. Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal. EMBO Rep. 2000, 1, 176-182.
-
(2000)
EMBO Rep.
, vol.1
, pp. 176-182
-
-
Watanabe, M.1
Masuyama, N.2
Fukuda, M.3
Nishida, E.4
-
54
-
-
0035694910
-
Smad regulation in TGF-beta signal transduction
-
Moustakas, A.; Souchelnytskyi, S.; Heldin, C. H. Smad regulation in TGF-beta signal transduction. J. Cell Sci. 2001, 114, 4359-4369.
-
(2001)
J. Cell Sci.
, vol.114
, pp. 4359-4369
-
-
Moustakas, A.1
Souchelnytskyi, S.2
Heldin, C.H.3
-
55
-
-
0035167095
-
Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner
-
Kurisaki, A.; Kose, S.; Yoneda, Y.; Heldin, C. H.; Moustakas, A. Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner. Mol. Biol. Cell, 2001, 12, 1079-1091.
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 1079-1091
-
-
Kurisaki, A.1
Kose, S.2
Yoneda, Y.3
Heldin, C.H.4
Moustakas, A.5
-
56
-
-
61749096309
-
Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling
-
Dai, F.; Lin, X.; Chang, C.; Feng, X. H. Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling. Dev. Cell, 2009, 16, 345-357.
-
(2009)
Dev. Cell
, vol.16
, pp. 345-357
-
-
Dai, F.1
Lin, X.2
Chang, C.3
Feng, X.H.4
-
57
-
-
0032582672
-
Transforming growth factor beta1 induces nuclear export of inhibitory Smad7
-
Itoh, S.; Landstrom, M.; Hermansson, A.; Itoh, F.; Heldin, C. H.; Heldin, N. E.; Ten, D. P. Transforming growth factor beta1 induces nuclear export of inhibitory Smad7. J. Biol. Chem. 1998, 273, 29195-29201.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 29195-29201
-
-
Itoh, S.1
Landstrom, M.2
Hermansson, A.3
Itoh, F.4
Heldin, C.H.5
Heldin, N.E.6
Ten, D.P.7
-
58
-
-
58149264873
-
Nucleocytoplasmic shuttling of Smad proteins
-
Hill, C. S. Nucleocytoplasmic shuttling of Smad proteins. Cell Res., 2009, 19, 36-46.
-
(2009)
Cell Res.
, vol.19
, pp. 36-46
-
-
Hill, C.S.1
-
59
-
-
20444430827
-
Nuclear targeting of transforming growth factor-beta-activated Smad complexes
-
Chen, H. B.; Rud, J. G.; Lin, K.; Xu, L. Nuclear targeting of transforming growth factor-beta-activated Smad complexes. J. Biol. Chem. 2005, 280, 21329-21336.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 21329-21336
-
-
Chen, H.B.1
Rud, J.G.2
Lin, K.3
Xu, L.4
-
60
-
-
84855176124
-
E-cadherin/beta-catenin complex and the epithelial barrier
-
Tian, X.; Liu, Z.; Niu, B.; Zhang, J.; Tan, T. K.; Lee, S. R.; Zhao, Y.; Harris, D. C.; Zheng, G. E-cadherin/beta-catenin complex and the epithelial barrier. J. Biomed. Biotechnol. 2011, 2011, 567305.
-
(2011)
J. Biomed. Biotechnol.
, vol.2011
, pp. 567305
-
-
Tian, X.1
Liu, Z.2
Niu, B.3
Zhang, J.4
Tan, T.K.5
Lee, S.R.6
Zhao, Y.7
Harris, D.C.8
Zheng, G.9
-
62
-
-
84856504393
-
TCFs and Wnt/beta-catenin signaling: More than one way to throw the switch
-
Cadigan, K. M. TCFs and Wnt/beta-catenin signaling: more than one way to throw the switch. Curr. Top. Dev. Biol. 2012, 98, 1-34.
-
(2012)
Curr. Top. Dev. Biol.
, vol.98
, pp. 1-34
-
-
Cadigan, K.M.1
-
63
-
-
57649107878
-
Activation of wingless targets requires bipartite recognition of DNA by TCF
-
Chang, M. V.; Chang, J. L.; Gangopadhyay, A.; Shearer, A.; Cadigan, K. M. Activation of wingless targets requires bipartite recognition of DNA by TCF. Curr. Biol. 2008, 18, 1877-1881.
-
(2008)
Curr. Biol.
, vol.18
, pp. 1877-1881
-
-
Chang, M.V.1
Chang, J.L.2
Gangopadhyay, A.3
Shearer, A.4
Cadigan, K.M.5
-
64
-
-
44349150869
-
Novel TCFbinding sites specify transcriptional repression by Wnt signalling
-
Blauwkamp, T. A.; Chang, M. V.; Cadigan, K. M. Novel TCFbinding sites specify transcriptional repression by Wnt signalling. EMBO J. 2008, 27, 1436-1446.
-
(2008)
EMBO J.
, vol.27
, pp. 1436-1446
-
-
Blauwkamp, T.A.1
Chang, M.V.2
Cadigan, K.M.3
-
65
-
-
0345599013
-
Autoregulation of E-cadherin expression by cadherin-cadherin interactions: The roles of betacatenin signaling, Slug, and MAPK
-
Conacci-Sorrell, M.; Simcha, I.; Ben-Yedidia, T.; Blechman, J.; Savagner, P.; Ben-Ze'ev, A. Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of betacatenin signaling, Slug, and MAPK. J. Cell Biol. 2003, 163, 847-857.
-
(2003)
J. Cell Biol.
, vol.163
, pp. 847-857
-
-
Conacci-Sorrell, M.1
Simcha, I.2
Ben-Yedidia, T.3
Blechman, J.4
Savagner, P.5
Ben-Ze'ev, A.6
-
66
-
-
44449111555
-
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
-
Onder, T. T.; Gupta, P. B.; Mani, S. A.; Yang, J.; Lander, E. S.; Weinberg, R. A. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res. 2008, 68, 3645-3654.
-
(2008)
Cancer Res.
, vol.68
, pp. 3645-3654
-
-
Onder, T.T.1
Gupta, P.B.2
Mani, S.A.3
Yang, J.4
Lander, E.S.5
Weinberg, R.A.6
-
67
-
-
35148851978
-
The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling
-
Ayyanathan, K.; Peng, H.; Hou, Z.; Fredericks, W. J.; Goyal, R. K.; Langer, E. M.; Longmore, G. D.; Rauscher, F. J. The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling. Cancer Res. 2007, 67, 9097-9106.
-
(2007)
Cancer Res.
, vol.67
, pp. 9097-9106
-
-
Ayyanathan, K.1
Peng, H.2
Hou, Z.3
Fredericks, W.J.4
Goyal, R.K.5
Langer, E.M.6
Longmore, G.D.7
Rauscher, F.J.8
-
68
-
-
42049123063
-
Ajuba LIM proteins are Snail/slug corepressors required for neural crest development in Xenopus
-
Langer, E. M.; Feng, Y.; Zhaoyuan, H.; Rauscher, F. J. 3rd; Kroll, K. L.; Longmore, G. D. Ajuba LIM proteins are Snail/slug corepressors required for neural crest development in Xenopus. Dev. Cell 2008, 14, 424-436.
-
(2008)
Dev. Cell
, vol.14
, pp. 424-436
-
-
Langer, E.M.1
Feng, Y.2
Zhaoyuan, H.3
Rauscher 3rd, F.J.4
Kroll, K.L.5
Longmore, G.D.6
-
69
-
-
0032510103
-
Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of beta-catenin
-
Fagotto, F.; Gluck, U.; Gumbiner, B. M. Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of beta-catenin. Curr. Biol. 1998, 8, 181-190.
-
(1998)
Curr. Biol.
, vol.8
, pp. 181-190
-
-
Fagotto, F.1
Gluck, U.2
Gumbiner, B.M.3
-
70
-
-
58149174376
-
Exploitation of the Notch signaling pathway as a novel target for cancer therapy
-
Wang, Z.; Li, Y.; Banerjee, S.; Sarkar, F. H. Exploitation of the Notch signaling pathway as a novel target for cancer therapy. Anticancer Res. 2008, 28, 3621-3630.
-
(2008)
Anticancer Res.
, vol.28
, pp. 3621-3630
-
-
Wang, Z.1
Li, Y.2
Banerjee, S.3
Sarkar, F.H.4
-
71
-
-
67349193226
-
Emerging role of Notch in stem cells and cancer
-
Wang, Z.; Li, Y.; Banerjee, S.; Sarkar, F. H. Emerging role of Notch in stem cells and cancer. Cancer Lett. 2009, 279, 8-12.
-
(2009)
Cancer Lett.
, vol.279
, pp. 8-12
-
-
Wang, Z.1
Li, Y.2
Banerjee, S.3
Sarkar, F.H.4
-
72
-
-
65549141305
-
Acquisition of epithelial-mesenchymal transition phenotype of gemcitabineresistant pancreatic cancer cells is linked with activation of the notch signaling pathway
-
Wang, Z.; Li, Y.; Kong, D.; Banerjee, S.; Ahmad, A.; Azmi, A. S.; Ali, S.; Abbruzzese, J. L.; Gallick, G. E.; Sarkar, F. H. Acquisition of epithelial-mesenchymal transition phenotype of gemcitabineresistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res. 2009, 69, 2400-2407.
-
(2009)
Cancer Res.
, vol.69
, pp. 2400-2407
-
-
Wang, Z.1
Li, Y.2
Kong, D.3
Banerjee, S.4
Ahmad, A.5
Azmi, A.S.6
Ali, S.7
Abbruzzese, J.L.8
Gallick, G.E.9
Sarkar, F.H.10
-
73
-
-
77953523118
-
The role of Notch signaling pathway in epithelial-mesenchymal transition (EMT) during development and tumor aggressiveness
-
Wang, Z.; Li, Y.; Kong, D.; Sarkar, F. H. The role of Notch signaling pathway in epithelial-mesenchymal transition (EMT) during development and tumor aggressiveness. Curr. Drug Targets 2010, 11, 745-751.
-
(2010)
Curr. Drug Targets
, vol.11
, pp. 745-751
-
-
Wang, Z.1
Li, Y.2
Kong, D.3
Sarkar, F.H.4
-
74
-
-
77953541796
-
Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor
-
Saad, S.; Stanners, S. R.; Yong, R.; Tang, O.; Pollock, C. A. Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor. Int. J. Biochem. Cell Biol. 2010, 42, 1115-1122.
-
(2010)
Int. J. Biochem. Cell Biol.
, vol.42
, pp. 1115-1122
-
-
Saad, S.1
Stanners, S.R.2
Yong, R.3
Tang, O.4
Pollock, C.A.5
-
75
-
-
9144246932
-
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation
-
Timmerman, L. A.; Grego-Bessa, J.; Raya, A.; Bertran, E.; Perez-Pomares, J. M.; Diez, J.; Aranda, S.; Palomo, S.; McCormick, F.; Izpisua-Belmonte, J. C.; de la Pompa, J. L. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev. 2004, 18, 99-115.
-
(2004)
Genes Dev.
, vol.18
, pp. 99-115
-
-
Timmerman, L.A.1
Grego-Bessa, J.2
Raya, A.3
Bertran, E.4
Perez-Pomares, J.M.5
Diez, J.6
Aranda, S.7
Palomo, S.8
McCormick, F.9
Izpisua-Belmonte, J.C.10
de la Pompa, J.L.11
-
76
-
-
84859270591
-
Notch signaling mediates TGF-beta1-induced epithelialmesenchymal transition through the induction of Snai1
-
Matsuno, Y.; Coelho, A. L.; Jarai, G.; Westwick, J.; Hogaboam, C. M. Notch signaling mediates TGF-beta1-induced epithelialmesenchymal transition through the induction of Snai1. Int. J. Biochem. Cell Biol. 2012, 44, 776-789.
-
(2012)
Int. J. Biochem. Cell Biol.
, vol.44
, pp. 776-789
-
-
Matsuno, Y.1
Coelho, A.L.2
Jarai, G.3
Westwick, J.4
Hogaboam, C.M.5
-
77
-
-
79957487931
-
Notch-1 induces epithelialmesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
-
Bao, B.; Wang, Z.; Ali, S.; Kong, D.; Li, Y.; Ahmad, A.; Banerjee, S.; Azmi, A. S.; Miele, L.; Sarkar, F. H. Notch-1 induces epithelialmesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells. Cancer Lett. 2011, 307, 26-36.
-
(2011)
Cancer Lett.
, vol.307
, pp. 26-36
-
-
Bao, B.1
Wang, Z.2
Ali, S.3
Kong, D.4
Li, Y.5
Ahmad, A.6
Banerjee, S.7
Azmi, A.S.8
Miele, L.9
Sarkar, F.H.10
-
78
-
-
0036890023
-
Intracellular mRNA localization: Motors move messages
-
Tekotte, H.; Davis, I. Intracellular mRNA localization: motors move messages. Trends Genet. 2002, 18, 636-642.
-
(2002)
Trends Genet.
, vol.18
, pp. 636-642
-
-
Tekotte, H.1
Davis, I.2
-
79
-
-
77956643127
-
Notch1 signaling is mediated by importins alpha 3, 4, and 7
-
Huenniger, K.; Kramer, A.; Soom, M.; Chang, I.; Kohler, M.; Depping, R.; Kehlenbach, R. H.; Kaether, C. Notch1 signaling is mediated by importins alpha 3, 4, and 7. Cell Mol. Life Sci. 2010, 67, 3187-3196.
-
(2010)
Cell Mol. Life Sci.
, vol.67
, pp. 3187-3196
-
-
Huenniger, K.1
Kramer, A.2
Soom, M.3
Chang, I.4
Kohler, M.5
Depping, R.6
Kehlenbach, R.H.7
Kaether, C.8
-
80
-
-
84890442009
-
Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276
-
[Epub ahead of print]
-
Schmidt, J.; Braggio, E.; Kortuem, K. M.; Egan, J. B.; Zhu, Y. X.; Xin, C. S.; Tiedemann, R. E.; Palmer, S. E.; Garbitt, V. M.; McCauley, D.; Kauffman, M.; Shacham, S.; Chesi, M.; Bergsagel, P. L.; Stewart, A. K. Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276. Leukemia 2013. [Epub ahead of print]
-
(2013)
Leukemia
-
-
Schmidt, J.1
Braggio, E.2
Kortuem, K.M.3
Egan, J.B.4
Zhu, Y.X.5
Xin, C.S.6
Tiedemann, R.E.7
Palmer, S.E.8
Garbitt, V.M.9
McCauley, D.10
Kauffman, M.11
Shacham, S.12
Chesi, M.13
Bergsagel, P.L.14
Stewart, A.K.15
-
81
-
-
84880069167
-
CRM1 and BRAF inhibition synergize and induce tumor regression in BRAF mutant melanoma
-
Salas Fragomeni, R. A.; Chung, H. W.; Landesman, Y.; Senapedis, W.; Saint-Martin, J. R.; Tsao, H.; Flaherty, K. T.; Shacham, S.; Kauffman, M.; Cusack, J. C. CRM1 and BRAF inhibition synergize and induce tumor regression in BRAF mutant melanoma. Mol. Cancer Ther. 2013, 12(7), 1171-1179.
-
(2013)
Mol. Cancer Ther.
, vol.12
, Issue.7
, pp. 1171-1179
-
-
Salas Fragomeni, R.A.1
Chung, H.W.2
Landesman, Y.3
Senapedis, W.4
Saint-Martin, J.R.5
Tsao, H.6
Flaherty, K.T.7
Shacham, S.8
Kauffman, M.9
Cusack, J.C.10
-
82
-
-
84891851776
-
CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: Molecular mechanisms and therapeutic implications
-
[Epub ahead of print]
-
Tai, Y. T.; Landesman, Y.; Acharya, C.; Calle, Y.; Zhong, M. Y.; Cea, M.; Tannenbaum, D.; Cagnetta, A.; Reagan, M.; Munshi, A. A.; Senapedis, W.; Saint-Martin, J. R.; Kashyap, T.; Shacham, S.; Kauffman, M.; Gu, Y.; Wu, L.; Ghobrial, I.; Zhan, F.; Kung, A. L.; Schey, S. A.; Richardson, P.; Munshi, N. C.; Anderson, K. C. CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications. Leukemia 2013. [Epub ahead of print]
-
(2013)
Leukemia
-
-
Tai, Y.T.1
Landesman, Y.2
Acharya, C.3
Calle, Y.4
Zhong, M.Y.5
Cea, M.6
Tannenbaum, D.7
Cagnetta, A.8
Reagan, M.9
Munshi, A.A.10
Senapedis, W.11
Saint-Martin, J.R.12
Kashyap, T.13
Shacham, S.14
Kauffman, M.15
Gu, Y.16
Wu, L.17
Ghobrial, I.18
Zhan, F.19
Kung, A.L.20
Schey, S.A.21
Richardson, P.22
Munshi, N.C.23
Anderson, K.C.24
more..
-
83
-
-
84875052270
-
KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia
-
Etchin, J.; Sanda, T.; Mansour, M. R.; Kentsis, A.; Montero, J.; Le, B. T.; Christie, A. L.; McCauley, D.; Rodig, S. J.; Kauffman, M.; Shacham, S.; Stone, R.; Letai, A.; Kung, A. L.; Thomas, L. A. KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. Br. J. Haematol. 2013, 161, 117-127.
-
(2013)
Br. J. Haematol.
, vol.161
, pp. 117-127
-
-
Etchin, J.1
Sanda, T.2
Mansour, M.R.3
Kentsis, A.4
Montero, J.5
Le, B.T.6
Christie, A.L.7
McCauley, D.8
Rodig, S.J.9
Kauffman, M.10
Shacham, S.11
Stone, R.12
Letai, A.13
Kung, A.L.14
Thomas, L.A.15
-
84
-
-
84877601009
-
CRM1 blockade by selective inhibitors of nuclear export attenuates kidney cancer growth
-
Inoue, H.; Kauffman, M.; Shacham, S.; Landesman, Y.; Yang, J.; Evans, C. P.; Weiss, R. H. CRM1 blockade by selective inhibitors of nuclear export attenuates kidney cancer growth. J. Urol. 2013, 189, 2317-2326.
-
(2013)
J. Urol.
, vol.189
, pp. 2317-2326
-
-
Inoue, H.1
Kauffman, M.2
Shacham, S.3
Landesman, Y.4
Yang, J.5
Evans, C.P.6
Weiss, R.H.7
-
85
-
-
85027917385
-
Consensus Induced Fit Docking (cIFD): Methodology, validation, and application to the discovery of novel Crm1 inhibitors
-
Kalid, O.; Toledo, W. D.; Shechter, S.; Sherman, W.; Shacham, S. Consensus Induced Fit Docking (cIFD): methodology, validation, and application to the discovery of novel Crm1 inhibitors. J. Comput. Aided Mol. Des. 2012, 26, 1217-1228.
-
(2012)
J. Comput. Aided Mol. Des.
, vol.26
, pp. 1217-1228
-
-
Kalid, O.1
Toledo, W.D.2
Shechter, S.3
Sherman, W.4
Shacham, S.5
-
86
-
-
84870502798
-
Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia
-
Lapalombella, R.; Sun, Q.; Williams, K.; Tangeman, L.; Jha, S.; Zhong, Y.; Goettl, V.; Mahoney, E.; Berglund, C.; Gupta, S.; Farmer, A.; Mani, R.; Johnson, A. J.; Lucas, D.; Mo, X.; Daelemans, D.; Sandanayaka, V.; Shechter, S.; McCauley, D.; Shacham, S.; Kauffman, M.; Chook, Y. M.; Byrd, J. C. Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia. Blood, 2012, 120, 4621-4634.
-
(2012)
Blood
, vol.120
, pp. 4621-4634
-
-
Lapalombella, R.1
Sun, Q.2
Williams, K.3
Tangeman, L.4
Jha, S.5
Zhong, Y.6
Goettl, V.7
Mahoney, E.8
Berglund, C.9
Gupta, S.10
Farmer, A.11
Mani, R.12
Johnson, A.J.13
Lucas, D.14
Mo, X.15
Daelemans, D.16
Sandanayaka, V.17
Shechter, S.18
McCauley, D.19
Shacham, S.20
Kauffman, M.21
Chook, Y.M.22
Byrd, J.C.23
more..
-
87
-
-
84870887672
-
Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma
-
Zhang, K.; Wang, M.; Tamayo, A. T.; Shacham, S.; Kauffman, M.; Lee, J.; Zhang, L.; Ou, Z.; Li, C.; Sun, L.; Ford, R. J.; Pham, L. V. Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma. Exp. Hematol. 2013, 41, 67-78.
-
(2013)
Exp. Hematol.
, vol.41
, pp. 67-78
-
-
Zhang, K.1
Wang, M.2
Tamayo, A.T.3
Shacham, S.4
Kauffman, M.5
Lee, J.6
Zhang, L.7
Ou, Z.8
Li, C.9
Sun, L.10
Ford, R.J.11
Pham, L.V.12
-
88
-
-
84873570648
-
Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells
-
Etchin, J.; Sun, Q.; Kentsis, A.; Farmer, A.; Zhang, Z. C.; Sanda, T.; Mansour, M. R.; Barcelo, C.; McCauley, D.; Kauffman, M.; Shacham, S.; Christie, A. L.; Kung, A. L.; Rodig, S. J.; Chook, Y. M.; Look, A. T. Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia 2013, 27, 66-74.
-
(2013)
Leukemia
, vol.27
, pp. 66-74
-
-
Etchin, J.1
Sun, Q.2
Kentsis, A.3
Farmer, A.4
Zhang, Z.C.5
Sanda, T.6
Mansour, M.R.7
Barcelo, C.8
McCauley, D.9
Kauffman, M.10
Shacham, S.11
Christie, A.L.12
Kung, A.L.13
Rodig, S.J.14
Chook, Y.M.15
Look, A.T.16
-
89
-
-
84865749132
-
Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia
-
Ranganathan, P.; Yu, X.; Na, C.; Santhanam, R.; Shacham, S.; Kauffman, M.; Walker, A.; Klisovic, R.; Blum, W.; Caligiuri, M.; Croce, C. M.; Marcucci, G.; Garzon, R. Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia. Blood 2012, 120, 1765-1773.
-
(2012)
Blood
, vol.120
, pp. 1765-1773
-
-
Ranganathan, P.1
Yu, X.2
Na, C.3
Santhanam, R.4
Shacham, S.5
Kauffman, M.6
Walker, A.7
Klisovic, R.8
Blum, W.9
Caligiuri, M.10
Croce, C.M.11
Marcucci, G.12
Garzon, R.13
-
90
-
-
0025014776
-
Effects of leptomycin B on the cell cycle of fibroblasts and fission yeast cells
-
Yoshida, M.; Nishikawa, M.; Nishi, K.; Abe, K.; Horinouchi, S.; Beppu, T. Effects of leptomycin B on the cell cycle of fibroblasts and fission yeast cells. Exp. Cell Res. 1990, 187, 150-156.
-
(1990)
Exp. Cell Res.
, vol.187
, pp. 150-156
-
-
Yoshida, M.1
Nishikawa, M.2
Nishi, K.3
Abe, K.4
Horinouchi, S.5
Beppu, T.6
-
91
-
-
0020571348
-
Leptomycins A and B, new antifungal antibiotics. II. Structure elucidation
-
Hamamoto, T.; Seto, H.; Beppu, T. Leptomycins A and B, new antifungal antibiotics. II. Structure elucidation. J. Antibiot. (Tokyo), 1983, 36, 646-650.
-
(1983)
J. Antibiot. (Tokyo)
, vol.36
, pp. 646-650
-
-
Hamamoto, T.1
Seto, H.2
Beppu, T.3
-
92
-
-
0020606355
-
Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization
-
Hamamoto, T.; Gunji, S.; Tsuji, H.; Beppu, T. Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization. J. Antibiot.(Tokyo), 1983, 36, 639-645.
-
(1983)
J. Antibiot.(Tokyo)
, vol.36
, pp. 639-645
-
-
Hamamoto, T.1
Gunji, S.2
Tsuji, H.3
Beppu, T.4
-
93
-
-
0022414531
-
Leptomycins A and B, new antifungal antibiotics. III. Mode of action of leptomycin B on Schizosaccharomyces pombe
-
Hamamoto, T.; Uozumi, T.; Beppu, T. Leptomycins A and B, new antifungal antibiotics. III. Mode of action of leptomycin B on Schizosaccharomyces pombe. J. Antibiot.(Tokyo), 1985, 38, 1573-1580.
-
(1985)
J. Antibiot.(Tokyo)
, vol.38
, pp. 1573-1580
-
-
Hamamoto, T.1
Uozumi, T.2
Beppu, T.3
-
94
-
-
0028318159
-
Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression
-
Nishi, K.; Yoshida, M.; Fujiwara, D.; Nishikawa, M.; Horinouchi, S.; Beppu, T. Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression. J. Biol. Chem. 1994, 269, 6320-6324.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 6320-6324
-
-
Nishi, K.1
Yoshida, M.2
Fujiwara, D.3
Nishikawa, M.4
Horinouchi, S.5
Beppu, T.6
-
95
-
-
0026535704
-
Leptomycin B-induced fixation of X-ray-related potentially lethal damage
-
Sasaki, H.; Yoshida, M.; Beppu, T. Leptomycin B-induced fixation of X-ray-related potentially lethal damage. Radiat. Res. 1992, 129, 163-170.
-
(1992)
Radiat. Res.
, vol.129
, pp. 163-170
-
-
Sasaki, H.1
Yoshida, M.2
Beppu, T.3
-
96
-
-
0029737848
-
Phase I trial of elactocin
-
Newlands, E. S.; Rustin, G. J.; Brampton, M. H. Phase I trial of elactocin. Br. J. Cancer 1996, 74, 648-649.
-
(1996)
Br. J. Cancer
, vol.74
, pp. 648-649
-
-
Newlands, E.S.1
Rustin, G.J.2
Brampton, M.H.3
-
97
-
-
58349104143
-
Identification of nuclear export inhibitors with potent anticancer activity in vivo
-
Mutka, S. C.; Yang, W. Q.; Dong, S. D.; Ward, S. L.; Craig, D. A.; Timmermans, P. B.; Murli, S. Identification of nuclear export inhibitors with potent anticancer activity in vivo. Cancer Res. 2009, 69, 510-517.
-
(2009)
Cancer Res.
, vol.69
, pp. 510-517
-
-
Mutka, S.C.1
Yang, W.Q.2
Dong, S.D.3
Ward, S.L.4
Craig, D.A.5
Timmermans, P.B.6
Murli, S.7
-
98
-
-
84881348592
-
Understanding XPO1 Target Networks Using Systems Biology and Mathematical Modeling
-
[Epub ahead of print]
-
Muqbil, I.; Kauffman, M.; Shacham, S.; Mohammad, R. M.; Azmi, A. S. Understanding XPO1 Target Networks Using Systems Biology and Mathematical Modeling. Curr. Pharm. Des. 2013. [Epub ahead of print].
-
(2013)
Curr. Pharm. Des.
-
-
Muqbil, I.1
Kauffman, M.2
Shacham, S.3
Mohammad, R.M.4
Azmi, A.S.5
-
99
-
-
84879566083
-
Selective inhibitors of nuclear export for the treatment of non-Hodgkin's Lymphomas
-
Azmi, A. S.; Al-Katib, A.; Aboukameel, A.; McCauley, D.; Kauffman, M.; Shacham, S.; Mohammad, R. M. Selective inhibitors of nuclear export for the treatment of non-Hodgkin's Lymphomas. Haematologica 2013, 98(7), 1098-1106.
-
(2013)
Haematologica
, vol.98
, Issue.7
, pp. 1098-1106
-
-
Azmi, A.S.1
Al-Katib, A.2
Aboukameel, A.3
McCauley, D.4
Kauffman, M.5
Shacham, S.6
Mohammad, R.M.7
-
100
-
-
84881323214
-
Selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in mice
-
Azmi, A. S.; Aboukameel, A.; Bao, B.; Sarkar, F. H.; Philip, P. A.; Kauffman, M.; Shacham, S.; Mohammad, R. M. Selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in mice. Gastroenterology 2013, 144, 447-456.
-
(2013)
Gastroenterology
, vol.144
, pp. 447-456
-
-
Azmi, A.S.1
Aboukameel, A.2
Bao, B.3
Sarkar, F.H.4
Philip, P.A.5
Kauffman, M.6
Shacham, S.7
Mohammad, R.M.8
-
101
-
-
0035991607
-
Direct evidence for a role of betacatenin/ LEF-1 signaling pathway in induction of EMT
-
Kim, K., Lu, Z., and Hay, E.D. Direct evidence for a role of betacatenin/ LEF-1 signaling pathway in induction of EMT. Cell Biol. Int. 2002, 26, 463-476.
-
(2002)
Cell Biol. Int.
, vol.26
, pp. 463-476
-
-
Kim, K.1
Lu, Z.2
Hay, E.D.3
-
102
-
-
0035210416
-
New evidence that nuclear import of endogenous beta-catenin is LEF-1 dependent, while LEF-1 independent import of exogenous beta-catenin leads to nuclear abnormalities
-
Kim, K.; Hay, E. D. New evidence that nuclear import of endogenous beta-catenin is LEF-1 dependent, while LEF-1 independent import of exogenous beta-catenin leads to nuclear abnormalities. Cell Biol. Int. 2001, 25, 1149-1161.
-
(2001)
Cell Biol. Int.
, vol.25
, pp. 1149-1161
-
-
Kim, K.1
Hay, E.D.2
|