Akt phosphorylation of BAD couples survival signals to the cell- intrinsic death machinery

Cell

Volumn 91, Issue 2, 1997, Pages 231-241

  Datta, Sandeep Robert ^a   Dudek, Henryk ^a,c   Xu, Tao ^a   Masters, Shane ^b   Haian, Fu ^b   Gotoh, Yukiko ^a   Greenberg, Michael E ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Ontogeny Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; PROTEIN BCL 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0030702123     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80405-5     Document Type: Article

References (57)

1. Ahmed, N.N., Grimes, H.L., Bellacosa, A., Chan, T.O., and Tsichlis, P.N. (1997).Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc. Natl. Acad. Sci. USA 94, 3627-3632.
2. Alessi, D.R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P., and Hemmings, B.A. (1996). Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15, 6541-6551.
3. Alessi, D.R., Caudwell, F.B., Andjelkovic, M., Hemmings, B.A., and Cohen, P. (1996). Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Lett. 399, 333-338.
4. Alessi, D.R., James, S.R., Downes, C.P., Holmes, A.B., Gaffney, P.R., Reese, C.B., and Cohen, P. (1997). Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinaseBα. Curr. Biol. 7, 261-269.
5. Ataliotis, P., and Mercola, M. (1997). Distribution and functions of platelet-derived growth factors and their receptors during embryogenesis. Int. Rev. Cytol. 172, 95-127.
6. Barres, B.A., Schmid, R., Sendnter, M., and Raff, M.C. (1993). Multiple extracellular signals are required for long-term oligodendrocyte survival. Development 118, 283-295.
7. Bellacosa, A., Testa, J.R., Staal, S.P., and Tsichlis, P.N. (1991). A retroviral oncogene, akt, encoding a serine threonine kinase containing an SH2-like region. Science 254, 274-277.
8. Boise, L.H., Gottschalk, A.R., Quintans, J., and Thompson, C.B. (1995). Bcl-2 and Bcl-2-related proteins in apoptosis regulation. Curr. Top. Microbiol. Immunol. 200, 107-121.
9. Burbelo, P.D., and Hall, A. (1995). 14-3-3 proteins. Hot numbers in signal transduction. Curr. Biol. 5, 95-96.
10. Burgering, B.M., and Coffer, P.J. (1995). Protein kinase B (c-Akt) in phosphatidylinosotol-3-OH kinase signal transduction. Nature 376, 599-602.
11. Carpenter, C.L., and Cantley, L.C. (1996). Phosphoinositide kinases. Curr. Opin. Cell Biol. 8, 153-158.
12. Chinnaiyan, A.M., and Dixit, V.M. (1996). The cell-death machine. Curr. Biol. 6, 555-562.
13. Coffer, P.J., and Woodgett, J.R. (1992). Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. Eur. J. Biochem. 205, 1217.
14. Cross, D.A., Alessi, D.R., Cohen, P., Andjelkovich, M., and Hemmings, B. (1995). Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378, 785-789.
15. D'Mello, S.R., Galli, C., Ciotti, T., and Calissano, P. (1993). Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc. Natl. Acad. Sci. USA 90, 10989-10993.
16. D'Mello, S.R., Borodezt, K., and Soltoff, S.P. (1997). Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: possible involvement of PI3-kinase in IGF-1 signaling. J. Neuroscience 17, 1548-1560.
17. Datta, K., Bellacosa, A., Chan, T.O., and Tsichlis, P.N. (1996). Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-Ras in Sf9 and mammalian cells. J. Biol. Chem. 271, 30835-30839.
18. Deckwerth, T.L., Elliot, J.L., Knudson, C.M., Johnson, E.M.J., Snider, W.D., and Korsmeyer, S.J. (1996). BAX is required for neuronal death after trophic factor deprivation and during development. Neuron 17, 401-411.
19. Deshmukh, M., Vasilakos, J., Deckwerth, T.J., Lampe, P.A., Shivers, B.D., and Johnson, E.M.J. (1996). Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases. J. Cell Biol. 135, 1341-1354.
20. Didichenko, S.A., Tilton, B., Hemmings, B.A., Ballmer-Hofer, K., and Thelen, M. (1996). Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane-targeted phosphoinositide 3-kinase. Curr. Biol. 6, 1271-1278.
21. Dudek, H., Datta, S.R., Franke, T.F., Birnbaum, M.J., Yao, R., Cooper, G.M., Segal, R.S., Kaplan, D.R., and Greenberg, M.E. (1997). Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275, 661-665.
22. Franke, T.F., Kaplan, D.R., Cantley, L.C., and Toker, A. (1997). Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275, 665-668.
23. Franke, T.F., Yang, S.I., Chan, T.O., Datta, K., Kazlauskas, A., Morrison, D.K., Kaplan, D.R., and Tsichlis, P.N. (1995). The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidlyinositol 3-kinase. Cell 81, 727-736.
24. Gajewski, T.F., and Thompson, C.B. (1996). Apoptosis meets signal transduction: elimination of a BAD influence. Cell 87, 589-592.
25. Galli, C., Meucci, O., Scorziello, A., Werge, T.M., Calissano, P., and Schettini, G. (1995). Apoptosis in cerebellar granule cells is blocked by high KCl, Forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis. J. Neurosci. 15, 1172-1179.
26. Hack, N., Hidaka, H., Wakefield, M.J., and Balazs, R. (1993). Promotion of granule cell survival by high K+ or excitatory amino acid treatment and Ca+/calmodulin-dependent protein kinase activity. Neurosci. 57, 9-20.
27. Hengartner, M.O., and Horvitz, H.R. (1994). Programmed cell death in Caenorhabditis elegans. Curr. Opin. Genet. Dev. 4, 581-586.
28. Jones, P.F., Jakubowicz, T., and Hemmings, B.A. (1991). Molecular cloning of a second form of rac protein kinase. Cell Reg. 2, 1001-1009.
29. Jones, P.F., Jakubowicz, T., Pitossi, F.J., Maurer, F., and Hemmings, B.A. (1991). Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger family. Proc. Natl. Acad. Sci. USA 88, 4171-4175.
30. Kauffmann-Zeh, A., Rodriguez-Vicana, P., Ulrich, E., Gilbert, C., Coffer, P., Downward, J., and Evan, G. (1997). Suppression of c-Myc-induced apoptosis by Ras signaling through PI (3)K and PKB. Nature 385, 544-548.
31. Kennedy, S.G., Wagner, A.J., Conzen, S.D., Jordan, J., Bellacosa, A., Tsichlis, P.N., and Hay, N. (1997). The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 11, 701-713.
32. Khwaja, A., Rodriguez-Viciana, P., Wennstrom, S., Warne, P.H., and Downward, J. (1997). Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16, 2783-2793.
33. Kuppel, A., Kavanaugh, W.M., Pot, D., and Williams, L.T. (1997). A specific product of phosphatidyinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. Mol. Cell. Biol. 17, 338-344.
34. Kodaki, T., Woscholski, R., Hallberg, B., Rodriguez-Viciana, P., Downward, J., and Parker, R.J. (1994). The activation of phosphatidylinositol 3-kinase by Ras. Curr. Biol. 4, 798-806.
35. Kohn, A.D., Summers, S.A., Mirnbaum, M.J., and Roth, R.A. (1996). Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J. Biol. Chem. 277, 31372-31378.
36. Kohn, A.D., Takeuchi, F., and Roth, R.A. (1996). Akt, a pleckstrin-homology domain containing kinase, is activated primarily by phosphorylation. J. Biol. Chem. 277, 21920-21926.
37. Konishi, H., Kuroda, S., Tanaka, M., Matsuzaki, H., Ono, Y., Kameyama, K., Haga, T., and Kikkawa, U. (1995). Molecular cloning and characterization of a new member of the rac protein kinase family: association of the pleckstrin homology domain of three types of rac protein kinase with protein kinase C subspecies and βγ subunits of G proteins. Biochem. Biophys. Res. Commun. 216, 526-534.
38. Kulik, G., Klippel, A., and Weber, M.J. (1997). Antiapoptotic signaling by the insulin-like growth factor I receptor, phosphatidlyinositol 3-kinase and Akt. Mol. Cell. Biol. 77, 1595-1606.
39. Merry, D.E., and Korsmeyer, S.J. (1997). Bcl-2 gene family in the nervous system. Annu. Rev. Neurosci. 20, 245-267.
40. Meyer-Franke, A., Kaplan, M.R., Pfrieger, F.W., and Barres, B.A. (1995). Characterization of signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture. Neuron 15, 805-819.
41. Miller, T.M., and Johnson, E.M., Jr. (1996). Metabolic and genetic analysis of apoptosis in potassium/serum-deprived rat cerebellar granule cells. J. Neurosci. 16, 7487-7495.
42. Morrison, D. (1994). 14-3-3: modulators of signaling proteins? Science 266, 56-57.
43. Reed, J.C. (1997). Double identity for proteins of the Bcl-2 family. Nature 387, 773-776.
44. Rodriguez-Viciana, P., Warne, P.H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M.J., Waterfield, M.D., and Downward, J. (1994). Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370, 527-532.
45. Rodriguez-Viciana, P., Warne, P.H., Vanhaesebroeck, B., Waterfield, M.D., and Downward, J. (1996). Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. EMBO J. 15, 2442-2451.
46. Rukenstein, A., Rydel, R.E., and Greene, L.A. (1991). Multiple agents rescue PC12 cells from serum-free cell death by translation and transcription-independent mechanisms. J. Neurosci. 11, 2552-2563.
47. Scheid, M.P., Lauener, R.W., and Duronio, V. (1995). Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoetic cells: phosphatidylinositol 3-OH kinase inhibitors reveal a difference in signaling between interleukin-3 and granulocyte-macrophage colony stimulating factor. Biochem. J. 312, 159-162.
48. Segal, R.A., and Greenberg, M.E.(1996). Intracellular signaling pathways activated by neurotrophic factors. Annu. Rev. Neurosci. 19, 463-489.
49. Steller, H. (1995). Mechanisms and genes of cellular suicide. Science 267, 1445-1448.
50. Stewart, C.E., and Rotwein, P. (1996). Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors. Physiol. Rev. 76, 1005-1026.
51. Vemuri, G.S., and McMorris, F.A. (1996). Oligodendrocytes and their precursors require phosphatidylinositol 3-kinase signaling for survival. Development 122, 2529-2537.
52. Wang, H.-G., Rapp, U.R., and Reed, J.C. (1996). Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell 87, 629-638.
53. Xia, Z., Dickens, M., Raingeaud, J., Davis, R.J., and Greenberg, M.E. (1995). Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.
54. Yang, E., Zha, J., Jockel, J., Boise, L.H., Thompson, C.B., and Korsmeyer, S.J. (1995). Bad, a heterodimeric partner for Bcl-xl and Bcl-2, displaces Bax and promotes cell death. Cell 80, 285-291.
55. Yao, R., and Cooper, G.M. (1995). Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267, 2003-2006.
56. Yao, R., and Cooper, G.M. (1996). Growth factor-dependent survival of rodent fibroblasts requires phosphtidylinsitol 3-kinase but is independent of pp70s6k activity. Oncogene 13, 343-351.
57. L. Cell 87, 619-628.