EGCG inhibits the invasion of highly invasive CL1-5 lung cancer cells through suppressing MMP-2 expression via JNK signaling and induces G2/M arrest

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 24, 2011, Pages 13318-13327

  Deng, Yea Tzy ^a   Lin, Jen Kun ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

EGCG; G2 M arrest; lung cancer; metastasis

Indexed keywords

ANTITUMOR EFFECT; CELL CYCLE; CELL INVASION; CELL MIGRATION; CLINICAL DRUGS; CYTOSOLS; DOCETAXEL; DOWN-REGULATION; EGCG; EPIGALLOCATECHIN-3-GALLATE; FLOW CYTOMETRY ANALYSIS; G2/M ARREST; GELATIN ZYMOGRAPHY; GREEN TEA; JUN N-TERMINAL KINASE; LUNG CANCER; LUNG CANCER CELLS; MATRIX METALLOPROTEINASE-2; METASTASIS; METASTATIC POTENTIAL; MRNA EXPRESSION; POLYPHENOLS; POTENT INHIBITOR; TRANSCRIPTIONAL FACTORS; TRANSCRIPTIONAL LEVELS; TUMOR METASTASIS; WESTERN-BLOT ANALYSIS;

CELL DEATH; CELL PROLIFERATION; DISEASES; DRUG PRODUCTS; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; PATHOLOGY; TRANSCRIPTION;

BIOLOGICAL ORGANS;

ANTINEOPLASTIC AGENT; CATECHIN; DRUG DERIVATIVE; EPIGALLOCATECHIN GALLATE; GELATINASE A;

APOPTOSIS; ARTICLE; CANCER INVASION; DRUG EFFECT; ENZYMOLOGY; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENETICS; HUMAN; LUNG TUMOR; M PHASE CELL CYCLE CHECKPOINT; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TEA; TUMOR CELL LINE;

ANTICARCINOGENIC AGENTS; APOPTOSIS; CATECHIN; CELL LINE, TUMOR; G2 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION; HUMANS; LUNG NEOPLASMS; M PHASE CELL CYCLE CHECKPOINTS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; NEOPLASM INVASIVENESS; TEA;

EID: 84255186213     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf204149c     Document Type: Article

References (35)

1. Ji, B. T.; Chow, W. H.; Hsing, A. W.; McLaughlin, J. K.; Dai, Q.; Gao, Y. T.; Blot, W. J.; Fraumeni, J. F., Jr. Green tea consumption and the risk of pancreatic and colorectal cancers Int. J. Cancer 1997, 70, 255-258
2. Yamane, T.; Nakatani, H.; Kikuoka, N.; Matsumoto, H.; Iwata, Y.; Kitao, Y.; Oya, K.; Takahashi, T. Inhibitory effects and toxicity of green tea polyphenols for gastrointestinal carcinogenesis Cancer 1996, 77, 1662-1667
3. Yang, C. S.; Wang, Z. Y. Tea and cancer J. Natl. Cancer Inst. 1993, 85, 1038-1049
4. Dona, M.; Dell'Aica, I.; Calabrese, F.; Benelli, R.; Morini, M.; Albini, A.; Garbisa, S. Neutrophil restraint by green tea: inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis J. Immunol. 2003, 170, 4335-4341
5. Kundu, J. K.; Na, H. K.; Chun, K. S.; Kim, Y. K.; Lee, S. J.; Lee, S. S.; Lee, O. S.; Sim, Y. C.; Surh, Y. J. Inhibition of phorbol ester-induced COX-2 expression by epigallocatechin gallate in mouse skin and cultured human mammary epithelial cells J. Nutr. 2003, 133, 3805S-3810S
6. Roy, M.; Chakrabarty, S.; Sinha, D.; Bhattacharya, R. K.; Siddiqi, M. Anticlastogenic, antigenotoxic and apoptotic activity of epigallocatechin gallate: a green tea polyphenol Mutat. Res. 2003, 523-524, 33-41
7. Li, G. X.; Chen, Y. K.; Hou, Z.; Xiao, H.; Jin, H.; Lu, G.; Lee, M. J.; Liu, B.; Guan, F.; Yang, Z.; Yu, A.; Yang, C. S. Pro-oxidative activities and dose-response relationship of (-)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitro Carcinogenesis 2010, 31, 902-910
8. Milligan, S. A.; Burke, P.; Coleman, D. T.; Bigelow, R. L.; Steffan, J. J.; Carroll, J. L.; Williams, B. J.; Cardelli, J. A. The green tea polyphenol EGCG potentiates the antiproliferative activity of c-Met and epidermal growth factor receptor inhibitors in non-small cell lung cancer cells Clin. Cancer Res. 2009, 15, 4885-4894
9. Shim, J. H.; Su, Z. Y.; Chae, J. I.; Kim, D. J.; Zhu, F.; Ma, W. Y.; Bode, A. M.; Yang, C. S.; Dong, Z. Epigallocatechin gallate suppresses lung cancer cell growth through Ras-GTPase-activating protein SH3 domain-binding protein 1 Cancer Prev. Res. 2010, 3, 670-679
10. Yamauchi, R.; Sasaki, K.; Yoshida, K. Identification of epigallocatechin-3-gallate in green tea polyphenols as a potent inducer of p53-dependent apoptosis in the human lung cancer cell line A549 Toxicol. In Vitro 2009, 23, 834-839
11. Sadava, D.; Whitlock, E.; Kane, S. E. The green tea polyphenol, epigallocatechin-3-gallate inhibits telomerase and induces apoptosis in drug-resistant lung cancer cells Biochem. Biophys. Res. Commun. 2007, 360, 233-237
12. Kweon, M. H.; Adhami, V. M.; Lee, J. S.; Mukhtar, H. Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate J. Biol. Chem. 2006, 281, 33761-33772
13. Hirsch, F. R.; Lippman, S. M. Advances in the biology of lung cancer chemoprevention J. Clin. Oncol. 2005, 23, 3186-3197
14. Brown, J. R.; DuBois, R. N. Cyclooxygenase as a target in lung cancer Clin. Cancer Res. 2004, 10, 4266s-4269s
15. Kim, E. S.; Hong, W. K.; Khuri, F. R. Prevention of lung cancer. The new millennium Chest Surg. Clin. N. Am. 2000, 10, 663-690
16. Noel, A.; Jost, M.; Maquoi, E. Matrix metalloproteinases at cancer tumor-host interface Semin. Cell Dev. Biol. 2008, 19, 52-60
17. Chambers, A. F.; Matrisian, L. M. Changing views of the role of matrix metalloproteinases in metastasis J. Natl. Cancer Inst. 1997, 89, 1260-1270
18. McCawley, L. J.; Matrisian, L. M. Matrix metalloproteinases: multifunctional contributors to tumor progression Mol. Med. Today 2000, 6, 149-156
19. Sternlicht, M. D.; Werb, Z. How matrix metalloproteinases regulate cell behavior Annu. Rev. Cell Dev. Biol. 2001, 17, 463-516
20. Nelson, A. R.; Fingleton, B.; Rothenberg, M. L.; Matrisian, L. M. Matrix metalloproteinases: biologic activity and clinical implications J. Clin. Oncol. 2000, 18, 1135-1149
21. Herbst, R. S.; Yano, S.; Kuniyasu, H.; Khuri, F. R.; Bucana, C. D.; Guo, F.; Liu, D.; Kemp, B.; Lee, J. J.; Hong, W. K.; Fidler, I. J. Differential expression of E-cadherin and type IV collagenase genes predicts outcome in patients with stage I non-small cell lung carcinoma Clin. Cancer Res. 2000, 6, 790-797
22. Vihinen, P.; Kahari, V. M. Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets Int. J. Cancer 2002, 99, 157-166
23. Liotta, L. A.; Abe, S.; Robey, P. G.; Martin, G. R. Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor Proc. Natl. Acad. Sci. U.S.A. 1979, 76, 2268-2272
24. Strongin, A. Y.; Collier, I.; Bannikov, G.; Marmer, B. L.; Grant, G. A.; Goldberg, G. I. Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease J. Biol. Chem. 1995, 270, 5331-5338
25. Ohbayashi, H. Matrix metalloproteinases in lung diseases Curr. Protein Pept. Sci. 2002, 3, 409-421
26. Chu, Y. W.; Yang, P. C.; Yang, S. C.; Shyu, Y. C.; Hendrix, M. J.; Wu, R.; Wu, C. W. Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line Am. J. Respir. Cell Mol. Biol. 1997, 17, 353-360
27. Attiga, F. A.; Fernandez, P. M.; Weeraratna, A. T.; Manyak, M. J.; Patierno, S. R. Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases Cancer Res. 2000, 60, 4629-4637
28. Kuo, W. H.; Yang, S. F.; Chu, S. C.; Lu, S. O.; Chou, F. P.; Hsieh, Y. S. Differential inductions of matrix metalloproteinase-2 and -9 in host tissues during the growth of ascitic sarcoma 180 cells in mice Cancer Lett 2003, 189, 103-112
29. Shivapurkar, N.; Reddy, J.; Chaudhary, P. M.; Gazdar, A. F. Apoptosis and lung cancer: a review J. Cell. Biochem. 2003, 88, 885-898
30. Pages, G.; Milanini, J.; Richard, D. E.; Berra, E.; Gothie, E.; Vinals, F.; Pouyssegur, J. Signaling angiogenesis via p42/p44 MAP kinase cascade Ann. N.Y. Acad. Sci. 2000, 902, 187-200
31. Uchida, C.; Gee, E.; Ispanovic, E.; Haas, T. L. JNK as a positive regulator of angiogenic potential in endothelial cells Cell Biol. Int. 2008, 32, 769-776
32. Boyd, P. J.; Doyle, J.; Gee, E.; Pallan, S.; Haas, T. L. MAPK signaling regulates endothelial cell assembly into networks and expression of MT1-MMP and MMP-2 Am. J. Physiol. 2005, 288, C659-C668
33. Lee, Y. C.; Lin, H. H.; Hsu, C. H.; Wang, C. J.; Chiang, T. A.; Chen, J. H. Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway Eur. J. Pharmacol. 2010, 632, 23-32
34. Sil, H.; Sen, T.; Moulik, S.; Chatterjee, A. Black tea polyphenol (theaflavin) downregulates MMP-2 in human melanoma cell line A375 by involving multiple regulatory molecules J. Environ. Pathol. Toxicol. Oncol. 2010, 29, 55-68
35. Lee, S. J.; Sakurai, H.; Oshima, K.; Kim, S. H.; Saiki, I. Anti-metastatic and anti-angiogenic activities of a new matrix metalloproteinase inhibitor, TN-6b Eur. J. Cancer 2003, 39, 1632-1641